collection
MENU ▼
Read by QxMD icon Read
search

TPH

shared collection
4 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26230954/pd-1-hi-tim-3-t-cells-associate-with-and-predict-leukemia-relapse-in-aml-patients-post-allogeneic-stem-cell-transplantation
#1
Y Kong, J Zhang, D F Claxton, W C Ehmann, W B Rybka, L Zhu, H Zeng, T D Schell, H Zheng
Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain 3 (TIM-3). To evaluate whether T-cell exhaustion and inhibitory pathways are involved in leukemia relapse post alloSCT, we performed phenotypic and functional studies on T cells from peripheral blood of acute myeloid leukemia patients receiving alloSCT...
July 31, 2015: Blood Cancer Journal
https://www.readbyqxmd.com/read/26185947/late-onset-epstein-barr-virus-related-disease-in-acute-leukemia-patients-after-haploidentical-hematopoietic-stem-cell-transplantation-is-associated-with-impaired-early-recovery-of-t-and-b-lymphocytes
#2
Jiangying Liu, Chenhua Yan, Chunli Zhang, Lanping Xu, Yanrong Liu, Xiaojun Huang
Epstein-Barr virus-related disease (EBVD) is a serious clinical complication in patients who have undergone haploidentical hematopoietic stem cell transplantation (haploHSCT). Some recipients develop EBVD relatively late after haploHSCT, and most of these patients suffer a poor outcome. This retrospective cohort study characterized the early adaptive immune recovery of patients with acute leukemia presenting with EBVD more than 100 d after haploHSCT. Patients with acute leukemia who received haploHSCT and developed EBVD 100 d later (n = 8) were compared with a matched control group without EBVD (n = 24) with regard to peripheral WBC, lymphocytes, and neutrophils (at 30, 60, and 90 d) and recoveries of B and T lymphocytes (at 30 and 90 d, via immunophenotyping/flow cytometry)...
October 2015: Clinical Transplantation
https://www.readbyqxmd.com/read/25642761/hematopoietic-sct-in-europe-2013-recent-trends-in-the-use-of-alternative-donors-showing-more-haploidentical-donors-but-fewer-cord-blood-transplants
#3
MULTICENTER STUDY
J R Passweg, H Baldomero, P Bader, C Bonini, S Cesaro, P Dreger, R F Duarte, C Dufour, J H F Falkenburg, D Farge-Bancel, A Gennery, N Kröger, F Lanza, A Nagler, A Sureda, M Mohty
A record number of 39,209 HSCT in 34,809 patients (14,950 allogeneic (43%) and 19,859 autologous (57%)) were reported by 658 centers in 48 countries to the 2013 survey. Trends include: more growth in allogeneic than in autologous HSCT, increasing use of sibling and unrelated donors and a pronounced increase in haploidentical family donors when compared with cord blood donors for those patients without a matched related or unrelated donor. Main indications were leukemias, 11,190 (32%; 96% allogeneic); lymphoid neoplasias, 19,958 (57%; 11% allogeneic); solid tumors, 1543 (4%; 4% allogeneic); and nonmalignant disorders, 1975 (6%; 91% allogeneic)...
April 2015: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/25634742/mir-29a-maintains-mouse-hematopoietic-stem-cell-self-renewal-by-regulating-dnmt3a
#4
Wenhuo Hu, James Dooley, Stephen S Chung, Dhruva Chandramohan, Luisa Cimmino, Siddhartha Mukherjee, Christopher E Mason, Bart de Strooper, Adrian Liston, Christopher Y Park
Hematopoietic stem cells (HSCs) possess the ability to generate all hematopoietic cell types and to self-renew over long periods, but the mechanisms that regulate their unique properties are incompletely understood. Herein, we show that homozygous deletion of the miR-29a/b-1 bicistron results in decreased numbers of hematopoietic stem and progenitor cells (HSPCs), decreased HSC self-renewal, and increased HSC cell cycling and apoptosis. The HSPC phenotype is specifically due to loss of miR-29a, because miR-29b expression is unaltered in miR-29a/b-1-null HSCs, and only ectopic expression of miR-29a restores HSPC function both in vitro and in vivo...
April 2, 2015: Blood
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"