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Biomarkers in childrens

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5 papers 0 to 25 followers
By Javier Castro Heart Failure And Heart Transplantation
https://www.readbyqxmd.com/read/26857388/prognostic-value-of-multiple-biomarkers-for-cardiovascular-mortality-in-adult-congenital-heart-disease-comparisons-of-single-two-ventricle-physiology-and-systemic-morphologically-right-left-ventricles
#1
Kenji Miyamoto, Daiji Takeuchi, Kei Inai, Tokuko Shinohara, Toshio Nakanishi
Although there are many biomarkers for heart failure, limited data are available regarding their prognostic value in adult congenital heart disease (ACHD). We investigated the potential of various biomarkers to predict ACHD mortality in a single-center, retrospective cohort study. Blood levels of neurohormones [angiotensin II, endothelin-1 (ET-1), norepinephrine (NE), aldosterone, and plasma renin activity]; inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), high-sensitivity tumor necrosis factor, soluble TNF receptor type I and II (sTNF-RI and sTNF-RII), and interleukin-6 (IL-6)]; and brain natriuretic peptide (BNP) were measured in 103 ACHD patients (median age 28 years)...
February 8, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/26937900/comparison-of-the-degree-of-exercise-tolerance-in-children-after-surgical-treatment-of-complex-cardiac-defects-assessed-using-ergospirometry-and-the-level-of-brain-natriuretic-peptide
#2
COMPARATIVE STUDY
Boguslaw Mazurek, Leslaw Szydlowski, Magdalena Mazurek, Grazyna Markiewicz-Loskot, Jacek Pajak, Aleksandra Morka
Children who underwent surgery for complex congenital heart defects present worse exercise capacity than their healthy peers. In adults and adolescents, heart failure is assessed on the basis of clinical symptoms using the New York Heart Association (NYHA) score, while in an infant Ross scale; heart failure can also be evaluated by other parameters. The purpose of this study was to compare the degree of exercise tolerance in children after surgery for complex heart defects, assessed by the ratio of maximum oxygen uptake (VO2max) and the brain natriuretic peptide (N-terminal fragment of the prohormone brain-type natriuretic peptide [NT-proBNP]) concentration...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26454435/cardiac-biomarkers-in-children-with-congenital-heart-disease
#3
REVIEW
Masaya Sugimoto, Seiko Kuwata, Clara Kurishima, Jeong Hye Kim, Yoich Iwamoto, Hideaki Senzaki
BACKGROUND: Most congenital heart diseases (CHDs) have specific hemodynamics, including volume and pressure overload, as well as cyanosis and pulmonary hypertension, associated with anatomical abnormalities. Such hemodynamic abnormalities can cause activation of neurohormones, inflammatory cytokines, fibroblasts, and vascular endothelial cells, which in turn contribute to the development of pathologic conditions such as cardiac hypertrophy, fibrosis, and cardiac cell damages and death...
November 2015: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/26123813/timing-of-dynamic-nt-probnp-and-hs-ctnt-response-to-exercise-challenge-in-asymptomatic-children-with-moderate-aortic-valve-regurgitation-or-moderate-aortic-valve-stenosis
#4
Wadi Mawad, Sylvia Abadir, Anne Fournier, Jean-Luc Bigras, Daniel Curnier, Lyes Kadem, Nagib Dahdah
Patients with congenital aortic valve stenosis (AVS) can remain asymptomatic but may develop progressive and often underestimated exercise intolerance. The risk of increased left ventricular (LV) wall stress, irreversible myocardial fibrosis and sudden death in untreated patients warrants earlier intervention. The timing for curative therapy for severe AVS is clear, but optimal timing for moderate stenosis (modAS) is unknown. AVS often coexists with aortic regurgitation, which adds a volume overload to an already pressure-overloaded LV, adding an additional challenge to the estimation of disease severity...
December 2015: Pediatric Cardiology
https://www.readbyqxmd.com/read/26123812/serum-level-of-heart-type-fatty-acid-binding-protein-h-fabp-before-and-after-treatment-of-congestive-heart-failure-in-children
#5
Amr Zoair, Wegdan Mawlana, Amany Abo-Elenin, Mostafa Korrat
Remodeling of the heart following injury affects the morbidity and mortality in children presented with heart failure (HF). Heart-type fatty acid binding protein (H-FABP) is a novel biomarker that could be of help to predict the prognosis and risk stratification in those children. We aimed to evaluate the diagnostic and prognostic value of H-FABP in children with heart failure before and after treatment. The study was conducted as a prospective cohort study. It included 30 children with HF as a patient group and 20 healthy children matched for age and sex as a control group...
December 2015: Pediatric Cardiology
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