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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Uk Renal Registry
No abstract text is available yet for this article.
2018: Nephron
Bridget Kuehn
No abstract text is available yet for this article.
July 10, 2018: JAMA: the Journal of the American Medical Association
L Zhang, Y Long, H Xiao, J Yang, P Toulon, Z Zhang
Individualized anticoagulation management and improvement of the safety and effectiveness of oral anticoagulant have always been the focus of clinicians' attention. D-dimer, a sensitive marker of thrombosis and coagulation activation, is not only traditionally used in the diagnosis of venous thromboembolism, acute aortic dissection, and disseminated intravascular coagulation but can also be used as a helpful marker in the management of oral anticoagulant, including evaluating the anticoagulation quality, predicting clinical outcomes, and determining the optimal duration and intensity of anticoagulation...
May 27, 2018: International Journal of Laboratory Hematology
Thomas B Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli
The northern white rhinoceros (NWR, Ceratotherium simum cottoni) is the most endangered mammal in the world with only two females surviving. Here we adapt existing assisted reproduction techniques (ART) to fertilize Southern White Rhinoceros (SWR) oocytes with NWR spermatozoa. We show that rhinoceros oocytes can be repeatedly recovered from live SWR females by transrectal ovum pick-up, matured, fertilized by intracytoplasmic sperm injection and developed to the blastocyst stage in vitro. Next, we generate hybrid rhinoceros embryos in vitro using gametes of NWR and SWR...
July 4, 2018: Nature Communications
J Michael Miller, Matthew J Binnicker, Sheldon Campbell, Karen C Carroll, Kimberle C Chapin, Peter H Gilligan, Mark D Gonzalez, Robert C Jerris, Sue C Kehl, Robin Patel, Bobbi S Pritt, Sandra S Richter, Barbara Robinson-Dunn, Joseph D Schwartzman, James W Snyder, Sam Telford, Elitza S Theel, Richard B Thomson, Melvin P Weinstein, Joseph D Yao
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the healthcare team. This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. This document presents a system-based approach rather than specimen-based approach, and includes bloodstream and cardiovascular system infections, central nervous system infections, ocular infections, soft tissue infections of the head and neck, upper and lower respiratory infections, infections of the gastrointestinal tract, intra-abdominal infections, bone and joint infections, urinary tract infections, genital infections, and other skin and soft tissue infections; or into etiologic agent groups, including arthropod-borne infections, viral syndromes, and blood and tissue parasite infections...
June 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Michele C Hlavsa, Bryanna L Cikesh, Virginia A Roberts, Amy M Kahler, Marissa Vigar, Elizabeth D Hilborn, Timothy J Wade, Dawn M Roellig, Jennifer L Murphy, Lihua Xiao, Kirsten M Yates, Jasen M Kunz, Matthew J Arduino, Sujan C Reddy, Kathleen E Fullerton, Laura A Cooley, Michael J Beach, Vincent R Hill, Jonathan S Yoder
No abstract text is available yet for this article.
July 2018: American Journal of Transplantation
Erikka Loftfield, Marilyn C Cornelis, Neil Caporaso, Kai Yu, Rashmi Sinha, Neal Freedman
Importance: Prospective cohorts in North America, Europe, and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain. Objective: To evaluate associations of coffee drinking with mortality by genetic caffeine metabolism score...
July 2, 2018: JAMA Internal Medicine
Andrew Wang, Jeffrey G Gaca, Vivian H Chu
Importance: Infective endocarditis occurs in approximately 15 of 100 000 people in the United States and has increased in incidence. Clinicians must make treatment decisions with respect to prophylaxis, surgical management, specific antibiotics, and the length of treatment in the setting of emerging, sometimes inconclusive clinical research findings. Observations: Community-associated infective endocarditis remains the predominant form of the disease; however, health care accounts for one-third of cases in high-income countries...
July 3, 2018: JAMA: the Journal of the American Medical Association
S G E Howard Luke, Barden Steven, Condliffe Robin, Connolly Vincent, W H Davies Christopher, Donaldson James, Everett Bernard, Free Catherine, Horner Daniel, Hunter Laura, Kaler Jasvinder, Nelson-Piercy Catherine, O'Dowd Emma, Patel Raj, Preston Wendy, Sheares Karen, Tait Campbell
No abstract text is available yet for this article.
