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270 papers 100 to 500 followers Insomnia, OSA, other sleep disorders
https://www.readbyqxmd.com/read/29966666/axon-and-schwann-cell-degeneration-in-nerves-of-upper-airway-relates-to-pharyngeal-dysfunction-in-snorers-and-patients-with-sleep-apnea
#1
Farhan Shah, Thorbjörn Holmlund, Eva Levring Jäghagen, Diana Berggren, Karl Franklin, Sture Forsgren, Per Stål
BACKGROUND: The pathophysiologic mechanism of nocturnal obstruction and swallowing dysfunction commonly occurring in patients with sleep apnea is unclear. The goal of this study was to investigate whether nerve injuries in the upper airways of snorers and patients with sleep apnea are associated with pharyngeal dysfunction and severity of sleep apnea. METHODS: Twenty-two patients undergoing palatal surgery due to snoring and sleep apnea were investigated for a swallowing dysfunction by using videoradiography...
June 30, 2018: Chest
https://www.readbyqxmd.com/read/29944522/society-of-anesthesia-and-sleep-medicine-guideline-on-intraoperative-management-of-adult-patients-with-obstructive-sleep-apnea
#2
Stavros G Memtsoudis, Crispiana Cozowicz, Mahesh Nagappa, Jean Wong, Girish P Joshi, David T Wong, Anthony G Doufas, Meltem Yilmaz, Mark H Stein, Megan L Krajewski, Mandeep Singh, Lukas Pichler, Satya Krishna Ramachandran, Frances Chung
The purpose of the Society of Anesthesia and Sleep Medicine Guideline on Intraoperative Management of Adult Patients With Obstructive Sleep Apnea (OSA) is to present recommendations based on current scientific evidence. This guideline seeks to address questions regarding the intraoperative care of patients with OSA, including airway management, anesthetic drug and agent effects, and choice of anesthesia type. Given the paucity of high-quality studies with regard to study design and execution in this perioperative field, recommendations were to a large part developed by subject-matter experts through consensus processes, taking into account the current scientific knowledge base and quality of evidence...
October 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29987027/circadian-misalignment-induces-fatty-acid-metabolism-gene-profiles-and-compromises-insulin-sensitivity-in-human-skeletal-muscle
#3
Jakob Wefers, Dirk van Moorsel, Jan Hansen, Niels J Connell, Bas Havekes, Joris Hoeks, Wouter D van Marken Lichtenbelt, Hélène Duez, Esther Phielix, Andries Kalsbeek, Mark V Boekschoten, Guido J Hooiveld, Matthijs K C Hesselink, Sander Kersten, Bart Staels, Frank A J L Scheer, Patrick Schrauwen
Circadian misalignment, such as in shift work, has been associated with obesity and type 2 diabetes. However, direct effects of circadian misalignment on skeletal muscle insulin sensitivity and the muscle molecular circadian clock have never been studied in humans. Here, we investigated insulin sensitivity and muscle metabolism in 14 healthy young lean men [age 22.4 ± 2.8 years; body mass index (BMI) 22.3 ± 2.1 kg/m2 (mean ± SD)] after a 3-d control protocol and a 3.5-d misalignment protocol induced by a 12-h rapid shift of the behavioral cycle...
July 24, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30046833/functional-connectivities-in-the-brain-that-mediate-the-association-between-depressive-problems-and-sleep-quality
#4
Wei Cheng, Edmund T Rolls, Hongtao Ruan, Jianfeng Feng
Importance: Depression is associated with poor sleep quality. Understanding the neural connectivity that underlies both conditions and mediates the association between them is likely to lead to better-directed treatments for depression and associated sleep problems. Objective: To identify the brain areas that mediate the association of depressive symptoms with poor sleep quality and advance understanding of the differences in brain connectivity in depression. Design, Setting, and Participants: This study collected data from participants in the Human Connectome Project using the Adult Self-report of Depressive Problems portion of the Achenbach Adult Self-Report for Ages 18-59, a survey of self-reported sleep quality, and resting-state functional magnetic resonance imaging...
July 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30039578/sleep-latency-versus-shuteye-latency-prevalence-predictors-and-relation-to-insomnia-symptoms-in-a-representative-sample-of-adults
#5
Liese Exelmans, Michael Gradisar, Jan Van den Bulck
Shuteye latency (SEL) refers to the time spent performing activities in bed before attempting sleep. This study investigates (a) the prevalence, duration and predictors of SEL, (b) its association with insomnia symptoms (sleep onset latency [SOL], sleep quality and fatigue), and (c) the activities engaged in during SEL. A representative sample of 584 adults (18-96 years old) participated in an online survey. Respondents reported their SEL on weekday nights (Sunday to Thursday) and weekend nights (Friday and Saturday), and activities during SEL...
