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https://www.readbyqxmd.com/read/27235203/hyperbilirubinemia-in-preterm-neonates
#1
REVIEW
Vinod K Bhutani, Ronald J Wong, David K Stevenson
Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity...
June 2016: Clinics in Perinatology
https://www.readbyqxmd.com/read/27453374/mandatory-closure-versus-nonintervention-for-patent-ductus-arteriosus-in-very-preterm-infants
#2
Se In Sung, Yun Sil Chang, Ji Young Chun, Shin Ae Yoon, Hye Soo Yoo, So Yoon Ahn, Won Soon Park
OBJECTIVE: To determine whether a nonintervention approach for treating hemodynamically significant patent ductus arteriosus (PDA) is associated with decreased mortality and/or morbidity compared with a mandatory closure approach in extremely low birth weight infants. STUDY DESIGN: We reviewed the medical records of 178 infants of 23-26 weeks' gestational age with PDA, requiring ventilator treatment, and with hemodynamically significant PDA ≥2 mm in size. Mandatory closure was used during period I (July 2009 to December 2011, n = 81), and nonintervention was used during period II (January 2012 to June 2014, n = 97)...
October 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27553590/neonatal-hypoglycaemia-learning-from-claims
#3
Jane M Hawdon, Jeanette Beer, Deborah Sharp, Michele Upton
OBJECTIVES: Neonatal hypoglycaemia is a potential cause of neonatal morbidity, and on rare but tragic occasions causes long-term neurodevelopmental harm with consequent emotional and practical costs for the family. The organisational cost to the NHS includes the cost of successful litigation claims. The purpose of the review was to identify themes that could alert clinicians to common pitfalls and thus improve patient safety. DESIGN: The NHS Litigation Authority (NHS LA) Claims Management System was reviewed to identify and review 30 claims for injury secondary to neonatal hypoglycaemia, which were notified to the NHS LA between 2002 and 2011...
August 23, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27576106/total-parenteral-nutrition-for-the-very-low-birth-weight-infant
#4
Pinkal Patel, Jatinder Bhatia
Preterm infants, especially very low birth weight (VLBW; <1500 g) and extremely low birth weight (ELBW; <1000 g) infants, are susceptible to growth failure in postnatal life if nutritional demands are not met. Poor postnatal growth in preterm infants is associated with adverse neurodevelopmental outcomes during childhood. Early parental nutrition is of paramount importance to provide appropriate protein and energy in VLBW infants when enteral nutrition is not feasible or is suboptimal. An "early and aggressive" approach of parenteral nutrition in preterm infants has been shown to prevent protein catabolism, induce positive nitrogen balance and improve postnatal growth...
August 26, 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27603528/zika-virus-what-have-we-learned
#5
Marco Aurélio Palazzi Sáfadi
No abstract text is available yet for this article.
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27603532/mesenchymal-stromal-cell-based-therapies-for-chronic-lung-disease-of-prematurity
#6
Lannae Strueby, Bernard Thébaud
Advances in perinatal care allow the survival of ever more premature infants. By approaching the biological limit of viability, survival free of injury becomes more challenging. As a consequence, bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, remains one of the main complications in infants born before 28 weeks' gestation. Currently, there is no treatment for BPD. Recent progress in understanding the biology of stem cells has opened unprecedented therapeutic options to mitigate lung injury and promote lung growth...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27603534/patent-ductus-arteriosus-and-short-and-long-term-respiratory-outcomes
#7
Eduardo Bancalari
The patency of the ductus arteriosus is very common in extremely premature infants. The increased pulmonary blood flow that results from left-to-right ductal shunting can produce an acute deterioration in lung function and some data suggest that it may increase the risk of chronic lung damage. However, there is no clear evidence that prophylactic or early closure of the patent ductus arteriosus (PDA) results in a clear reduction in bronchopulmonary dysplasia. For this reason, and because of the side effects of the available therapies to close the ductus, there is a wide variation in the approach to the PDA in this population and most clinicians will intervene to close the ductus only in cases of significant shunt with hemodynamic decompensation...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27603538/newborn-critical-congenital-heart-disease-screening-using-pulse-oximetry-nursing-aspects
#8
