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CCR Highlights

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15 papers 0 to 25 followers
Wenju Chang, Ye Wei, Li Ren, Yunshi Zhong, Yiyi Yu, Jingwen Chen, Dexiang Zhu, Lechi Ye, Chunzhi Qin, Naiqing Zhao, Weixin Niu, Xinyu Qin, Jianmin Xu
OBJECTIVES: The optimal time to initiate adjuvant chemotherapy after surgery in patients with colon cancer is not clear. We investigated the benefit of combined intraportal chemotherapy administered during radical surgery with adjuvant chemotherapy for treating stage II and III colon cancer. METHODS: Patients were randomly assigned to OCTREE arm (intraportal chemotherapy plus mFOLFOX6) or a standard adjuvant chemotherapy arm (mFOLFOX6). The primary study endpoint was disease-free survival...
March 2016: Annals of Surgery
Sung Uk Bae, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
BACKGROUND: The treatment strategy and benefit of extended lymph node dissection among patients with preoperatively diagnosed paraaortic lymph node metastasis (PALNM) in colon cancer remains highly controversial. In the current study, we analyzed the oncologic outcomes of patients who underwent extraregional lymph node dissection for colon cancer with isolated PALNM. METHODS: From March 2000 to December 2009, the study group included 1082 patients who underwent curative surgery for colonic adenocarcinoma with pathological lymph node metastasis...
May 2016: Annals of Surgical Oncology
Anne K Danielsen, Jennifer Park, Jens E Jansen, David Bock, Stefan Skullman, Anette Wedin, Adiela Correa Marinez, Eva Haglind, Eva Angenete, Jacob Rosenberg
OBJECTIVE: The objective was to study morbidity and mortality associated with early closure (8-13 days) of a temporary stoma compared with standard procedure (closure after > 12 weeks) after rectal resection for cancer. BACKGROUND: A temporary ileostomy may reduce the risk of pelvic sepsis after anastomotic dehiscence. However, the temporary ileostomy is afflicted with complications and requires a second surgical procedure (closure) with its own complications...
June 17, 2016: Annals of Surgery
Karyn A Goodman
Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision has been the standard of care for locally advanced patients with rectal cancer. Some patients achieve a pathologic complete response (pCR) to CRT and the oncologic outcomes are particularly favorable in this group. The role of surgery in patients with a pCR is now being questioned as radical rectal resection is associated with significant morbidity and long-term effects on quality of life. In an attempt to better tailor therapy, there is an interest in a "watch-and-wait" approach in patients who have a clinical complete response (cCR) after CRT with the goal of omitting surgery and allowing for organ preservation...
July 2016: Seminars in Radiation Oncology
Mira D Franken, Miriam Koopman, Martijn G H van Oijen
No abstract text is available yet for this article.
April 2016: American Journal of Clinical Oncology
Guillaume Passot, Yun Shin Chun, Scott E Kopetz, Daria Zorzi, Kristoffer Watten Brudvik, Bradford J Kim, Claudius Conrad, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: In patients with bilateral colorectal liver metastases (CLM) not resectable in 1 operation, 2-stage hepatectomy is the standard surgical approach. The objective of this study was to determine factors associated with safety and efficacy of 2-stage hepatectomy. STUDY DESIGN: The study included all 109 patients for whom 2-stage hepatectomy for CLM was planned during 2003 to 2014. The RAS mutation status and other clinicopathologic factors were evaluated for association with major complications and survival using multivariate analysis...
July 2016: Journal of the American College of Surgeons
Samuel A Käser, Diana Mattiello, Christoph A Maurer
PURPOSE: The aim of this study was to investigate whether metastatic colorectal cancer (Union for International Cancer Control stage IV disease) represents a risk factor for anastomotic leakage after colorectal surgery without major hepatic resection. METHODS: This retrospective cohort study was based on an existing prospective colorectal database of all consecutive colorectal resections undertaken at the authors' institution from July 2002 to July 2012 (n = 2104)...
March 2016: Annals of Surgical Oncology
Nicola de'Angelis, Salah Alghamdi, Andrea Renda, Daniel Azoulay, Francesco Brunetti
BACKGROUND: Robotic surgery for transverse colon cancer has rarely been described. This study reports our initial experience in robotic resection for transverse colon cancer, by comparing robotic transverse colectomy (RC) to laparoscopic transverse colectomy (LC) in terms of safety, feasibility, short-term outcomes, and the surgeon's psychological stress and physical pain. METHODS: The study population included the first 22 consecutive patients who underwent RC between March 2013 and December 2014 for histologically confirmed transverse colon adenocarcinoma...
