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CKD Progression

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Hugh C Rayner, Steven Jay Rosansky
No abstract text is available yet for this article.
July 2018: Kidney International
C Yang, J W Wang, Y Z Yang, K H Bai, B X Gao, M H Zhao, L X Zhang, S L Wu, F Wang
OBJECTIVE: To explore the association between anemia and cardiovascular disease and all-cause mortality among diabetic patients, and whether the association is modified by the presence of chronic kidney disease (CKD). METHODS: Physical examination data of 8 563 patients with diabetes who met the inclusion and exclusion criteria between 2010 and 2011 were collected, based on the prospective cohort data of Kailuan study. The deadline of the follow-up was December 31, 2015, and the endpoints comprised all-cause mortality and cardiovascular disease...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Alan S Go, Jingrong Yang, Thida C Tan, Claudia S Cabrera, Bergur V Stefansson, Peter J Greasley, Juan D Ordonez
BACKGROUND: Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether factors associated with fast progression vary by diabetes status is also not well understood. We examined a large community-based cohort of adults with CKD to identify predictors of fast progression during the first 2 years of follow-up in the presence or absence of diabetes mellitus...
June 22, 2018: BMC Nephrology
Moin A Saleem
Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945-953] it has been found that there is a link between suPAR and renal disease in several guises, and a key question is whether it is a driver or a marker of renal disease, and if so of which types of kidney damage. Subject of Review: Circulating suPAR has been postulated to cause acute proteinuric kidney disease, specifically focal segmental glomerulosclerosis (FSGS), though both the animal models and clinical data in the original reports have been challenged...
June 15, 2018: Nephron
Valerie A Luyckx, Marcello Tonelli, John W Stanifer
Kidney disease has been described as the most neglected chronic disease. Reliable estimates of the global burden of kidney disease require more population-based studies, but specific risks occur across the socioeconomic spectrum from poverty to affluence, from malnutrition to obesity, in agrarian to post-industrial settings, and along the life course from newborns to older people. A range of communicable and noncommunicable diseases result in renal complications and many people who have kidney disease lack access to care...
June 1, 2018: Bulletin of the World Health Organization
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. METHODS: We analyzed 8717 subjects with normal renal function recruited from the KoGES cohort. Based on food frequency questionnaire, coffee consumption was categorized into five groups: 0/week, <1 cup/week, 1-6 cups/week, 1 cup/day, and ≥2 cups/day...
June 12, 2018: American Journal of Medicine
Anthony Fenton, Mark D Jesky, Rachel Webster, Stephanie J Stringer, Punit Yadav, Iain Chapple, Indranil Dasgupta, Stephen J Harding, Charles J Ferro, Paul Cockwell
BACKGROUND: Patients with chronic kidney disease (CKD) are at an increased risk of developing end-stage renal disease (ESRD). We assessed for the first time whether urinary free light chains (FLC) are independently associated with risk of ESRD in patients with CKD, and whether they offer incremental value in risk stratification. MATERIALS AND METHODS: We measured urinary FLCs in 556 patients with CKD from a prospective cohort study. The association between urinary kappa/creatinine (KCR) and lambda/creatinine (LCR) ratios and development of ESRD was assessed by competing-risks regression (to account for the competing risk of death)...
2018: PloS One
Raymond Vanholder, Steven Van Laecke, Griet Glorieux, Francis Verbeke, Esmeralda Castillo-Rodriguez, Alberto Ortiz
The uremic syndrome, which is the clinical expression of chronic kidney disease (CKD), is a complex amalgam of accelerated aging and organ dysfunctions, whereby cardio-vascular disease plays a capital role. In this narrative review, we offer a summary of the current conservative (medical) treatment options for cardio-vascular and overall morbidity and mortality risk in CKD. Since the progression of CKD is also associated with a higher cardio-vascular risk, we summarize the interventions that may prevent the progression of CKD as well...
June 12, 2018: Toxins
Laurence Black, Jeremie M Lever, Amie M Traylor, Bo Chen, Zhengqin Yang, Stephanie Esman, Yanlin Jiang, Gary Cutter, Ravindra Boddu, James George, Anupam Agarwal
Chronic kidney disease (CKD) is a condition with significant morbidity and mortality that affects 15% of adults in the United States. One cause of CKD is acute kidney injury (AKI), which commonly occurs secondary to sepsis, ischemic events, and drug-induced nephrotoxicity. Unilateral ischemia-reperfusion injury (UIRI) without contralateral nephrectomy (CLN) and repeated low dose cisplatin (RLDC) models of AKI to CKD demonstrate responses characteristic of the transition; however, previous studies have not effectively compared the pathogenesis...
