Junichi Nishimura, Kiyokazu Nakajima, Yoshihito Souma, Tsuyoshi Takahashi, Naoki Ikeguchi, Rei Takenaka, Naoki Shinohara, Toshirou Nishida, Yuichiro Doki, Masaki Mori
PURPOSE: Collagen and fibrin are known to have potential use as a local drug-delivery system. This experimental study was designed to evaluate whether a fibrinogen-based collagen (FBC) fleece, coated with thrombin and aprotinin, can be used as an antibiotic delivery system. METHODS: In an in vitro study, gentamicin, fosfomycin, ampicillin, ciprofloxacin and dibekacin were absorbed by the FBC, Kirby-Bauer disks (KBDs), and expanded polytetrafluoroethylene. After washing with saline or phosphate buffer saline (PBS) 3 times for 6, 12 and 24 h, each sample was analyzed for antibiotic retention...
February 2013: Surgery Today