Lisa A Hom, Gerard R Martin
Congenital heart disease (CCHD) is the most common birth defect. Screening for the most critical forms (CCHD) using pulse oximetry was added to the Recommended Uniform Screening Panel in the United States in 2011. Since then, CCHD screening has become nearly universal in the United States. Nurses are ideally situated to contribute to the development of best practices for implementation and provide education to families on CCHD screening. Much of the standardization, advocacy, and development of national recommendations occurred with key input from nurses...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27603539/mechanisms-of-lung-injury-and-bronchopulmonary-dysplasia
#9
Alan H Jobe
Although bronchopulmonary dysplasia (BPD) is the most frequent adverse outcome for infants born at < 30 weeks gestational age, there remain major gaps in understanding the pathophysiology, and thus there are few effective targeted therapies to prevent and treat BPD. This review will focus on the substantial problems and knowledge gaps for the clinician and investigator when considering lung injury and BPD. The epidemiology of BPD is clear: BPD is a lung injury syndrome predominantly in extremely low-birth-weight infants with an incidence that increases as gestation/birth weight decrease, with growth restriction, in males and with fetal exposures and with injury from postdelivery respiratory care...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27603540/neonatal-transfusion-practice-when-do-neonates-need-red-blood-cells-or-platelets
#10
Antonio Del Vecchio, Caterina Franco, Flavia Petrillo, Gabriele D'Amato
Based on small studies and not on statistically valid clinical trials, guidelines for neonatal transfusions remain controversial and practices vary greatly. Premature infants and critically ill neonates in the neonatal intensive care unit (NICU) often require blood transfusions and extremely preterm neonates receive at least one red blood cell transfusion during their hospital stay. Transfusions to neonates convey both benefits and risks and consequently it is imperative to establish specific guidelines to improve practice and avoid unnecessary transfusions...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27788532/umbilical-artery-lactate-correlates-with-brain-lactate-in-term-infants
#11
Alison G Cahill, George A Macones, Christopher D Smyser, Julia D López, Terrie E Inder, Amit M Mathur
Objective The objective of this study was to determine the correlation between umbilical artery lactate with brain lactate in nonanomalous term infants. Study Design We performed a nested case-control study within an on-going prospective cohort of more than 8,000 consecutive singleton term (≥ 37 weeks) nonanomalous infants. Neonates underwent cerebral magnetic resonance imaging (MRI) within the first 72 hours of life. Cases (umbilical artery pH ≤ 7.10) were gender and race matched 1:3 to controls (umbilical artery pH > 7...
October 27, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27788534/acute-appendicitis-in-pregnancy-predictive-clinical-factors-and-pregnancy-outcomes
#12
Lauren H Theilen, Vincent M Mellnick, Anthony L Shanks, Methodius G Tuuli, Anthony O Odibo, George A Macones, Alison G Cahill
Objective The objective of this study was to identify clinical factors predictive of appendicitis in pregnant women and associated obstetric outcomes. Study Design We performed a single-center, retrospective cohort study of pregnant women who underwent magnetic resonance imaging for suspected appendicitis from 2007 to 2012. Rates and odds of appendicitis based on presenting signs and symptoms were estimated. We also estimated rates and odds of adverse obstetric outcomes among women with a diagnosis of appendicitis...
October 27, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27426911/docosahexaenoic-acid-and-arachidonic-acid-nutrition-in-early-development
#13
REVIEW
Susan E Carlson, John Colombo
No abstract text is available yet for this article.
August 2016: Advances in Pediatrics
https://www.readbyqxmd.com/read/27740976/patent-ductus-arteriosus-in-the-preterm-infant-diagnostic-and-treatment-options
#14
Stephanie Prescott, Jessica Keim-Malpass
BACKGROUND: The incidence of hemodynamically significant patent ductus arteriosus (hsPDA) increases with decreasing gestational age and is associated with many common morbidities of extreme prematurity. Controversies remain surrounding the definition of hsPDA, the population of infants requiring treatment, the appropriate timing and method of treatment, and the outcomes associated with PDA and its therapies. PURPOSE: This integrative literature review focuses on diagnostic and treatment recommendations derived from the highest levels of evidence...
