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44 papers 0 to 25 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28419531/urinary-incontinence-and-hydration-a-population-based-analysis
#1
Marcella Willis-Gray, Jennifer M Wu, Alayne Markland
AIMS: To determine if there is an association between urinary incontinence (UI) and an objective measure of hydration status in men and women in a nationwide, population-based sample. METHODS: We utilized data from the 2009 to 2010 and 2011 to 2012 National Health and Nutrition Examination Surveys (NHANES), cross sectional surveys of the US non-institutionalized population. Our primary outcome was moderate/severe UI measured using a validated scale. Our exposure of interest was hydration status...
April 18, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28412719/combined-measurement-of-factor-xiii-and-d-dimer-is-helpful-for-differential-diagnosis-in-patients-with-suspected-pulmonary-embolism
#2
Ning Tang, Ziyong Sun, Dengju Li, Jun Yang, Shiyu Yin, Qing Guan
BACKGROUND: D-dimer has been used to rule out pulmonary embolism (PE). Based on previous reports of decreased concentrations of coagulation factor XIII (FXIII) in venous thromboembolism, and no change in FXIII concentration in patients with acute cardiovascular disease, we evaluated the benefit of simultaneously measuring D-dimer and FXIII concentrations for diagnosing PE. METHODS: In this prospective single-center study, we enrolled 209 patients initially suspected of having PE, and measured their D-dimer and FXIII concentrations...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28395969/ultrasmall-polymeric-nanocarriers-for-drug-delivery-to-podocytes-in-kidney-glomerulus
#3
Riccardo Bruni, Paolo Possenti, Carlotta Bordignon, Min Li, Stefania Ordanini, Piergiorgio Messa, Maria Pia Rastaldi, Francesco Cellesi
We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to podocytes, in order to overcome the failure of current therapeutic regimens in patients with proteinuric (i.e. abnormal amount of proteins in the urine) diseases. Podocytes are glomerular cells which are mainly responsible for glomerular filtration and are primarily or secondarily involved in chronic kidney diseases. Therefore, the possibility to utilise a podocyte-targeted drug delivery could represent a major breakthrough in kidney disease research, particularly in terms of dosage reduction and elimination of systemic side effects of current therapies...
April 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28375872/something-old-something-new-something-borrowed-something-black
#4
Myles Wolf, David A Bushinsky
No abstract text is available yet for this article.
April 1, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28372505/can-salivary-creatinine-and-urea-levels-be-used-to-diagnose-chronic-kidney-disease-in-children-as-accurately-as-serum-creatinine-and-urea-levels-a-case-control-study
#5
Rahime Renda
BACKGROUND AND AIM: Children with chronic kidney disease (CKD) develop many metabolic changes in blood that often necessitate frequent biochemical analysis. Serum analysis is an invasive and painful procedure. It would be highly beneficial if a noninvasive alternative process to serum analysis in children were identified. Saliva can be collected noninvasively, repeatedly, and without the use of healthcare personnel. The aims of this study were to compare serum and salivary urea and creatinine levels in children with CKD and healthy controls, and to determine if salivary creatinine and urea levels can be used to diagnose CKD in children as accurately as serum creatinine and urea levels...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28340832/the-most-frequently-cited-100-articles-in-liver-transplantation-literature
#6
M Özbilgin, T Ünek, T Egeli, C Ağalar, Ş Özbilgin, V Hancı, H Ellidokuz, I Astarcıoğlu
INTRODUCTION: We investigated the liver transplantation literature since 1975 and found the most frequently cited 100 articles and assessed the distribution of authors and journals of these articles. METHOD: Using the advanced mode of the Institute for Scientific Information (ISI) Web of Science (WOS) search engine, the words "SU = transplantation AND TI = liver OR SU = transplantation AND TS = liver" were used to scan articles and determine the most-cited 100 articles on July 18, 2016...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28342442/comparison-of-qsofa-and-sirs-for-predicting-adverse-outcomes-of-patients-with-suspicion-of-sepsis-outside-the-intensive-care-unit
#7
Eli J Finkelsztein, Daniel S Jones, Kevin C Ma, Maria A Pabón, Tatiana Delgado, Kiichi Nakahira, John E Arbo, David A Berlin, Edward J Schenck, Augustine M K Choi, Ilias I Siempos
BACKGROUND: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) for identification of patients at risk of sepsis outside the intensive care unit (ICU). We attempted to compare the discriminatory capacity of the qSOFA versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting mortality, ICU-free days, and organ dysfunction-free days in patients with suspicion of infection outside the ICU...
