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Platelets and Kidney

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63 papers 0 to 25 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29026786/the-relationship-between-type-2-diabetes-and-platelet-indicators
#1
Xiangyu Chen, Le Fang, Hongbo Lin, Peng Shen, Tao Zhang, Hui Li, Xiaoyong Li, Min Yu, Chunxiao Xu, Jie Zhang, Feng Lu, Xiaofu DU, Ruying Hu, Jieming Zhong
BACKGROUND: Currently, the studies on the relationship between type 2 diabetes and platelets indicators were carried out on a selective small sample population generally. Large sample studies in this area are rare, especially in Chinese population. In this study, we aimed to investigate the relationship between type 2 diabetes and the mean platelet volume (MPV), platelet count (PLT) and platelet distribution width (PDW). METHODS: This is a cross-sectional analysis of the routine health examination data from 20128 participants with complete baseline data in Yinzhou District 2013...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28882170/prognostic-value-of-platelet-to-lymphocyte-ratios-among-critically-ill-patients-with-acute-kidney-injury
#2
Chen-Fei Zheng, Wen-Yue Liu, Fang-Fang Zeng, Ming-Hua Zheng, Hong-Ying Shi, Ying Zhou, Jing-Ye Pan
BACKGROUND: Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value of the PLR in predicting the outcomes of critically ill patients with AKI. METHODS: Patient data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care Database III version 1...
September 8, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28721136/mean-platelet-volume-changes-before-and-after-glycated-hemoglobin-hba1c-improvement-in-a-large-study-population
#3
Yasar Sertbas, Meltem Sertbas, Nalan Okuroglu, Mehmet Akif Ozturk, Kerem Yigit Abacar, Ali Ozdemir
INTRODUCTION: Diabetes mellitus (DM) is a metabolic disorder associated with both microvascular and macrovascular complications. Mean platelet volume (MPV) is a marker of platelet activity, which plays a major role in the development of vascular complications of DM. The aim of this study is to compare the MPV levels before and after the decrease of glycated hemoglobin (HbA1c) levels in a large diabetic population. MATERIAL AND METHODS: This was a retrospective study conducted on type 2 diabetic patients from the outpatient clinic for 1 year between 2014 and 2015 with the participation of 595 diabetic patients...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28756545/single-emergency-room-measurement-of-neutrophil-lymphocyte-ratio-for-early-detection-of-acute-kidney-injury-aki
#4
Mohsen Abu Alfeilat, Itzchak Slotki, Linda Shavit
Neutrophil-to-lymphocyte ratio (NLR) is considered a readily available biomarker of systemic inflammation. An association between elevated NLR and adverse outcomes in a variety of medical and surgical conditions including CKD has been demonstrated in several studies. In this study, we evaluated the accuracy of single Emergency Department (ED) measurement of NLR for early diagnosis of acute kidney injury (AKI). We prospectively studied 294 patients aged 71.6 ± 17. We measured NLR at presentation to the ED...
July 29, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28714524/simple-platelet-markers-mean-platelet-volume-and-congestive-heart-failure-coexistent-with-periodontal-disease-pilot-studies
#5
Maciej R Czerniuk, Zbigniew Bartoszewicz, Iwona Dudzik-Niewiadomska, Tomasz Pilecki, Renata Górska, Krzysztof J Filipiak
BACKGROUND: Conducted pilot study concerning mean platelet volume parameter among patients suffering from congestive heart failure and periodontal disease. METHODS: Examination of dynamic changes of platelet and periodontal markers in group of 50 patients before and an average of 6 months subsequent to professional periodontal treatment. RESULTS: Both platelet and periodontal parameters decreased after periodontal treatment, what is more, the decrease of mean platelet volume (MPV) value due to periodontal disease/mm improvement was shown to be statistically significant (p = 0...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28580812/platelet-reactivity-in-stable-cardiovascular-patients-with-chronic-kidney-disease
#6
Thomas A Mavrakanas, Ahsan Alam, Jean-Luc Reny, Pierre Fontana
The study aimed to evaluate antiplatelet drug responsiveness in stable outpatients with cardiovascular disease and chronic kidney disease (CKD) and examine whether impaired antiplatelet drug responsiveness is associated with worse clinical outcomes in this population. Stable cardiovascular patients (n = 771) were enrolled at least one month after an acute ischemic atherothrombotic event. Antiplatelet drug responsiveness was assessed with specific assays (serum TxA2 for aspirin, the VASP assay for clopidogrel) and other aggregation-based assays using different agonists...
