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Allerimmunogastro

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305 papers 100 to 500 followers Allergy, immune, and GI related conditions
https://www.readbyqxmd.com/read/26198702/probiotics-for-prevention-of-atopic-diseases-in-infants-systematic-review-and-meta-analysis
#1
REVIEW
G Zuccotti, F Meneghin, A Aceti, G Barone, M L Callegari, A Di Mauro, M P Fantini, D Gori, F Indrio, L Maggio, L Morelli, L Corvaglia
Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic supplementation in childhood might prevent atopic diseases. The aim of the present systematic review and meta-analysis was to evaluate the effect of probiotic supplementation during pregnancy and early infancy in preventing atopic diseases. PubMed, Embase and Cochrane Library were searched for randomized controlled trials evaluating the use of probiotics during pregnancy or early infancy for prevention of allergic diseases...
November 2015: Allergy
https://www.readbyqxmd.com/read/22153774/low-diversity-of-the-gut-microbiota-in-infants-with-atopic-eczema
#2
Thomas R Abrahamsson, Hedvig E Jakobsson, Anders F Andersson, Bengt Björkstén, Lars Engstrand, Maria C Jenmalm
BACKGROUND: It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts. OBJECTIVE: We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development...
February 2012: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27812181/altered-gut-microbiota-composition-associated-with-eczema-in-infants
#3
Huajun Zheng, Hong Liang, Yuezhu Wang, Maohua Miao, Tao Shi, Fen Yang, Enuo Liu, Wei Yuan, Zai-Si Ji, De-Kun Li
Eczema is frequently the first manifestation of an atopic diathesis and alteration in the diversity of gut microbiota has been reported in infants with eczema. To identify specific bacterial communities associated with eczema, we conducted a case-control study of 50 infants with eczema (cases) and 51 healthy infants (controls). We performed high-throughput sequencing for V3-V4 hypervariable regions of the 16S rRNA genes from the gut fecal material. A total of 12,386 OTUs (operational taxonomic units) at a 97% similarity level were obtained from the two groups, and we observed a difference in taxa abundance, but not the taxonomic composition, of gut microbiota between the two groups...
2016: PloS One
https://www.readbyqxmd.com/read/28386004/reovirus-infection-triggers-inflammatory-responses-to-dietary-antigens-and-development-of-celiac-disease
#4
Romain Bouziat, Reinhard Hinterleitner, Judy J Brown, Jennifer E Stencel-Baerenwald, Mine Ikizler, Toufic Mayassi, Marlies Meisel, Sangman M Kim, Valentina Discepolo, Andrea J Pruijssers, Jordan D Ernest, Jason A Iskarpatyoti, Léa M M Costes, Ian Lawrence, Brad A Palanski, Mukund Varma, Matthew A Zurenski, Solomiia Khomandiak, Nicole McAllister, Pavithra Aravamudhan, Karl W Boehme, Fengling Hu, Janneke N Samsom, Hans-Christian Reinecker, Sonia S Kupfer, Stefano Guandalini, Carol E Semrad, Valérie Abadie, Chaitan Khosla, Luis B Barreiro, Ramnik J Xavier, Aylwin Ng, Terence S Dermody, Bana Jabri
Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen...
April 7, 2017: Science
https://www.readbyqxmd.com/read/28390477/current-guidelines-for-the-evaluation-and-management-of-atopic-dermatitis-a%C3%A2-comparison-of-the-joint-task-force-practice-parameter-and-american-academy-of-dermatology-guidelines
#5
REVIEW
Lawrence F Eichenfield, Jusleen Ahluwalia, Andrea Waldman, Jenna Borok, Jeremy Udkoff, Mark Boguniewicz
Atopic dermatitis (AD) is a chronic pruritic inflammatory disease that commonly presents in the pediatric population. Although definitions and diagnosis of AD have largely been agreed upon, allergists and dermatologists have similar and divergent approaches to the management of AD. This review facilitated integration of the American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma & Immunology Joint Task Force 2012 AD Practice Parameter and the 2014 American Academy of Dermatology guidelines to highlight the basic principles of AD management and discuss therapies and management of AD from the distinct perspectives of the allergist and dermatologist...
