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CKD Progression

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256 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29656901/different-rates-of-progression-and-mortality-in-patients-with-chronic-kidney-disease-at-outpatient-nephrology-clinics-across-europe
#1
Katharina Brück, Kitty J Jager, Carmine Zoccali, Aminu K Bello, Roberto Minutolo, Kyriakos Ioannou, Francis Verbeke, Henry Völzke, Johan Arnlöv, Daniela Leonardis, Pietro Manuel Ferraro, Hermann Brenner, Ben Caplin, Philip A Kalra, Christoph Wanner, Alberto Martinez Castelao, Jose Luis Gorriz, Stein Hallan, Dietrich Rothenbacher, Dino Gibertoni, Luca De Nicola, Georg Heinze, Wim Van Biesen, Vianda S Stel
The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR...
April 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29656903/improving-the-prognosis-of-patients-with-severely-decreased-glomerular-filtration-rate-ckd-g4-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#2
Kai-Uwe Eckardt, Nisha Bansal, Josef Coresh, Marie Evans, Morgan E Grams, Charles A Herzog, Matthew T James, Hiddo J L Heerspink, Carol A Pollock, Paul E Stevens, Manjula Kurella Tamura, Marcello A Tonelli, David C Wheeler, Wolfgang C Winkelmayer, Michael Cheung, Brenda R Hemmelgarn
Patients with severely decreased glomerular filtration rate (GFR) (i.e., chronic kidney disease [CKD] G4+) are at increased risk for kidney failure, cardiovascular disease (CVD) events (including heart failure), and death. However, little is known about the variability of outcomes and optimal therapeutic strategies, including initiation of kidney replacement therapy (KRT). Kidney Disease: Improving Global Outcomes (KDIGO) organized a Controversies Conference with an international expert group in December 2016 to address this gap in knowledge...
April 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29653769/estimating-time-to-esrd-in-children-with-ckd
#3
Susan L Furth, Chris Pierce, Wun Fung Hui, Colin A White, Craig S Wong, Franz Schaefer, Elke Wühl, Alison G Abraham, Bradley A Warady
RATIONALE & OBJECTIVE: The KDIGO (Kidney Disease: Improving Global Outcomes) guideline for chronic kidney disease (CKD) presented an international classification system that ranks patients' risk for CKD progression. Few data for children informed guideline development. STUDY DESIGN: Observational cohort study. SETTINGS & PARTICIPANTS: Children aged 1 to 18 years enrolled in the North American Chronic Kidney Disease in Children (CKiD) cohort study and the European Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CRF in Pediatric Patients (ESCAPE) trial...
April 4, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29644066/patterns-of-progression-of-chronic-kidney-disease-at-later-stages
#4
Fernando Caravaca-Fontán, Lilia Azevedo, Enrique Luna, Francisco Caravaca
Background: At later stages of chronic kidney disease (CKD), a pattern of linear and irreversible renal function decline is thought to be the most common. The objective of this study was to describe the characteristics of the different patterns of CKD progression, and to investigate potentially modifiable factors associated with the rate of decline of renal function. Methods: This was a retrospective, observational study in a cohort of adult patients with CKD Stage 4 or 5 not on dialysis...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29636065/urinary-mir-196a-predicts-disease-progression-in-patients-with-chronic-kidney-disease
#5
Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen, Zhihong Liu
BACKGROUND: Urinary miRNAs may potentially serve as noninvasive biomarkers in various kidney diseases to reflect disease activity, severity and progression, especially those correlated with the pathogenesis of kidney diseases. This study demonstrates that urinary miR-196a, a kidney-enriched miRNA, can predict progression of chronic kidney disease (CKD). METHODS: Focal segmental glomerulosclerosis (FSGS) cohorts were used as the representative example of CKD. First, correlation of miR-196a with disease activity was analyzed using paired urine and plasma samples from FSGS patients with nephrotic-range proteinuria (FSGS-A), complete remission (FSGS-CR) and normal controls (NCs)...
April 10, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29633704/diastolic-blood-pressure-variability-in-24-hour-abpm-and-outcomes-of-chronic-kidney-disease
#6
Tuncay Sahutoglu, Tamer Sakaci
BACKGROUND: Blood pressure variability (BPV) has been associated with increased morbidity and mortality. There are a few studies that reported worse outcomes of chronic kidney disease (CKD) with greater visit-to-visit BPV (VVV), but data with ambulatory blood pressure monitoring (ABPM) is scarce. MATERIALS AND METHODS: Ambulatory hypertensive CKD (stage 2 - 4) patients (> 18 years old) with complete 24 hours of ABPM study (SpaceLabs), who were followed up between January 2012 and December 2016, were retrospectively analyzed for the baseline characteristics and outcomes of CKD...
April 10, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29630690/appropriate-time-for-chronic-dialysis-initiation-a-cause-for-humility
#7
Zijin Chen, Chi-Yuan Hsu
No abstract text is available yet for this article.
