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CKD Progression

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230 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29452887/protein-intake-and-long-term-change-in-glomerular-filtration-rate-in-the-jackson-heart-study
#1
Rakesh Malhotra, Loren Lipworth, Kerri L Cavanaugh, Bessie A Young, Katherine L Tucker, Teresa C Carithers, Herman A Taylor, Adolfo Correa, Edmond K Kabagambe, T Alp Ikizler
OBJECTIVE: Dietary protein intake could have deleterious renal effects in populations at risk for chronic kidney disease. Here, we examined whether higher protein intake (≥80th percentile of energy from protein) is associated with decline in kidney function and whether this decline varies by diabetes status. DESIGN: Observational cohort study. SUBJECTS AND SETTINGS: Participants were African-Americans (n = 5,301), who enrolled in the Jackson Heart Study between 2000 and 2004...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29453850/the-role-of-the-immune-system-in-kidney-disease
#2
REVIEW
Josefine Tecklenborg, David Clayton, Stefan Siebert, Shana M Coley
The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect renal effects. Direct immune-mediated kidney diseases are usually a consequence of autoantibodies directed against a constituent renal antigen, such as collagen IV in anti-glomerular basement membrane disease...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29404927/fast-gfr-decline-and-progression-to-ckd-among-primary-care-patients-with-preserved-gfr
#3
Farrukh M Koraishy, Denise Hooks-Anderson, Joanne Salas, Michael Rauchman, Jeffrey F Scherrer
BACKGROUND: Fast glomerular filtration rate (GFR) decline is associated with adverse outcomes, but the associated risk factors among patients without chronic kidney disease (CKD) are not well defined. METHODS: From a primary care registry of 37,796, we identified 2219 (6%) adults with at least three estimated (e)GFR values and a baseline eGFR between 60 and 119 ml/min/1.73 m2 during an observation period of 8 years. We defined fast GFR decline as > 5 ml/min/1...
February 5, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29398328/relation-of-asymmetrical-dimethylarginine-levels-with-renal-outcomes-in-hypertensive-patients-with-and-without-type-2-diabetes-mellitus
#4
Cristina B Triches, Marie Quinto, Saurus Mayer, Marcelo Batista, Maria Teresa Zanella
AIM: The aim of the study was to evaluate the association between high plasma ADMA levels, a biomarker of endothelial dysfunction, with the progression of albuminuria and chronic kidney disease (CKD) in hypertensive patients, with and without type 2 diabetes mellitus. METHODS: We successfully contacted 213 of 644 patients who had been evaluated between 2004 and 2005 and for whom basal data were available. After the exclusion of 51 patients, 162 hypertensive patients who were free from albuminuria were stratified into the following 4 groups according to the presence of diabetes and plasma ADMA percentiles: general hypertensive patients with high levels of plasma ADMA (>P4 or ADMA > 0...
December 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29395334/metabolic-syndrome-but-not-obesity-measures-are-risk-factors-for-accelerated-age-related-glomerular-filtration-rate-decline-in-the-general-population
#5
Vidar T N Stefansson, Jørgen Schei, Marit D Solbu, Trond G Jenssen, Toralf Melsom, Bjørn O Eriksen
Rapid age-related glomerular filtration rate (GFR) decline increases the risk of end-stage renal disease, and a low GFR increases the risk of mortality and cardiovascular disease. High body mass index and the metabolic syndrome are well-known risk factors for patients with advanced chronic kidney disease, but their role in accelerating age-related GFR decline independent of cardiovascular disease, hypertension and diabetes is not adequately understood. We studied body mass index, waist circumference, waist-hip ratio and metabolic syndrome as risk factors for accelerated GFR decline in 1261 middle-aged people representative of the general population without diabetes, cardiovascular disease or kidney disease...
