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Allerimmunogastro

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317 papers 100 to 500 followers Allergy, immune, and GI related conditions
https://www.readbyqxmd.com/read/28676207/effects-of-allergen-sensitization-on-response-to-therapy-in-children-with-eosinophilic-esophagitis
#1
Robert D Pesek, Mallikarjuna Rettiganti, Erin O'Brien, Sarah Beckwith, Caroline Daniel, Chunqiao Luo, Amy M Scurlock, Peggy Chandler, Rebecca A Levy, Tamara T Perry, Joshua L Kennedy, Sheva Chervinskiy, Maryelle Vonlanthen, Helen Casteel, Stephen C Fiedorek, Troy Gibbons, Stacie M Jones
BACKGROUND: In children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits. OBJECTIVE: To determine the effects of environmental allergen sensitization on response to treatment in children with EoE in the southeastern United States. METHODS: Patients 2 to 18 years old who were referred to the Arkansas Children's Hospital Eosinophilic Gastrointestinal Disorders Clinic from January 2012 to January 2016 were enrolled in a prospective, longitudinal cohort study with collection of demographics, clinical symptoms, medical history, allergy sensitization profiles, and response to treatment over time...
July 1, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28695906/no-association-between-proton-pump-inhibitor-use-and-risk-of-alzheimer-s-disease
#2
Heidi Taipale, Anna-Maija Tolppanen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer's disease (AD). METHODS: A Finnish nationwide nested case-control study MEDALZ includes all community-dwelling individuals with newly diagnosed AD during 2005-2011 (N=70,718), and up to four age-, sex-, and region of residence-matched comparison individuals for each case (N=282,858). Data were extracted from Finnish nationwide health-care registers...
July 11, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28719593/long-term-treatment-of-eosinophilic-esophagitis-with-swallowed-topical-corticosteroids-development-and-evaluation-of-a-therapeutic-concept
#3
Thomas Greuter, Christian Bussmann, Ekaterina Safroneeva, Alain M Schoepfer, Luc Biedermann, Stephan R Vavricka, Alex Straumann
OBJECTIVES: Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE). Hitherto, it has not been evaluated whether long-lasting remission can be achieved, and whether treatment can be stopped once patients have achieved this remission. METHODS: Since 2007, EoE patients included into a large database at the Swiss EoE Clinics were put on STCs as induction/maintenance therapy...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28600901/influences-of-environmental-bacteria-and-their-metabolites-on-allergies-asthma-and-host-microbiota
#4
REVIEW
G Jatzlauk, S Bartel, H Heine, M Schloter, S Krauss-Etschmann
The prevalence of allergic diseases and asthma has dramatically increased over the last decades, resulting in a high burden for patients and health care systems. Thus, there is an unmet need to develop preventative strategies for these diseases. Epidemiological studies show that reduced exposure to environmental bacteria in early life (e.g birth by cesarian section, being formula-fed, growing up in an urban environment or with less contact to various persons) is associated with an increased risk to develop allergies and asthma later in life...
June 10, 2017: Allergy
https://www.readbyqxmd.com/read/28721213/diagnostic-approaches-and-treatment-of-eosinophilic-esophagitis-a-review-article
#5
REVIEW
Hossein Akhondi
Eosinophilic Esophagitis (EoE) is a condition that involves eosinophilic influx into the esophageal epithelium. It affects both children and adults; Adults present with dysphagia whereas children with vague abdominal complaints. The clinical symptoms as well as pathologic features of EoE and gastro esophageal reflux disease (GERD) are similar. Since eosinophilia in the esophagus is a non-specific finding, the clinical presentation in conjunction with endoscopic findings and pathology, is crucial in determining a differential diagnosis...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28774845/epidemiology-and-natural-history-of-eosinophilic-esophagitis
#6
Evan S Dellon, Ikuo Hirano
Eosinophilic esophagitis (EoE) has emerged over the past 2 decades as a major cause of upper gastrointestinal morbidity. Over this time, the epidemiology of EoE has also rapidly evolved. EoE has transformed from a rare case-reportable condition to disease that is commonly encountered in the gastroenterology clinic, hospital emergency room, and endoscopy suite. The incidence and prevalence are increasing at rates that outpace increased disease recognition. Current incidence estimates range from 5 to 10 cases per 100,000, and current prevalence estimates range from 0...
July 31, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28099424/the-establishment-of-cow-s-milk-protein-allergy-in-infants-is-related-with-a-deficit-of-regulatory-t-cells-treg-and-vitamin-d
#7
Laura Perezabad, Jacobo López-Abente, Elena Alonso-Lebrero, Elena Seoane, Marjorie Pion, Rafael Correa-Rocha
BACKGROUND: Cow's milk protein allergy (CMPA) is the most common food allergy in infants. However, little is known about which specific immune mechanisms are related with the CMPA onset. The objective was to investigate which immune alterations constitute differential factors between allergy and tolerance, and hence could be implicated in the CMPA establishment in infants. METHODS: An extensive analysis of immune subsets, including Treg and cytokine-secreting cells was performed in blood samples from 28 infants younger than 9 mo obtained 1-4 d after the first adverse reaction to milk...