March 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28340252/urinary-tract-infection-recent-insight-into-the-evolutionary-arms-race-between-uropathogenic-escherichia-coli-and-our-immune-system
#8
Sebastian Schwab, Katarzyna Jobin, Christian Kurts
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide. Humans evolved various immune-dependent and independent defense mechanisms, while pathogens evolved multiple virulence factors to fight back. This article summarizes recent findings regarding the arms race between hosts and pathogens in UTIs. It was recently reported that macrophage subsets regulate neutrophil-mediated defense in primary UTIs but seem to subvert adaptive immunity upon re-infection. Moreover, some bacterial strains can survive inside macrophages, leading to recurrent infections...
March 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28241230/the-tightrope-of-resuming-anticoagulation-therapy-after-a-bleed
#9
Patrick G O'Malley
No abstract text is available yet for this article.
April 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28070258/a-scientific-correlation-between-dystemprament-in-unani-medicine-and-diseases-a-systematic-review
#10
REVIEW
Sepideh Miraj, Sara Kiani
BACKGROUND: Temperament or mezaj refers to four different humors differentiating in individuals and, as a result, proposes specific therapy for their diseases. OBJECTIVE: The aim of this study was to overview the scientific correlation between temperaments in Unani medicine and diseases. METHODS: This study was carried out from March 2015 to February 2016. A computerized search of published articles was performed using PubMed, Google Scholar, Scopus and Web of Science, and Medline databases as well as local and regional resources between 1983 and 2014...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/27992617/comparison-of-hospital-mortality-and-readmission-rates-for-medicare-patients-treated-by-male-vs-female-physicians
#11
Yusuke Tsugawa, Anupam B Jena, Jose F Figueroa, E John Orav, Daniel M Blumenthal, Ashish K Jha
Importance: Studies have found differences in practice patterns between male and female physicians, with female physicians more likely to adhere to clinical guidelines and evidence-based practice. However, whether patient outcomes differ between male and female physicians is largely unknown. Objective: To determine whether mortality and readmission rates differ between patients treated by male or female physicians. Design, Setting, and Participants: We analyzed a 20% random sample of Medicare fee-for-service beneficiaries 65 years or older hospitalized with a medical condition and treated by general internists from January 1, 2011, to December 31, 2014...
February 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27928947/oral-glucose-lowering-drugs-and-cardiovascular-outcomes-from-the-negative-record-and-accord-to-neutral-tecos-and-promising-empa-reg
#12
C Tsioufis, E Andrikou, C Thomopoulos, N Papanas, D Tousoulis
Cardiovascular (CV) morbidity and mortality are higher among patients with diabetes mellitus type 2 (T2DM), particularly those with concomitant CV diseases, compared with other populations. In patients with T2DM, intensive glucose lowering reduces microvascular disease, but has a smaller and debated effect on CV events or mortality. In this setting, the US Food and Drug Administration (FDA) required in 2008 that all new agents for the treatment of T2DM should be evaluated in terms of CV safety. Metformin has long been established as first-line pharmacological therapy in patients with T2DM, due to its proven beneficial CV effects...
December 8, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27906866/inherited-and-acquired-disorders-of-magnesium-homeostasis
#13
Matthias Tilmann Florian Wolf
PURPOSE OF REVIEW: Magnesium (Mg) imbalances are frequently overlooked. Hypermagnesemia usually occurs in preeclamptic women after Mg therapy or in end-stage renal disease patients, whereas hypomagnesemia is more common with a prevalence of up to 15% in the general population. Increasing evidence points toward a role for mild-to-moderate chronic hypomagnesemia in the pathogenesis of hypertension, type 2 diabetes mellitus, and metabolic syndrome. RECENT FINDINGS: The kidneys are the major regulator of total body Mg homeostasis...
