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CKD Progression

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328 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Piotr Kuczera, Katarzyna Kwiecień, Marcin Adamczak, Teresa Bączkowska, Jolanta Gozdowska, Katarzyna Madziarska, Hanna Augustyniak-Bartosik, Marian Klinger, Magdalena Durlik, Eberhard Ritz, Andrzej Wiecek
BACKGROUND/AIMS: Arterial hypertension is one of the leading factors aggravating the course of chronic kidney disease (CKD). It seems that the novel parameters used in the assessment of the blood pressure (BP) load (i.e. central blood pressure, nighttime blood pressure) may be more precise in predicting the cardiovascular risk and the progression of CKD in comparison with the traditional peripheral blood pressure measurements in the office conditions. The aim of the study was to assess the impact of the central, or nighttime blood pressure on the progression of CKD in patients with mild or no-proteinuria (autosomal, dominant polycystic kidney disease or IgA nephropathy)...
2018: Kidney & Blood Pressure Research
Simone Vettoretti, Lara Caldiroli, Francesca Zanoni, Valeria Azzini, Anna Villarini, Roberto Meazza, Piergiorgio Messa
BACKGROUND/AIMS: In patients with chronic kidney disease (CKD) strict blood pressure (BP) control is reno-protective. However, renal benefits from BP control might depend also on the etiology of CKD. We investigated if maintenance of BP at target is equally effective in subjects with hypertensive nephropathy (HN+) and in those with other nephropathies (HN-). METHODS: We evaluated 148 patients with CKD (stages 3-5) in two visits at least 12 months apart. BP was measured both as office BP and 24h ambulatory blood pressure (ABP)...
November 23, 2018: Kidney & Blood Pressure Research
Lesley A Inker, Hiddo L Heerspink
No abstract text is available yet for this article.
December 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jeroen P Kooman, Len A Usvyat, Marijke J E Dekker, Dugan W Maddux, Jochen G Raimann, Frank M van der Sande, Xiaoling Ye, Yuedong Wang, Peter Kotanko
Patients with end-stage renal disease (ESRD) experience unique patterns in their lifetime, such as the start of dialysis and renal transplantation. In addition, there is also an intricate link between ESRD and biological time patterns. In terms of cyclic patterns, the circadian blood pressure (BP) rhythm can be flattened, contributing to allostatic load, whereas the circadian temperature rhythm is related to the decline in BP during hemodialysis (HD). Seasonal variations in BP and interdialytic-weight gain have been observed in ESRD patients in addition to a profound relative increase in mortality during the winter period...
November 16, 2018: Blood Purification
Pietro E Cippà, Bo Sun, Jing Liu, Liang Chen, Maarten Naesens, Andrew P McMahon
BACKGROUND: The molecular understanding of the progression from acute to chronic organ injury is limited. Ischemia/reperfusion injury (IRI) triggered during kidney transplantation can contribute to progressive allograft dysfunction. METHODS: Protocol biopsies (n = 163) were obtained from 42 kidney allografts at 4 time points after transplantation. RNA sequencing-mediated (RNA-seq-mediated) transcriptional profiling and machine learning computational approaches were employed to analyze the molecular responses to IRI and to identify shared and divergent transcriptional trajectories associated with distinct clinical outcomes...
November 15, 2018: JCI Insight
Carl P Walther, Maulin Shah, Sankar D Navaneethan
No abstract text is available yet for this article.
November 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Kei Sugiyama, Tsutomu Inoue, Eito Kozawa, Masahiro Ishikawa, Akira Shimada, Naoki Kobayashi, Junji Tanaka, Hirokazu Okada
Background: Although chronic hypoxia and fibrosis may be a key to the progression of chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet available. Here, using blood oxygen level-dependent (BOLD) and diffusion-weighted (DW) magnetic resonance imaging (MRI), we assessed changes in renal tissue oxygenation and fibrosis, respectively, and evaluated their correlation with prognosis for renal function. Methods: The study was conducted under a single-center, longitudinal, retrospective observational design...
November 12, 2018: Nephrology, Dialysis, Transplantation
Bingjuan Yan, Xiaole Su, Boyang Xu, Xi Qiao, Lihua Wang
BACKGROUND: Dietary protein restriction has long been thought to play an important role in the progression of chronic kidney disease (CKD); however, the effect of dietary protein on the rate of decline in kidney function remains controversial. OBJECTIVE: We undertook a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the influence of protein restriction on chronic kidney disease. METHOD: Ovid MEDLINE (from 1946 to March 5, 2016), EMBASE (from 1966 to March 5, 2016), and the Cochrane Library (Inception to March 5, 2016) were searched to identify RCTs comparing different levels of protein intake for at least 24 weeks in adult patients with CKD...
