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Pediatric Heart Transplantation

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87 papers 0 to 25 followers
By Javier Castro Heart Failure And Heart Transplantation
https://www.readbyqxmd.com/read/30040193/center-volume-and-outcomes-in-pediatric-heart-transplantation-bigger-is-better-until-it-isn-t
#1
EDITORIAL
Janet Scheel, Charles E Canter
No abstract text is available yet for this article.
December 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30043916/rational-use-of-mechanical-circulatory-support-as-a-bridge-to-pediatric-and-congenital-heart-transplantation
#2
Leonardo A Miana, Guilherme Viotto Rodrigues da Silva, Luiz Fernando Caneo, Aida Luisa Turquetto, Carla Tanamati, Gustavo Foronda, Maria Raquel Massoti, Juliano G Penha, Estela Azeka, Filomena R B G Galas, Fabio B Jatene, Marcelo B Jatene
INTRODUCTION: Donor shortage and organ allocation is the main problem in pediatric heart transplant. Mechanical circulatory support is known to increase waiting list survival, but it is not routinely used in pediatric programs in Latin America. METHODS: All patients listed for heart transplant and supported by a mechanical circulatory support between January 2012 and March 2016 were included in this retrospective single-center study. The endpoints were mechanical circulatory support time, complications, heart transplant survival and discharge from the hospital...
May 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29492382/current-state-of-pediatric-cardiac-transplantation
#3
REVIEW
Anne I Dipchand
Pediatric heart transplantation is standard of care for children with end-stage heart failure. The diverse age range, diagnoses, and practice variations continue to challenge the development of evidence-based practices and new technologies. Outcomes in the most recent era are excellent, especially with the more widespread use of ventricular assist devices (VADs). Waitlist mortality remains high and knowledge of risk factors for death while waiting and following transplantation contributes to decision-making around transplant candidacy and timing of listing...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29575396/changes-in-left-ventricular-strain-parameters-following-pediatric-heart-transplantation
#4
Justin Godown, Debra A Dodd, Michael Stanley, Corey Havens, Meng Xu, James C Slaughter, David W Bearl, Jonathan H Soslow
STE is increasingly utilized to assess strain in a variety of pathologies. Strain measurements have demonstrated utility following HTx and may aid in the detection of rejection and CAV. Strain parameters have not been well defined in the pediatric HTx population. This study aimed to describe strain in pediatric HTx recipients compared to controls and assess changes over time. All pediatric HTx recipients with available echocardiograms (2004-2015) without rejection or CAV were identified. Longitudinal and circumferential strain was measured at <1 month, 1 year, 3 years, and 5 years post-transplant and compared to controls...
August 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29217110/end-stage-renal-disease-after-pediatric-heart-transplantation-a-25-year-national-cohort-study
#5
EDITORIAL
Estela Azeka
No abstract text is available yet for this article.
November 15, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29226563/fatal-cardiac-arrest-in-pediatric-heart-transplant-recipients-query-of-the-unos-database
#6
Robert W Loar, Susan W Denfield, Shaine A Morris, Hari P Tunuguntla, Antonio G Cabrera, Jack F Price, Wei Zhang, Katherine Hosek, Jeffrey J Kim, William J Dreyer, Aamir Jeewa
The incidence of death by CA after PHTx is unknown. We aimed to determine the incidence and factors for fatal CA after PHTx, and whether a PM affects survival. Retrospective cohort study utilizing the United Network of Organ Sharing registry of patients transplanted ≤18 years. Multivariable analyses in hazard-function domain and Kaplan-Meier analyses were performed for an outcome of death due to CA. There were 7719 PHTx patients queried. CA was the reported cause of death in 11%. Age ≥13 years at time of transplant, presence of a PM, and depressed EF were identified as significant factors for fatal CA...
February 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29246510/echocardiographic-detection-of-increased-ventricular-diastolic-stiffness-in-pediatric-heart-transplant-recipients-a-pilot-study
#7
Shahryar M Chowdhury, Ryan J Butts, Anthony M Hlavacek, Carolyn L Taylor, Karen S Chessa, Varsha M Bandisode, Girish S Shirali, Arni Nutting, G Hamilton Baker
BACKGROUND: Pediatric heart transplant recipients are at risk for increased left ventricular (LV) diastolic stiffness. However, the noninvasive evaluation of LV stiffness has remained elusive in this population. The objective of this study was to compare novel echocardiographic measures of LV diastolic stiffness versus gold-standard measures derived from pressure-volume loop (PVL) analysis in pediatric heart transplant recipients. METHODS: Patients undergoing left heart catheterization were prospectively enrolled...
