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Platelets and Kidney

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43 papers 0 to 25 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/27914126/effects-of-platelet-rich-plasma-on-kidney-regeneration-in-gentamicin-induced-nephrotoxicity
#1
Abbas Moghadam, Tahereh Talaei Khozani, Afsaneh Mafi, Mohammad Reza Namavar, Farzaneh Dehghani
Platelet-rich plasma (PRP) as a source of growth factors may induce tissue repairing and improve fibrosis. This study aimed to assess the effects of PRP on kidney regeneration and fibrosis in gentamicin (GM)-induced nephrotoxicity rat model by stereological study. Thirty-two male rats were selected. Nephrotoxicity was induced in animals by administration of GM (80 mg/kg/daily, intraperitoneally [IP], 8 day) and animals were treated by PRP (100 μL, intra-cortical injection using surgical microscopy, single dose)...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27906969/the-predictive-role-of-red-cell-distribution-width-in-mortality-among-chronic-kidney-disease-patients
#2
Yao-Peng Hsieh, Chia-Chu Chang, Chew-Teng Kor, Yu Yang, Yao-Ko Wen, Ping-Fang Chiu
BACKGROUND: Recently, accumulating evidence has demonstrated that RDW independently predicts clinically important outcomes in many populations. However, the role of RDW has not been elucidated in chronic kidney disease (CKD) patients. We conducted the present study with the aim to evaluate the predictive value of RDW in CKD patients. METHODS: A retrospective observational cohort study of 1075 stage 3-5 CKD patients was conducted in a medical center. The patients' baseline information included demographic data, laboratory values, medications, and comorbid conditions...
2016: PloS One
https://www.readbyqxmd.com/read/27885913/platelet-index-levels-and-cardiovascular-mortality-in-incident-peritoneal-dialysis-patients-a-cohort-study
#3
Fenfen Peng, Zhijian Li, Chunyan Yi, Qunying Guo, Rui Yang, Haibo Long, Fengxian Huang, Xueqing Yu, Xiao Yang
Prior studies have shown that the levels of some platelet (PLT) indices were associated with mortality in patients undergoing hemodialysis. We aimed to investigate whether the changes in PLT indices associated with mortality in patients on peritoneal dialysis (PD). A single-center, retrospective observational cohort study was conducted in incident PD patients from 1 January 2006 to 31 December 2012, and followed up until 31 December 2014. Cox proportional hazard models were used to examine the relationships between the levels of PLT indices including PLT, plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), and mortality...
November 25, 2016: Platelets
https://www.readbyqxmd.com/read/27737645/haemodiafiltration-elicits-less-platelet-activation-compared-to-haemodialysis
#4
Gergely Becs, Renáta Hudák, Zsolt Fejes, Ildikó Beke Debreceni, Harjit Pal Bhattoa, József Balla, János Kappelmayer
BACKGROUND: Mortality in patients with end-stage renal disorders is often a consequence of cardiovascular complications. Renal replacement therapies may contribute to this morbidity by promoting cellular activation. In renal failure patients peripheral blood samples were investigated for platelet and endothelial cell activation markers to compare the effects of haemodiafiltration (HDF) and haemodialysis (HD). METHODS: Overall 28 patients were included in the study...
October 13, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27748388/acute-kidney-injury-role-of-platelet-activation-and-nets-in-renal-iri
#5
Ellen F Carney
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27705977/the-prognostic-value-of-red-blood-cell-distribution-width-in-patients-on-maintenance-hemodialysis
#6
Xiaohong Chen, Bo Shen, Jianzhou Zou, Zhonghua Liu, Wenlv Lv, Xuesen Cao, Jiawei Yu, Yuxin Nie, Jiarui Xu, Li Wang, Xiaoqiang Ding
AIMS: To examine the association between red blood cell distribution width (RDW) and mortality in hemodialysis (HD) patients. METHODS: Three hundred fifty six patients on HD for >3 months were enrolled and followed for 2 years. Patients were divided into 2 groups according to the median RDW value. Patient survival and risk factors for mortality were investigated. RESULTS: The 2-year survival rate was significantly lower in the high-RDW group (>14...
October 6, 2016: Blood Purification
https://www.readbyqxmd.com/read/27692564/release-of-extracellular-dna-influences-renal-ischemia-reperfusion-injury-by-platelet-activation-and-formation-of-neutrophil-extracellular-traps
#7
Marcel P B Jansen, Diba Emal, Gwendoline J D Teske, Mark C Dessing, Sandrine Florquin, Joris J T H Roelofs
Acute kidney injury is often the result of ischemia reperfusion injury, which leads to activation of coagulation and inflammation, resulting in necrosis of renal tubular epithelial cells. Platelets play a central role in coagulation and inflammatory processes, and it has been shown that platelet activation exacerbates acute kidney injury. However, the mechanism of platelet activation during ischemia reperfusion injury and how platelet activation leads to tissue injury are largely unknown. Here we found that renal ischemia reperfusion injury in mice leads to increased platelet activation in immediate proximity of necrotic cell casts...
