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CKD Progression

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150 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28288579/the-cost-effectiveness-of-using-chronic-kidney-disease-risk-scores-to-screen-for-early-stage-chronic-kidney-disease
#1
Benjamin O Yarnoff, Thomas J Hoerger, Siobhan K Simpson, Alyssa Leib, Nilka R Burrows, Sundar S Shrestha, Meda E Pavkov
BACKGROUND: Better treatment during early stages of chronic kidney disease (CKD) may slow progression to end-stage renal disease and decrease associated complications and medical costs. Achieving early treatment of CKD is challenging, however, because a large fraction of persons with CKD are unaware of having this disease. Screening for CKD is one important method for increasing awareness. We examined the cost-effectiveness of identifying persons for early-stage CKD screening (i.e., screening for moderate albuminuria) using published CKD risk scores...
March 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/27401688/the-substantial-loss-of-nephrons-in-healthy-human-kidneys-with-aging
#2
Aleksandar Denic, John C Lieske, Harini A Chakkera, Emilio D Poggio, Mariam P Alexander, Prince Singh, Walter K Kremers, Lilach O Lerman, Andrew D Rule
Nephron number may be an important determinant of kidney health but has been difficult to study in living humans. We evaluated 1638 living kidney donors at Mayo Clinic (MN and AZ sites) and Cleveland Clinic. We obtained cortical volumes of both kidneys from predonation computed tomography scans. At the time of kidney transplant, we obtained and analyzed the sections of a biopsy specimen of the cortex to determine the density of both nonsclerotic and globally sclerotic glomeruli; the total number of glomeruli was estimated from cortical volume×glomerular density...
January 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28223468/high-ambulatory-arterial-stiffness-index-is-an-independent-risk-factor-for-rapid-age-related-glomerular-filtration-rate-decline-in-the-general-middle-aged-population
#3
Bjørn Odvar Eriksen, Vidar Tor Nyborg Stefansson, Trond Geir Jenssen, Ulla Dorte Mathisen, Jørgen Schei, Marit Dahl Solbu, Tom Wilsgaard, Toralf Melsom
Arterial stiffness is a risk factor for cardiovascular and chronic kidney disease. However, the role of arterial stiffness as a predictor of the age-related glomerular filtration rate (GFR) decline in the general population remains unresolved because of difficulty in measuring GFR with sufficient precision in epidemiological studies. The ambulatory arterial stiffness index (AASI) is a proposed indicator of arterial stiffness easily calculated from ambulatory blood pressure. We investigated whether AASI could predict GFR decline measured as iohexol clearance in the general population...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28236138/progression-of-kidney-disease-in-elderly-stage-3-and-4-chronic-kidney-disease-patients
#4
Pradeep Arora, Kabir Jalal, Anu Gupta, Randolph L Carter, James W Lohr
PURPOSE: The prevalence of chronic kidney disease (CKD) has been rising steadily in the elderly population. We studied the rate of progression of CKD in this population and the factors associated with progression of CKD to better identify patients who are likely to progress to ESRD. METHODS: This was an observational study including 4562 patients older than 65 years with two outpatient estimated glomerular filtration rates (eGFRs) of <60 ml/min/1.73 m(2), at least 90 days apart with no intervening eGFR >60 ml/min/1...
February 24, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28241912/end-stage-renal-disease-outcomes-among-the-kaiser-permanente-southern-california-creatinine-safety-program-creatinine-surenet-opportunities-to-reflect-and-improve
#5
John J Sim, Michael Batech, Kim N Danforth, Mark P Rutkowski, Steven J Jacobsen, Michael H Kanter
OBJECTIVES: The Kaiser Permanente Southern California (KPSC) creatinine safety program (Creatinine SureNet) identifies and outreaches to thousands of people annually who may have had a missed diagnosis for chronic kidney disease (CKD). We sought to determine the value of this outpatient program and evaluate opportunities for improvement. METHODS: Longitudinal cohort study (February 2010 through December 2015) of KPSC members captured into the creatinine safety program who were characterized using demographics, laboratory results, and different estimations of glomerular filtration rate...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28253839/effectiveness-of-integrated-care-on-delaying-progression-of-stage-3-4-chronic-kidney-disease-in-rural-communities-of-thailand-escort-study-a-cluster-randomized-controlled-trial
#6
Teerayuth Jiamjariyapon, Atiporn Ingsathit, Krit Pongpirul, Kotcharat Vipattawat, Suphattra Kanchanakorn, Akhathai Saetie, Duangjit Kanistanon, Patimaporn Wongprompitak, Vinai Leesmidt, Watcharapong Watcharasaksilp, Wei Wang, Anil K Chandraker, Kriang Tungsanga
BACKGROUND: In developing countries, renal specialists are scarce and physician-to-patient contact time is limited. While conventional hospital-based, physician-oriented approach has been the main focus of chronic kidney disease (CKD) care, a comprehensive multidisciplinary health care program (Integrated CKD Care) has been introduced as an alternate intervention to delay CKD progression in a community population. The main objective is to assess effectiveness of Integrated CKD Care in delaying CKD progression...
