Masaya Sugimoto, Seiko Kuwata, Clara Kurishima, Jeong Hye Kim, Yoich Iwamoto, Hideaki Senzaki
BACKGROUND: Most congenital heart diseases (CHDs) have specific hemodynamics, including volume and pressure overload, as well as cyanosis and pulmonary hypertension, associated with anatomical abnormalities. Such hemodynamic abnormalities can cause activation of neurohormones, inflammatory cytokines, fibroblasts, and vascular endothelial cells, which in turn contribute to the development of pathologic conditions such as cardiac hypertrophy, fibrosis, and cardiac cell damages and death...
November 2015: World Journal of Pediatrics: WJP