2018: PloS One
Radmila Žeravica, Branislava Ilinčić, Velibor Čabarkapa, Isidora Radosavkić, Jelena Samac, Katarina Nikoletić, Zoran Stošić
AIM: Elevated fractional excretion of magnesium (FEMg) is a noninvasive biomarker of kidney damage, but its association with kidney functional parameters in nondiabetic chronic kidney disease (CKD) patients has not been sufficiently explored thus far. METHODS: We enrolled 111 adult patients with nondiabetic CKD and 30 controls. To precisely investigate kidney function, the following parameters were assessed measured glomerular filtration rate (mGFR), effective renal plasma flow (ERPF), Cystatin C, albuminuria, and fractional excretion of magnesium (FEMg)...
May 1, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Bjørn O Eriksen, Silje Småbrekke, Trond G Jenssen, Ulla D Mathisen, Jon V Norvik, Jørgen Schei, Henrik Schirmer, Marit D Solbu, Vidar T N Stefansson, Toralf Melsom
The decline in glomerular filtration rate (GFR) associated with aging is one of the most important predisposing causes of kidney failure in old age. Identifying persons at risk for accelerated GFR decline is an essential first step in the development of preventive measures to preserve kidney function in the elderly. Heart rate (HR) has not yet been studied as a risk factor for GFR decline in the general population. In the RENIS-T6 (Renal Iohexol-Clearance Survey in Tromsø 6), we measured baseline ambulatory HR and GFR as iohexol clearance in a representative, middle-aged cohort of 1627 persons without self-reported diabetes mellitus, cardiovascular disease, or kidney disease...
September 2018: Hypertension
Shinji Machida, Yugo Shibagaki, Tsutomu Sakurada
BACKGROUND: Chronic kidney disease (CKD) is a significant health problem in Japan, and prevention programs to slow disease progression are necessary. In this study, we evaluated the effectiveness of a 1-week inpatient education program, delivered during the predialysis stage of CKD, in slowing the deterioration in renal function over the subsequent 2 years, and identified factors influencing the program's effectiveness. METHODS: We retrospectively evaluated the estimated glomerular filtration rate (eGFR) of 105 consecutive patients who completed the program, at the following time points: 6 months prior to program initiation, at program initiation and, at 6, 12, 18, and 24 months after the program...
October 19, 2018: Clinical and Experimental Nephrology
Yoshihiko Imamura, Yasunori Takahashi, Toshihide Hayashi, Masateru Iwamoto, Rie Nakamura, Mikiko Goto, Kazuyo Takeba, Makoto Shinohara, Shun Kubo, Nobuhiko Joki
BACKGROUND: Comprehensive education about lifestyle, nutrition, medications and other types of treatment is important to prevent renal dysfunction in patients with chronic kidney disease (CKD). However, the effectiveness of multidisciplinary care on CKD progression has not been evaluated in detail. We aimed to determine whether multidisciplinary care at our hospital could help prevent worsening renal function associated with CKD. METHODS: A total of 150 pre-dialysis CKD outpatients accompanied (n = 68) or not (n = 82) with diabetes mellitus (DM) were enrolled into this study...
October 19, 2018: Clinical and Experimental Nephrology
Gesine F C Weckmann, Sylvia Stracke, Annekathrin Haase, Jacob Spallek, Fabian Ludwig, Aniela Angelow, Jetske M Emmelkamp, Maria Mahner, Jean-François Chenot
BACKGROUND: Chronic kidney disease (CKD) is age-dependent and has a high prevalence in the general population. Most patients are managed in ambulatory care. This systematic review provides an updated overview of quality and content of international clinical practice guidelines for diagnosis and management of non-dialysis CKD relevant to patients in ambulatory care. METHODS: We identified guidelines published from 2012-to March 2018 in guideline portals, databases and by manual search...
October 11, 2018: BMC Nephrology
Megumi Oshima, Tadashi Toyama, Masakazu Haneda, Kengo Furuichi, Tetsuya Babazono, Hiroki Yokoyama, Kunitoshi Iseki, Shinichi Araki, Toshiharu Ninomiya, Shigeko Hara, Yoshiki Suzuki, Masayuki Iwano, Eiji Kusano, Tatsumi Moriya, Hiroaki Satoh, Hiroyuki Nakamura, Miho Shimizu, Akinori Hara, Hirofumi Makino, Takashi Wada
BACKGROUND: According to studies by the National Kidney Foundation and Food and Drug Administration, 30% and 40% declines in estimated glomerular filtration rate (eGFR) could be used as surrogate endpoints of end-stage renal disease (ESRD). However, the benefits of using these endpoints in diabetic patients remain unclear. METHODS: This cohort study comprised Japanese patients with type 2 diabetes; those with repeated serum creatinine measurements during a baseline period of 2 years (n = 1868) or 3 years (n = 2001) were enrolled...