September 27, 2016: Kidney International
https://www.readbyqxmd.com/read/27686008/new-roles-for-mean-platelet-volume-measurement-in-the-clinical-practice
#8
Patrizia Noris, Federica Melazzini, Carlo L Balduini
Several hundreds of studies recently investigated mean platelet volume (MPV) as measured by electronic cell counters in a wide variety of acquired diseases, and most of them found that platelet size was significantly increased with respect to healthy subjects. On this basis, it has been suggested that MPV can be used for diagnostic purposes. Moreover, investigation of subjects with arterial thrombosis not only revealed that their platelets were larger than those of controls, but also found that a high MPV predicted poor prognosis...
September 30, 2016: Platelets
https://www.readbyqxmd.com/read/27600469/mean-paltelet-volume-mpv-the-neglected-marker-of-cardiovascular-risk-and-glycosylated-hemoglobin-in-diabetic-patient
#9
Jatin Agrawal, Veer Bahadur Singh, Babulal Meena, Rajesh Yadav, Mohammad Shareef, Vishnu Saini
INTRODUCTION: Platelets activation and aggregation play fundamental role in thrombotic events in diabetes. MPV marker of platelet activity determines this cardiovascular risk. So by using simple parameter like MPV we can indirectly assess vascular complication in diabetic patient in periphery. AIMS AND OBJECTIVES: Determining MPV of both T1DM and T2DM with their controls and Relation between HbA1C and MPV in Diabetes Mellitus (DM). METHODOLOGY: This cross-sectional study was conducted in department of medicine, SPMC Bikaner from June 2014 - December 2014, included 100 patients attending medical outdoor and 100 healthy matched controls...
August 31, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27551718/effects-of-platelet-rich-plasma-prp-on-a-model-of-renal-ischemia-reperfusion-in-rats
#10
Oriol Martín-Solé, Joan Rodó, Lluís García-Aparicio, Josep Blanch, Victoria Cusí, Asteria Albert
Renal ischemia-reperfusion injury is a major cause of acute renal failure, causing renal cell death, a permanent decrease of renal blood flow, organ dysfunction and chronic kidney disease. Platelet-rich plasma (PRP) is an autologous product rich in growth factors, and therefore able to promote tissue regeneration and angiogenesis. This product has proven its efficacy in multiple studies, but has not yet been tested on kidney tissue. The aim of this work is to evaluate whether the application of PRP to rat kidneys undergoing ischemia-reperfusion reduces mid-term kidney damage...
2016: PloS One
https://www.readbyqxmd.com/read/27539521/-association-between-23-urinary-metals-and-mean-platelet-volume-among-a-community-dwelling-population-in-wuhan-china
#11
W Feng, X S He, Y Q Yu, Yyn Li-Gu, X M Zhang, J Yuan, W H Chen, T C Wu
OBJECTIVE: To investigate the potential association between 23 urinary metals and mean platelet volume (MPV) among a community population in Wuhan. METHODS: A total of 3 053 community residents who lived in the sampling buildings for more than 5 years, aged from 18 to 80 years, were recruited using a stratified, cluster sampling approach in Wuhan city, China. Blood and urine samples were obtained from participants in the morning under fasting conditions. Urinary metals, including aluminum, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, barium, tungsten, thallium, lead and uranium, were measured by inductively coupled plasma mass spectrometry...
August 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27504801/mean-platelet-volume-to-platelet-count-ratio-as-a-promising-predictor-of-early-mortality-in-severe-sepsis
#12
Geun Ho Oh, Sung Phil Chung, Yoo Seok Park, Jung Hwa Hong, Hye Sun Lee, Hyun Soo Chung, Je Sung You, Jong Woo Park, Incheol Park
PURPOSE: We evaluated the mean platelet volume (MPV) to platelet ratio to determine its significance as a prognostic marker for early mortality in critically ill patients with suspected sepsis receiving early goal-directed therapy (EGDT). METHODS: We retrospectively reviewed the records from a prospective EGDT registry and screened eligible adult patients who were admitted to the emergency department (ED) with severe sepsis and/or septic shock. The MPV/platelet ratio was estimated as the MPV value divided by the platelet count on each day of hospitalization...