January 22, 2018: Kidney International
https://www.readbyqxmd.com/read/29398341/inflammation-and-nutritional-status-assessment-by-malnutrition-inflammation-score-and-its-outcome-in-pre-dialysis-chronic-kidney-disease-patients
#6
D Jagadeswaran, E Indhumathi, A J Hemamalini, V Sivakumar, P Soundararajan, M Jayakumar
BACKGROUND: Malnutrition-inflammation complex syndrome (MICS), hyperhomocysteinemia, calcium and phosphate levels derangement have been predicted as important contributing factors for the progression of cardiovascular burden. Among patients with earlier stage of CKD, hypoalbuminaemia and inflammation deliberated as non-traditional cardiovascular risk factors, which add more burden to circulatory disease, mortality and rapid advancement to CKD stage 5. AIM: The aim of the study is to evaluate inflammation and nutritional status of CKD patients not on dialysis using Malnutrition inflammation score (MIS) and to verify the association with mortality in the follow-up period...
January 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29357423/acid-retention-in-chronic-kidney-disease-is-inversely-related-to-gfr
#7
Nimrit Goraya, Jan Simoni, Lauren N Sager, Jessica Pruszynski, Donald Everett Wesson
Greater H+ retention in animal models of chronic kidney disease (CKD) mediates faster GFR decline and dietary H+ reduction slows eGFR decline in CKD patients with reduced eGFR and H+ retention due to the high acid (H+) diets of developed societies. We examined if H+ retention in CKD is inversely associated with estimated GFR (eGFR) using cross-sectional and longitudinal analysis of individuals with CKD stage 1 (>90 ml/min/1.73m2), CKD stage 2 (60-89 ml/min/1.73m2), and CKD stage 3 (30-59 ml/min/1.73m2) eGFR...
January 3, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29359019/impact-of-sustained-virologic-response-on-chronic-kidney-disease-progression-in-hepatitis-c
#8
Elizabeth S Aby, Tien S Dong, Jenna Kawamoto, Joseph R Pisegna, Jihane N Benhammou
AIM: To determine how sustained virological response at 12 wk (SVR12) with direct acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) infection affects chronic kidney disease (CKD) progression. METHODS: A retrospective analysis was performed in patients aged ≥ 18 years treated for HCV with DAAs at the VA Greater Los Angeles Healthcare System from 2014-2016. The treatment group was compared to patients with HCV from 2011-2013 who did not undergo HCV treatment, prior to the introduction of DAAs; the control group was matched to the study group in terms of age, gender, and ethnicity...
December 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29339356/kidney-biomarkers-and-decline-in-egfr-in-patients-with-type-2-diabetes
#9
Katherine G Garlo, William B White, George L Bakris, Faiez Zannad, Craig A Wilson, Stuart Kupfer, Muthiah Vaduganathan, David A Morrow, Christopher P Cannon, David M Charytan
BACKGROUND AND OBJECTIVES: Biomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. However, available biomarkers remain incompletely validated for risk stratification and prediction modeling. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined serum cystatin C, urinary kidney injury molecule-1 (uKIM-1), and urinary neutrophil gelatinase-associated lipocalin (UNGAL) in 5367 individuals with type 2 diabetes mellitus and recent acute coronary syndromes enrolled in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial...
January 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29340320/association-of-a-low-protein-diet-with-slower-progression-of-ckd
#10
Marie Metzger, Wen Lun Yuan, Jean-Philippe Haymann, Martin Flamant, Pascal Houillier, Eric Thervet, Jean-Jacques Boffa, François Vrtovsnik, Marc Froissart, Lise Bankir, Denis Fouque, Bénédicte Stengel
Introduction: Reducing protein intake is recommended for slowing chronic kidney disease (CKD) progression, but assessment of its true effectiveness is sparse. Methods: Using the Maroni formula, we assessed dietary protein intake (DPI) from 24-hour urinary urea excretion in 1594 patients (67% men and 33% women) with CKD, 784 of whom also had 7-day food records. Cause-specific hazard ratios (HRs) and 95% confidence intervals for the competing risks of DPI-associated end-stage renal disease (ESRD) or death were estimated in 1412 patients with baseline glomerular filtration rate ≥15 ml/min per 1...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29342207/prognosis-of-chronic-kidney-disease-with-normal-range-proteinuria-the-ckd-route-study
#11
Soichiro Iimori, Shotaro Naito, Yumi Noda, Hidehiko Sato, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Shinichi Uchida, Tatemitsu Rai
BACKGROUND: Although lower estimated glomerular filtration rate (eGFR) and higher proteinuria are high risks for mortality and kidney outcomes, the prognosis of chronic kidney disease (CKD) in patients with normal-range proteinuria remains unclear. METHODS: In this prospective cohort study, 1138 newly visiting stage G2-G5 CKD patients were stratified into normal-range and abnormal-range proteinuria groups. Study endpoints were CKD progression (>50% eGFR loss or initiation of dialysis), cardiovascular events, and all-cause death...