April 9, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29361307/renal-tubule-injury-a-driving-force-toward-chronic-kidney-disease
#8
REVIEW
Bi-Cheng Liu, Tao-Tao Tang, Lin-Li Lv, Hui-Yao Lan
Renal tubules are the major component of the kidney and are vulnerable to a variety of injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has long been believed that tubules are the victim of injury. In this review, we shift this concept to renal tubules as a driving force in the progression of kidney diseases. In response to injury, tubular epithelial cells undergo changes and function as inflammatory and fibrogenic cells, with the consequent production of various bioactive molecules that drive interstitial inflammation and fibrosis...
March 2018: Kidney International
https://www.readbyqxmd.com/read/28835851/a-survey-of-canadian-nephrologists-assessing-prognostication-in-end-stage-renal-disease
#9
Brian Forzley, Helen H L Chiu, Ognjenka Djurdjev, Rachel C Carson, Gaylene Hargrove, Dan Martinusen, Mohamud Karim
BACKGROUND: Patients with end-stage renal disease (ESRD) frequently have a relatively poor prognosis with complex care needs that depend on prognosis. While many means of assessing prognosis are available, little is known about how Canadian nephrologists predict prognosis, whether they routinely share prognostic information with their patients, and how this information guides management. OBJECTIVE: To guide improvements in the management of patients with ESRD, we aimed to better understand how Canadian nephrologists consider prognosis during routine care...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29615173/outcome-of-chronic-kidney-disease-patients-on-the-basis-of-referral-to-nephrologist-a-one-year-follow-up-study
#10
Muhammad Anees, Yasir Hussain, Muhammad Ibrahim, Irfan Ilahi, Sajjad Ahmad, Khushbakht Isma Asif, Amina Jameel
OBJECTIVE: To determine the outcome of chronic kidney disease (CKD) patients presenting for dialysis on the basis of referral to nephrologist. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Nephrology Department of King Edward Medical University/Mayo Hospital, Lahore, from January 2014 to January 2016. METHODOLOGY: All patients who were presented in nephrology outpatients department and with the indication of dialysis were included in study...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29610272/age-content-of-a-protein-load-is-responsible-for-renal-performances-a-pilot-study
#11
Gabrielle Normand, Sandrine Lemoine, Marjorie Villien, Didier Lebars, Ines Merida, Zacharie Irace, Thomas Troalen, Nicolas Costes, Laurent Juillard
OBJECTIVE: Chronic kidney disease is associated with higher morbidity and mortality in patients with diabetes. A low-protein diet is recommended to slow diabetic nephropathy progression because each protein load leads to renal hemodynamic variations. The aim of our study was to evaluate whether the advanced glycation end products (AGE) content of a protein load is responsible for the protein-induced renal hemodynamic variations in humans. RESEARCH DESIGN AND METHODS: Ten healthy subjects were assigned to a high-protein (1 g/kg) low-AGE (3,000 kU AGE) versus high-AGE (30,000 kU AGE) meal...
April 2, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29606094/can-increased-vigilance-for-chronic-kidney-disease-in-hospitalised-patients-decrease-late-referral-and-improve-dialysis-free-survival
#12
M De Wilde, M Speeckaert, W Van Biesen
BACKGROUND: Insufficient vigilance for renal insufficiency is associated with late referral, increased morbidity and mortality. The present study examines whether increased vigilance for chronic kidney disease (CKD) leads to quicker referral to and better follow-up by a nephrologist, and whether it is associated with an improved outcome. METHODS: Patients with an eGFR < 45 ml/min/1.73 m2 during hospitalisation at the Ghent University Hospital were enrolled during a period of 100 days...
April 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29605094/predicting-timing-of-clinical-outcomes-in-patients-with-chronic-kidney-disease-and-severely-decreased-glomerular-filtration-rate
#13
Morgan E Grams, Yingying Sang, Shoshana H Ballew, Juan Jesus Carrero, Ognjenka Djurdjev, Hiddo J L Heerspink, Kevin Ho, Sadayoshi Ito, Angharad Marks, David Naimark, Danielle M Nash, Sankar D Navaneethan, Mark Sarnak, Benedicte Stengel, Frank L J Visseren, Angela Yee-Moon Wang, Anna Köttgen, Andrew S Levey, Mark Woodward, Kai-Uwe Eckardt, Brenda Hemmelgarn, Josef Coresh
Patients with chronic kidney disease and severely decreased glomerular filtration rate (GFR) are at high risk for kidney failure, cardiovascular disease (CVD) and death. Accurate estimates of risk and timing of these clinical outcomes could guide patient counseling and therapy. Therefore, we developed models using data of 264,296 individuals in 30 countries participating in the international Chronic Kidney Disease Prognosis Consortium with estimated GFR (eGFR)s under 30 ml/min/1.73m2 . Median participant eGFR and urine albumin-to-creatinine ratio were 24 ml/min/1...