May 2017: Pediatric Research
https://www.readbyqxmd.com/read/28474799/non-allergic-rhinitis-position-paper-of-the-european-academy-of-allergology-and-clinical-immunology
#8
P W Hellings, L Klimek, C Cingi, I Agache, C Akdis, C Bachert, J Bousquet, P Demoly, P Gevaert, V Hox, C Hupin, L Kalogjera, F Manole, R Mösges, J Mullol, N B Muluk, A Muraro, N Papadopoulos, R Pawankar, C Rondon, M Rundenko, S F Seys, E Toskala, L Van Gerven, L Zhang, N Zhang, W J Fokkens
This EAACI position paper aims at providing a state-of-the-art overview on non-allergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as non-allergic non-infectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of minimal 2 nasal symptoms like nasal obstruction, rhinorrhoea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28599992/natural-history-of-skin-prick-test-reactivity-a-20-year-prospective-study-of-a-random-population-sample-of-children-and-adolescents
#9
Jesper Schou Nielsen, Howraman Meteran, Charlotte Suppli Ulrik, Celeste Porsbjerg, Vibeke Backer
BACKGROUND: Allergic reactions to airborne allergens may have important consequences for affected individuals and are believed to be unstable through life, although evidence from longitudinal studies is limited. OBJECTIVE: To assess changes in skin prick reactivity during 20 years in a random population sample of children and adolescents in relation to symptoms of rhinitis. METHODS: A total of 983 individuals, aged 7 to 17 years, were randomly selected in 1986 and invited to 4 examinations during a 20-year period...
June 6, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28557044/timing-of-food-introduction-and-development-of-food-sensitization-in-a-prospective-birth-cohort
#10
Maxwell M Tran, Diana L Lefebvre, David Dai, Christoffer Dharma, Padmaja Subbarao, Wendy Lou, Meghan B Azad, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The effect of infant feeding practices on the development of food allergy remains controversial. We examined the relationship between timing and patterns of food introduction and sensitization to foods at age 1 year in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. METHODS: Nutrition questionnaire data prospectively collected at age 3, 6, 12, 18 and 24 months were used to determine timing of introduction of cow's milk products, egg and peanut...
May 29, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28475890/metabolic-instruction-of-immunity
#11
REVIEW
Michael D Buck, Ryan T Sowell, Susan M Kaech, Erika L Pearce
Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease...
May 4, 2017: Cell
https://www.readbyqxmd.com/read/28390478/clinical-phenotypes-and-endophenotypes-of-atopic-dermatitis-where-are-we-and-where-should-we-go
#12
Thomas Bieber, Angelo M D'Erme, Cezmi A Akdis, Claudia Traidl-Hoffmann, Roger Lauener, Georg Schäppi, Peter Schmid-Grendelmeier
Atopic dermatitis (AD) is a paradigmatic chronic inflammatory skin disease characterized by a complex pathophysiology and a wide spectrum of the clinical phenotype. Despite this high degree of heterogeneity, AD is still considered a single disease and usually treated according to the "one-size-fits-all" approach. Thus more tailored prevention and therapeutic strategies are still lacking. As for other disciplines, such as oncology or rheumatology, we have to approach AD in a more differentiated way (ie, to dissect and stratify the complex clinical phenotype into more homogeneous subgroups based on the endophenotype [panel of biomarkers]) with the aim to refine the management of this condition...
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26198702/probiotics-for-prevention-of-atopic-diseases-in-infants-systematic-review-and-meta-analysis
#13
REVIEW
G Zuccotti, F Meneghin, A Aceti, G Barone, M L Callegari, A Di Mauro, M P Fantini, D Gori, F Indrio, L Maggio, L Morelli, L Corvaglia
Growing evidence underlines the pivotal role of infant gut colonization in the development of the immune system. The possibility to modify gut colonization through probiotic supplementation in childhood might prevent atopic diseases. The aim of the present systematic review and meta-analysis was to evaluate the effect of probiotic supplementation during pregnancy and early infancy in preventing atopic diseases. PubMed, Embase and Cochrane Library were searched for randomized controlled trials evaluating the use of probiotics during pregnancy or early infancy for prevention of allergic diseases...
November 2015: Allergy
https://www.readbyqxmd.com/read/22153774/low-diversity-of-the-gut-microbiota-in-infants-with-atopic-eczema
#14
Thomas R Abrahamsson, Hedvig E Jakobsson, Anders F Andersson, Bengt Björkstén, Lars Engstrand, Maria C Jenmalm
BACKGROUND: It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts. OBJECTIVE: We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development...
