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Renal Biopsy

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34 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29680021/global-glomerulosclerosis-in-primary-nephrotic-syndrome-including-age-as-a-variable-to-predict-renal-outcomes
#1
Jeffrey B Kopp
With normal aging, there are increased numbers of globally sclerotic glomeruli. Global glomerulosclerosis is also a feature of chronic kidney disease. In this issue, Hommos and colleagues provide data on the fraction of globally sclerotic glomeruli in healthy kidney donor biopsies. This provides reference for evaluation of whether isolated global glomerulosclerosis is evidence of pathology.
May 2018: Kidney International
https://www.readbyqxmd.com/read/29569185/indications-and-results-of-renal-biopsy-in-children-a-36-year-experience
#2
Luisa Santangelo, Giuseppe Stefano Netti, Paolo Giordano, Vincenza Carbone, Marida Martino, Diletta Domenica Torres, Michele Rossini, Anna Maria Di Palma, Loreto Gesualdo, Mario Giordano
BACKGROUND: This study was conducted to investigate retrospectively the indications for renal biopsy (RB) in native kidneys and to analyze pathological findings in a single tertiary pediatric hospital in Southern Italy for the last 36 years. METHODS: All patients who underwent RB at our hospital from 1979 to 2014 were included. All renal tissue specimens were studied under light and immunofluorescent microscopy, while electron microscopy was performed only for specific clinical indications...
March 22, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29291760/bringing-renal-biopsy-interpretation-into-the-molecular-age-with-single-cell-rna-sequencing
#3
REVIEW
Andrew F Malone, Haojia Wu, Benjamin D Humphreys
The renal biopsy provides critical diagnostic and prognostic information to clinicians including cases of acute kidney injury, chronic kidney disease, and allograft dysfunction. Today, biopsy specimens are read using a combination of light microscopy, electron microscopy, and indirect immunofluorescence, with a limited number of antibodies. These techniques all were perfected decades ago with only incremental changes since then. By contrast, recent advances in single-cell genomics are transforming scientists' ability to characterize cells...
January 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29262805/arteriovenous-fistulae-after-renal-biopsy-diagnosis-and-outcomes-using-doppler-ultrasound-assessment
#4
R Haridian Sosa-Barrios, Victor Burguera, Nuria Rodriguez-Mendiola, Cristina Galeano, Sandra Elias, Gloria Ruiz-Roso, Sara Jimenez-Alvaro, Fernando Liaño, Maite Rivera-Gorrin
BACKGROUND: Percutaneous renal biopsy (PRB) is an important technique providing relevant information to guide diagnosis and treatment in renal disease. As an invasive procedure it has complications. Most studies up to date have analysed complications related to bleeding. We report the largest single-center experience on routine Doppler ultrasound (US) assessment post PRB, showing incidence and natural history of arteriovenous fistulae (AVF) post PRB. METHODS: We retrospectively analysed 327 consecutive adult PRB performed at Ramon Cajal University Hospital between January 2011 and December 2014...
December 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29250674/in-vivo-confocal-microscopy-quantification-of-reactive-oxygen-species-a-working-model-in-rat-kidney
#5
Adrian Ovidiu Văduva, Cosmin Glămeanu, Romeo Negrea, Mirela Danina Muntean, Alis Liliana Carmen Dema
Oxidative stress is a culprit responsible for the development of acute and chronic kidney diseases. We aimed to establish a working model for the dynamic in vivo assessment of reactive oxygen species (ROS) production in rat kidney. A randomized controlled study was performed in 36 adult male Wistar rats subjected to unilateral urinary obstruction (UUO) via ureteral ligation and compared to SHAM controls. Dihydroethidium (DHE) was injected in the femoral vein and in vivo confocal microscopy was performed in the 2nd, 6th and 10th day, respectively after surgery...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29208969/association-of-kidney-fibrosis-with-urinary-peptides-a-path-towards-non-invasive-liquid-biopsies
#6
Pedro Magalhães, Martin Pejchinovski, Katerina Markoska, Miroslaw Banasik, Marian Klinger, Dominika Švec-Billá, Ivan Rychlík, Merita Rroji, Arianna Restivo, Giovambattista Capasso, Flaviu Bob, Adalbert Schiller, Alberto Ortiz, Maria Vanessa Perez-Gomez, Pablo Cannata, Maria Dolores Sanchez-Niño, Radomir Naumovic, Voin Brkovic, Momir Polenakovic, William Mullen, Antonia Vlahou, Petra Zürbig, Lars Pape, Franco Ferrario, Colette Denis, Goce Spasovski, Harald Mischak, Joost P Schanstra
Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29154749/complications-and-monitoring-of-percutaneous-renal-biopsy-a-retrospective-study
#7
Yvette Feldmann, Klaas Böer, Gunter Wolf, Martin Busch
BACKGROUND AND AIMS: Percutaneous renal biopsy is a necessary tool to diagnose renal diseases but complications may still occur. The aims of this study were to detect the rate of complications, possible risk factors and to identify the necessity of routine post-biopsy controls at 4 - 6, and 24 hours. MATERIALS AND METHODS: This single-center retrospective study included 500 consecutive biopsies of native and allograft kidneys performed at the Jena University Hospital...
