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Allerimmunogastro

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366 papers 100 to 500 followers Allergy, immune, and GI related conditions
https://www.readbyqxmd.com/read/29980278/epithelial-origin-of-eosinophilic-esophagitis
#1
REVIEW
Mark Rochman, Nurit P Azouz, Marc E Rothenberg
Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the esophagus characterized predominantly by eosinophilic inflammation, leading to esophageal dysfunction. Converging data have placed the esophageal epithelium at the center of disease pathogenesis. In particular, the main EoE disease susceptibility loci at 2p23 and 5p22 encode for gene products that are produced by the esophageal epithelium: the intracellular protease calpain 14 and thymic stromal lymphopoietin, respectively...
July 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25732419/a-meta-analysis-of-the-utility-of-c-reactive-protein-erythrocyte-sedimentation-rate-fecal-calprotectin-and-fecal-lactoferrin-to-exclude-inflammatory-bowel-disease-in-adults-with-ibs
#2
REVIEW
Stacy B Menees, Corey Powell, Jacob Kurlander, Akash Goel, William D Chey
OBJECTIVES: Irritable bowel syndrome (IBS) is viewed as a diagnosis of exclusion by most providers. The aim of our study was to perform a systematic review and meta-analysis to evaluate the utility of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin, and fecal lactoferrin to distinguish between patients with IBS and inflammatory bowel disease (IBD) and healthy controls (HCs). METHODS: A systematic online database search was performed...
March 2015: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29692253/advances-in-food-allergy-diagnosis
#3
Alexandra F Santos, Joana Gomes-Belo, Farah Hannachi, Kate Swan
An accurate diagnosis of food allergy is extremely important to guide safe and yet not overly restrictive dietary management. The cornerstone of the diagnosis of food allergy is the clinical history; it allows appropriate selection of the allergens to be tested and interpretation of the results of allergy tests, namely skin prick test (SPT), specific IgE (sIgE) to allergen extracts and, more recently, specific IgE to allergen components and the basophil activation test (BAT). SPT and sIgE to allergen extracts are very sensitive methods to detect IgE sensitization to a specific food...
April 22, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29980277/allergic-components-of-eosinophilic-esophagitis
#4
REVIEW
Jonathan Spergel, Seema S Aceves
Eosinophilic esophagitis (EoE) is a disorder of increasing prevalence worldwide, causing clinical symptoms of vomiting, failure to thrive, and dysphagia and complications of esophageal remodeling with strictures and food impactions. Molecular profiling demonstrates EoE to be an eosinophil-predominant disorder with a TH 2 cytokine profile reminiscent of other allergic diseases, such as asthma, allergic rhinitis, and atopic dermatitis. Environmental antigens in the form of foods and aeroallergens induce eosinophil, basophil, mast cell, and T-cell infiltration...
July 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29998106/vaccine-immunotherapy-for-celiac-disease
#5
Antonio Di Sabatino, Marco V Lenti, Gino R Corazza, Carmen Gianfrani
Autoimmune and allergic disorders are highly prevalent conditions in which an altered or abnormal immune response is mounted against self- or environmental antigens, respectively. Antigen-based immunotherapy is a therapeutic option aimed at restoring the specific immune tolerance toward pathogenic antigens while leaving the rest of the immune system unaffected. This strategy proved efficacy especially in allergic diseases, including asthma, allergic rhinitis, and food allergies, but still has shortcomings for the treatment of autoimmune diseases...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29678750/specific-igg-4-antibodies-to-cow-s-milk-proteins-in-pediatric-patients-with-eosinophilic-esophagitis
#6
Alexander J Schuyler, Jeffrey M Wilson, Anubha Tripathi, Scott P Commins, Princess U Ogbogu, Patrice G Kruzsewski, Barrett H Barnes, Emily C McGowan, Lisa J Workman, Jonas Lidholm, Sheryl L Rifas-Shiman, Emily Oken, Diane R Gold, Thomas A E Platts-Mills, Elizabeth A Erwin
BACKGROUND: Allergen-specific IgG4 (sIgG4 ) antibodies are often associated with tolerance, but sIgG4 antibodies to causally relevant foods have been reported recently in adults with eosinophilic esophagitis (EoE). Prevalence and levels of food sIgG4 are not well established in the general pediatric population. OBJECTIVE: We sought to investigate serum food sIgG4 with component diagnostics in children with EoE and children from an unselected birth cohort and to explore the effects of sex, age, and milk consumption on sIgG4 levels...
