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https://www.readbyqxmd.com/read/29316169/elevated-blood-pressure-during-emergency-departments-visit-is-associated-with-increased-rate-of-hospitalization-for-heart-failure-a-retrospective-cohort-study
#1
Irit Ayalon-Dangur, Yaron Rudman, Tzippy Shochat, Shachaf Shiber, Alon Grossman
There is a limited literature discussing the long-term outcome of patients admitted to the emergency department with elevated blood pressure. The aim of the present study was to evaluate outcomes of patients with hypertension who attended an emergency department. All patients with hypertension who attended an emergency department without target organ damage were evaluated. A composite end point at 18 months, which included all-cause mortality, acute coronary syndrome, cerebrovascular accident, or hospitalization for heart failure, were compared between patients with hypertension and those with normotension...
January 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/18367735/rapid-disuse-atrophy-of-diaphragm-fibers-in-mechanically-ventilated-humans
#2
Sanford Levine, Taitan Nguyen, Nyali Taylor, Michael E Friscia, Murat T Budak, Pamela Rothenberg, Jianliang Zhu, Rajeev Sachdeva, Seema Sonnad, Larry R Kaiser, Neal A Rubinstein, Scott K Powers, Joseph B Shrager
BACKGROUND: The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm. METHODS: We obtained biopsy specimens from the costal diaphragms of 14 brain-dead organ donors before organ harvest (case subjects) and compared them with intraoperative biopsy specimens from the diaphragms of 8 patients who were undergoing surgery for either benign lesions or localized lung cancer (control subjects)...
March 27, 2008: New England Journal of Medicine
https://www.readbyqxmd.com/read/26045965/mechanical-ventilation-of-acute-respiratory-distress-syndrome
#3
REVIEW
Ryoichi Ochiai
Acute respiratory distress syndrome (ARDS) has been intensively and continuously studied in various settings, but its mortality is still as high as 30-40 %. For the last 20 years, lung protective strategy has become a standard care for ARDS, but we still do not know the best way to ventilate patients with ARDS. Tidal volume itself does not seem to have an important role to develop ventilator-induced lung injury (VILI), but the driving pressure, which is inspiratory plateau pressure-PEEP, is the most important to predict and affect the outcome of ARDS, though there is no safe limit for the driving pressure...
2015: Journal of Intensive Care
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