April 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/28992289/transcriptomics-in-kidney-biopsy-is-an-untapped-resource-for-precision-therapy-in-nephrology-a-systematic-review
#8
Francesco Paolo Schena, Ionut Nistor, Claudia Curci
Background: The diagnosis of glomerular diseases is based on the evaluation of histological lesions in renal tissue by means of light and electronic microscopy, and immunofluorescence technique. Frozen and archival formalin-fixed paraffin-embedded kidney biopsies represent a stored resource for high-throughput technologies. Transcriptomics makes it possible to study the whole gene-expression profile of cells and tissues in a specific period and/or condition. The results, whether considered alone or integrated with other omics data, could help to improve existing knowledge about the pathogenetic mechanisms of glomerulopathies...
August 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28967966/transcriptomics-in-kidney-biopsy-is-an-untapped-resource-for-precision-therapy-in-nephrology-a-systematic-review
#9
Francesco Paolo Schena, Ionut Nistor, Claudia Curci
No abstract text is available yet for this article.
October 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28858910/digital-pathology-in-nephrology-clinical-trials-research-and-pathology-practice
#10
Laura Barisoni, Jeffrey B Hodgin
PURPOSE OF REVIEW: In this review, we will discuss (i) how the recent advancements in digital technology and computational engineering are currently applied to nephropathology in the setting of clinical research, trials, and practice; (ii) the benefits of the new digital environment; (iii) how recognizing its challenges provides opportunities for transformation; and (iv) nephropathology in the upcoming era of kidney precision and predictive medicine. RECENT FINDINGS: Recent studies highlighted how new standardized protocols facilitate the harmonization of digital pathology database infrastructure and morphologic, morphometric, and computer-aided quantitative analyses...
November 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28664406/renal-biopsy-driven-molecular-target-identification-in-glomerular-disease
#11
REVIEW
Maja T Lindenmeyer, Matthias Kretzler
Chronic kidney disease has severe impacts on the patient and represents a major burden to the health care systems worldwide. Despite an increased knowledge of pathophysiological processes involved in kidney diseases, the progress in defining novel treatment strategies has been limited. One reason is the descriptive disease categorization used in nephrology based on clinical findings or histopathological categories irrespective of potential different molecular disease mechanisms. To accelerate progress toward a targeted treatment, a definition of human disease extending from phenotypic disease classification to mechanism-based disease definitions is needed...
August 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28638600/quantification-of-bleeding-volume-using-computed-tomography-and-clinical-complications-after-percutaneous-renal-biopsy
#12
Yoichiro Chikamatsu, Ken Matsuda, Yoichi Takeuchi, Saeko Kagaya, Yoshie Ojima, Hirotaka Fukami, Hiroyuki Sato, Ayako Saito, Yoshitsugu Iwakura, Tasuku Nagasawa
Background: The aim of this study was to investigate specific bleeding volume after percutaneous renal biopsy (PRB) and the correlation between bleeding volume and clinical parameters. Methods: A retrospective study of 252 consecutive patients (153 male patients and 99 female patients) who underwent PRB at the Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, between July 2013 and January 2016 was conducted. PRB was performed under ultrasound guidance using an automated spring-loaded biopsy device and a 16-cm, 16-gauge needle...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28648933/effectiveness-and-safety-of-two-18-gauge-needle-types-on-native-and-allograft-renal-biopsies
#13
Clarissa A Cassol, Juarez R Braga, Samer Dabbo, K Khalili, C Avila-Casado
Percutaneous biopsy is a key diagnostic tool for both native and allograft kidney diseases. Adequacy criteria vary, but at a minimum, a biopsy should allow the pathologist to reach a diagnosis and provide prognostic information such as the degree of interstitial fibrosis and tubular atrophy (IF/TA) and percentage of glomerulosclerosis. Whereas most studies use glomerular counts as a surrogate for biopsy adequacy, the amount and preservation of tubulointerstitium is equally important, considering IF/TA is a major prognostic parameter for most medical renal diseases...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28523502/maldi-ms-imaging-in-the-study-of-glomerulonephritis
#14
Andrew Smith, Manuel Galli, Vincenzo L'Imperio, Fabio Pagni, Fulvio Magni
Glomerulonephritis (GNs) are one of the most frequent causes of chronic kidney disease (CKD), a renal condition that often leads to end-stage renal failure, and a careful assessment of these diseases is essential for prognostic and therapeutic purposes. The application of MALDI-MSI directly on bioptic renal tissue represents a new stimulating perspective and facilitates the detection of specific proteomic indicators that are directly correlated with the pathological alterations that occur within the glomeruli during the development of glomerulonephritis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28601117/tubular-urinary-indexes-reliably-distinguish-between-primary-tubulointerstitial-and-primary-glomerular-diseases-in-patients-referred-for-kidney-biopsy
#15
Andrej Škoberne, Špela Borštnar, Nuša Avguštin, Damjan Kovač, Andreja Aleš Rigler, Željka Večerić-Haler, Jernej Pajek, Mladen Krsnik, Nika Kojc, Dušan Ferluga, Jelka Lindič
AIMS: Kidney biopsy remains the gold standard for accurately diagnosing renal diseases. Urinalysis and assessment of renal function are the cornerstones for assessment of patients prior to biopsy. There is significant overlap in the results of routine urine parameters (proteinuria, erythrocyturia, leukocyturia) among different kidney diseases, which hinders the possibility of adequately estimating disease etiology prior to the biopsy. The aim of our study was to assess whether diverse markers of glomerular and tubular proteinuria - urinary albumin, IgG, α-1-microglobulin (α-1-m) and N-acetyl-β-D-glucosaminidase (NAG) - are capable of distinguishing between patients with primary tubulointerstitial (TID) and primary glomerular disease (GLOM)...
