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CKD Progression

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316 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Gesine F C Weckmann, Sylvia Stracke, Annekathrin Haase, Jacob Spallek, Fabian Ludwig, Aniela Angelow, Jetske M Emmelkamp, Maria Mahner, Jean-François Chenot
BACKGROUND: Chronic kidney disease (CKD) is age-dependent and has a high prevalence in the general population. Most patients are managed in ambulatory care. This systematic review provides an updated overview of quality and content of international clinical practice guidelines for diagnosis and management of non-dialysis CKD relevant to patients in ambulatory care. METHODS: We identified guidelines published from 2012-to March 2018 in guideline portals, databases and by manual search...
October 11, 2018: BMC Nephrology
Megumi Oshima, Tadashi Toyama, Masakazu Haneda, Kengo Furuichi, Tetsuya Babazono, Hiroki Yokoyama, Kunitoshi Iseki, Shinichi Araki, Toshiharu Ninomiya, Shigeko Hara, Yoshiki Suzuki, Masayuki Iwano, Eiji Kusano, Tatsumi Moriya, Hiroaki Satoh, Hiroyuki Nakamura, Miho Shimizu, Akinori Hara, Hirofumi Makino, Takashi Wada
BACKGROUND: According to studies by the National Kidney Foundation and Food and Drug Administration, 30% and 40% declines in estimated glomerular filtration rate (eGFR) could be used as surrogate endpoints of end-stage renal disease (ESRD). However, the benefits of using these endpoints in diabetic patients remain unclear. METHODS: This cohort study comprised Japanese patients with type 2 diabetes; those with repeated serum creatinine measurements during a baseline period of 2 years (n = 1868) or 3 years (n = 2001) were enrolled...
2018: PloS One
Stephen Zewinger, Thomas Rauen, Michael Rudnicki, Giuseppina Federico, Martina Wagner, Sarah Triem, Stefan J Schunk, Ioannis Petrakis, David Schmit, Stefan Wagenpfeil, Gunnar H Heine, Gert Mayer, Jürgen Floege, Danilo Fliser, Hermann-Josef Gröne, Thimoteus Speer
BACKGROUND: The individual course of CKD may vary, and improved methods for identifying which patients will experience short-term eGFR loss are needed. Assessing urinary Dickkopf-3 (DKK3), a stress-induced tubular epithelia-derived profibrotic glycoprotein, may provide information about ongoing tubulointerstitial fibrosis and short-term eGFR loss. METHODS: To investigate urinary DKK3's potential as a biomarker of short-term eGFR loss (over 12 months), we prospectively assessed eGFR and urinary DKK3 levels in patients with CKD of various etiologies at baseline and annual follow-ups...
October 2, 2018: Journal of the American Society of Nephrology: JASN
Rafael Santamaría, Juan M Díaz-Tocados, M Victoria Pendón-Ruiz de Mier, Ana Robles, M Dolores Salmerón-Rodríguez, Erena Ruiz, Noemi Vergara, Escolástico Aguilera-Tejero, Ana Raya, Rosa Ortega, Arnold Felsenfeld, Juan R Muñoz-Castañeda, Alejandro Martín-Malo, Pedro Aljama, Mariano Rodríguez
In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2-3 patients, we evaluated whether increased phosphaturia accelerates CKD progression...
September 12, 2018: Scientific Reports
Ilaria Petrucci, Anna Clementi, Concetto Sessa, Irene Torrisi, Mario Meola
Chronic kidney disease (CKD) includes all clinical features and complications during the progression of various kidney conditions towards end-stage renal disease (ESRD). These conditions include immune and inflammatory disease such as: primary and hepatitis C virus (HCV)-related glomerulonephritis; infectious disease such as pyelonephritis with or without reflux and tuberculosis; vascular disease such as chronic ischemic nephropathy; hereditary and congenital disease such as polycystic disease and congenital cystic dysplasia; metabolic disease including diabetes and hyperuricemia; and systemic disease (collagen disease, vasculitis, myeloma)...
September 6, 2018: Journal of Nephrology
Dadi Helgason, Thorir E Long, Solveig Helgadottir, Runolfur Palsson, Gisli H Sigurdsson, Tomas Gudbjartsson, Olafur S Indridason, Ingibjorg J Gudmundsdottir, Martin I Sigurdsson
BACKGROUND: We studied the incidence and risk factors of acute kidney injury (AKI) following coronary angiography (CA) and examined short- and long-term outcomes of patients who developed AKI, including progression of chronic kidney disease (CKD). METHODS: This was a retrospective study of all patients undergoing CA in Iceland from 2008 to 2015, with or without percutaneous coronary intervention. All procedures were performed with iso-osmolar contrast. AKI was defined according to the SCr component of the KDIGO criteria...