2015: World Journal of Surgical Oncology
Marwan G Fakih
Substantial improvements have been made in the management of metastatic colorectal cancer over the last two decades. The overall survival of patients diagnosed with unresectable metastatic colorectal cancer has increased from approximately 1 year during the era of fluoropyrimidine monotherapy to more than 30 months with the integration of multiple cytotoxic agents and targeted therapies. More effective therapeutic combinations have increased the rate of curative-intent surgical resections, resulting in median survival in this subgroup that exceed 5 years...
June 1, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
J Lerut, A Foss
No abstract text is available yet for this article.
December 2015: British Journal of Surgery
Ane L Appelt, John Pløen, Henrik Harling, Frank S Jensen, Lars H Jensen, Jens C R Jørgensen, Jan Lindebjerg, Søren R Rafaelsen, Anders Jakobsen
BACKGROUND: Abdominoperineal resection is the standard treatment for patients with distal T2 or T3 rectal cancers; however, the procedure is extensive and mutilating, and alternative treatment strategies are being investigated. We did a prospective observational trial to assess whether high-dose radiotherapy with concomitant chemotherapy followed by observation (watchful waiting) was successful for non-surgical management of low rectal cancer. METHODS: Patients with primary, resectable, T2 or T3, N0-N1 adenocarcinoma in the lower 6 cm of the rectum were given chemoradiotherapy (60 Gy in 30 fractions to tumour, 50 Gy in 30 fractions to elective lymph node volumes, 5 Gy endorectal brachytherapy boost, and oral tegafur-uracil 300 mg/m(2)) every weekday for 6 weeks...
August 2015: Lancet Oncology
Renato M Lupinacci, Julie Agostini, Mircea Chirica, Pierre Balladur, Najim Chafaï, Yann Parc, Emmanuel Tiret, François Paye
BACKGROUND: Stoma reversal can be performed during liver resection (LR) in patients with colorectal liver metastases (CRCLM) whose primary colorectal tumor has been previously resected with a diverting loop ileostomy. This combined procedure is reputed to be associated with an increased morbidity. This study investigates the impact of simultaneous loop ileostomy closure (LIC) on the postoperative outcome of LR for CRCLM. METHODS: From November 1996 to April 2012, 408 patients who underwent LR for CRCLM were retrospectively studied from a prospective database...
September 2015: American Journal of Surgery
Brice Malgras, Laura Brullé, Réa Lo Dico, Fatima El Marjou, Sylvie Robine, Amu Therwath, Marc Pocard
BACKGROUND: Colonic self-expanding metallic stents (SEMS) are used in obstructive colorectal cancer patients as a bridge to surgery. However, its oncologic safety remains uncertain. Therefore, we attempted to clarify this further with an experimental study and constructed a mouse model of colonic cancer. METHODS: CT26 cells were injected in the rectal wall, and to mimic SEMS, a cardiac stent was inserted under endoscopy in occlusive (75 % lumen occlusion) tumors...
December 2015: Annals of Surgical Oncology
Matthew D Hall, Timothy E Schultheiss, David D Smith, Marwan G Fakih, Joseph Kim, Jeffrey Y C Wong, Yi-Jen Chen
PURPOSE: Current guidelines recommend that a minimum of 12 lymph nodes (LNs) be dissected to accurately stage rectal cancer patients. Neoadjuvant chemoradiation therapy (CRT) decreases the number of LNs retrieved at surgery. The purpose of this study was to assess the impact of the number of LNs dissected on overall survival (OS) for localized rectal cancer patients treated with neoadjuvant CRT. METHODS: Treatment data were obtained on all patients treated for rectal cancer (2000-2013) in the National Oncology Data Alliance™, a proprietary database of merged tumor registries...
December 2015: Annals of Surgical Oncology
John Primrose, Stephen Falk, Meg Finch-Jones, Juan Valle, Derek O'Reilly, Ajith Siriwardena, Joanne Hornbuckle, Mark Peterson, Myrddin Rees, Tim Iveson, Tamas Hickish, Rachel Butler, Louise Stanton, Elizabeth Dixon, Louisa Little, Megan Bowers, Siân Pugh, O James Garden, David Cunningham, Tim Maughan, John Bridgewater
BACKGROUND: Surgery for colorectal liver metastases results in an overall survival of about 40% at 5 years. Progression-free survival is increased with the addition of oxaliplatin and fluorouracil chemotherapy. The addition of cetuximab to these chemotherapy regimens results in an overall survival advantage in patients with advanced disease who have the KRAS exon 2 wild-type tumour genotype. We aimed to assess the benefit of addition of cetuximab to standard chemotherapy in patients with resectable colorectal liver metastasis...
May 2014: Lancet Oncology
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