June 5, 2017: Platelets
https://www.readbyqxmd.com/read/28422358/is-mean-platelet-volume-a-better-biomarker-in-pre-eclampsia
#7
Gustavo Vilchez, Moraima Lagos, Komal Kumar, Pedro Argoti
AIM: Platelet activation and destruction is a well recognized feature of pre-eclampsia, but the current literature is contradictory regarding the role of mean platelet volume (MPV) in the diagnosis of this condition. We investigated whether MPV, compared with other routine laboratory markers such as platelet count, is a more significant biomarker of pre-eclampsia, giving special attention to the intrapartum period. METHODS: Biochemical and hematological markers along pregnancy including MPV were compared retrospectively between pre-eclampsia and matched controls...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28403540/monocyte-lymphocyte-ratio-as-a-better-predictor-of-cardiovascular-and-all-cause-mortality-in-hemodialysis-patients-a-prospective-cohort-study
#8
Fangfang Xiang, Rongyi Chen, Xuesen Cao, Bo Shen, Zhonghua Liu, Xiao Tan, Xiaoqiang Ding, Jianzhou Zou
INTRODUCTION: Patients with chronic kidney disease, especially those with end-stage renal disease, have an increased risk of death. Previous studies have suggested neutrophil/lymphocyte ratio (NLR) was related to worse outcome in patients undergoing hemodialysis (HD). However, monocyte/lymphocyte ratio (MLR) has not been evaluated in HD patients. In this study, we prospectively studied the predictive value of MLR for all-cause and cardiovascular mortality in HD patients and compared it with NLR...
April 12, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28385106/association-between-hemogram-parameters-and-survival-of-critically-ill-patients
#9
Ibrahim Karagoz, Gulali Aktas, Hamit Yoldas, Isa Yildiz, Muhammet Nur Ogun, Murat Bilgi, Abdullah Demirhan
AIM: Recently, hemogram parameters, such as mean platelet volume (MPV), had been proposed as novel inflammatory and prognostic factors. In present retrospective analysis, we aimed to determine and compare MPV of survived and dead patients whom admitted to intensive care unit (ICU) of our institution. METHODS: We recorded hemogram parameters and other laboratory data and demographic characteristics of patients treated in ICU. Patients are divided into 2 groups-dead patients and survived patients...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28367021/platelet-volume-indices-as-predictive-biomarkers-for-diabetic-complications-in-type-2-diabetic-patients
#10
Archana Buch, Supreet Kaur, Rahul Nair, Ambuj Jain
BACKGROUND: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR) are the indicators of increased platelet activity and can be considered as potential biomarkers for diabetic complications. PURPOSE: To study PVI in Type 2 diabetics with and without complications in comparison to nondiabetic patients. MATERIALS AND METHODS: A case-control study was conducted on 300 Type 2 diabetics and 200 nondiabetics...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28357442/mean-platelet-volume-is-associated-with-lower-risk-of-overall-and-non-vascular-mortality-in-a-general-population-results-from-the-moli-sani-study
#11
Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Amalia de Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Larger mean platelet volume (MPV) has been associated with adverse health outcomes in high-risk populations or patients with cardiovascular disease (CVD). We tested the association of MPV with mortality in a prospective cohort study including 17,402 subjects randomly recruited from an adult general population within the Moli-sani study (2005-2010). Two distinct subgroups (with or without CVD at baseline) were subsequently analysed. Hazard ratios (HR) were calculated using multivariable Cox-proportional hazard models...
March 30, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28348030/association-between-monocyte-count-and-risk-of-incident-ckd-and-progression-to-esrd
#12
Benjamin Bowe, Yan Xie, Hong Xian, Tingting Li, Ziyad Al-Aly
BACKGROUND AND OBJECTIVES: Experimental evidence suggests a role for monocytes in the biology of kidney disease progression; however, whether monocyte count is associated with risk of incident CKD, CKD progression, and ESRD has not been examined in large epidemiologic studies. DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: We built a longitudinal observational cohort of 1,594,700 United States veterans with at least one eGFR during fiscal year 2004 (date of last eGFR during this period designated time zero) and no prior history of ESRD, dialysis, or kidney transplant...