2018: PloS One
https://www.readbyqxmd.com/read/29333149/a-summary-of-worldwide-national-activities-in-chronic-kidney-disease-ckd-testing
#12
Roberto Ruiz-Arenas, Rosa Sierra-Amor, David Seccombe, Stella Raymondo, Maria Stella Graziani, Mauro Panteghini, Tewogbade A Adedeji, Shanthi Naidu Kamatham, Vanja Radišić Biljak
Chronic kidney disease (CKD) is a major public health issue worldwide and is associated with adverse health outcomes, especially in low- and middle-income countries. In a cash limited healthcare system, guidelines that improve the efficiency of health care free up resources needed for other healthcare services. This short review presents some examples from national acitivities in CKD testing, including countries throughout the globe: Mexico in North America, Uruguay in South America, Italy in Europe, Nigeria in Africa and India in Asia...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29325997/reduced-cortical-oxygenation-predicts-a-progressive-decline-of-renal-function-in-patients-with-chronic-kidney-disease
#13
Menno Pruijm, Bastien Milani, Edward Pivin, Agata Podhajska, Bruno Vogt, Matthias Stuber, Michel Burnier
Renal tissue hypoxia is a final pathway in the development and progression of chronic kidney disease (CKD), but whether renal oxygenation predicts renal function decline in humans has not been proven. Therefore, we performed a prospective study and measured renal tissue oxygenation by blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in 112 patients with CKD, 47 with hypertension without CKD, and 24 healthy control individuals. Images were analyzed with the twelve-layer concentric objects method that divided the renal parenchyma in 12 layers of equal thickness and reports the mean R2* value of each layer (a high R2* corresponds to low oxygenation), along with the change in R2* between layers called the R2* slope...
January 9, 2018: Kidney International
https://www.readbyqxmd.com/read/29313136/klotho-g-395a-gene-polymorphism-impact-on-progression-of-end-stage-renal-disease-and-development-of-cardiovascular-complications-in-children-on-dialysis
#14
Eman A Elghoroury, Fatina I Fadel, Manal F Elshamaa, Dina Kandil, Doaa M Salah, Marwa M El-Sonbaty, Hebatallah Farouk, Mona Raafat, Soha Nasr
BACKGROUND: Klotho G-395-A gene polymorphism may impact children with end-stage renal disease (ESRD). We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients. METHODS: Fifty-five children with chronic kidney disease (CKD) and seventy healthy children were genotyped for Klotho G-395A. RESULTS: Incidence of GA/AA genotypes and A allele were higher in ESRD patients compared with controls (54...
