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Allerimmunogastro

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338 papers 100 to 500 followers Allergy, immune, and GI related conditions
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#1
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk for atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of one year. 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), versus a healthy untreated control group (N=285) (AB-)...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29074457/step-up-empiric-elimination-diet-for-pediatric-and-adult-eosinophilic-esophagitis-the-2-4-6-study
#2
Javier Molina-Infante, Ángel Arias, Javier Alcedo, Ruth Garcia-Romero, Sergio Casabona-Frances, Alicia Prieto-Garcia, Ines Modolell, Pedro L Gonzalez-Cordero, Isabel Perez-Martinez, Jose Luis Martin-Lorente, Carlos Guarner-Argente, Maria L Masiques, Victor Vila-Miravet, Roger Garcia-Puig, Edoardo Savarino, Carlos Teruel Sanchez-Vegazo, Cecilio Santander, Alfredo J Lucendo
BACKGROUND: Numerous dietary restrictions and endoscopies limit the implementation of empiric elimination diets in patients with eosinophilic esophagitis (EoE). Milk and wheat/gluten are the most common food triggers. OBJECTIVE: We sought to assess the effectiveness of a step-up dietary strategy for EoE. METHODS: We performed a prospective study conducted in 14 centers. Patients underwent a 6-week 2-food-group elimination diet (TFGED; milk and gluten-containing cereals)...
October 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29054706/quality-of-life-for-parents-of-children-with-food-allergy-in-peanut-restricted-versus-peanut-free-schools-in-the-united-states-and-canada
#3
Dipika R Patel, Julia E M Upton, Julie Wang, Laurie Harada, Danielle Guffey, Charles G Minard, Jordan Orange, Carla M Davis
No abstract text is available yet for this article.
October 17, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28595764/food-allergy-and-anxiety-and-depression-among-ethnic-minority-children-and-their-caregivers
#4
Renee D Goodwin, Sandra Rodgin, Rachel Goldman, Juliana Rodriguez, Gabriele deVos, Denise Serebrisky, Jonathan M Feldman
OBJECTIVE: To investigate the relationship between food allergy and symptoms of anxiety and depression among ethnic minority, low socioeconomic status (SES) children and their caregivers. STUDY DESIGN: Pediatric patients ages 4-12 years with and without food allergy and their caregivers were recruited from urban pediatric outpatient clinics. Statistical analyses were used to examine the prevalence of symptoms of anxiety and depression among patients and their caregivers with and without food allergy, adjusting for asthma...
August 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29099466/association-of-proton-pump-inhibitor-use-with-serum-biomarkers-of-inflammation-insulin-resistance-cardiovascular-risk-and-renal-function
#5
Gregory L Austin, Jennifer R Weiskopf, Jennifer L Czwornog
BACKGROUND AND GOALS: Proton pump inhibitor (PPI) use has been associated with cardiovascular disease, chronic kidney disease, and dementia. Prior studies did not account for key confounders and little is known about the association of PPIs with serum biomarkers of inflammation, insulin resistance, cardiovascular risk, and renal function. Our aims were to investigate differences in these biomarkers between PPI users and nonusers. METHODS: Our data are from the National Health and Nutrition Examination Survey (NHANES), a complex cross-sectional multistage probability sample of the US civilian population...
November 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29087399/proton-pump-inhibitor-therapy-for-eosinophilic-esophagitis-a-paradigm-shift
#6
Javier Molina-Infante, Alfredo J Lucendo
No abstract text is available yet for this article.