June 13, 2018: American Journal of Physiology. Renal Physiology
Priya Vart, Morgan E Grams, Shoshana H Ballew, Mark Woodward, Josef Coresh, Kunihiro Matsushita
Background: There is strong evidence of an association between socioeconomic status (SES) and end-stage renal disease (ESRD). However, the association of SES with the risk of chronic kidney disease (CKD) and the rate of change in kidney function is unclear. Methods: A cohort of 14 086 participants with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 at baseline in the Atherosclerosis Risk in Communities study (1987-89) were studied. The association of annual household income, educational attainment and neighborhood deprivation with incident ESRD, incident CKD and change in eGFR using four measurements over ∼23 years was assessed...
June 11, 2018: Nephrology, Dialysis, Transplantation
Christopher McCudden, Ayub Akbari, Christine A White, Mohan Biyani, Swapnil Hiremath, Pierre Antoine Brown, Navdeep Tangri, Scott Brimble, Greg Knoll, Peter G Blake, Manish M Sood
The Kidney Failure Risk Equation (KFRE) predicts the need for dialysis or transplantation using age, sex, estimated glomerular filtration rate (eGFR), and urine albumin to creatinine ratio (ACR). The eGFR and ACR have known biological and analytical variability. We examined the effect of biological and analytical variability of eGFR and ACR on the 2-year KFRE predicted kidney failure probabilities using single measure and the average of repeat measures of simulated eGFR and ACR. Previously reported values for coefficient of variation (CV) for ACR and eGFR were used to calculate day to day variability...
2018: PloS One
Derek K Ng, Anthony A Portale, Susan L Furth, Bradley A Warady, Alvaro Muñoz
PURPOSE: Coefficients of determination (R2 ) for continuous longitudinal data are typically reported as time constant, if they are reported at all. The widely used mixed model with random intercepts and slopes yields the total outcome variance as a time-varying function. We propose a generalized and intuitive approach based on this variance function to estimate the time-varying predictive power (R2 ) of a variable on outcome levels and changes. METHODS: Using longitudinal estimated glomerular filtration rate (eGFR) from the Chronic Kidney Disease in Children Study, linear mixed models characterized the R2 for two chronic kidney disease (CKD) risk factors measured at baseline: a traditional marker (proteinuria) and a novel marker (fibroblast growth factor 23 [FGF23])...
May 17, 2018: Annals of Epidemiology
Haitian Liu, Zhangjian Zhou, Xiang Li, Chenxia Li, Rong Wang, Yuelang Zhang, Gang Niu
OBJECTIVE: To evaluate stages of chronic kidney disease (CKD) by apparent diffusion coefficient (ADC) obtained from diffusion weighted imaging (DWI) using a meta-analysis. METHODS: Literature databases were searched from PubMed, Web of Science, Cochrane and Embase to identify relevant articles about DWI in CKD between 1999 and 2017. ADC values were extracted from the healthy group and CKD patients with different stages. Meta-analysis was conducted using STATA version 12...
June 11, 2018: British Journal of Radiology
Joshua D Bundy, Lydia A Bazzano, Dawei Xie, Janet Cohan, Jacqueline Dolata, Jeffrey C Fink, Chi-Yuan Hsu, Kenneth Jamerson, James Lash, Gail Makos, Susan Steigerwalt, Xue Wang, Katherine T Mills, Jing Chen, Jiang He
BACKGROUND AND OBJECTIVES: Previous studies suggest that tobacco, alcohol, and illicit drug use is associated with CKD. We examined the associations of substance use with CKD progression and all-cause mortality among patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Chronic Renal Insufficiency Cohort Study is a prospective, longitudinal cohort study among 3939 participants with CKD in the United States. Self-reported tobacco smoking, alcohol drinking, marijuana use, and hard illicit drug (cocaine, heroin, or methamphetamine) use were obtained at baseline and annual follow-up visits...