October 2018: Journal of Nephrology
Yuichi Maruta, Takeshi Hasegawa, Etsuko Yamakoshi, Hiroki Nishiwaki, Fumihiko Koiwa, Enyu Imai, Akira Hishida
BACKGROUND: Metabolic acidosis, which reduces serum bicarbonate levels, contributes to the progression of chronic kidney disease (CKD). The difference between sodium and chloride (Na-Cl) may theoretically predict serum bicarbonate levels. This study aimed to evaluate serum Na-Cl level as a risk factor for renal function decline among patients who participated in the chronic kidney disease Japan cohort (CKD-JAC) study. METHODS: The association between low Na-Cl concentration (< 34 mmol/L) and composite renal function decline events (any initiation of renal replacement therapy or 50% decline in estimated glomerular filtration rate) was evaluated among 2143 patients with CKD stage G3a-4...
August 24, 2018: Clinical and Experimental Nephrology
Kubra Esmeray, Oguzhan S. Dizdar, Selahattin Erdem, Ali Ihsan Gunal
OBJECTIVE: The aim of this study was to examine the effect of volume status on the progressions of renal disease in normovolemic or hypervolemic patients with advanced non-dialysis-dependent CKD who were apparently normovolemic in conventional physical examination. MATERIALS AND METHODS: This was a prospective interventional study, performed in a group of stage 3 to 5 CKD patients with one year follow-up. Three measurements were made for volume and renal status for every patient...
August 27, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Miao Liu, Jiaqi Li, Xianyu Lv, Yao He
AIMS: This study aimed to evaluate the association between baseline bilirubin (TBiL) and follow-up TBiL changes for diabetic kidney disease (DKD) incidence and progression based on a 5 years' cohort study. METHODS: This cohort study was conducted in Beijing between 2009 and 2013. The subjects were consisted of 5342male diabetic patients with baseline retinopathy. Cox proportional risk model was used to calculate hazards ratio (HR). RESULTS: The mean age of the 5342 diabetic patients was 78...
November 2018: Journal of Diabetes and its Complications
Jonathan Suarez, Jordana B Cohen, Vishnu Potluri, Wei Yang, David E Kaplan, Marina Serper, Siddharth P Shah, Peter Philip Reese
BACKGROUND: Incident rates of ESRD are much higher among black and Hispanic patients than white patients. Access to nephrology care before progression to ESRD is associated with better clinical outcomes among patients with CKD. However, it is unknown whether black or Hispanic patients with CKD experience lower pre-ESRD nephrology consultation rates compared with their white counterparts, or whether such a disparity contributes to worse outcomes among minorities. METHODS: We assembled a retrospective cohort of patients with CKD who received care through the Veterans Health Administration from 2003 to 2015, focusing on individuals with incident CKD stage 4 who had an initial eGFR≥60 ml/min per 1...
August 17, 2018: Journal of the American Society of Nephrology: JASN
Kristien Daenen, Asmin Andries, Djalila Mekahli, Ann Van Schepdael, François Jouret, Bert Bammens
Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to cells due to the excessive generation of highly reactive oxygen (ROS) and nitrogen (RNS) species. When the balance is not disturbed, OS has a role in physiological adaptations and signal transduction. However, an excessive amount of ROS and RNS results in the oxidation of biological molecules such as lipids, proteins, and DNA. Oxidative stress has been reported in kidney disease, due to both antioxidant depletions as well as increased ROS production...
August 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Mengyuan Li, Xinhua Li, Yan Liu, Xinying Liu, Yaxiang Song, Jian Zhao, Chandra Mohan, Tianfu Wu, Ai Peng, Ling Qin
It is known that inflammation and oxidative stress have strong influences on chronic kidney disease (CKD). As an antioxidant, bilirubin is currently under extensive scrutiny. However, there are disagreements with regard to the oxidative and antioxidative roles of serum uric acid (SUA). This study aimed to investigate the relationship between serum bilirubin and the progression of renal function in CKD patients with hyperuricemia (HUA). This retrospective longitudinal study included 427 CKD patients. The endpoint was renal replacement therapy or death...
August 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Takeshi Hasegawa, Kentaro Sakamaki, Fumihiko Koiwa, Tadao Akizawa, Akira Hishida
BACKGROUND: Reliable prediction tools are needed to identify patients with chronic kidney disease (CKD) at greater risk of developing end-stage kidney failure (ESKF). We developed and validated clinical prediction models (CPMs) for CKD progression to ESKF under pre-dialysis nephrology care using CKD-Japan Cohort (CKD-JAC) data. METHODS: We prospectively followed up 2034 participants with CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1...