November 30, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27891570/pragmatic-approach-to-manage-new-oral-anticoagulants-in-patients-undergoing-dental-extractions-a-prospective-case-control-study
#14
Isabel Miclotte, Maarten Vanhaverbeke, Jimoh Olubanwo Agbaje, Paul Legrand, Thomas Vanassche, Peter Verhamme, Constantinus Politis
OBJECTIVES: The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. MATERIALS AND METHODS: This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) treated with dabigatran, rivaroxaban, or apixaban and 26 matched controls. Regardless of timing of extraction, drug regimen, or renal function, patients were instructed to skip only the dose on the morning of the procedure...
November 28, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27579880/effect-of-aqueous-extract-of-the-vigna-angularis-in-rats-subjected-to-an-experimental-model-of-moderate-chronic-kidney-disease
#15
Nilo César do Vale Baracho, Natália Fechus Monteiro, Manuela Guedes Borges, Raíssa Robles de Moura Arguelho
PURPOSE: To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease. METHODS: Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control): distilled water. Group 2 (Azuki): Vigna angularis 5% aqueous extract. Group 3 (Treatment): 10mg/kg of enalapril maleate...
August 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27471129/a-chapter-a-day-association-of-book-reading-with-longevity
#16
Avni Bavishi, Martin D Slade, Becca R Levy
Although books can expose people to new people and places, whether books also have health benefits beyond other types of reading materials is not known. This study examined whether those who read books have a survival advantage over those who do not read books and over those who read other types of materials, and if so, whether cognition mediates this book reading effect. The cohort consisted of 3635 participants in the nationally representative Health and Retirement Study who provided information about their reading patterns at baseline...
September 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/26903336/developing-a-new-definition-and-assessing-new-clinical-criteria-for-septic-shock-for-the-third-international-consensus-definitions-for-sepsis-and-septic-shock-sepsis-3
#17
REVIEW
Manu Shankar-Hari, Gary S Phillips, Mitchell L Levy, Christopher W Seymour, Vincent X Liu, Clifford S Deutschman, Derek C Angus, Gordon D Rubenfeld, Mervyn Singer
IMPORTANCE: Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the validity of this definition. OBJECTIVE: To develop a new definition and clinical criteria for identifying septic shock in adults. DESIGN, SETTING, AND PARTICIPANTS: The Society of Critical Care Medicine and the European Society of Intensive Care Medicine convened a task force (19 participants) to revise current sepsis/septic shock definitions...
February 23, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26984838/0-9-saline-is-neither-normal-nor-physiological
#18
REVIEW
Heng Li, Shi-ren Sun, John Q Yap, Jiang-hua Chen, Qi Qian
The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic acid-base balance and renal hemodynamics. Studies have shown that electrolyte balance, including effects of saline infusion on serum electrolytes, is often poorly understood among practicing physicians and inappropriate saline prescribing can cause increased morbidity and mortality. Large-volume (>2 L) saline infusion in healthy adults induces hyperchloremia which is associated with metabolic acidosis, hyperkalemia, and negative protein balance...
March 2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/26946706/-nephrology-what-s-new-in-2015
#19
Sophie De Seigneux, Patrick Saudan
Isotonic saline and buffered crystalloid solutions may carry an equivalent risk of acute kidney injury in critically ill patients. In hemodialyzed patients, highly dialyzable beta-blockers are less cardioprotective than non-dialyzable beta-blockers, cooling the dialyzate may protect their cerebral white matter and too much parenteral iron may be deleterious. A promising treatment for amyloid deposits is underway. A well tolerated treatment for hyperkalemia has emerged. Low serum magnesium and diminished phosphaturia may be associated with an increased risk of chronic kidney disease...
January 13, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26964844/urinary-stone-disease-advancing-knowledge-patient-care-and-population-health
#20
Charles D Scales, Gregory E Tasian, Andrew L Schwaderer, David S Goldfarb, Robert A Star, Ziya Kirkali
Expanding epidemiologic and physiologic data suggest that urinary stone disease is best conceptualized as a chronic metabolic condition punctuated by symptomatic, preventable stone events. These acute events herald substantial future chronic morbidity, including decreased bone mineral density, cardiovascular disease, and CKD. Urinary stone disease imposes a large and growing public health burden. In the United States, 1 in 11 individuals will experience a urinary stone in their lifetime. Given this high incidence and prevalence, urinary stone disease is one of the most expensive urologic conditions, with health care charges exceeding $10 billion annually...
July 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
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