August 8, 2016: Shock
https://www.readbyqxmd.com/read/27511481/the-relationship-of-mean-platelet-volume-with-microalbuminuriain-type-2-diabetic-patients
#13
Seyit Murat Bayram, Gül Gürsoy, Aslı Araz Güngör, Fatih Güngör, Eray Atalay
BACKGROUND/AIM: Activation and size of platelets have been suggested to be involved in the pathogenesis of vascular complications in diabetes mellitus. The purpose of the present study was to investigate the association of mean platelet volume with microalbuminuria in type 2 diabetic patients. MATERIALS AND METHODS: Mean platelet volume levels were investigated in healthy participants and type 2 diabetic patients with and without microalbuminuria. After their mean platelet volume values were compared, correlation of mean platelet volume with sex, duration of diabetes, microalbuminuria, fasting blood glucose, hemoglobin A1c, creatinine clearance, and body mass index was examined...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27460742/the-effect-of-smoking-on-neutrophil-lymphocyte-and-platelet-lymphocyte-ratio-and-platelet-%C3%A4-ndices-a-retrospective-study
#14
Y K Tulgar, S Cakar, S Tulgar, O Dalkilic, B Cakiroglu, B S Uyanik
OBJECTIVE: Smoking commonly leads to death. Although the neutrophil/lymphocyte Ratio, platelet/lymphocyte ratio and platelet indices have been shown to be important for the diagnosis, prognosis and severity of some diseases, the smoking status of patients in these studies has not been well defined. In this study, we compared ratios derived from complete blood count and platelet indices to smoking status and length in smokers and non-smokers. PATIENTS AND METHODS: The data of healthy males and females aged between 18-60 years who presented to our institute for a routine check-up were collected, and subjects were divided in two groups - smokers and non-smokers...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27473864/platelet-to-lymphocyte-ratio-predicts-contrast-induced-acute-kidney-injury-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#15
Yalcin Velibey, Ahmet Oz, Ozan Tanik, Tolga Sinan Guvenc, Koray Kalenderoglu, Ayca Gumusdag, Evliya Akdeniz, Mehmet Bozbay, Ahmet Ilker Tekkesin, Ozge Guzelburc, Mert Ilker Hayiroglu, Ahmet Taha Alper, Murat Ugur, Mehmet Eren
We aimed to investigate the relationship between platelet-to-lymphocyte ratio (PLR) and contrast-induced acute kidney injury (CI-AKI) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). A total of 2563 patients diagnosed with STEMI and underwent primary pPCI were retrospectively included in the study. Levels of PLR and creatinine were measured before and at 72 hours after pPCI. Patients were divided into 2 groups: non-CI-AKI group and CI-AKI group...
July 29, 2016: Angiology
https://www.readbyqxmd.com/read/27433766/platelet-counts-acute-kidney-injury-and-mortality-after-coronary-artery-bypass-grafting-surgery
#16
Shangyi Hui, Chunhua Yu
No abstract text is available yet for this article.
August 2016: Anesthesiology
https://www.readbyqxmd.com/read/27400185/mean-platelet-volume-and-mortality-risk-in-a-national-incident-hemodialysis-cohort
#17
Steven Kim, Miklos Z Molnar, Gregg C Fonarow, Elani Streja, Jiaxi Wang, Daniel L Gillen, Rajnish Mehrotra, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Connie M Rhee
BACKGROUND: Higher mean platelet volume (MPV) is an indicator of larger, reactive platelets, and has been associated with a higher risk of thrombosis and cardiovascular events in the general population. Hemodialysis patients have a higher risk for cardiovascular death and predisposition to platelet dysfunction (thrombosis and bleeding diathesis), but the relationship between MPV and mortality in this population is unknown. METHODS: Among a 5-year cohort (1/2007-12/2011) of 149,118 incident hemodialysis patients from a large national dialysis organization, we examined the association between MPV and all-cause mortality...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27359035/pre-analytical-standardization-should-be-mandatory-before-reference-ranges-for-mean-platelet-volume-are-determined
#18
Cengiz Beyan, Esin Beyan
No abstract text is available yet for this article.
June 30, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27388283/were-the-measurements-standardized-sufficiently-in-published-studies-about-mean-platelet-volume
#19
Cengiz Beyan, Esin Beyan
Recently, several studies about mean platelet volume (MPV) changes in various pathological conditions were published. The aim of this study was to evaluate the accuracy of the measurement in these studies. The study was performed using the data of 181 studies containing a healthy control groups within 1181 studies about MPV indexed PubMed database since 2012. A total of 81 studies were included retrospectively. The distributions of sex, age, and platelet counts were not reported in 16, 12, and 28 studies, respectively...
July 6, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27392197/serum-uric-acid-levels-and-inflammatory-markers-with-respect-to-dipping-status-a-retrospective-analysis-of-hypertensive-patients-with-or-without-chronic-kidney-disease
#20
Elbis Ahbap, Tamer Sakaci, Ekrem Kara, Tuncay Sahutoglu, Yener Koc, Taner Basturk, Mustafa Sevinc, Cuneyt Akgol, Barıs Hasbal, Mahmoud Isleem, Perin Nazif, Feyza Bayraktar Caglayan, Abdulkadir Unsal
BACKGROUND: The aim of this study was to evaluate serum uric acid levels, inflammatory markers [C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)] and mean platelet volume (MPV) among hypertensive patients with or without chronic kidney disease (CKD) with respect to dipping status. METHODS: A total of 432 hypertensive patients with (n = 340) or without (n = 92) CKD who had ambulatory blood pressure monitoring recordings were included...
2016: Clinical and Experimental Hypertension: CHE
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