July 23, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29868785/the-economic-cost-of-inadequate-sleep
#6
David Hillman, Scott Mitchell, Jared Streatfeild, Chloe Burns, Dorothy Bruck, Lynne Pezzullo
Study Objectives: To estimate the economic cost (financial and nonfinancial) of inadequate sleep in Australia for the 2016-2017 financial year and relate this to likely costs in similar economies. Methods: Analysis was undertaken using prevalence, financial, and nonfinancial cost data derived from national surveys and databases. Costs considered included the following: (1) financial costs associated with health care, informal care provided outside healthcare sector, productivity losses, nonmedical work and vehicle accident costs, deadweight loss through inefficiencies relating to lost taxation revenue and welfare payments; and (2) nonfinancial costs of loss of well-being...
August 1, 2018: Sleep
https://www.readbyqxmd.com/read/29790200/sleep-duration-and-mortality-does-weekend-sleep-matter
#7
Torbjörn Åkerstedt, Francesca Ghilotti, Alessandra Grotta, Hongwei Zhao, Hans-Olov Adami, Ylva Trolle-Lagerros, Rino Bellocco
Previous studies have found a U-shaped relationship between mortality and (weekday) sleep duration. We here address the association of both weekday and weekend sleep duration with overall mortality. A cohort of 43,880 subjects was followed for 13 years through record-linkages. Cox proportional hazards regression models with attained age as time-scale were fitted to estimate multivariable-adjusted hazard ratios and 95% confidence intervals for mortality; stratified analyses on age (<65 years, ≥65 years) were conducted...
May 22, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29600089/diagnostic-criteria-for-obstructive-sleep-apnea-time-for-reappraisal
#8
EDITORIAL
Walter T McNicholas
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29968150/proteomic-biomarkers-of-cognitive-impairment-in-obstructive-sleep-apnea-syndrome
#9
Chitra Lal, Gary Hardiman, Suchit Kumbhare, Charlie Strange
PURPOSE: There are currently no biomarkers that are associated with cognitive impairment (CI) in patients with obstructive sleep apnea syndrome (OSAS). This pilot study performed an exploratory plasma proteomic analysis to discover potential biomarkers and explore proteomic pathways that differentiate OSAS subjects with and without CI. METHODS: Participants were selected from a cohort of women within 5 years of menopause not on hormone replacement therapy between the ages of 45-60 years...
July 2, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29632177/%C3%AE-amyloid-accumulation-in-the-human-brain-after-one-night-of-sleep-deprivation
#10
Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E Wiers, Sukru B Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste, Nora D Volkow
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented. Here we used PET and 18 F-florbetaben to measure brain Aβ burden (ABB) in 20 healthy controls tested after a night of rested sleep (baseline) and after a night of sleep deprivation. We show that one night of sleep deprivation, relative to baseline, resulted in a significant increase in Aβ burden in the right hippocampus and thalamus. These increases were associated with mood worsening following sleep deprivation, but were not related to the genetic risk (APOE genotype) for Alzheimer's disease...
April 24, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29482803/sexsomnia-a-diagnostic-challenge-a-case-report
#11
Marina Mioč, Elena Antelmi, Marco Filardi, Fabio Pizza, Francesca Ingravallo, Lino Nobili, Carlo Alberto Tassinari, Carlos H Schenck, Giuseppe Plazzi
No abstract text is available yet for this article.
March 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29526461/a-circadian-clock-in-the-blood-brain-barrier-regulates-xenobiotic-efflux
#12
Shirley L Zhang, Zhifeng Yue, Denice M Arnold, Gregory Artiushin, Amita Sehgal
Endogenous circadian rhythms are thought to modulate responses to external factors, but mechanisms that confer time-of-day differences in organismal responses to environmental insults/therapeutic treatments are poorly understood. Using a xenobiotic, we find that permeability of the Drosophila "blood"-brain barrier (BBB) is higher at night. The permeability rhythm is driven by circadian regulation of efflux and depends on a molecular clock in the perineurial glia of the BBB, although efflux transporters are restricted to subperineurial glia (SPG)...
March 22, 2018: Cell
https://www.readbyqxmd.com/read/14715839/melatonin-in-patients-with-reduced-rem-sleep-duration-two-randomized-controlled-trials
#13
RANDOMIZED CONTROLLED TRIAL
Dieter Kunz, Richard Mahlberg, Cordula Müller, Amely Tilmann, Frederik Bes
Recent data suggest that melatonin may influence human physiology, including the sleep-wake cycle, in a time-dependent manner via the body's internal clock. Rapid-eye-movement (REM) sleep expression is strongly circadian modulated, and the impact of REM sleep on primary brain functions, metabolic processes, and immune system function has become increasingly clear over the past decade. In our study, we evaluated the effects of exogenous melatonin on disturbed REM sleep in humans. Fourteen consecutive outpatients (five women, nine men; mean age, 50 yr) with unselected neuropsychiatric sleep disorders and reduced REM sleep duration (25% or more below age norm according to diagnostic polysomnography) were included in two consecutive, randomized, double-blind, placebo-controlled, parallel design clinical trials...
