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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Nilo César do Vale Baracho, Natália Fechus Monteiro, Manuela Guedes Borges, Raíssa Robles de Moura Arguelho
PURPOSE: To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease. METHODS: Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control): distilled water. Group 2 (Azuki): Vigna angularis 5% aqueous extract. Group 3 (Treatment): 10mg/kg of enalapril maleate...
August 2016: Acta Cirúrgica Brasileira
Avni Bavishi, Martin D Slade, Becca R Levy
Although books can expose people to new people and places, whether books also have health benefits beyond other types of reading materials is not known. This study examined whether those who read books have a survival advantage over those who do not read books and over those who read other types of materials, and if so, whether cognition mediates this book reading effect. The cohort consisted of 3635 participants in the nationally representative Health and Retirement Study who provided information about their reading patterns at baseline...
September 2016: Social Science & Medicine
Manu Shankar-Hari, Gary S Phillips, Mitchell L Levy, Christopher W Seymour, Vincent X Liu, Clifford S Deutschman, Derek C Angus, Gordon D Rubenfeld, Mervyn Singer
IMPORTANCE: Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the validity of this definition. OBJECTIVE: To develop a new definition and clinical criteria for identifying septic shock in adults. DESIGN, SETTING, AND PARTICIPANTS: The Society of Critical Care Medicine and the European Society of Intensive Care Medicine convened a task force (19 participants) to revise current sepsis/septic shock definitions...
February 23, 2016: JAMA: the Journal of the American Medical Association
Heng Li, Shi-ren Sun, John Q Yap, Jiang-hua Chen, Qi Qian
The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic acid-base balance and renal hemodynamics. Studies have shown that electrolyte balance, including effects of saline infusion on serum electrolytes, is often poorly understood among practicing physicians and inappropriate saline prescribing can cause increased morbidity and mortality. Large-volume (>2 L) saline infusion in healthy adults induces hyperchloremia which is associated with metabolic acidosis, hyperkalemia, and negative protein balance...
March 2016: Journal of Zhejiang University. Science. B
Sophie De Seigneux, Patrick Saudan
Isotonic saline and buffered crystalloid solutions may carry an equivalent risk of acute kidney injury in critically ill patients. In hemodialyzed patients, highly dialyzable beta-blockers are less cardioprotective than non-dialyzable beta-blockers, cooling the dialyzate may protect their cerebral white matter and too much parenteral iron may be deleterious. A promising treatment for amyloid deposits is underway. A well tolerated treatment for hyperkalemia has emerged. Low serum magnesium and diminished phosphaturia may be associated with an increased risk of chronic kidney disease...
January 13, 2016: Revue Médicale Suisse
Charles D Scales, Gregory E Tasian, Andrew L Schwaderer, David S Goldfarb, Robert A Star, Ziya Kirkali
Expanding epidemiologic and physiologic data suggest that urinary stone disease is best conceptualized as a chronic metabolic condition punctuated by symptomatic, preventable stone events. These acute events herald substantial future chronic morbidity, including decreased bone mineral density, cardiovascular disease, and CKD. Urinary stone disease imposes a large and growing public health burden. In the United States, 1 in 11 individuals will experience a urinary stone in their lifetime. Given this high incidence and prevalence, urinary stone disease is one of the most expensive urologic conditions, with health care charges exceeding $10 billion annually...
July 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Mervyn Singer, Clifford S Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annane, Michael Bauer, Rinaldo Bellomo, Gordon R Bernard, Jean-Daniel Chiche, Craig M Coopersmith, Richard S Hotchkiss, Mitchell M Levy, John C Marshall, Greg S Martin, Steven M Opal, Gordon D Rubenfeld, Tom van der Poll, Jean-Louis Vincent, Derek C Angus
IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. OBJECTIVE: To evaluate and, as needed, update definitions for sepsis and septic shock. PROCESS: A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine...
February 23, 2016: JAMA: the Journal of the American Medical Association
Yi Wang, Yujin Feng, Xiaoyun Yang, Liyan Zhang, Tongdi Zhang, Wengang Wang
BACKGROUND The aim of this study was to investigate the differences in shear wave velocity (SWV) in renal cortex, renal medulla, and renal sinuses between gestational hypertension and normal pregnant women. MATERIAL AND METHODS Ninety patients with gestational hypertension and 30 women with normal pregnancy were enrolled in this study. Kidney biopsy was performed within 6 weeks to 3 months postpartum to determine the pathological nature of renal injury. According to the classification criteria for gestational hypertension, the patients were divided into 3 groups...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
David G Lalloo, Delane Shingadia, David J Bell, Nicholas J Beeching, Christopher J M Whitty, Peter L Chiodini
1.Malaria is the tropical disease most commonly imported into the UK, with 1300-1800 cases reported each year, and 2-11 deaths. 2. Approximately three quarters of reported malaria cases in the UK are caused by Plasmodium falciparum, which is capable of invading a high proportion of red blood cells and rapidly leading to severe or life-threatening multi-organ disease. 3. Most non-falciparum malaria cases are caused by Plasmodium vivax; a few cases are caused by the other species of plasmodium: Plasmodium ovale, Plasmodium malariae or Plasmodium knowlesi...
