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261 papers 100 to 500 followers Insomnia, OSA, other sleep disorders
https://www.readbyqxmd.com/read/29632177/%C3%AE-amyloid-accumulation-in-the-human-brain-after-one-night-of-sleep-deprivation
#1
Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E Wiers, Sukru B Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste, Nora D Volkow
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented. Here we used PET and 18 F-florbetaben to measure brain Aβ burden (ABB) in 20 healthy controls tested after a night of rested sleep (baseline) and after a night of sleep deprivation. We show that one night of sleep deprivation, relative to baseline, resulted in a significant increase in Aβ burden in the right hippocampus and thalamus. These increases were associated with mood worsening following sleep deprivation, but were not related to the genetic risk (APOE genotype) for Alzheimer's disease...
April 24, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29482803/sexsomnia-a-diagnostic-challenge-a-case-report
#2
Marina Mioč, Elena Antelmi, Marco Filardi, Fabio Pizza, Francesca Ingravallo, Lino Nobili, Carlo Alberto Tassinari, Carlos H Schenck, Giuseppe Plazzi
No abstract text is available yet for this article.
March 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29526461/a-circadian-clock-in-the-blood-brain-barrier-regulates-xenobiotic-efflux
#3
Shirley L Zhang, Zhifeng Yue, Denice M Arnold, Gregory Artiushin, Amita Sehgal
Endogenous circadian rhythms are thought to modulate responses to external factors, but mechanisms that confer time-of-day differences in organismal responses to environmental insults/therapeutic treatments are poorly understood. Using a xenobiotic, we find that permeability of the Drosophila "blood"-brain barrier (BBB) is higher at night. The permeability rhythm is driven by circadian regulation of efflux and depends on a molecular clock in the perineurial glia of the BBB, although efflux transporters are restricted to subperineurial glia (SPG)...
March 22, 2018: Cell
https://www.readbyqxmd.com/read/14715839/melatonin-in-patients-with-reduced-rem-sleep-duration-two-randomized-controlled-trials
#4
RANDOMIZED CONTROLLED TRIAL
Dieter Kunz, Richard Mahlberg, Cordula Müller, Amely Tilmann, Frederik Bes
Recent data suggest that melatonin may influence human physiology, including the sleep-wake cycle, in a time-dependent manner via the body's internal clock. Rapid-eye-movement (REM) sleep expression is strongly circadian modulated, and the impact of REM sleep on primary brain functions, metabolic processes, and immune system function has become increasingly clear over the past decade. In our study, we evaluated the effects of exogenous melatonin on disturbed REM sleep in humans. Fourteen consecutive outpatients (five women, nine men; mean age, 50 yr) with unselected neuropsychiatric sleep disorders and reduced REM sleep duration (25% or more below age norm according to diagnostic polysomnography) were included in two consecutive, randomized, double-blind, placebo-controlled, parallel design clinical trials...
January 2004: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26762193/disturbed-sleep-in-attention-deficit-hyperactivity-disorder-adhd-is-not-a-question-of-psychiatric-comorbidity-or-adhd-presentation
#5
Anne Virring, Rikke Lambek, Per H Thomsen, Lene R Møller, Poul J Jennum
Attention-deficit hyperactivity disorder (ADHD) is a heterogeneous psychiatric disorder with three different presentations and high levels of psychiatric comorbidity. Serious sleep complaints are also common, but the role of the presentations and comorbidity in sleep is under-investigated in ADHD. Consequently, the goal of the study was to investigate sleep problems in medicine-naive school-aged children (mean age = 9.6 years) with ADHD compared to controls using objective methods and to examine the role of comorbidity and presentations...
June 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/16309961/intermittent-hypoxia-causes-rem-sleep-deficits-and-decreases-eeg-delta-power-in-nrem-sleep-in-the-c57bl-6j-mouse
#6
Vsevolod Y Polotsky, Arnon E Rubin, Alex Balbir, Terry Dean, Philip L Smith, Alan R Schwartz, Christopher P O'Donnell
BACKGROUND AND PURPOSE: Obstructive sleep apnea (OSA) severely impairs sleep architecture. We hypothesized that both intermittent hypoxia (IH) and non-hypoxic arousals of OSA result in significant disruption of non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS). PATIENTS AND METHODS: Polysomnography was performed in C57BL/6J mice (n=5) exposed to IH (cycling of FIO2 from 20.9 to 5.0%) or sleep fragmentation (SF: high flow air blasts) throughout the 12-h light phase over 5 consecutive days...