October 8, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27322828/cooling-effect-on-skin-microcirculation-in-asphyxiated-newborn-infants-with-increased-c-reactive-protein
#15
Siv Fredly, Cathrine S Nygaard, Janne H Skranes, Tom Stiris, Drude Fugelseth
BACKGROUND: Therapeutic hypothermia is presumed to suppress inflammatory processes after perinatal asphyxia. In a previous study of neonatal hypoxic-ischemic encephalopathy (HIE) we found altered skin microcirculation in about a third of the infants after rewarming. We speculated whether this could be linked to increased inflammatory responses, such as high C-reactive protein (CRP). The present study further explored this question. OBJECTIVE: The aim of this study was to explore the differences in skin microcirculation and its oxygen delivery ability during cooling and after rewarming in HIE infants with or without high CRP...
2016: Neonatology
https://www.readbyqxmd.com/read/27260974/the-role-of-antenatal-corticosteroids-in-twin-pregnancies-complicated-by-preterm-birth
#16
Nir Melamed, Jyotsna Shah, Eugene W Yoon, Ermelinda Pelausa, Shoo K Lee, Prakesh S Shah, Kellie E Murphy
BACKGROUND: Data regarding the effects of antenatal corticosteroids in twin pregnancies are limited because of the insufficient number of women with twins enrolled in randomized controlled trials on antenatal corticosteroids. Furthermore, the interpretation of available data is limited by the fact that the interval from the administration of antenatal corticosteroids to delivery is greater than 7 days in a large proportion of twins, a factor that has been shown to affect the efficacy of antenatal corticosteroids and has not been controlled for in previous studies...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27354382/non-invasive-high-frequency-oscillatory-ventilation-in-neonates-review-of-physiology-biology-and-clinical-data
#17
Daniele De Luca, Valentina Dell'Orto
Non-invasive high-frequency oscillatory ventilation (NHFOV) consists of the application of a bias flow generating a continuous distending positive pressure with superimposed oscillations, which have constant frequency and active expiratory phase. NHFOV matches together the advantages of high-frequency ventilation (no need for synchronisation, high efficacy in removing CO2) and nasal continuous positive airway pressure (CPAP) (non-invasive interface, increase in functional residual capacity allowing oxygenation to improve)...
June 28, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27388500/newborn-resuscitation-training-in-resource-limited-settings-a-systematic-literature-review
#18
REVIEW
Jonathan Reisman, Lauren Arlington, Lloyd Jensen, Henry Louis, Daniela Suarez-Rebling, Brett D Nelson
CONTEXT: Birth asphyxia contributes substantially to neonatal mortality in low- and middle-income countries (LMICs). The effects of training birth attendants in neonatal resuscitation (NR) on mortality are limited by falloff of skills and knowledge over time and transference of learned skills into clinical practice. OBJECTIVE: This review examined acquisition and retention of NR knowledge and skills by birth attendants in LMICs and the effectiveness of interventions to improve them...
August 2016: Pediatrics
https://www.readbyqxmd.com/read/27464032/prematurity
#19
Ben H Lee, Istvan Seri
No abstract text is available yet for this article.
August 1, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/23765172/a-standardized-nutrition-approach-for-very-low-birth-weight-neonates-improves-outcomes-reduces-cost-and-is-not-associated-with-increased-rates-of-necrotizing-enterocolitis-sepsis-or-mortality
#20
COMPARATIVE STUDY
T J Butler, L J Szekely, J L Grow
OBJECTIVE: To assess how a standard practice for nutrition support in very low birth weight (VLBW) neonates would impact on their hospital course. STUDY DESIGN: This was a prospective, single center, before vs after comparison of a non-standardized approach to nutrition in VLBW neonates to a standardized approach. Standardization of feeding initiation, feeding volume and caloric advancement, management of feeding aspirates (residuals), use of starter parenteral nutrition (PN), use of breast milk and donor breast milk, initiation and discontinuation of intravenous (IV) intralipids, documentation of protein use, and utilization of percutaneously inserted central venous catheters were performed...
November 2013: Journal of Perinatology: Official Journal of the California Perinatal Association
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