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27663157/food-allergen-mediated-exacerbations-of-oral-lichen-planus
#6
H X Chen, W J Yount, D A Culton
Erosive oral lichen planus (OLP) is a chronic autoimmune condition of unknown aetiology, characterized by periods of exacerbation and quiescence. Many patients with OLP report triggers of flares that overlap with triggers of other oral diseases, including oral allergy syndrome (OAS), an IgE-mediated food allergy. We report a case that, to our knowledge, is the first reported case of concurrent OLP and OAS diagnoses, which provides insight into the triggers of OLP and the role of trigger avoidance. A woman in her 60s presented with erosive OLP refractory to prednisone and azathioprine...
October 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28366582/association-between-atopic-manifestations-and-eosinophilic-esophagitis-a-systematic-review-and-meta-analysis
#7
Jesús González-Cervera, Ángel Arias, Olga Redondo-González, María M Cano-Mollinedo, Ingrid Terreehorst, Alfredo J Lucendo
BACKGROUND: Eosinophilic esophagitis (EoE) has repeatedly been associated with atopic manifestations, which are reported more frequently in these patients than in the general population. OBJECTIVE: To systematically assess the evidence and strength of the associations between EoE and atopy. METHODS: We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for case-control studies comparing the frequency of atopic diatheses among patients with EoE and control subjects representing the general population without EoE...
May 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27999171/cured-meat-intake-is-associated-with-worsening-asthma-symptoms
#8
Zhen Li, Marta Rava, Annabelle Bédard, Orianne Dumas, Judith Garcia-Aymerich, Bénédicte Leynaert, Christophe Pison, Nicole Le Moual, Isabelle Romieu, Valérie Siroux, Carlos A Camargo, Rachel Nadif, Raphaëlle Varraso
BACKGROUND: Cured meat intake-a recent carcinogenic factor-may increase the risk of COPD, but its association with asthma remains unknown. Though body mass index (BMI) is a likely risk factor for asthma, its role in the diet-asthma association as a mediator has never been studied. We investigated the association between cured meat intake and worsening asthma symptoms in adults, and the role of BMI as a potential mediator. METHODS: Using data from the French prospective EGEA study (baseline: 2003-2007; follow-up: 2011-2013), we applied a mediation analysis in the counterfactual framework, a marginal structural model (MSM), to estimate the direct effect of baseline cured meat intake (<1, 1-3...
March 2017: Thorax
https://www.readbyqxmd.com/read/28387947/diagnostic-tools-in-ocular-allergy
#9
Andrea Leonardi, Serge Doan, Jean Luc Fauquert, Banu Bozkurt, Pia Allegri, Farid Marmouz, Carmen Rondon, Monica Jedrzejczak, Peter Hellings, Luis Delgado, Virginia Calder
Ocular allergy (OA) includes a group of common and less frequent hypersensitivity disorders frequently misdiagnosed and not properly managed. The diagnosis of OA is usually based on clinical history and signs and symptoms, with the support of in vivo and in vitro tests when identification of the specific allergen is required. To date, no specific test is available for the diagnosis of the whole spectrum of the different forms of OA. The lack of recommendations on diagnosis of OA is considered a medical need not only for allergists but also for ophthalmologists...
April 7, 2017: Allergy
https://www.readbyqxmd.com/read/28266703/changes-to-infant-feeding-guidelines-relevance-to-dermatologists
#10
REVIEW
Celestine C Wong, Katrina J Allen, David Orchard
The newly revised Australian Infant Feeding Guidelines recommends that all infants, including those at high risk of allergy, be introduced foods traditionally considered allergenic (such as peanut butter, dairy, wheat and egg) within the first year of life. High-risk infants are those with early onset eczema (<3-months old) or with moderate to severe eczema not responding to treatment (<6-months old). Eczema can also represent a symptom of allergy presentation and the recommended introduction of some foods in this group may lead to allergic reactions at home...