2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28418995/kidney-biopsy-yield-an-examination-of-influencing-factors
#16
Miroslav Sekulic, Gretchen S Crary
Kidney biopsies are conducted under varying scenarios, presenting variables that could potentially influence yield and adequacy of tissue collected. We retrospectively reviewed 636 native and allograft kidney biopsies, and compared tissue collected between differing practitioners performing the biopsy (nephrologists or radiologists), imaging modalities for guidance (ultrasound or computed tomography), gauge needle used (18 or 16 G), and between on-site evaluators of biopsy adequacy conducted at the time of biopsy (general pathologists, renal pathologists, nephrologists)...
July 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28419667/a-simple-risk-score-for-prediction-of-hemorrhagic-complications-after-a-percutaneous-renal-biopsy
#17
Juan M Mejía-Vilet, Manuel A Márquez-Martínez, Bertha M Cordova-Sanchez, Mónica Chapa Ibargüengoitia, Ricardo Correa-Rotter, Luis E Morales-Buenrostro
AIM: To derive a simple risk score to predict the individual risk of major complications for patients undergoing a percutaneous renal biopsy procedure of native kidneys. METHODS: The risk score was derived from a cohort of 1,205 adult patients subject to percutaneous renal biopsy and assigned to training and validation datasets. Factors associated with major complications were derived from univariate analysis and then modeled by stepwise multivariate logistic regression...
April 16, 2017: Nephrology
https://www.readbyqxmd.com/read/28359537/macrophage-density-in-early-surveillance-biopsies-predicts-future-renal-transplant-function
#18
Jan Hinrich Bräsen, Abedalrazag Khalifa, Jessica Schmitz, Wei Dai, Gunilla Einecke, Anke Schwarz, Michael Hallensleben, Bernhard M W Schmidt, Hans H Kreipe, Hermann Haller, Sibylle von Vietinghoff
Inflammation impairs renal allograft survival but is difficult to quantify by eye at low densities. Here we measured leukocyte abundance in early surveillance biopsies by digital image analysis to test for a role of chemokine receptor genotypes and analyze the predictive value of leukocyte subsets to allograft function. In six-week surveillance biopsies, T-cell (CD3), B-cell (CD20), macrophage (CD68), and dendritic cell (CD209) densities were assessed in whole slide scans. Renal cortical CD3, CD20, and CD68 were significantly higher in histologic rejection...
August 2017: Kidney International
https://www.readbyqxmd.com/read/28352011/biopsy-of-small-kidneys-a-safe-and-a-useful-guide-to-potentially-treatable-kidney-disease
#19
Kamel El-Reshaid, Wael El-Reshaid, Dalal Al-Bader, Jozsef Varro, John Madda, Hosameldin Tawfik Sallam
Over the past four years, all patients with unexplained rapid progression of their renal disease were subjected to kidney biopsy, despite their small size (<9 cm), to define its etiology. Children, pregnant women, morbidly obese patients, and those with an unstable cardiovascular state, septicemia, bleeding diathesis as well as those kidney size with size <6 cm were excluded from the study. Doppler ultrasound was used to exclude renovascular/ischemic nephropathy. The procedure was performed by an interventional radiologist using a biopsy gun technique and under ultrasound guidance...
March 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28186959/percutaneous-ultrasound-guided-renal-biopsy-a-comparison-of-axial-vs-sagittal-probe-location
#20
REVIEW
Farnaz Shamshirgar, Seyed Morteza Bagheri
BACKGROUND: Renal biopsy is an important method for diagnosis of renal parenchymal abnormalities. Here, we compare the effectiveness and complications of percutaneous ultrasound-guided renal biopsy using axial vs. sagittal probe locations. METHODS: In a cross-sectional survey, in 2012, patients with a nephrologist order were biopsied by a radiology resident. Renal biopsy was done on 15 patients using axial (A group) and the same number of biopsies done with sagittal probe location (S group)...
June 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
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