January 2006: Sleep Medicine
https://www.readbyqxmd.com/read/27150557/rem-sleep-homeostasis-in-the-absence-of-rem-sleep-effects-of-antidepressants
#7
Andrew McCarthy, Keith Wafford, Elaine Shanks, Marcin Ligocki, Dale M Edgar, Derk-Jan Dijk
Most antidepressants suppress rapid eye movement (REM) sleep, which is thought to be important to brain function, yet the resulting REM sleep restriction is well tolerated. This study investigated the impact of antidepressants with different mechanisms of action, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCA), on the regulation of REM sleep in rats. REM sleep was first demonstrated to be homeostatically regulated using 5, 8 and 10 h of REM-sleep specific restriction through EEG-triggered arousals, with an average of 91 ± 10% of lost REM sleep recovered following a 26-29 -hour recovery period...
September 2016: Neuropharmacology
https://www.readbyqxmd.com/read/28944066/immune-mediated-cerebellar-ataxias-from-bench-to-bedside
#8
REVIEW
Hiroshi Mitoma, Mario Manto, Christiane S Hampe
The cerebellum is a vulnerable target of autoimmunity in the CNS. The category of immune-mediated cerebellar ataxias (IMCAs) was recently established, and includes in particular paraneoplastic cerebellar degenerations (PCDs), gluten ataxia (GA) and anti-GAD65 antibody (Ab) associated-CA, all characterized by the presence of autoantibodies. The significance of onconeuronal autoantibodies remains uncertain in some cases. The pathogenic role of anti-GAD65Ab has been established both in vitro and in vivo, but a consensus has not been reached yet...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/21537570/sleep-disorders-in-cerebellar-ataxias
#9
REVIEW
José L Pedroso, Pedro Braga-Neto, André C Felício, Camila C H Aquino, Lucila B Fernandes do Prado, Gilmar Fernandes do Prado, Orlando G P Barsottini
Cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. Recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias, specially in autosomal dominant spinocerebellar ataxias (SCA). Among these non-motor dysfunctions, sleep disorders have been recognized, although still under or even misdiagnosed. In this review, we highlight the main sleep disorders related to cerebellar ataxias focusing on REM sleep behavior disorder (RBD), restless legs syndrome (RLS), periodic limb movement in sleep (PLMS), excessive daytime sleepiness (EDS), insomnia and sleep apnea...
April 2011: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29425582/identifying-the-best-sleep-measure-to-screen-clinical-insomnia-in-a-psychiatric-population
#10
Lee Seng Esmond Seow, Edimansyah Abdin, Sherilyn Chang, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: Insomnia symptoms are highly prevalent among patients with psychiatric disorders, and this mandates the need to identify the best self-administered sleep measure to screen for clinical insomnia among them. METHODS: A total of 400 psychiatric outpatients completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index (ISI), Epworth Sleepiness Scale, Flinders Fatigue Scale, Functional Outcomes of Sleep Questionnaire, and Dysfunctional Beliefs and Attitudes about Sleep Scale in a cross-sectional study...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29178036/neuropathic-pain-and-sleep-a-review
#11
REVIEW
Luigi Ferini-Strambi
Neuropathic pain is associated with sleep disturbances, and in turn poor sleep quality leads to increased pain sensitivity, so it is essential to assess sleep alongside neuropathic pain. Responses to drugs are inconsistent and identifying the best treatment option that will reduce pain and improve sleep quality remains challenging for clinicians. Anticonvulsants such as pregabalin and gabapentin improve neuropathic pain and have a positive effect on comorbid sleep disturbances. Opioids and antidepressants are effective in reducing pain but can exacerbate sleep disturbances...
December 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29335916/association-between-obstructive-sleep-apnea-and-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#12
REVIEW
Shanshan Jin, Suwen Jiang, Airong Hu
The relationship between obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) has been an issue of great concern. The primary purpose of this study was to determine the influence of OSA on the levels of liver enzymes including alanine transaminase (ALT) and aspartate transaminase (AST). The secondary purpose was to estimate the effect of OSA on the histological lesions of NAFLD, such as steatosis, lobular inflammation, ballooning degeneration, fibrosis, as well as NAFLD activity score (NAS)...
January 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29280229/subjective-sleep-related-variables-in-those-who-have-and-have-not-experienced-sleep-paralysis
#13
Dan Denis, Christopher C French, Melanie N Schneider, Alice M Gregory
Research suggests that poor sleep quality is related to the occurrence of sleep paralysis, although the precise relationship between these two variables is unknown. This association has generated interest due to the related possibility that improving sleep quality could help to combat episodes of sleep paralysis. To date, studies examining the association between sleep quality and sleep paralysis have typically measured sleep quality using general measures such as the global score of the Pittsburgh Sleep Quality Index (PSQI)...