March 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29250877/charges-and-resource-utilization-for-pediatric-heart-transplantation-across-a-positive-virtual-and-or-cytotoxicity-crossmatch
#8
Shawn C West, Steven A Webber, Adriana Zeevi, Susan A Miller, Victor O Morell, Brian Feingold
There is growing acceptance of transplantation across a positive crossmatch for highly allosensitized pediatric HT candidates. While survival may be similar to patients transplanted across a negative crossmatch, costs are unknown. Among 60 HT recipients at our center from 5/07 to 6/12, we analyzed hospital charges and length of stay from the day of HT to discharge and through the first year after transplant. Median age at HT was 6.2 years (15 days-20.5 years). Charges in the first year post-HT were greater for crossmatch-positive patients ($907 678 vs $549 754; P = ...
February 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29258675/the-number-of-refusals-for-donor-organ-quality-does-not-impact-heart-transplant-outcomes-in-children
#9
Raheel Rizwan, Farhan Zafar, Roosevelt Bryant, James S Tweddell, Angela Lorts, Clifford Chin, David L Morales
BACKGROUND: Waitlist mortality is more than 12% for pediatric heart transplantation, with strikingly high rates of organ refusal, many of which are due to donor quality. However, some centers use these organs despite refusals by other centers for donor quality. We hypothesize that the number of refusals for donor quality (RDQ) does not affect pediatric heart transplantation outcomes. METHODS: Pediatric heart transplants from 2000 to 2015 were identified using the United Network for Organ Sharing database and were matched against the potential transplant recipients dataset with donor refusal codes...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29286569/patterns-of-kidney-injury-in-pediatric-nonkidney-solid-organ-transplant-recipients
#10
C Williams, K Borges, T Banh, J Vasilevska-Ristovska, R Chanchlani, V L Ng, A I Dipchand, M Solomon, D Hebert, S J Kim, B C Astor, R S Parekh
The incidence of acute kidney injury (AKI) and its impact on chronic kidney disease (CKD) following pediatric nonkidney solid organ transplantation is unknown. We aimed to determine the incidence of AKI and CKD and examine their relationship among children who received a heart, lung, liver, or multiorgan transplant at the Hospital for Sick Children between 2002 and 2011. AKI was assessed in the first year posttransplant. Among 303 children, perioperative AKI (within the first week) occurred in 67% of children, and AKI after the first week occurred in 36%, with the highest incidence among lung and multiorgan recipients...
June 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29316050/psychosocial-functioning-in-pediatric-heart-transplant-recipients-and-their-families
#11
Melissa K Cousino, Kurt R Schumacher, Kelly E Rea, Sally Eder, Mary Zamberlan, Jessica Jordan, Emily M Fredericks
Across pediatric organ transplant populations, patient and family psychosocial functioning is associated with important health-related outcomes. Research has suggested that pediatric heart transplant recipients and their families are at increased risk for adverse psychosocial outcomes; however, recent investigation of psychosocial functioning in this population is lacking. This study aimed to provide a contemporary characterization of psychosocial functioning in pediatric heart transplant recipients and their families...
March 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29322518/pediatric-heart-transplantation-what-are-the-risk-factors-for-pacemaker-implantation-and-how-much-pacing-is-required
#12
Florian Ernst Martin Herrmann, Petra Wellmann, Christian Hagl, Gerd Juchem
BACKGROUND: In an attempt to improve pacemaker therapy after pediatric transplantation, we investigated risk factors, indication for pacing, and pacing burden after pediatric heart transplantation. METHODS AND RESULTS: In this retrospective study, 139 pediatric heart transplant recipients, of whom 122 did not and 17 did require pacemakers, were investigated. Eleven of the 17 patients requiring a permanent pacemaker (PPM) received their heart from a female donor (68...
March 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29340730/age-dependent-association-between-pre-transplant-blood-transfusion-and-outcomes-of-pediatric-heart-transplantation
#13
C McKee, D Tumin, B R Alevriadou, K K Nicol, A R Yates, D Hayes, J D Tobias
Avoidance of red blood cell (RBC) transfusions in patients awaiting heart transplantation (HTx) has been suggested to minimize the risk of allosensitization. Although recent studies have suggested that an immature immune system in younger HTx recipients may reduce risks associated with RBC transfusion, the role of age in moderating the influence of transfusion on HTx outcomes remains unclear. We used available data from a national transplant registry to explore whether the association between pre-transplant transfusions and outcomes of pediatric HTx varies by patient age...
