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Allerimmunogastro

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295 papers 25 to 100 followers Allergy, immune, and GI related conditions
https://www.readbyqxmd.com/read/28246468/lymphocytic-esophagitis-still-an-enigma-a-decade-later
#1
REVIEW
Carol Rouphael, Ilyssa O Gordon, Prashanthi N Thota
Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28151767/increasing-incidence-and-altered-presentation-in-a-population-based-study-of-pediatric-celiac-disease-in-north-america
#2
Eyad Almallouhi, Katherine S King, Bhavisha Patel, Chung Wi, Young J Juhn, Joseph A Murray, Imad Absah
OBJECTIVES: Celiac disease (CD) is a common immune-mediated disorder that affects up to 1% of the general population. Recent reports suggest that the incidence of CD has reached a plateau in many countries. We aim to study the incidence and altered presentation of childhood CD in a well-defined population. METHODS: Using the Rochester Epidemiology Project, we retrospectively reviewed Mayo Clinic and Olmsted Medical Center medical records from January 1994 to December 2014...
February 1, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28131390/calpain-14-and-its-association-with-eosinophilic-esophagitis
#3
REVIEW
Vladislav A Litosh, Mark Rochman, Jeffrey K Rymer, Aleksey Porollo, Leah C Kottyan, Marc E Rothenberg
Calpains are a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory processes, including cytoskeletal dynamics, cell-cycle progression, signal transduction, gene expression, and apoptosis. These enzymes have been implicated in a number of disease processes, notably for this review involving eosinophilic tissue inflammation, such as eosinophilic esophagitis (EoE), a chronic inflammatory disorder triggered by allergic hypersensitivity to food and associated with genetic variants in calpain 14 (CAPN14)...
January 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28167094/international-consensus-guidelines-for-the-diagnosis-and-management-of-food-protein-induced-enterocolitis-syndrome-executive-summary-workgroup-report-of-the-adverse-reactions-to-foods-committee-american-academy-of-allergy-asthma-immunology
#4
Anna Nowak-Węgrzyn, Mirna Chehade, Marion E Groetch, Jonathan M Spergel, Robert A Wood, Katrina Allen, Dan Atkins, Sami Bahna, Ashis V Barad, Cecilia Berin, Terri Brown Whitehorn, A Wesley Burks, Jean-Christoph Caubet, Antonella Cianferoni, Marisa Conte, Carla Davis, Alessandro Fiocchi, Kate Grimshaw, Ruchi Gupta, Brittany Hofmeister, J B Hwang, Yitzhak Katz, George N Konstantinou, Stephanie A Leonard, Jennifer Lightdale, Sean McGhee, Sami Mehr, Stefano Miceli Sopo, Giovanno Monti, Antonella Muraro, Stacey Katherine Noel, Ichiro Nomura, Sally Noone, Hugh A Sampson, Fallon Schultz, Scott H Sicherer, Cecilia C Thompson, Paul J Turner, Carina Venter, A Amity Westcott-Chavez, Matthew Greenhawt
Food protein-induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group...
February 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188724/shared-genetic-variants-suggest-common-pathways-in-allergy-and-autoimmune-diseases
#5
Eskil Kreiner, Johannes Waage, Marie Standl, Susanne Brix, Tune H Pers, Alexessander Couto Alves, Nicole M Warrington, Carla Mt Tiesler, Elaine Fuertes, Lude Franke, Joel N Hirschhorn, Alan James, Angela Simpson, Joyce Y Tung, Gerard H Koppelman, Dirkje S Postma, Craig E Pennell, Marjo-Riitta Jarvelin, Adnan Custovic, Nicholas Timpson, Manuel A Ferreira, David P Strachan, John Henderson, David Hinds, Hans Bisgaard, Klaus Bønnelykke
BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: To investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms. METHODS: We meta-analyzed two GWAS on self-reported allergy and sensitization comprising a total of 62,330 individuals. These results were used to calculate enrichment for SNPs previously associated with autoimmune diseases...
February 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28192145/population-based-familial-aggregation-of-eosinophilic-esophagitis-suggests-a-genetic-contribution
#6
Kristina Allen-Brady, Rafael Firszt, John C Fang, Jathine Wong, Ken R Smith, Kathryn A Peterson
BACKGROUND: Prior familial clustering studies have observed an increased risk of eosinophilic esophagitis (EoE) mostly among first-degree relatives, suggesting a genetic contribution to EoE, and twin studies have suggested a powerful contribution from environmental factors. OBJECTIVE: This study sought to clarify the contribution of genetic factors to EoE through estimation of familial aggregation and risk of EoE in extended relatives. METHODS: The Utah Population Database, a population-based genealogy resource linked to electronic medical records for health care systems across the state of Utah, was used to identify EoE cases and age, sex, and birthplace-matched controls at a 5:1 ratio...