June 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Cynthia J Janmaat, Merel van Diepen, Cheyenne Ce van Hagen, Joris I Rotmans, Friedo W Dekker, Olaf M Dekkers
Purpose: Substantial heterogeneity exists in reported kidney function decline in pre-dialysis chronic kidney disease (CKD). By design, kidney function decline can be studied in CKD 3-5 cohorts or dialysis-based studies. In the latter, patients are selected based on the fact that they initiated dialysis, possibly leading to an overestimation of the true underlying kidney function decline in the pre-dialysis period. We performed a systematic review and meta-analysis to compare the kidney function decline during pre-dialysis in CKD stage 3-5 patients, in these two different study types...
2018: Clinical Epidemiology
Serena Low, Xiao Zhang, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Keven Kue Loong Ang, Wern Ee Tang, Pek Yee Kwan, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim
AIM: Glomerular hyperfiltration usually occurs early in development of kidney complications in diabetes. To understand hyperfiltration as a marker of renal disease progression in type 2 diabetes mellitus, we aimed to examine association between glomerular hyperfiltration (estimated glomerular filtration rate ⩾ 120 mL/min/1.73 m2 ) and rapid renal decline (annual estimated glomerular filtration rate loss ⩾ 3 mL/min/1.73 m2 ). METHODS: This was a prospective cohort comprising 1014 patients with type 2 diabetes mellitus attending a Diabetes Centre of a regional hospital in 2002-2014...
May 1, 2018: Diabetes & Vascular Disease Research
Bethany Warren, Casey M Rebholz, Yingying Sang, Alexandra K Lee, Josef Coresh, Elizabeth Selvin, Morgan E Grams
OBJECTIVE: Long-term kidney disease trajectories in persons with and without diabetes in a general population are largely uncharacterized. RESEARCH DESIGN AND METHODS: We classified 15,517 participants in the community-based Atherosclerosis Risk in Communities (ARIC) study by diabetes status at baseline (1987-1989; no diabetes, undiagnosed diabetes, and diagnosed diabetes). We used linear mixed models with random intercepts and slopes to quantify estimated glomerular filtration rate (eGFR) trajectories at four visits over 26 years...
June 1, 2018: Diabetes Care
Yusuke Sakaguchi, Takayuki Hamano, Yoshitaka Isaka
Experimental and clinical studies have demonstrated that magnesium deficiency leads to hypertension, insulin resistance, and endothelial dysfunction, and is associated with an increased risk of cardiovascular events. Given that cardiovascular disease and CKD share similar risk factors, the low magnesium status may also contribute to CKD progression. In fact, lower serum magnesium levels and lower dietary magnesium intake are associated with an increased risk of incident CKD and progression to end-stage kidney disease...
May 2018: Advances in Chronic Kidney Disease
Shakia T Hardy, Donglin Zeng, Abhijit V Kshirsagar, Anthony J Viera, Christy L Avery, Gerardo Heiss
While much of the chronic kidney disease (CKD) literature focuses on the role of blood pressure reduction in delaying CKD progression, little is known about the benefits of modest population-wide decrements in blood pressure on incident CKD. The authors used multivariable linear regression to characterize the impact on incident CKD of two approaches for blood pressure management: (1) a 1-mm Hg reduction in systolic BP across the entire study population; and (2) a 10% reduction in participants with unaware, untreated, and uncontrolled BP above goal as defined by the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) thresholds...
May 23, 2018: Journal of Clinical Hypertension
Esteban A Cedillo-Couvert, Ana C Ricardo, Jinsong Chen, Janet Cohan, Michael J Fischer, Marie Krousel-Wood, John W Kusek, Swati Lederer, Eva Lustigova, Akinlolu Ojo, Anna C Porter, Lisa K Sharp, James Sondheimer, Clarissa Diamantidis, Xue Wang, Jason Roy, James P Lash
Introduction: In the general population, medication nonadherence contributes to poorer outcomes. However, little is known about medication adherence among adults with chronic kidney disease (CKD). We evaluated the association of self-reported medication adherence with CKD progression and all-cause death in patients with CKD. Methods: In this prospective observational study of 3305 adults with mild-to-moderate CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study, the baseline self-reported medication adherence was assessed by responses to 3 questions and categorized as high, medium, and low...
May 2018: KI Reports
2018-06-04 15:33:17
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