April 3, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28320333/delta-neutrophil-index-is-an-independent-predictor-of-mortality-in-septic-acute-kidney-injury-patients-treated-with-continuous-renal-replacement-therapy
#13
In Mi Han, Chang-Yun Yoon, Dong Ho Shin, Youn Kyung Kee, Seung Gyu Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
BACKGROUND: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). METHOD: This is a retrospective analysis of consecutively CRRT treated patients...
March 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28316378/high-neutrophil-to-lymphocyte-ratio-predicts-cardiovascular-mortality-in-chronic-hemodialysis-patients
#14
Han Li, Xiangxue Lu, Ruifang Xiong, Shixiang Wang
The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28316334/chronic-kidney-disease-uraemic-toxin-induced-platelet-hyperactivity
#15
Susan J Allison
No abstract text is available yet for this article.
May 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28275234/association-between-mean-platelet-volume-and-hypertension-incidence
#16
Li Gang, Zhang Yanyan, Zhu Zhongwei, Du Juan
Mean platelet volume (MPV) is increased in various cardiovascular diseases. We sought to determine the prognostic value of MPV for hypertension. We performed a retrospective cohort study. Baseline characteristics were measured in 9168 individuals without hypertension, and the follow-up period was 9 years. Hypertension was confirmed in 2881 participants during the follow-up period. When the participants were grouped according to MPV quartiles, the hazard ratio of future hypertension gradually increased across the MPV quartiles...
August 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28187736/thrombocytopenia-on-the-first-day-of-emergency-department-visit-predicts-higher-risk-of-acute-kidney-injury-among-elderly-patients
#17
Chia-Ter Chao, Hung-Bin Tsai, Chih-Kang Chiang, Jenq-Wen Huang
BACKGROUND: Few studies have addressed risk factors for acute kidney injury (AKI) in geriatric patients. We investigated whether thrombocytopenia was a risk factor for AKI in geriatric patients with medical illnesses. METHODS: A prospective cohort study was conducted, by recruiting elderly (≥65 years) patients who visited the emergency department (ED) for medical illnesses during 2014. They all received hemogram for platelet count determination, and were stratified according to the presence of thrombocytopenia (platelets, <150 K/μL) during their initial ED evaluation...
February 10, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28178405/statin-and-ezetimibe-combination-therapy-decreases-mean-platelet-volume-compared-to-statin-monotherapy
#18
Jun-Beom Lee, Gyeong-Seon Kim, Han-Na Cho
No abstract text is available yet for this article.
January 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28095482/an-increase-in-mean-platelet-volume-platelet-count-ratio-is-associated-with-vascular-access-failure-in-hemodialysis-patients
#19
COMPARATIVE STUDY
Dong Ho Shin, So Yon Rhee, Hee Jung Jeon, Ji-Young Park, Shin-Wook Kang, Jieun Oh
After stenosis of arteriovenous vascular access in hemodialysis patients, platelets play a crucial role in subsequent thrombus formation, leading to access failure. In a previous study, the mean platelet volume (MPV)/platelet count ratio, but not MPV alone, was shown to be an independent predictor of 4-year mortality after myocardial infarction. However, little is known about the potential influence of MPV/platelet count ratio on vascular access patency in hemodialysis patients. A total of 143 patients undergoing routine hemodialysis were recruited between January 2013 and February 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28098108/the-relationship-between-mean-platelet-volume-and-neutrophil-lymphocyte-ratio-with-inflammation-and-proteinuria-in-chronic-kidney-disease
#20
Gulay Yilmaz, Can Sevinc, Sedat Ustundag, Yasemin Coskun Yavuz, Tuba Hacıbekiroglu, Esra Hatipoglu, Mehmet Baysal
Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbidity and mortality in chronic kidney disease (CKD). In this study, we investigated the relationship of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with inflammation and proteinuria in patients with CKD Stage 3-4. Healthy individuals who applied to nephrology clinic for checkup purposes acted as controls. Fifty-three patients and 30 healthy controls were included in the study. Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded from the study...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
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