April 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29549437/treatment-of-eosinophilic-esophagitis-in-the-pediatric-patient-an-evidence-based-approach
#7
REVIEW
Mery Munoz-Persy, Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a unique form of non-IgE-mediated food allergy characterized by esophageal eosinophilic infiltration that commonly causes dysphagia and food impaction in children and adolescents. Assessing the efficacy of dietary restrictions or drug therapies to achieve clinical and histologic resolution of EoE through randomized controlled trials and meta-analyses has resulted in new evidence-based guidelines. Avoiding food triggers is the only therapy targeting the cause of the disease...
May 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29374615/prolonged-time-to-diagnosis-of-eosinophilic-esophagitis-despite-increasing-knowledge-of-the-disease
#8
Craig C Reed, Nathaniel T Koutlas, Benjamin S Robey, Jason Hansen, Evan S Dellon
No abstract text is available yet for this article.
January 31, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29508712/new-treatment-directions-in-food-allergy
#9
REVIEW
Vanitha Sampath, Sayantani B Sindher, Wenming Zhang, Kari C Nadeau
No abstract text is available yet for this article.
March 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29620602/a-new-paradigm-in-the-treatment-of-eosinophilic-esophagitis-proton-pump-inhibitors-are-safe-aim-for-deep-remission
#10
Samuel Ellison, Hamish Philpott
No abstract text is available yet for this article.
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470322/pediatric-gastroesophageal-reflux-clinical-practice-guidelines-joint-recommendations-of-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-and-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#11
Rachel Rosen, Yvan Vandenplas, Maartje Singendonk, Michael Cabana, Carlo DiLorenzo, Frederic Gottrand, Sandeep Gupta, Miranda Langendam, Annamaria Staiano, Nikhil Thapar, Neelesh Tipnis, Merit Tabbers
This document serves as an update of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) 2009 clinical guidelines for the diagnosis and management of gastroesophageal reflux disease (GERD) in infants and children and is intended to be applied in daily practice and as a basis for clinical trials. Eight clinical questions addressing diagnostic, therapeutic and prognostic topics were formulated...
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29510130/new-eosinophilic-esophagitis-concepts-call-for-change-in-proton-pump-inhibitor-management-before-diagnostic-endoscopy
#12
EDITORIAL
Eunice Odiase, Armond Schwartz, Rhonda F Souza, Jason Martin, Vani Konda, Stuart Jon Spechler
No abstract text is available yet for this article.
April 2018: Gastroenterology
https://www.readbyqxmd.com/read/29373438/pediatric-gastroesophageal-reflux-clinical-practice-guidelines-joint-recommendations-of-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-naspghan-and-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#13
Rachel Rosen, Yvan Vandenplas, Maartje Singendonk, Michael Cabana, Carlo Di Lorenzo, Frederic Gottrand, Sandeep Gupta, Miranda Langendam, Annamaria Staiano, Nikhil Thapar, Neelesh Tipnis, Merit Tabbers
This document serves as an update of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) 2009 clinical guidelines for the diagnosis and management of gastroesophageal reflux disease (GERD) in infants and children and is intended to be applied in daily practice and as a basis for clinical trials. Eight clinical questions addressing diagnostic, therapeutic and prognostic topics were formulated...
January 25, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29273125/clinical-approach-to-the-patient-with-refractory-atopic-dermatitis
#14
REVIEW
Neema Izadi, Donald Y M Leung
No abstract text is available yet for this article.