March 7, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28246468/lymphocytic-esophagitis-still-an-enigma-a-decade-later
#11
REVIEW
Carol Rouphael, Ilyssa O Gordon, Prashanthi N Thota
Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28151767/increasing-incidence-and-altered-presentation-in-a-population-based-study-of-pediatric-celiac-disease-in-north-america
#12
Eyad Almallouhi, Katherine S King, Bhavisha Patel, Chung Wi, Young J Juhn, Joseph A Murray, Imad Absah
OBJECTIVES: Celiac disease (CD) is a common immune-mediated disorder that affects up to 1% of the general population. Recent reports suggest that the incidence of CD has reached a plateau in many countries. We aim to study the incidence and altered presentation of childhood CD in a well-defined population. METHODS: Using the Rochester Epidemiology Project, we retrospectively reviewed Mayo Clinic and Olmsted Medical Center medical records from January 1994 to December 2014...
February 1, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28131390/calpain-14-and-its-association-with-eosinophilic-esophagitis
#13
REVIEW
Vladislav A Litosh, Mark Rochman, Jeffrey K Rymer, Aleksey Porollo, Leah C Kottyan, Marc E Rothenberg
Calpains are a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory processes, including cytoskeletal dynamics, cell-cycle progression, signal transduction, gene expression, and apoptosis. These enzymes have been implicated in a number of disease processes, notably for this review involving eosinophilic tissue inflammation, such as eosinophilic esophagitis (EoE), a chronic inflammatory disorder triggered by allergic hypersensitivity to food and associated with genetic variants in calpain 14 (CAPN14)...
January 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28167094/international-consensus-guidelines-for-the-diagnosis-and-management-of-food-protein-induced-enterocolitis-syndrome-executive-summary-workgroup-report-of-the-adverse-reactions-to-foods-committee-american-academy-of-allergy-asthma-immunology
#14
Anna Nowak-Węgrzyn, Mirna Chehade, Marion E Groetch, Jonathan M Spergel, Robert A Wood, Katrina Allen, Dan Atkins, Sami Bahna, Ashis V Barad, Cecilia Berin, Terri Brown Whitehorn, A Wesley Burks, Jean-Christoph Caubet, Antonella Cianferoni, Marisa Conte, Carla Davis, Alessandro Fiocchi, Kate Grimshaw, Ruchi Gupta, Brittany Hofmeister, J B Hwang, Yitzhak Katz, George N Konstantinou, Stephanie A Leonard, Jennifer Lightdale, Sean McGhee, Sami Mehr, Stefano Miceli Sopo, Giovanno Monti, Antonella Muraro, Stacey Katherine Noel, Ichiro Nomura, Sally Noone, Hugh A Sampson, Fallon Schultz, Scott H Sicherer, Cecilia C Thompson, Paul J Turner, Carina Venter, A Amity Westcott-Chavez, Matthew Greenhawt
Food protein-induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group...
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188724/shared-genetic-variants-suggest-common-pathways-in-allergy-and-autoimmune-diseases
#15
Eskil Kreiner, Johannes Waage, Marie Standl, Susanne Brix, Tune H Pers, Alexessander Couto Alves, Nicole M Warrington, Carla M T Tiesler, Elaine Fuertes, Lude Franke, Joel N Hirschhorn, Alan James, Angela Simpson, Joyce Y Tung, Gerard H Koppelman, Dirkje S Postma, Craig E Pennell, Marjo-Riitta Jarvelin, Adnan Custovic, Nicholas Timpson, Manuel A Ferreira, David P Strachan, John Henderson, David Hinds, Hans Bisgaard, Klaus Bønnelykke
BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms. METHODS: We meta-analyzed 2 genome-wide association studies on self-reported allergy and sensitization comprising a total of 62,330 subjects. These results were used to calculate enrichment for single nucleotide polymorphisms (SNPs) previously associated with autoimmune diseases...