October 31, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043012/checklist-for-a-complete-chronic-urticaria-medical-history-an-easy-tool
#7
Ivan Cherrez-Ojeda, Karla Robles-Velasco, Pamela Bedoya-Riofrío, Peter Schmid-Grendelmeier, Sofía Cherrez, Florian Colbatzky, Ricardo Cardona, Pedro Barberan-Torres, Erick Calero, Annia Cherrez
BACKGROUND: Existing guidelines do not offer a quick, efficient alternative to the patient's recollection of relevant clinical features during anamnesis and physical examination for chronic urticaria (CU). This study aimed to identify specific items reflecting the main characteristics of CU that should be included in a comprehensive medical history for patients with CU. We also aimed to clarify possible eliciting factors for CU to support accurate diagnosis of the disease. METHODS: A panel of postgraduate dermatologists conducted a literature search for relevant studies on CU using Medline, the Cochrane database, and PubMed...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29176476/safety-and-efficacy-of-reslizumab-for-children-and-adolescents-with-eosinophilic-esophagitis-treated-over-nine-years
#8
Jonathan E Markowitz, Laura Jobe, Michelle Miller, Carrie Frost, Zegilor Laney, Ransome Eke
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic disease characterized by infiltration of eosinophils in the esophageal epithelium. There are limited treatment options for EoE. RATIONALE: To evaluate the long term safety and efficacy of reslizumab (RSZ) in pediatric patients who received RSZ in a randomized controlled trial (RCT) and expanded access program. METHODS: Records of patients who received RSZ in our center were reviewed. Patients received RSZ 2 mg/kg (or placebo) every 4 weeks as part of the RCT, open label extension (OLE), and compassionate use (CU)...
November 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26852959/mast-cells-in-gastrointestinal-disorders
#9
REVIEW
Stephan C Bischoff
Mast cells are constitutively found in the gastrointestinal (GI) tract. The three major physiological functions of GI mast cells comprise of - as far as we know - regulation of GI functions, namely epithelial and endothelial functions, crosstalk with the enteric nervous system, and contribution to the host defense against bacterial, viral and parasitic agents. A number of chronic GI diseases, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, irritable bowel syndrome, and food allergies, are thought to be associated with mast cell hyperplasia and humoral activity...
May 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26194403/the-role-of-mast-cells-in-functional-gi-disorders
#10
REVIEW
Mira M Wouters, Maria Vicario, Javier Santos
Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16-26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier function and aberrant neuronal sensitivity...
January 2016: Gut
https://www.readbyqxmd.com/read/15710782/hyperadrenergic-postural-tachycardia-syndrome-in-mast-cell-activation-disorders
#11
Cyndya Shibao, Carmen Arzubiaga, L Jackson Roberts, Satish Raj, Bonnie Black, Paul Harris, Italo Biaggioni
Postural tachycardia syndrome (POTS) is a disabling condition that commonly affects otherwise normal young females. Because these patients can present with a flushing disorder, we hypothesized that mast cell activation (MCA) can contribute to its pathogenesis. Here we describe POTS patients with MCA (MCA+POTS), diagnosed by episodes of flushing and abnormal increases in urine methylhistamine, and compared them to POTS patients with episodic flushing but normal urine methylhistamine and to normal healthy age-matched female controls...
March 2005: Hypertension
https://www.readbyqxmd.com/read/26162709/mast-cell-activation-disease-an-underappreciated-cause-of-neurologic-and-psychiatric-symptoms-and-diseases
#12
REVIEW
Lawrence B Afrin, Dieter Pöhlau, Martin Raithel, Britta Haenisch, Franz L Dumoulin, Juergen Homann, Uwe M Mauer, Sabrina Harzer, Gerhard J Molderings
Neurologists and psychiatrists frequently encounter patients whose central and/or peripheral neurologic and/or psychiatric symptoms (NPS) are accompanied by other symptoms for which investigation finds no unifying cause and for which empiric therapy often provides little to no benefit. Systemic mast cell activation disease (MCAD) has rarely been considered in the differential diagnosis in such situations. Traditionally, MCAD has been considered as just one rare (neoplastic) disease, mastocytosis, generally focusing on the mast cell (MC) mediators tryptase and histamine and the suggestive, blatant symptoms of flushing and anaphylaxis...