March 2, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28224265/effect-of-serum-albumin-on-the-prognosis-of-elderly-patients-with-stage-3-4-chronic-kidney-disease
#7
Hongru Fan, Jihong Yang, Lili Liu, Yu Qiao, Meng Wang, Lei Qiu, Hong Shi, Huan Xi, Yao Wang
OBJECTIVE: To investigate the influence of serum albumin on the prognosis of elderly patients with stage 3-4 chronic kidney disease (CKD). METHODS: From July 2013 to November 2015, elderly CKD patients (≥60 years), with eGFR ≥15 mL/min/1.73 m(2) and <60 mL/min/1.73 m(2), with CKD stage 3-4 in the geriatric nephrology clinic were enrolled. General information and underlying diseases were recorded. Laboratory indices were evaluated. Composite endpoint events (CEE) including renal endpoint events, cardiocerebral vascular endpoint events, and death were elucidated...
February 21, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28240304/association-of-renal-elasticity-and-renal-function-progression-in-patients-with-chronic-kidney-disease-evaluated-by-real-time-ultrasound-elastography
#8
Hugo You-Hsien Lin, Yu-Li Lee, Kun-Der Lin, Yi-Wen Chiu, Shyi-Jang Shin, Shang-Jyh Hwang, Hung-Chun Chen, Chi-Chih Hung
Glomerulosclerosis and tubulointerstitial fibrosis are associated with lower renal parenchymal elasticity. This study was designed to evaluate the predictive ability of renal elasticity in patients with chronic kidney disease (CKD). 148 non-CKD patients and 227 patients with CKD were recruited. 145 (38.7%) were female, 166 (73.1%) had diabetes, the mean estimated glomerular filtration rate (eGFR) was 33.9 ± 15.8 ml/min/1.73 m(2) and the median urinary protein-to-creatinine ratio (UPCR) 502 (122-1491) mg/g...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196649/diabetes-control-and-the-risks-of-esrd-and-mortality-in%C3%A2-patients%C3%A2-with-ckd
#9
Sankar D Navaneethan, Jesse D Schold, Stacey E Jolly, Susana Arrigain, Wolfgang C Winkelmayer, Joseph V Nally
BACKGROUND: Diabetes is the leading cause of end-stage renal disease (ESRD) and a significant contributor to mortality in the general population. We examined the associations of hemoglobin A1c (HbA1c) levels with ESRD and death in a population with diabetes and chronic kidney disease (CKD). STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: 6,165 patients with diabetes (treated with oral hypoglycemic agents and/or insulin) and CKD stages 1 to 5 at a large health care system...
February 10, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28195182/prognostic-significance-of-left-ventricular-mass-index-and-renal-function-decline-rate-in-chronic-kidney-disease-g3-and-g4
#10
Jiun-Chi Huang, Szu-Chia Chen, Yi-Chun Tsai, I-Ching Kuo, Yi-Wen Chiu, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
The effect of left ventricular mass index (LVMI) and estimated glomerular filtration rate (eGFR) decline rate on outcome prediction in patients with chronic kidney disease (CKD) remains unclear. We included 306 CKD G3 and G4 patients with LVMI assessed through echocardiography. Rapid decline in renal function was defined as the eGFR slope <-3 mL/min/1.73 m(2)/year. Patients were stratified into four groups using sex-specific median values of LVMI and rapid eGFR decline. The composite outcome was progression to maintenance dialysis or death...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28186540/early-low-dose-erythropoiesis-stimulating-agent-therapy-and-progression-of-moderate-chronic-kidney-disease-a-randomized-placebo-controlled-trial
#11
Danilo Fliser, Frank Dellanna, Michael Koch, Alfons Wiggenhauser
No abstract text is available yet for this article.