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29307409/treatment-for-food-allergy
#15
REVIEW
A Wesley Burks, Hugh A Sampson, Marshall Plaut, Gideon Lack, Cezmi A Akdis
The prevalence of IgE-mediated food allergy is an increasing public health concern effecting millions of persons worldwide. The current standard of treatment is strict avoidance of the offending food or foods, and to date, there are no regulatory approved treatments for food allergy. A significant amount of research has been directed at various forms of food immunotherapy, including oral, sublingual, and epicutaneous delivery routes. Although oral immunotherapy has shown the greatest promise for efficacy in terms of the amount of protein that can be ingested, it has also demonstrated less tolerability and a less favorable safety profile compared with sublingual immunotherapy and epicutaneous immunotherapy, which offers the least protection but has the best safety and tolerability profile...
January 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29258790/the-allergist-s-role-in-anaphylaxis-and-food-allergy-management-in-the-school-and-childcare-setting
#16
Julie Wang, Theresa Bingemann, Anne F Russell, Michael C Young, Scott H Sicherer
Anaphylaxis and food allergy management in childcare facilities and schools are growing challenges. An increasing number of children experience severe allergic reactions on school grounds as evidenced by reports of epinephrine use. Data also suggest that the prevalence of food allergy may be increasing, with a large percentage of school-aged children at risk for anaphylaxis. Moreover, anaphylaxis may occur for the first time in a previously undiagnosed child at school or childcare setting, suggesting that general preparedness is essential...
March 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29406201/proton-pump-inhibitors-review-of-emerging-concerns
#17
REVIEW
Avinash K Nehra, Jeffrey A Alexander, Conor G Loftus, Vandana Nehra
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are currently approved by the US Food and Drug Administration for the management of a variety of gastrointestinal disorders including symptomatic peptic ulcer disease, gastroesophageal reflux disease, and nonulcer dyspepsia as well as for prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy. PPIs inhibit gastric acid secretion, and the most commonly associated adverse effects include abdominal pain, diarrhea, and headache...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29126710/immunologic-microbial-and-epithelial-interactions-in-atopic-dermatitis
#18
REVIEW
Patrick M Brunner, Donald Y M Leung, Emma Guttman-Yassky
OBJECTIVE: To provide an overview of studies contributing to the understanding of immunologic, microbial, and epithelial interactions in atopic dermatitis. DATA SOURCES: PubMed literature review (2000-2017) and meeting abstracts from recent international dermatology conferences. STUDY SELECTIONS: Articles discussing primarily human disease. RESULTS: Clinical studies showed that atopic dermatitis is a type 2 immune-centered disease with a systemic inflammatory component but with heterogeneous treatment responses...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29273127/role-of-behavioral-health-in-management-of-pediatric-atopic-dermatitis
#19
REVIEW
Mary D Klinnert, Genery Booster, Mandy Copeland, Jennifer Moyer Darr, Lisa J Meltzer, Michael Miller, Alyssa Oland, Shauna Perry, Brian K Wise, Bruce G Bender
OBJECTIVE: To describe the behavioral components and complications in treating pediatric patients with atopic dermatitis (AD) and the critical role of behavioral health professionals in addressing disease impact and behavioral aspects of disease management for these patients and families. DATA SOURCES: Studies and review articles were selected from medical and psychology databases for relevance to pertinent topics. RESULTS: AD has significant negative effects in affected individuals and their families on quality of life, behavioral, emotional, and sleep disturbances, and family functioning...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29273131/association-between-atopic-dermatitis-and-serious-cutaneous-multiorgan-and-systemic-infections-in-us-adults
#20
Shanthi Narla, Jonathan I Silverberg
BACKGROUND: Atopic dermatitis (AD) is associated with barrier disruption, immune dysregulation, and immunosuppressing treatments that can increase the association with an unusual number of infections. OBJECTIVE: To determine whether adults with AD have an unusually large number of serious infections and related outcomes. METHODS: Data from the 2002 to 2012 National Inpatient Sample were analyzed, including an approximately 20% sample of all US hospitalizations (n = 72,108,077 adults)...
January 2018: Annals of Allergy, Asthma & Immunology
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