February 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28192145/population-based-familial-aggregation-of-eosinophilic-esophagitis-suggests-a-genetic-contribution
#16
Kristina Allen-Brady, Rafael Firszt, John C Fang, Jathine Wong, Ken R Smith, Kathryn A Peterson
BACKGROUND: Prior familial clustering studies have observed an increased risk of eosinophilic esophagitis (EoE) mostly among first-degree relatives, suggesting a genetic contribution to EoE, and twin studies have suggested a powerful contribution from environmental factors. OBJECTIVE: This study sought to clarify the contribution of genetic factors to EoE through estimation of familial aggregation and risk of EoE in extended relatives. METHODS: The Utah Population Database, a population-based genealogy resource linked to electronic medical records for health care systems across the state of Utah, was used to identify EoE cases and age, sex, and birthplace-matched controls at a 5:1 ratio...
February 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188747/high-incidence-of-celiac-disease-in-a-long-term-study-of-adolescents-with-susceptibility-genotypes
#17
Edwin Liu, Fran Dong, Anna E Barón, Iman Taki, Jill M Norris, Brigitte I Frohnert, Edward J Hoffenberg, Marian Rewers
BACKGROUND & AIMS: Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. METHODS: We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed up for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA)...
May 2017: Gastroenterology
https://www.readbyqxmd.com/read/28194801/differences-in-eosinophil-molecular-profiles-between-children-and-adults-with-eosinophilic-esophagitis
#18
C Lingblom, T Käppi, H Bergquist, M Bove, R Arkel, R Saalman, C Wennerås
BACKGROUND: Eosinophilic esophagitis (EoE) afflicts both children and adults. It has been debated whether pediatric EoE and adult EoE represent different disease entities. The objectives of this study were to determine whether the blood eosinophil molecular pattern of children with EoE is (i) distinct from that of healthy children; and (ii) different from that of adults with EoE. METHODS: Blood eosinophils from children and adults with EoE, and healthy controls, were analyzed with flow cytometry regarding levels of CD23, CD44, CD54, CRTH2, FOXP3, and galectin-10...
February 14, 2017: Allergy
https://www.readbyqxmd.com/read/28173607/review-suggests-that-the-immunoregulatory-and-anti-inflammatory-properties-of-allergenic-foods-can-provoke-oral-tolerance-if-introduced-early-to-infants-diets
#19
REVIEW
Despina-Zoe T Mermiri, Theodora Lappa, Athina L Papadopoulou
For years, the advice was to postpone introducing allergenic foods, in order to prevent food allergies. However, food allergies have escalated rather than declined and our review of the latest epidemiological, immunological and nutritional research suggests that early weaning practices may be beneficial. The most allergenic foods, such as fish, eggs and peanuts, have proved to be inherently rich in tolerogenic substances that can play a significant role in preventing allergies. CONCLUSION: We found evidence that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to both low-risk and high-risk infants...
February 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27998193/update-on-dietary-therapy-for-eosinophilic-esophagitis-in-children-and-adults
#20
Javier Molina-Infante, Pedro Luis Gonzalez-Cordero, Angel Arias, Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease triggered predominantly, but not excusively, by food antigens. Elimination diet thus remains the only therapy targeting the cause of the disease. Importantly, EoE is a unique form of non-IgE mediated food allergy, largely dependant upon delayed, cell-mediated hypersensitivity. Areas covered: A comprehensive review of literature to summarize and update the most relevant advances on dietary therapy for pediatric and adult EoE patients is conducted...
February 2017: Expert Review of Gastroenterology & Hepatology
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