March 24, 2018: Kidney International
https://www.readbyqxmd.com/read/29602779/time-centered-approach-to-understanding-risk-factors-for-the-progression-of-ckd
#14
Elaine Ku, Kirsten L Johansen, Charles McCulloch
BACKGROUND AND OBJECTIVES: Traditional approaches to modeling risk of CKD progression do not provide estimates of the time it takes for disease progression to occur, which could be useful in guiding therapeutic interactions between patients and providers. Our objective was to estimate median time spent in each of CKD stages 3a-5 and how the time differs according to risk factors associated with progression of disease. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We included 3682 participants of the Chronic Renal Insufficiency Cohort in mixed models to estimate person-specific trajectories of function, and used these trajectories to estimate time spent in each CKD stage...
March 30, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29593020/ethnic-differences-in-the-progression-of-chronic-kidney-disease-and-risk-of-death-in-a-uk-diabetic-population-an-observational-cohort-study
#15
Rohini Mathur, Gavin Dreyer, Magdi M Yaqoob, Sally A Hull
OBJECTIVE: To determine ethnic differences in the progression of chronic kidney disease (CKD) and risk of end-stage renal failure (ESRF) and death in adults with type 2 diabetes mellitus (T2DM), and to identify predictors of rapid renal decline. DESIGN: Observational community-based cohort study undertaken from 2006 to 2016 with nested case-control study. SETTING: 135 inner London primary care practices contributing to the east London Database...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29580660/ckd-self-management-phenotypes-and-associations-with-clinical-outcomes
#16
Sarah J Schrauben, Jesse Y Hsu, Sylvia E Rosas, Bernard G Jaar, Xiaoming Zhang, Rajat Deo, Georges Saab, Jing Chen, Swati Lederer, Radhika Kanthety, L Lee Hamm, Ana C Ricardo, James P Lash, Harold I Feldman, Amanda H Anderson
BACKGROUND: To slow chronic kidney disease (CKD) progression and its complications, patients need to engage in self-management behaviors. The objective of this study was to classify CKD self-management behaviors into phenotypes and assess the association of these phenotypes with clinical outcomes. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Adults with mild to moderate CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study...
March 24, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29581540/lower-serum-calcium-is-independently-associated-with-ckd-progression
#17
Cynthia J Janmaat, Merel van Diepen, Alessandro Gasparini, Marie Evans, Abdul Rashid Qureshi, Johan Ärnlöv, Peter Barany, Carl-Gustaf Elinder, Joris I Rotmans, Marc Vervloet, Friedo W Dekker, Juan Jesus Carrero
Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at cohort entry, we investigated the association between baseline serum calcium and the subsequent change in estimated glomerular filtration rate (eGFR, by CKD-EPI) decline using linear mixed models...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29559377/retinal-capillary-and-arteriolar-changes-in-patients-with-chronic-kidney-disease
#18
Agnes Bosch, Johannes B Scheppach, Joanna M Harazny, Ulrike Raff, Kai-Uwe Eckardt, Roland E Schmieder, Markus P Schneider
RATIONALE: Premature cardiovascular disease is a leading cause of death in patients with chronic kidney disease (CKD). In animal models CKD has been shown to cause renal and extrarenal vascular remodeling and capillary rarefaction, but data in humans with CKD are sparse. Retinal arteriolar wall-to-lumen ratio (WLR) is an established marker of early end-organ damage and there is evidence that arteriolar and capillary changes in the retinal circulation mirror those in the general and in particular the cerebrovascular microcirculation...
March 17, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29396621/progressive-kidney-disease-may-not-alter-the-association-of-hyponatremia-with-mortality
#19
Ladan Golestaneh, Joel Neugarten, Frederick Kaskel, Aileen P McGinn
BACKGROUND: Hyponatremia is a common electrolyte disorder and a prognostic marker for mortality. We hypothesize that in advanced chronic or acute kidney disease, hyponatremia is not independently associated with mortality because of the contribution of kidney failure to its pathophysiology. METHODS: Clinical Looking Glass, Montefiore's clinical database, was used to build a cohort of all patients hospitalized between January of 2009 and December of 2011. A chronic kidney disease (CKD) group and an acute kidney injury (AKI) group were defined based on GFR measurements during and before index hospitalization...
February 2, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29554320/increased-urinary-osmolyte-excretion-indicates-chronic-kidney-disease-severity-and-progression-rate
#20
Ryan B Gil, Alberto Ortiz, Maria D Sanchez-Niño, Katerina Markoska, Eva Schepers, Raymond Vanholder, Griet Glorieux, Philippe Schmitt-Kopplin, Silke S Heinzmann
Background: Chronic kidney disease (CKD) is a recognized global health problem. While some CKD patients remain stable after initial diagnosis, others can rapidly progress towards end-stage renal disease (ESRD). This makes biomarkers capable of detecting progressive forms of CKD extremely valuable, especially in non-invasive biofluids such as urine. Screening for metabolite markers using non-targeted metabolomic techniques like nuclear magnetic resonance spectroscopy is increasingly applied to CKD research...
March 14, 2018: Nephrology, Dialysis, Transplantation
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