February 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188747/high-incidence-of-celiac-disease-in-a-long-term-study-of-adolescents-with-susceptibility-genotypes
#7
Edwin Liu, Fran Dong, Anna E Barón, Iman Taki, Jill M Norris, Brigitte I Frohnert, Edward J Hoffenberg, Marian Rewers
BACKGROUND & AIMS: Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. METHODS: We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA)...
February 7, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28194801/differences-in-eosinophil-molecular-profiles-between-children-and-adults-with-eosinophilic-esophagitis
#8
Christine Lingblom, Timo Käppi, Henrik Bergquist, Mogens Bove, Rikard Arkel, Robert Saalman, Christine Wennerås
BACKGROUND: Eosinophilic esophagitis (EoE) afflicts both children and adults. It has been debated whether pediatric and adult EoE represent different disease entities. The objectives of this study were to determine if the blood eosinophil molecular pattern of children with EoE is: 1) distinct from that of healthy children; and 2) different from that of adults with EoE. METHODS: Blood eosinophils from children and adults with EoE, and healthy controls, were analyzed with flow cytometry regarding levels of CD23, CD44, CD54, CRTH2, FOXP3 and galectin-10...
February 14, 2017: Allergy
https://www.readbyqxmd.com/read/28173607/review-suggests-that-the-immunoregulatory-and-anti-inflammatory-properties-of-allergenic-foods-can-provoke-oral-tolerance-if-introduced-early-to-infants-diets
#9
REVIEW
Despina-Zoe T Mermiri, Theodora Lappa, Athina L Papadopoulou
For years, the advice was to postpone introducing allergenic foods, in order to prevent food allergies. However, food allergies have escalated rather than declined and our review of the latest epidemiological, immunological and nutritional research suggests that early weaning practices may be beneficial. The most allergenic foods, such as fish, eggs and peanuts, have proved to be inherently rich in tolerogenic substances that can play a significant role in preventing allergies. CONCLUSION: We found evidence that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to both low-risk and high-risk infants...
February 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27998193/update-on-dietary-therapy-for-eosinophilic-esophagitis-in-children-and-adults
#10
Javier Molina-Infante, Pedro Luis Gonzalez-Cordero, Angel Arias, Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease triggered predominantly, but not excusively, by food antigens. Elimination diet thus remains the only therapy targeting the cause of the disease. Importantly, EoE is a unique form of non-IgE mediated food allergy, largely dependant upon delayed, cell-mediated hypersensitivity. Areas covered: A comprehensive review of literature to summarize and update the most relevant advances on dietary therapy for pediatric and adult EoE patients is conducted...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27766109/adrenal-suppression-in-children-treated-with-swallowed-fluticasone-and-oral-viscous-budesonide-for-eosinophilic-esophagitis
#11
Alexandra Ahmet, Eric I Benchimol, Ellen B Goldbloom, Janice L Barkey
BACKGROUND: Adrenal suppression (AS), a glucocorticoid (GC) side effect associated with significant morbidity, is well described related to inhaled corticosteroid therapy for asthma. Swallowed topical glucocorticoid therapy is the main pharmacotherapy treatment for eosinophilic esophagitis (EoE) and therefore children with EoE are potentially at increased risk of AS. METHODS: In this prospective cohort study, we included children and youth <18 years diagnosed with EoE and treated with swallowed fluticasone or oral viscous budesonide for more than 1 month...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27617420/pediatric-gastrointestinal-endoscopy-european-society-of-gastrointestinal-endoscopy-esge-and-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-espghan-guideline-executive-summary
#12
Andrea Tringali, Mike Thomson, Jean-Marc Dumonceau, Marta Tavares, Merit M Tabbers, Raoul Furlano, Manon Spaander, Cesare Hassan, Christos Tzvinikos, Hanneke Ijsselstijn, Jérôme Viala, Luigi Dall'Oglio, Marc Benninga, Rok Orel, Yvan Vandenplas, Radan Keil, Claudio Romano, Eva Brownstone, Štěpán Hlava, Patrick Gerner, Werner Dolak, Rosario Landi, Wolf Dietrich Huber, Simon Everett, Andreas Vecsei, Lars Aabakken, Jorge Amil-Dias, Alessandro Zambelli
This Executive summary of the Guideline on pediatric gastrointestinal endoscopy from the European Society of Gastrointestinal Endoscopy (ESGE) and the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) refers to infants, children, and adolescents aged 0 - 18 years. The areas covered include: indications for diagnostic and therapeutic esophagogastroduodenoscopy and ileocolonoscopy; endoscopy for foreign body ingestion; endoscopic management of corrosive ingestion and stricture/stenosis; upper and lower gastrointestinal bleeding; endoscopic retrograde cholangiopancreatography, and endoscopic ultrasonography...