April 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/28198130/psychosocial-predictors-of-medication-adherence-in-pediatric-heart-and-lung-organ-transplantation
#14
Michael O Killian
Few studies have identified the psychosocial characteristics of those children and their families associated with future non-adherence to immunosuppressive medications following a heart or lung transplant. UNOS data and medical records information were used to test the association between patient and family psychosocial characteristics and medication adherence. Medication adherence outcomes were obtained using the physician assessments in the UNOS data and measured through patient-level standard deviation scores of immunosuppressive medication blood levels...
June 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28127883/striking-a-balance-between-equity-and-exceptionality-in-pediatric-heart-transplantation
#15
EDITORIAL
Steven J Kindel
No abstract text is available yet for this article.
February 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28145649/clinical-characteristics-of-transplant-associated-encephalopathy-in-children
#16
Yun Jeong Lee, Mi Sun Yum, Eun Hee Kim, Min Jee Kim, Kyung Mo Kim, Ho Joon Im, Young Hwue Kim, Young Seo Park, Tae Sung Ko
We aimed to analyze characteristics of encephalopathy after both hematopoietic stem cell and solid organ pediatric transplantation. We retrospectively reviewed medical records of 662 pediatric transplant recipients (201 with liver transplantation [LT], 55 with heart transplantation [HT], and 67 with kidney transplantation [KT], 339 with allogeneic hematopoietic stem cell transplantation [HSCT]) who received their graft organs at Asan Medical Center between January 2000 and July 2014. Of the 662 patients, 50 (7...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28161809/alteration-of-cardiac-deformation-in-acute-rejection-in-pediatric-heart-transplant-recipients
#17
Nitin Chanana, Charlotte S Van Dorn, Melanie D Everitt, Hsin Yi Weng, Dylan V Miller, Shaji C Menon
The objective of this study is to assess changes in cardiac deformation during acute cellular- and antibody-mediated rejection in pediatric HT recipients. Pediatric HT recipients aged ≤18 years with at least one episode of biopsy-diagnosed rejection from 2006 to 2013 were included. Left ventricular systolic S (SS) and SR (SSr) data were acquired using 2D speckle tracking on echocardiograms obtained within 12 h of right ventricular endomyocardial biopsy. A mixed effect model was used to compare cardiac deformation during CR (Grade ≥ 1R), AMR (pAMR ≥ 2), and mixed rejection (CR and AMR positive) versus no rejection (Grade 0R and pAMR 0 or 1)...
April 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28163432/early-primary-graft-failure-after-a-pediatric-heart-transplant-and-successful-rescue-with-plasmapheresis-immunoglobulins-and-alemtuzumab
#18
Shashi Raj, Phillip Ruiz, Paolo Rusconi
Early primary graft failure after pediatric orthotopic heart transplantation (OHT) has a high mortality rate and can occur due to several causes including but not limited to prolonged graft ischemia time, suboptimal preimplant myocardial preservation, hyperacute rejection, and maladaptation of the graft to the host's hemodynamic status. Mechanical circulatory support with either extracorporeal membrane oxygenation (ECMO) or ventricular assist device has been used for the rescue of primary graft failure in pediatric patients after heart transplant...
January 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28181355/measures-of-and-changes-in-heart-rate-variability-in-pediatric-heart-transplant-recipients
#19
T Williams, X Tang, G Gilmore, J Gossett, K R Knecht
Heart rate variability is primarily regulated by the autonomic nervous system. Heart transplant recipients undergo surgical denervation of the graft, which results in interruption of autonomic innervation with resultant diminished heart rate variability although some degree of autonomic control may return. This study aimed to characterize heart rate variability in this population. We report a retrospective review of Holter monitor data from transplanted patients between 2005 and 2013. Studies with significant atrial or ventricular arrhythmias were excluded...
June 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28181361/a-systematic-review-of-parent-and-family-functioning-in-pediatric-solid-organ-transplant-populations
#20
REVIEW
Melissa K Cousino, Kelly E Rea, Kurt R Schumacher, John C Magee, Emily M Fredericks
The process of pediatric solid organ transplantation (SOT) places new and increased stressors on patients and family members. Measures of family functioning may predict psychological and health outcomes for pediatric patients and their families, and provide opportunity for targeted intervention. This systematic review investigated parent and family functioning and factors associated with poorer functioning in the pediatric SOT population. Thirty-seven studies were identified and reviewed. Studies featured a range of organ populations (eg, heart, liver, kidney, lung, intestine) at various stages in the transplant process...
May 2017: Pediatric Transplantation
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