August 1, 2018: Clinical and Experimental Nephrology
Michele Provenzano, Paolo Chiodini, Roberto Minutolo, Carmine Zoccali, Vincenzo Bellizzi, Giuseppe Conte, Francesco Locatelli, Giovanni Tripepi, Lucia Del Vecchio, Francesca Mallamaci, Lucia Di Micco, Domenico Russo, Hiddo J L Heerspink, Luca De Nicola
Background: In non-dialysis chronic kidney disease (CKD), absolute proteinuria (Uprot) depends on the extent of kidney damage and residual glomerular filtration rate (GFR). We therefore evaluated, as compared with Uprot, the strength of association of proteinuria indexed to estimated GFR (eGFR) with end-stage renal disease (ESRD) risk. Methods: In a multi-cohort prospective study in 3957 CKD patients of Stages G3-G5 referred to nephrology clinics, we tested two multivariable Cox models for ESRD risk, with either Uprot (g/24 h) or filtration-adjusted proteinuria (F-Uprot) calculated as Uprot/eGFR ×100...
July 23, 2018: Nephrology, Dialysis, Transplantation
Hua Zhou, Min Yang, Zhenxing Jiang, Jiule Ding, Jia Di, Li Cui
BACKGROUND: Blood oxygen level-dependent (BOLD)-MRI is a novel and noninvasive tool that can assess renal oxygenation. The R2* value is a parameter of tissue deoxyhemoglobin concentration detected by BOLD-MRI. The purpose of the current study was to determine the relationships between renal R2* values and clinical parameters and to determine whether renal R2* values were associated with the risk for progression of chronic kidney disease (CKD). METHODS: Sixty patients with CKD were enrolled in this prospective observational study in China from March 2013 to August 2014...
2018: American Journal of Nephrology
Bing Zhao, Hui Han, Xiaowei Yang, Rong Wang
There are various equations for estimating glomerular filtration rate (eGFR), mainly including abbreviated Modification of Diet in Renal Disease Study Equations (aMDRD), c-aMDRD for the Chinese population, Chronic Kidney Disease Epidemiology Collaboration Equation (CKD-EPI 2009) and Creatinine-Cystatin C equation (CKD-EPI 2012). Currently, it is unclear which eGFR equation more realistically predicts and reflects the development of complications closely associated with chronic loss of kidney function. Our study selected a total of 1,012 nondialysis patients at stages 2 through 4 chronic kidney disease (CKD) to assess these complications using eGFR calculated by these four equations...
July 19, 2018: Clinical Nephrology
Elaine Ku, Joachim H Ix, Kenneth Jamerson, Navdeep Tangri, Feng Lin, Jennifer Gassman, Miroslaw Smogorzewski, Mark J Sarnak
BACKGROUND: During intensive BP lowering, acute declines in renal function are common, thought to be hemodynamic, and potentially reversible. We previously showed that acute declines in renal function ≥20% during intensive BP lowering were associated with higher risk of ESRD. Here, we determined whether acute declines in renal function during intensive BP lowering were associated with mortality risk among 1660 participants of the African American Study of Kidney Disease and Hypertension and the Modification of Diet in Renal Disease Trial...
September 2018: Journal of the American Society of Nephrology: JASN
Ray El Boustany, Irina Tasevska, Esther Meijer, Lyanne M Kieneker, Sofia Enhörning, Guillaume Lefèvre, Kamel Mohammedi, Michel Marre, Frédéric Fumeron, Beverley Balkau, Nadine Bouby, Lise Bankir, Stephan Jl Bakker, Ronan Roussel, Olle Melander, Ron T Gansevoort, Gilberto Velho
BACKGROUND: The prevalence of chronic kidney disease (CKD) is increasing worldwide. The identification of factors contributing to its progression is important for designing preventive measures. Previous studies have suggested that chronically high vasopressin is deleterious to renal function. Here, we evaluated the association of plasma copeptin, a surrogate of vasopressin, with the incidence of CKD in the general population. METHODS: We studied 3 European cohorts: DESIR (n = 5,047; France), MDCS-CC (n = 3,643; Sweden), and PREVEND (n = 7,684; the Netherlands)...
July 12, 2018: JCI Insight
Silvio Borrelli, Carlo Garofalo, Francesca Mallamaci, Giovanni Tripepi, Giovanna Stanzione, Michele Provenzano, Giuseppe Conte, Luca De Nicola, Carmine Zoccali, Roberto Minutolo
OBJECTIVE: In chronic kidney disease (CKD), few cross-sectional studies evidenced an association between short-term BP variability (BPV) derived from ambulatory blood pressure (ABP) monitoring and renal damage. However, no study has evaluated the association of short-term BPV with the risk of CKD progression. METHODS: We performed a cohort study to assess the correlates and the predictive value for incident renal outcomes of short-term BPV in hypertensive patients with CKD stage G1-5...
July 10, 2018: Journal of Hypertension
Toralf Melsom, Marit Dahl Solbu, Jørgen Schei, Vidar Tor Nyborg Stefansson, Jon Viljar Norvik, Trond Geir Jenssen, Tom Wilsgaard, Bjørn Odvar Eriksen
Introduction: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, cardiovascular, or chronic kidney disease. Methods: In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1567 middle-aged nondiabetic individuals with an ACR <3...
July 2018: KI Reports
2018-07-12 09:43:04
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