January 8, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29306476/the-cha-2-ds-2-vasc-score-strongly-correlates-with-glomerular-filtration-rate-and-predicts-renal-function-decline-over-time-in-elderly-patients-with-atrial-fibrillation-and-chronic-kidney-disease
#15
Jan Beyer-Westendorf, Reinhold Kreutz, Florian Posch, Cihan Ay
BACKGROUND: The decline of renal function affects stroke risk in patients with atrial fibrillation (AF). Here, we aim to study the predictive value of the CHA 2 DS 2 -VASc score, a stroke-risk stratification model in AF, for renal function and renal decline in patients with AF and chronic kidney disease (CKD). METHODS: Two electronic health record cohorts with AF and CKD stage III/IV were evaluated (Cohort #1 (IMS-DA, Germany): 18,539 patients with 125,149 estimated glomerular filtration rate (eGFR) measurements; Cohort #2 (IMS-THIN, United Kingdom): 18,240 patients with 133,676 eGFR measurements)...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29255845/use-of-the-kidney-failure-risk-equation-to-determine-the-risk-of-progression-to-end-stage-renal-disease-in-children-with-chronic-kidney-disease
#16
Erica Winnicki, Charles E McCulloch, Mark M Mitsnefes, Susan L Furth, Bradley A Warady, Elaine Ku
Importance: The kidney failure risk equation (KFRE) has been shown to accurately estimate progression to kidney failure in adults with chronic kidney disease (CKD). Use of the KFRE in children with CKD, if accurate, would help to optimize planning for end-stage renal disease (ESRD) care. Objective: To determine whether the KFRE adequately discriminates the risk of ESRD in children with CKD. Design, Setting, and Participants: This retrospective cohort study included 603 children with an estimated glomerular filtration rate of less than 60 mL/min/1...
December 18, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29257031/association-between-the-age-related-decline-in-renal-function-and-lumbar-spine-bone-mineral-density-in-healthy-chinese-postmenopausal-women
#17
Wen Han, Xiao-Juan Bai, Lu-Lu Han, Sebastian Akhtari, Xue-Feng Sun, Xiang-Mei Chen
OBJECTIVES: The relationship between the decline of renal function and bone mineral density (BMD) in healthy populations is not well-researched. The aim of this study was to investigate the association between the age-related decline in renal function and lumbar spine BMD (LBMD) in a community-based cross-sectional study of 390 healthy postmenopausal women (mean age 62.97 ± 8.79 years) from Shenyang, China. METHODS: Dual-energy x-ray absorptiometry was used to measure LBMD...
December 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29217305/longitudinal-weight-change-during-ckd-progression-and-its-association-with-subsequent-mortality
#18
Elaine Ku, Joel D Kopple, Kirsten L Johansen, Charles E McCulloch, Alan S Go, Dawei Xie, Feng Lin, L Lee Hamm, Jiang He, John W Kusek, Sankar D Navaneethan, Ana C Ricardo, Hernan Rincon-Choles, Miroslaw Smogorzewski, Chi-Yuan Hsu
BACKGROUND: Few studies have investigated the changes in weight that may occur over time among adults with the progression of chronic kidney disease (CKD). Whether such weight changes are independently associated with death after the onset of end-stage renal disease has also not been rigorously examined. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: We studied 3,933 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a longitudinal cohort of patients with CKD...
December 4, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29187194/treatment-effects-of-renin-angiotensin-aldosterone-system-blockade-on-kidney-failure-and-mortality-in-chronic-kidney-disease-patients
#19
Phisitt Vejakama, Atiporn Ingsathit, Gareth J McKay, Alexander P Maxwell, Mark McEvoy, John Attia, Ammarin Thakkinstian
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of death before and after onset of end-stage renal disease (ESRD). Knowing treatments that can delay disease progression will lead to reduced mortality. We therefore aimed to estimate the effectiveness of renin angiotensin aldosterone system (RAAS) blockade on CKD progression. METHODS: We conducted a retrospective CKD cohort at Ubon Ratchathani province, Thailand from 1997 to 2011. ESRD was defined as estimated glomerular filtration rate (eGFR) <15 ml/min/1...
November 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29193529/renal-ultrasound-and-doppler-parameters-as-markers-of-renal-function-and-histopathological-damage-in-children-with-ckd
#20
Happy Sawires, Doaa Salah, Rania Hachem, Wesam Ismail, Amr Salem, Osama Botros, Hadeel Seif
BACKGROUND: Doppler ultrasonography can be used to assess the progression of vascular (arterial sclerosis) and parenchymal (glomerular sclerosis and crescents) renal damage. The aim of this study was to evaluate the significance of some sonographic and Doppler parameters as non-invasive markers of glomerular filtration rate (GFR) and renal histopathological damage in children. METHODOLOGY: A cohort of 84 children were enrolled in a case-control study (42 with CKD stages 2-5 and 42 healthy children)...
November 30, 2017: Nephrology
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