January 2017: Endoscopy
https://www.readbyqxmd.com/read/28092694/proton-pump-inhibitors-risks-of-long-term-use
#13
REVIEW
Leonardo Henry Eusebi, Stefano Rabitti, Maria Laura Artesiani, Dania Gelli, Marco Montagnani, Rocco Maurizio Zagari, Franco Bazzoli
Proton pump inhibitors are among the most commonly prescribed classes of drugs and their use is increasing, in particular for long term treatment, often being over-prescribed and used for inappropriate conditions. In recent years, considerable attention has been directed towards a wide range of adverse effects, and even when a potential underlying biological mechanism is plausible, the clinical evidence of the adverse effect is often weak. Several long term side effects have been investigated ranging from interaction with other drugs, increased risk of infection, reduced intestinal absorption of vitamins and minerals, and more recently kidney damage and dementia...
January 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26904346/eosinophilic-esophagitis-in-two-patients-with-systemic-sclerosis
#14
Tracy M Frech, Kathleen Boynton, Erinn Downs-Kelly, Bryan Jones, John D Kriesel, Kathryn Peterson
The gastrointestinal tract (GIT) is the most common extracutaneous organ system damaged in systemic sclerosis (SSc) and is the presenting feature in 10% of patients. The esophagus as the portion of the GIT is the most commonly affected and there is an association of gastroesophageal reflux (GER) with SSc interstitial lung disease (ILD). Thus, an aggressive treatment for GER is recommended in all SSc patients with ILD; however, it is recognized that a long-term benefit to this treatment is needed to understand its impact...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27582492/cow-s-milk-protein-allergy
#15
Grace Mousan, Deepak Kamat
Cow's milk protein allergy (CMPA) is a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life. Formula and breast-fed babies can present with symptoms of CMPA. It is important to accurately diagnose CMPA to avoid the consequences of either under- or overdiagnosis. CMPA is classically categorized into immunoglobulin E (IgE)- or non-IgE-mediated reaction that vary in clinical manifestations, diagnostic evaluation, and prognosis. The most commonly involved systems in patients with CMPA are gastrointestinal, skin, and respiratory...
October 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/28112686/value-of-iga-ttg-in-predicting-mucosal-recovery-in-children-with-celiac-disease-on-a-gluten-free-diet
#16
Maureen M Leonard, Dascha C Weir, Maya DeGroote, Paul D Mitchell, Prashant Singh, Jocelyn A Silvester, Alan M Leichtner, Alessio Fasano
OBJECTIVES: Our objective was to determine the rate of mucosal recovery in pediatric patients with celiac disease on a gluten-free diet. We also sought to determine whether immunoglobulin A tissue transglutaminase (tTG) correlates with mucosal damage at the time of a repeat endoscopy with duodenal biopsy in these patients. METHODS: We performed a retrospective chart review of 103 pediatric patients, younger than 21 years, with a diagnosis of celiac disease defined as Marsh 3 histology, and who underwent a repeat endoscopy with duodenal biopsy at least 12 months after initiating a gluten-free diet...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28118289/utility-of-gastric-and-duodenal-biopsies-during-follow-up-endoscopy-in-children-with-eosinophilic-esophagitis
#17
Sunpreet Kaur, John M Rosen, Alyssa A Kriegermeier, Joshua B Wechsler, Amir F Kagalwalla, Jeffrey B Brown
OBJECTIVES: Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disorder of the esophagus. Consensus guidelines recommend obtaining esophageal, gastric and duodenal biopsies at diagnostic endoscopy when EoE is suspected. The utility of repeated gastric and duodenal biopsies during follow-up endoscopy in patients previously diagnosed with EoE is not established. The aim of this study was to explore the role of gastric and duodenal biopsies in children with an established diagnosis of EoE undergoing repeat endoscopy to assess histological response to treatment...
January 21, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28111307/jak1-gain-of-function-causes-an-autosomal-dominant-immune-dysregulatory-and-hypereosinophilic-syndrome
#18
Kate L Del Bel, Robert J Ragotte, Aabida Saferali, Susan Lee, Suzanne M Vercauteren, Sara A Mostafavi, Richard A Schreiber, Julie S Prendiville, Min S Phang, Jessica Halparin, Nicholas Au, John M Dean, John J Priatel, Emily Jewels, Anne K Junker, Paul C Rogers, Michael Seear, Margaret L McKinnon, Stuart E Turvey
No abstract text is available yet for this article.
January 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28079560/prenatal-exposures-and-the-development-of-childhood-wheezing-illnesses
#19
Christian Rosas-Salazar, Tina V Hartert
PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28122115/precision-medicine-in-allergic-disease-food-allergy-drug-allergy-and-anaphylaxis-practall-document-of-the-european-academy-of-allergy-and-clinical-immunology-and-the-american-academy-of-allergy-asthma-immunology
#20
REVIEW
Antonella Muraro, Robert F Lemanske, Mariana Castells, Maria J Torres, David Khan, Hans-Uwe Simon, Carsten Bindslev-Jensen, Wesley Burks, Lars K Poulsen, Hugh A Sampson, Margitta Worm, Kari C Nadeau
This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology (EAACI) and the American Academy of Allergy, Asthma and Immunology (AAAAI), which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease...
January 25, 2017: Allergy
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