February 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28187985/a-systematic-review-and-meta-analysis-suggests-obesity-predicts-onset-of-chronic-kidney-disease-in-the-general-population
#12
Carlo Garofalo, Silvio Borrelli, Roberto Minutolo, Paolo Chiodini, Luca De Nicola, Giuseppe Conte
Obesity and chronic kidney disease (CKD) are public health priorities that share core pathophysiological mechanisms. However, whether high body mass index (BMI) increases risk of CKD de novo remains ill-defined. To evaluate the role of BMI in predicting CKD onset in the general adult population, we performed a systematic review and meta-analysis of PubMed and ISI Web of Science databases articles published between January 2000 and August 2016 without language restriction. We selected studies in adult individuals from a general population with normal renal function at baseline that reported the risk of low estimated glomerular filtration (eGFR) (under 60 mL/min/1...
February 7, 2017: Kidney International
https://www.readbyqxmd.com/read/28152653/chronic-kidney-disease-progression-a-retrospective-analysis-of-3-year-adherence-to-a-low-protein-diet
#13
Felipe Rizzetto, Viviane de Oliveira Leal, Leonardo Soares Bastos, Denis Fouque, Denise Mafra
The potential benefits and dangers of dietary protein restriction in chronic kidney disease (CKD) are still controversial. Thus, the aim of this study is to evaluate the effect of low protein diet (LPD) on the renal function in nondialysis CKD patients. A retrospective study was conducted from 321 nondialysis CKD patient's medical files (65.1 ± 12.7 yrs, 58.2% men). These patients received individualized dietary protein prescription (0.6-0.8 g protein/kg/day). Protein intake was evaluated by food diary and 24 h-food recall...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28148896/investigated-the-safety-of-intra-renal-arterial-transfusion-of-autologous-cd34-cells-and-time-courses-of-creatinine-levels-endothelial-dysfunction-biomarkers-and-micro-rnas-in-chronic-kidney-disease-patients-phase-i-clinical-trial
#14
Mel S Lee, Fan-Yen Lee, Yung-Lung Chen, Pei-Hsun Sung, Hsin-Ju Chiang, Kuan-Hung Chen, Tien-Hung Huang, Yi-Ling Chen, John Y Chiang, Tsung-Cheng Yin, Hsueh-Wen Chang, Hon-Kan Yip
This was a phase I clinical trial to investigate the safety of autologous peripheral-blood-derived CD34+ cell therapy for patients with chronic kidney disease (CKD-treatment) (i.e., at Stages III and IV). Between November 2014 and October 2015, a total of 10 study patients were prospectively enrolled into this phase I trial. Patients who failed to enroll into the trial in the initial state of eligibility assessment were served as CKD-control group (n = 9). The health-control group was composed of 10 volunteers for the purposes of comparing (1) circulation level of endothelial progenitor cells (EPCs), (2) angiogenesis ability, and (3) anti-apoptotic miRNAs between healthy subjects and CKD patients...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28147348/the-association-between-biomarker-profiles-etiology-of-chronic-kidney-disease-and-mortality
#15
David Langsford, Mila Tang, Hicham I Cheikh Hassan, Ognjenka Djurdjev, Manish M Sood, Adeera Levin
BACKGROUND: Prognosis in chronic kidney disease (CKD) for adverse outcomes differs substantially based on the etiology of CKD. We examined whether the biomarker profile differed based on CKD etiology and whether they were associated with mortality. METHODS: Prospective observational study of 1,157 patients, 663 with diabetic kidney disease (DKD), 273 with glomerulonephritis (GN), and 221 with cystic/interstitial disease (polycystic kidney disease, pyelonephritis or chronic tubulointerstitial nephritis [PCK/TIN]) were identified in the Canadian Study of Prediction of Dialysis, Death and Interim Cardiovascular events over Time cohort...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28143672/echocardiographic-measures-and-estimated-gfr-decline-among-african-americans-the-jackson-heart-study
#16
Leila R Zelnick, Ronit Katz, Bessie A Young, Adolfo Correa, Bryan R Kestenbaum, Ian H de Boer, Nisha Bansal
BACKGROUND: Cardiac structural abnormalities, common in African Americans, are associated with adverse clinical outcomes. Associations between echocardiography-measured subclinical heart failure and kidney function decline are unknown and may identify novel risk factors for kidney disease in this population. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 2,418 Jackson Heart Study participants with baseline echocardiograms and longitudinal measures of estimated glomerular filtration rate (eGFR) calculated from the CKD-EPI creatinine equation...