2018: PloS One
Stephen Zewinger, Thomas Rauen, Michael Rudnicki, Giuseppina Federico, Martina Wagner, Sarah Triem, Stefan J Schunk, Ioannis Petrakis, David Schmit, Stefan Wagenpfeil, Gunnar H Heine, Gert Mayer, Jürgen Floege, Danilo Fliser, Hermann-Josef Gröne, Thimoteus Speer
BACKGROUND: The individual course of CKD may vary, and improved methods for identifying which patients will experience short-term eGFR loss are needed. Assessing urinary Dickkopf-3 (DKK3), a stress-induced tubular epithelia-derived profibrotic glycoprotein, may provide information about ongoing tubulointerstitial fibrosis and short-term eGFR loss. METHODS: To investigate urinary DKK3's potential as a biomarker of short-term eGFR loss (over 12 months), we prospectively assessed eGFR and urinary DKK3 levels in patients with CKD of various etiologies at baseline and annual follow-ups...
November 2018: Journal of the American Society of Nephrology: JASN
Rafael Santamaría, Juan M Díaz-Tocados, M Victoria Pendón-Ruiz de Mier, Ana Robles, M Dolores Salmerón-Rodríguez, Erena Ruiz, Noemi Vergara, Escolástico Aguilera-Tejero, Ana Raya, Rosa Ortega, Arnold Felsenfeld, Juan R Muñoz-Castañeda, Alejandro Martín-Malo, Pedro Aljama, Mariano Rodríguez
In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2-3 patients, we evaluated whether increased phosphaturia accelerates CKD progression...
September 12, 2018: Scientific Reports
Ilaria Petrucci, Anna Clementi, Concetto Sessa, Irene Torrisi, Mario Meola
Chronic kidney disease (CKD) includes all clinical features and complications during the progression of various kidney conditions towards end-stage renal disease (ESRD). These conditions include immune and inflammatory disease such as: primary and hepatitis C virus (HCV)-related glomerulonephritis; infectious disease such as pyelonephritis with or without reflux and tuberculosis; vascular disease such as chronic ischemic nephropathy; hereditary and congenital disease such as polycystic disease and congenital cystic dysplasia; metabolic disease including diabetes and hyperuricemia; and systemic disease (collagen disease, vasculitis, myeloma)...
December 2018: Journal of Nephrology
Dadi Helgason, Thorir E Long, Solveig Helgadottir, Runolfur Palsson, Gisli H Sigurdsson, Tomas Gudbjartsson, Olafur S Indridason, Ingibjorg J Gudmundsdottir, Martin I Sigurdsson
BACKGROUND: We studied the incidence and risk factors of acute kidney injury (AKI) following coronary angiography (CA) and examined short- and long-term outcomes of patients who developed AKI, including progression of chronic kidney disease (CKD). METHODS: This was a retrospective study of all patients undergoing CA in Iceland from 2008 to 2015, with or without percutaneous coronary intervention. All procedures were performed with iso-osmolar contrast. AKI was defined according to the SCr component of the KDIGO criteria...
October 2018: Journal of Nephrology
Yuichi Maruta, Takeshi Hasegawa, Etsuko Yamakoshi, Hiroki Nishiwaki, Fumihiko Koiwa, Enyu Imai, Akira Hishida
BACKGROUND: Metabolic acidosis, which reduces serum bicarbonate levels, contributes to the progression of chronic kidney disease (CKD). The difference between sodium and chloride (Na-Cl) may theoretically predict serum bicarbonate levels. This study aimed to evaluate serum Na-Cl level as a risk factor for renal function decline among patients who participated in the chronic kidney disease Japan cohort (CKD-JAC) study. METHODS: The association between low Na-Cl concentration (< 34 mmol/L) and composite renal function decline events (any initiation of renal replacement therapy or 50% decline in estimated glomerular filtration rate) was evaluated among 2143 patients with CKD stage G3a-4...
August 24, 2018: Clinical and Experimental Nephrology
Kubra Esmeray, Oguzhan Sıtkı Dizdar, Selahattin Erdem, Ali İhsan Gunal
OBJECTIVE: The aim of this study was to examine the effect of volume status on the progressions of renal disease in normovolemic and hypervolemic patients with advanced non-dialysis-dependent chronic kidney disease (CKD) who were apparently normovolemic in conventional physical exam-ination. MATERIALS AND METHODS: This was a prospective interventional study performed in a group of stage 3-5 CKD patients followed up for 1 year. Three measurements were made for volume and renal status for every patient...
2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
2018-08-29 12:16:54
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