January 2004: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26762193/disturbed-sleep-in-attention-deficit-hyperactivity-disorder-adhd-is-not-a-question-of-psychiatric-comorbidity-or-adhd-presentation
#14
Anne Virring, Rikke Lambek, Per H Thomsen, Lene R Møller, Poul J Jennum
Attention-deficit hyperactivity disorder (ADHD) is a heterogeneous psychiatric disorder with three different presentations and high levels of psychiatric comorbidity. Serious sleep complaints are also common, but the role of the presentations and comorbidity in sleep is under-investigated in ADHD. Consequently, the goal of the study was to investigate sleep problems in medicine-naive school-aged children (mean age = 9.6 years) with ADHD compared to controls using objective methods and to examine the role of comorbidity and presentations...
June 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/16309961/intermittent-hypoxia-causes-rem-sleep-deficits-and-decreases-eeg-delta-power-in-nrem-sleep-in-the-c57bl-6j-mouse
#15
Vsevolod Y Polotsky, Arnon E Rubin, Alex Balbir, Terry Dean, Philip L Smith, Alan R Schwartz, Christopher P O'Donnell
BACKGROUND AND PURPOSE: Obstructive sleep apnea (OSA) severely impairs sleep architecture. We hypothesized that both intermittent hypoxia (IH) and non-hypoxic arousals of OSA result in significant disruption of non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS). PATIENTS AND METHODS: Polysomnography was performed in C57BL/6J mice (n=5) exposed to IH (cycling of FIO2 from 20.9 to 5.0%) or sleep fragmentation (SF: high flow air blasts) throughout the 12-h light phase over 5 consecutive days...
January 2006: Sleep Medicine
https://www.readbyqxmd.com/read/27150557/rem-sleep-homeostasis-in-the-absence-of-rem-sleep-effects-of-antidepressants
#16
Andrew McCarthy, Keith Wafford, Elaine Shanks, Marcin Ligocki, Dale M Edgar, Derk-Jan Dijk
Most antidepressants suppress rapid eye movement (REM) sleep, which is thought to be important to brain function, yet the resulting REM sleep restriction is well tolerated. This study investigated the impact of antidepressants with different mechanisms of action, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCA), on the regulation of REM sleep in rats. REM sleep was first demonstrated to be homeostatically regulated using 5, 8 and 10 h of REM-sleep specific restriction through EEG-triggered arousals, with an average of 91 ± 10% of lost REM sleep recovered following a 26-29 -hour recovery period...
September 2016: Neuropharmacology
https://www.readbyqxmd.com/read/28944066/immune-mediated-cerebellar-ataxias-from-bench-to-bedside
#17
REVIEW
Hiroshi Mitoma, Mario Manto, Christiane S Hampe
The cerebellum is a vulnerable target of autoimmunity in the CNS. The category of immune-mediated cerebellar ataxias (IMCAs) was recently established, and includes in particular paraneoplastic cerebellar degenerations (PCDs), gluten ataxia (GA) and anti-GAD65 antibody (Ab) associated-CA, all characterized by the presence of autoantibodies. The significance of onconeuronal autoantibodies remains uncertain in some cases. The pathogenic role of anti-GAD65Ab has been established both in vitro and in vivo, but a consensus has not been reached yet...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/21537570/sleep-disorders-in-cerebellar-ataxias
#18
REVIEW
José L Pedroso, Pedro Braga-Neto, André C Felício, Camila C H Aquino, Lucila B Fernandes do Prado, Gilmar Fernandes do Prado, Orlando G P Barsottini
Cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. Recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias, specially in autosomal dominant spinocerebellar ataxias (SCA). Among these non-motor dysfunctions, sleep disorders have been recognized, although still under or even misdiagnosed. In this review, we highlight the main sleep disorders related to cerebellar ataxias focusing on REM sleep behavior disorder (RBD), restless legs syndrome (RLS), periodic limb movement in sleep (PLMS), excessive daytime sleepiness (EDS), insomnia and sleep apnea...
April 2011: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29425582/identifying-the-best-sleep-measure-to-screen-clinical-insomnia-in-a-psychiatric-population
#19
Lee Seng Esmond Seow, Edimansyah Abdin, Sherilyn Chang, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: Insomnia symptoms are highly prevalent among patients with psychiatric disorders, and this mandates the need to identify the best self-administered sleep measure to screen for clinical insomnia among them. METHODS: A total of 400 psychiatric outpatients completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index (ISI), Epworth Sleepiness Scale, Flinders Fatigue Scale, Functional Outcomes of Sleep Questionnaire, and Dysfunctional Beliefs and Attitudes about Sleep Scale in a cross-sectional study...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29178036/neuropathic-pain-and-sleep-a-review
#20
REVIEW
Luigi Ferini-Strambi
Neuropathic pain is associated with sleep disturbances, and in turn poor sleep quality leads to increased pain sensitivity, so it is essential to assess sleep alongside neuropathic pain. Responses to drugs are inconsistent and identifying the best treatment option that will reduce pain and improve sleep quality remains challenging for clinicians. Anticonvulsants such as pregabalin and gabapentin improve neuropathic pain and have a positive effect on comorbid sleep disturbances. Opioids and antidepressants are effective in reducing pain but can exacerbate sleep disturbances...
December 2017: Pain and Therapy
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