January 28, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28090763/sodium-and-fluid-management-in-the-conservative-management-of-chronic-kidney-disease
#17
Morgan Marcuccilli, Jessica Kendrick, Michel Chonchol
Chronic kidney disease (CKD) imposes a significant global health burden. In the United States, one in three adults are at risk for CKD currently affecting over 28 million Americans. While several studies have demonstrated the benefit of treating traditional risk factors in CKD, including hypertension with pharmacologic agents such as blockade of the renin-angiotensin system (RAAS), there is scarce data on the advantages of sodium and fluid management in this population. Both experimental and observational studies have shown improvement in hypertension and cardiovascular outcomes with sodium restriction to ≤2...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28123142/investigation-of-metabolic-factors-associated-with-egfr-decline-over-1-year-in-a-japanese-population-without-ckd
#18
Kaori Hayashi, Michiyo Takayama, Takayuki Abe, Takeshi Kanda, Hiroshi Hirose, Ryoko Shimizu-Hirota, Eisuke Shiomi, Yasushi Iwao, Hiroshi Itoh
AIM: Early intervention before the progression of chronic kidney disease (CKD) is essential to prevent end-stage renal disease (ESRD) and cardiovascular complications. This study evaluated the correlation between metabolic and lifestyle-related factors and the decline of estimated glomerular filtration rate (eGFR) over 1 year in a Japanese population without CKD. METHODS: Subjects who received two consecutive annual health checkups from 2013 to 2015 were involved...
January 26, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28131398/recombinant-%C3%AE-klotho-may-be-prophylactic-and-therapeutic-for-acute-to-chronic-kidney-disease-progression-and-uremic-cardiomyopathy
#19
Ming Chang Hu, Mingjun Shi, Nancy Gillings, Brianna Flores, Masaya Takahashi, Makoto Kuro-O, Orson W Moe
α-Klotho is highly expressed in the kidney, and its extracellular domain is cleaved and released into the circulation. Chronic kidney disease (CKD) is a state of α-Klotho deficiency, which exerts multiple negative systemic effects on numerous organs including the cardiovascular system. Since acute kidney injury (AKI) greatly escalates the risk of CKD development, we explored the effect of α-Klotho on prevention and treatment on post-AKI to CKD progression and cardiovascular disease. Therein, ischemia reperfusion injury-induced AKI was followed by early administration of recombinant α-Klotho or vehicle starting one day and continued for four days after kidney injury (CKD prevention protocol)...
January 25, 2017: Kidney International
https://www.readbyqxmd.com/read/28126239/renal-morphology-clinical-findings-and-progression-rate-in-mesoamerican-nephropathy
#20
Julia Wijkström, Marvin González-Quiroz, Mario Hernandez, Zulma Trujillo, Kjell Hultenby, Anneli Ring, Magnus Söderberg, Aurora Aragón, Carl-Gustaf Elinder, Annika Wernerson
BACKGROUND: Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting rural inhabitants in Central America. We have previously described the renal morphology in 8 patients from El Salvador. To confirm the renal pathology, we have studied kidney biopsies from patients with MeN in Nicaragua. Follow-up urine and blood samples from both biopsy studies were collected to investigate the natural history. STUDY DESIGN: Case series. SETTINGS & PARTICIPANTS: In the kidney biopsy study, 19 male sugarcane workers in Nicaragua with suspected MeN were investigated with questionnaires, kidney biopsies, and blood and urine analysis...
January 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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