July 2018: Thorax
Philip Ambery, Victoria E Parker, Michael Stumvoll, Maximilian G Posch, Tim Heise, Leona Plum-Moerschel, Lan-Feng Tsai, Darren Robertson, Meena Jain, Marcella Petrone, Cristina Rondinone, Boaz Hirshberg, Lutz Jermutus
BACKGROUND: Weight loss is often key in the management of obese or overweight patients with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight loss. We aimed to assess the efficacy, tolerability, and safety of treatment with MEDI0382, a balanced glucagon-like peptide-1 and glucagon receptor dual agonist developed to provide glycaemic control and weight loss, in patients with type 2 diabetes. METHODS: This randomised, placebo-controlled, double-blind, combined multiple-ascending dose (MAD) and phase 2a study was done at 11 study sites (hospitals and contract research organisations) in Germany...
June 22, 2018: Lancet
Maurizio Cecconi, Laura Evans, Mitchell Levy, Andrew Rhodes
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arising from research in the past 10 years have increased understanding of this problem among clinicians and lay people, and have led to improved outcomes. The World Health Assembly and WHO made sepsis a global health priority in 2017 and have adopted a resolution to improve the prevention, diagnosis, and management of sepsis...
June 21, 2018: Lancet
Jing Zhang, Wen Xu, Peng Wang, Juan Huang, Jun-Qi Bai, Zhi-Hai Huang, Xu-Sheng Liu, Xiao-Hui Qiu
Bupi Yishen Formula (BYF), a Chinese medicine preparation, has been clinically applied for the recovery of chronic kidney disease and for delaying its progress. Nevertheless, the chemical components in BYF have yet to be fully clarified. Ultra-high performance liquid chromatography with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MSn ) and triple-quadrupole tandem mass spectrometry (UHPLC-TQ-MS/MS) methods were developed for qualitative chemical profiling and multi-components quantitative analysis in BYF...
2018: Frontiers in Pharmacology
Vicki Stover Hertzberg, Howard Weiss, Lisa Elon, Wenpei Si, Sharon L Norris
With over 3 billion airline passengers annually, the inflight transmission of infectious diseases is an important global health concern. Over a dozen cases of inflight transmission of serious infections have been documented, and air travel can serve as a conduit for the rapid spread of newly emerging infections and pandemics. Despite sensational media stories and anecdotes, the risks of transmission of respiratory viruses in an airplane cabin are unknown. Movements of passengers and crew may facilitate disease transmission...
April 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
Kymberly D Watt
No abstract text is available yet for this article.
February 2015: Transplant International: Official Journal of the European Society for Organ Transplantation
Melissa A Ilardo, Ida Moltke, Thorfinn S Korneliussen, Jade Cheng, Aaron J Stern, Fernando Racimo, Peter de Barros Damgaard, Martin Sikora, Andaine Seguin-Orlando, Simon Rasmussen, Inge C L van den Munckhof, Rob Ter Horst, Leo A B Joosten, Mihai G Netea, Suhartini Salingkat, Rasmus Nielsen, Eske Willerslev
Understanding the physiology and genetics of human hypoxia tolerance has important medical implications, but this phenomenon has thus far only been investigated in high-altitude human populations. Another system, yet to be explored, is humans who engage in breath-hold diving. The indigenous Bajau people ("Sea Nomads") of Southeast Asia live a subsistence lifestyle based on breath-hold diving and are renowned for their extraordinary breath-holding abilities. However, it is unknown whether this has a genetic basis...
April 19, 2018: Cell
(no author information available yet)
No abstract text is available yet for this article.
April 5, 2018: Nature
Dominic Wilkinson, Sarah Barclay, Julian Savulescu
No abstract text is available yet for this article.
June 9, 2018: Lancet
Alvaro J Idrovo
No abstract text is available yet for this article.
June 9, 2018: Lancet
David Garcia, Doruk Erkan
New England Journal of Medicine, Volume 378, Issue 21, Page 2010-2021, May 2018.
May 24, 2018: New England Journal of Medicine
Kathleen M Finn, Joshua P Metlay, Yuchiao Chang, Amulya Nagarur, Shaun Yang, Christopher P Landrigan, Christiana Iyasere
Importance: While the relationship between resident work hours and patient safety has been extensively studied, little research has evaluated the role of attending physician supervision on patient safety. Objective: To determine the effect of increased attending physician supervision on an inpatient resident general medical service on patient safety and educational outcomes. Design, Setting, and Participants: This 9-month randomized clinical trial performed on an inpatient general medical service of a large academic medical center used a crossover design...
July 1, 2018: JAMA Internal Medicine
2018-06-07 09:46:08
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