June 2016: Journal of Infection
Stefan R Bornstein, Bruno Allolio, Wiebke Arlt, Andreas Barthel, Andrew Don-Wauchope, Gary D Hammer, Eystein S Husebye, Deborah P Merke, M Hassan Murad, Constantine A Stratakis, David J Torpy
OBJECTIVE: This clinical practice guideline addresses the diagnosis and treatment of primary adrenal insufficiency. PARTICIPANTS: The Task Force included a chair, selected by The Clinical Guidelines Subcommittee of the Endocrine Society, eight additional clinicians experienced with the disease, a methodologist, and a medical writer. The co-sponsoring associations (European Society of Endocrinology and the American Association for Clinical Chemistry) had participating members...
February 2016: Journal of Clinical Endocrinology and Metabolism
Gavin J Becker, Giuseppe Garigali, Giovanni B Fogazzi
Urine microscopy is an important tool for the diagnosis and management of several conditions affecting the kidneys and urinary tract. In this review, we describe the automated instruments, based either on flow cytometry or digitized microscopy, that are currently in use in large clinical laboratories. These tools allow the examination of large numbers of samples in short periods. We also discuss manual urinary microscopy commonly performed by nephrologists, which we encourage. After discussing the advantages of phase contrast microscopy over bright field microscopy, we describe the advancements of urine microscopy in various clinical conditions...
June 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Muhammad U Sharif, Mohamed E Elsayed, Austin G Stack
Amidst the rising tide of chronic kidney disease (CKD) burden, the global nephrology workforce has failed to expand in order to meet the growing healthcare needs of this vulnerable patient population. In truth, this shortage of nephrologists is seen in many parts of the world, including North America, Europe, Australia, New Zealand, Asia and the African continent. Moreover, expert groups on workforce planning as well as national and international professional organizations predict further reductions in the nephrology workforce over the next decade, with potentially serious implications...
February 2016: Clinical Kidney Journal
Jeanette M Smith
No abstract text is available yet for this article.
December 22, 2015: JAMA: the Journal of the American Medical Association
M Therese Southgate
No abstract text is available yet for this article.
December 1, 1999: JAMA: the Journal of the American Medical Association
Banne Nemeth, Luuk J J Scheres, Willem M Lijfering, Frits R Rosendaal
OBJECTIVE: To assess whether, as has been hypothesised since medieval times, acute fear can curdle blood. DESIGN: Crossover trial. SETTING: Main meeting room of Leiden University's Department of Clinical Epidemiology, the Netherlands, converted to a makeshift cinema. PARTICIPANTS: 24 healthy volunteers aged ≤30 years recruited among students, alumni, and employees of the Leiden University Medical Center: 14 were assigned to watch a frightening (horror) movie followed by a non-threatening (educational) movie and 10 to watch the movies in reverse order...
2015: BMJ: British Medical Journal
Karlmeinrad Giesinger, David F Hamilton, Matthias Erschbamer, Bernhard Jost, Johannes M Giesinger
OBJECTIVE: To evaluate doctors' coffee consumption at work and differences between specialties. DESIGN: Single centre retrospective cohort study. SETTING: Large teaching hospital in Switzerland. PARTICIPANTS: 766 qualified doctors (425 men, 341 women) from all medical specialties (201 internal medicine, 76 general surgery, 67 anaesthetics, 54 radiology, 48 orthopaedics, 43 gynaecology, 36 neurology, 23 neurosurgery, 96 other specialties)...
2015: BMJ: British Medical Journal
R A Abeysekera, S Wijetunge, N Nanayakkara, A W M Wazil, N V I Ratnatunga, T Jayalath, A Medagama
BACKGROUND: Star fruit (Averrhoa carambola) is commonly consumed as a herbal remedy for various ailments in tropical countries. However, the dangers associated with consumption of star fruit are not commonly known. Although star fruit induced oxalate nephrotoxicity in those with existing renal impairment is well documented, reports on its effect on those with normal renal function are infrequent. We report two unique clinical presentation patterns of star fruit nephrotoxicity following consumption of the fruit as a remedy for diabetes mellitus-the first, in a patient with normal renal function and the second case which we believe is the first reported case of chronic kidney disease (CKD) due to prolonged and excessive consumption of star fruits...
December 17, 2015: BMC Research Notes
Lucinda Whitton
No abstract text is available yet for this article.
2015: BMJ: British Medical Journal
Thomas Perneger
OBJECTIVE: To understand the underlying mechanism of the "curse of the rainbow jersey," the lack of wins that purportedly affects the current cycling world champion. DESIGN: Historical cohort study. SETTING: On the road. PARTICIPANTS: Professional cyclists who won the World Championship Road Race or the Tour of Lombardy, 1965-2013. MAIN OUTCOME MEASURES: Number of professional wins per season in the year when the target race was won (year 0) and in the two following years (years 1 and 2; the world champion wears the rainbow jersey in year 1)...
2015: BMJ: British Medical Journal
Tara C Smith
No abstract text is available yet for this article.
2015: BMJ: British Medical Journal
2015-12-21 10:15:23
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