December 27, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29271015/the-effect-of-daytime-napping-and-full-night-sleep-on-the-consolidation-of-declarative-and-procedural-information
#14
Frank J van Schalkwijk, Cornelia Sauter, Kerstin Hoedlmoser, Dominik P J Heib, Gerhard Klösch, Doris Moser, Georg Gruber, Peter Anderer, Josef Zeitlhofer, Manuel Schabus
Many studies investigating sleep and memory consolidation have evaluated full-night sleep rather than alternative sleep periods such as daytime naps. This multi-centre study followed up on, and was compared with, an earlier full-night study (Schabus et al., 2004) investigating the relevance of daytime naps for the consolidation of declarative and procedural memory. Seventy-six participants were randomly assigned to a nap or wake group, and performed a declarative word-pair association or procedural mirror-tracing task...
December 22, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29145189/rem-sleep-behavior-disorder
#15
Claudio L Bassetti, Panagiotis Bargiotas
Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of neurodegenerative disorders including Parkinson's disease, multisystem atrophy, and dementia with Lewy body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29174558/anesthesia-and-sleep-apnea
#16
REVIEW
Renaud Tamisier, Fanny Fabre, Fergal O'Donoghue, Patrick Lévy, Jean-François Payen, Jean-Louis Pépin
Due to its low rate of diagnosis, in the general population over half of those experiencing obstructive sleep apnea (OSA) are unaware that they have the condition. However, any acute medical event may exacerbate OSA and could have serious health consequences. In this context the management of the perioperative period, from anesthesia through the surgery itself and into the postoperative period, is more problematic for patients with sleep disordered breathing than for others. There is prolific literature in this area although large randomized trials are few due to the high sample size needed and possible ethical difficulties of withholding OSA treatment in the perioperative period...
November 21, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29220873/effect-of-sleep-on-overnight-csf-amyloid-%C3%AE-kinetics
#17
Brendan P Lucey, Terry J Hicks, Jennifer S McLeland, Cristina D Toedebusch, Jill Boyd, Donald L Elbert, Bruce W Patterson, Jack Baty, John C Morris, Vitaliy Ovod, Kwasi G Mawuenyega, Randall J Bateman
Sleep disturbances are associated with future risk of Alzheimer's disease. Disrupted sleep increases soluble amyloid-β, suggesting a mechanism for sleep disturbances to increase Alzheimer's disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with13 C6 -leucine to measure amyloid-β kinetics. We found that sleep deprivation increased overnight amyloid-β-38, amyloid-β-40, and amyloid-β-42 levels by 25-30% via increased overnight amyloid-β production relative to sleeping controls...
December 8, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29195726/cardiovascular-effects-of-oral-appliance-therapy-in-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#18
REVIEW
Grietje E de Vries, Peter J Wijkstra, Ewout J Houwerzijl, Huib A M Kerstjens, Aarnoud Hoekema
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. This study systematically reviews the effects of oral appliance therapy (OAT) on a broad spectrum of cardiovascular outcomes. A literature search was performed up to December 31st 2016. Twenty-five relevant full-text articles were retrieved. Sixteen articles were considered methodologically sufficient, including 11 randomized controlled trials. Pooled data of the RCTs showed significant reductions in daytime systolic and diastolic blood pressure compared to baseline, but no significant reductions in heart rate, except for daytime heart rate when compared to inactive/placebo OAT...
October 26, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29106402/selective-neuronal-lapses-precede-human-cognitive-lapses-following-sleep-deprivation
#19
Yuval Nir, Thomas Andrillon, Amit Marmelshtein, Nanthia Suthana, Chiara Cirelli, Giulio Tononi, Itzhak Fried
Sleep deprivation is a major source of morbidity with widespread health effects, including increased risk of hypertension, diabetes, obesity, heart attack, and stroke. Moreover, sleep deprivation brings about vehicle accidents and medical errors and is therefore an urgent topic of investigation. During sleep deprivation, homeostatic and circadian processes interact to build up sleep pressure, which results in slow behavioral performance (cognitive lapses) typically attributed to attentional thalamic and frontoparietal circuits, but the underlying mechanisms remain unclear...
December 2017: Nature Medicine
https://www.readbyqxmd.com/read/29105874/nocturnal-nasal-obstruction-is-frequent-and-reduces-sleep-quality-in-patients-with-obstructive-sleep-apnea
#20
Maria Värendh, Morgan Andersson, Erla Bjørnsdottir, Harald Hrubos-Strøm, Arne Johannisson, Erna S Arnardottir, Thorarinn Gislason, Sigurdur Juliusson
The prevalence and consequences of nasal obstruction in untreated obstructive sleep apnea patients are not known. The study objectives were to investigate the frequency of subjective and objective nasal obstruction in untreated sleep apnea patients and the associations with sleep and quality of life. Patients in the Icelandic Sleep Apnea Cohort were subjected to a type 3 sleep study, answered questionnaires and had their nasal dimensions measured by acoustic rhinometry. In total, 810 patients participated (including 153 females), aged 54...
November 6, 2017: Journal of Sleep Research
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