February 2012: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27812181/altered-gut-microbiota-composition-associated-with-eczema-in-infants
#15
Huajun Zheng, Hong Liang, Yuezhu Wang, Maohua Miao, Tao Shi, Fen Yang, Enuo Liu, Wei Yuan, Zai-Si Ji, De-Kun Li
Eczema is frequently the first manifestation of an atopic diathesis and alteration in the diversity of gut microbiota has been reported in infants with eczema. To identify specific bacterial communities associated with eczema, we conducted a case-control study of 50 infants with eczema (cases) and 51 healthy infants (controls). We performed high-throughput sequencing for V3-V4 hypervariable regions of the 16S rRNA genes from the gut fecal material. A total of 12,386 OTUs (operational taxonomic units) at a 97% similarity level were obtained from the two groups, and we observed a difference in taxa abundance, but not the taxonomic composition, of gut microbiota between the two groups...
2016: PloS One
https://www.readbyqxmd.com/read/28386004/reovirus-infection-triggers-inflammatory-responses-to-dietary-antigens-and-development-of-celiac-disease
#16
Romain Bouziat, Reinhard Hinterleitner, Judy J Brown, Jennifer E Stencel-Baerenwald, Mine Ikizler, Toufic Mayassi, Marlies Meisel, Sangman M Kim, Valentina Discepolo, Andrea J Pruijssers, Jordan D Ernest, Jason A Iskarpatyoti, Léa M M Costes, Ian Lawrence, Brad A Palanski, Mukund Varma, Matthew A Zurenski, Solomiia Khomandiak, Nicole McAllister, Pavithra Aravamudhan, Karl W Boehme, Fengling Hu, Janneke N Samsom, Hans-Christian Reinecker, Sonia S Kupfer, Stefano Guandalini, Carol E Semrad, Valérie Abadie, Chaitan Khosla, Luis B Barreiro, Ramnik J Xavier, Aylwin Ng, Terence S Dermody, Bana Jabri
Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen...
April 7, 2017: Science
https://www.readbyqxmd.com/read/28390477/current-guidelines-for-the-evaluation-and-management-of-atopic-dermatitis-a%C3%A2-comparison-of-the-joint-task-force-practice-parameter-and-american-academy-of-dermatology-guidelines
#17
REVIEW
Lawrence F Eichenfield, Jusleen Ahluwalia, Andrea Waldman, Jenna Borok, Jeremy Udkoff, Mark Boguniewicz
Atopic dermatitis (AD) is a chronic pruritic inflammatory disease that commonly presents in the pediatric population. Although definitions and diagnosis of AD have largely been agreed upon, allergists and dermatologists have similar and divergent approaches to the management of AD. This review facilitated integration of the American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma & Immunology Joint Task Force 2012 AD Practice Parameter and the 2014 American Academy of Dermatology guidelines to highlight the basic principles of AD management and discuss therapies and management of AD from the distinct perspectives of the allergist and dermatologist...
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27663157/food-allergen-mediated-exacerbations-of-oral-lichen-planus
#18
H X Chen, W J Yount, D A Culton
Erosive oral lichen planus (OLP) is a chronic autoimmune condition of unknown aetiology, characterized by periods of exacerbation and quiescence. Many patients with OLP report triggers of flares that overlap with triggers of other oral diseases, including oral allergy syndrome (OAS), an IgE-mediated food allergy. We report a case that, to our knowledge, is the first reported case of concurrent OLP and OAS diagnoses, which provides insight into the triggers of OLP and the role of trigger avoidance. A woman in her 60s presented with erosive OLP refractory to prednisone and azathioprine...
October 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28366582/association-between-atopic-manifestations-and-eosinophilic-esophagitis-a-systematic-review-and-meta-analysis
#19
REVIEW
Jesús González-Cervera, Ángel Arias, Olga Redondo-González, María M Cano-Mollinedo, Ingrid Terreehorst, Alfredo J Lucendo
BACKGROUND: Eosinophilic esophagitis (EoE) has repeatedly been associated with atopic manifestations, which are reported more frequently in these patients than in the general population. OBJECTIVE: To systematically assess the evidence and strength of the associations between EoE and atopy. METHODS: We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for case-control studies comparing the frequency of atopic diatheses among patients with EoE and control subjects representing the general population without EoE...
May 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27999171/cured-meat-intake-is-associated-with-worsening-asthma-symptoms
#20
Zhen Li, Marta Rava, Annabelle Bédard, Orianne Dumas, Judith Garcia-Aymerich, Bénédicte Leynaert, Christophe Pison, Nicole Le Moual, Isabelle Romieu, Valérie Siroux, Carlos A Camargo, Rachel Nadif, Raphaëlle Varraso
BACKGROUND: Cured meat intake-a recent carcinogenic factor-may increase the risk of COPD, but its association with asthma remains unknown. Though body mass index (BMI) is a likely risk factor for asthma, its role in the diet-asthma association as a mediator has never been studied. We investigated the association between cured meat intake and worsening asthma symptoms in adults, and the role of BMI as a potential mediator. METHODS: Using data from the French prospective EGEA study (baseline: 2003-2007; follow-up: 2011-2013), we applied a mediation analysis in the counterfactual framework, a marginal structural model (MSM), to estimate the direct effect of baseline cured meat intake (<1, 1-3...
March 2017: Thorax
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