November 2015: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27909577/advances-in-the-understanding-and-clinical-management-of-mastocytosis-and-clonal-mast-cell-activation-syndromes
#13
REVIEW
David González-de-Olano, Almudena Matito, Alberto Orfao, Luis Escribano
Clonal mast cell activation syndromes and indolent systemic mastocytosis without skin involvement are two emerging entities that sometimes might be clinically difficult to distinguish, and they involve a great challenge for the physician from both a diagnostic and a therapeutic point of view. Furthermore, final diagnosis of both entities requires a bone marrow study; it is recommended that this be done in reference centers. In this article, we address the current consensus and guidelines for the suspicion, diagnosis, classification, treatment, and management of these two entities...
2016: F1000Research
https://www.readbyqxmd.com/read/23212667/immunology-and-clinical-manifestations-of-non-clonal-mast-cell-activation-syndrome
#14
REVIEW
Juan-Carlos Cardet, Mariana C Castells, Matthew J Hamilton
There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment...
February 2013: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/23642289/expanding-spectrum-of-mast-cell-activation-disorders-monoclonal-and-idiopathic-mast-cell-activation-syndromes
#15
REVIEW
Matthieu Picard, Pedro Giavina-Bianchi, Veronica Mezzano, Mariana Castells
BACKGROUND: In recent years, 2 new syndromes of mast cell activation have been described in patients with episodes of mast cell mediator release that range from flushing and abdominal cramping to anaphylaxis: monoclonal mast cell activation syndrome (MMAS) and idiopathic mast cell activation syndrome (MCAS). OBJECTIVE: This review will discuss these 2 new syndromes in the larger context of mast cell activation disorders as well as the diagnostic and treatment approaches for these conditions...
May 2013: Clinical Therapeutics
https://www.readbyqxmd.com/read/21621255/mast-cell-activation-syndrome-a-newly-recognized-disorder-with-systemic-clinical-manifestations
#16
Matthew J Hamilton, Jason L Hornick, Cem Akin, Mariana C Castells, Norton J Greenberger
BACKGROUND: Diagnostic criteria for mast cell (MC) activation syndrome have been recently proposed, but clinical studies to validate these criteria are lacking. OBJECTIVE: We sought to determine the clinical manifestations of this newly recognized syndrome in a cohort of patients. METHODS: We prospectively evaluated 18 patients seen at our institution with MC activation syndrome from 2006 to 2009. Patients enrolled had at least 4 of the signs and symptoms of abdominal pain, diarrhea, flushing, dermatographism, memory and concentration difficulties, or headache...
July 2011: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/23409940/mast-cell-activation-syndromes-definition-and-classification
#17
REVIEW
P Valent
Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including genetic predisposition, the number and releasability of mast cells involved in the reaction, the type of allergen, presence of specific IgE, and presence of certain comorbidities. In severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above baseline...
April 2013: Allergy
https://www.readbyqxmd.com/read/21035176/mast-cell-activation-syndrome-proposed-diagnostic-criteria
#18
Cem Akin, Peter Valent, Dean D Metcalfe
The term mast cell activation syndrome (MCAS) is finding increasing use as a diagnosis for subjects who present with signs and symptoms involving the dermis, gastrointestinal track, and cardiovascular system frequently accompanied by neurologic complaints. Such patients often have undergone multiple extensive medical evaluations by different physicians in varied disciplines without a definitive medical diagnosis until the diagnosis of MCAS is applied. However, MCAS as a distinct clinical entity has not been generally accepted, nor do there exist definitive criteria for diagnosis...
December 2010: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28780942/mast-cell-activation-syndromes
#19
REVIEW
Cem Akin
Mast cell activation is common and possibly necessary for maintenance of survival. Disordered mast cell activation occurs when mast cells are pathologically overproduced or if their activation is out of proportion to the perceived threat to homeostasis. Mast cell activation syndrome refers to a group of disorders with diverse causes presenting with episodic multisystem symptoms as the result of mast cell mediator release. Despite introduction of diagnostic criteria and some advances in treatment in the last decade, many areas of mast cell activation syndrome are in need of research...
August 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28868771/coeliac-disease-and-psychological-symptoms
#20
David Isaacs
No abstract text is available yet for this article.
September 2017: Journal of Paediatrics and Child Health
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