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Hematological Parameters and Kidney

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74 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29636871/no-indications-for-platelet-activation-in-acute-clinical-myocardial-or-renal-ischemia-reperfusion-injury
#1
Kirsten A Kortekaas, Dorottya K de Vries, Mark Roest, Marlies Ej Reinders, Eric P van der Veer, Robert Jm Klautz, Philip G de Groot, Alexander F Schaapherder, Jan H Lindeman
The pathophysiology of ischemia/reperfusion (I/R) injury is complex and poorly understood. Animal studies imply platelet activation as an initiator of the inflammatory response upon reperfusion. However, it remains unclear whether and how these results translate to clinical I/R. This study evaluates putative platelet activation in the context of two forms of clinical I/R (heart valve surgery with aortic-cross clamping, n = 39 and kidney transplantation, n = 34). The technique of sequential selective arteriovenous (AV) measurements over the reperfused organs was applied to exclude the influence of systemic changes occurring during surgery while simultaneously maximizing sensitivity...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29627837/combination-of-mean-platelet-volume-platelet-count-ratio-and-the-apache-ii-score-better-predicts-the-short-term-outcome-in-patients-with-acute-kidney-injury-receiving-continuous-renal-replacement-therapy
#2
Junhui Li, Yingchuan Li, Xiaohua Sheng, Feng Wang, Dongsheng Cheng, Guihua Jian, Yongguang Li, Liang Feng, Niansong Wang
BACKGROUND/AIMS: Both the Acute physiology and Chronic Health Evaluation (APACHE II) score and mean platelet volume/platelet count Ratio (MPR) can independently predict adverse outcomes in critically ill patients. This study was aimed to investigate whether the combination of them could have a better performance in predicting prognosis of patients with acute kidney injury (AKI) who received continuous renal replacement therapy (CRRT). METHODS: Two hundred twenty-three patients with AKI who underwent CRRT between January 2009 and December 2014 in a Chinese university hospital were enrolled...
March 29, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29619869/platelet-indices-and-stroke
#3
Tarik Yildirim, Fatih Akin, Ibrahim Altun, Seda Elcim Yildirim, Ozcan Basaran, Mustafa Ozcan Soylu
No abstract text is available yet for this article.
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29616601/does-neutrophil-to-lymphocyte-ratio-demonstrate-deterioration-in-renal-function
#4
Senol Tonyali, Cavit Ceylan, Sedat Yahsi, Mine Sebnem Karakan
INTRODUCTION: Chronic kidney disease (CKD) is a major health issue worldwide, which leads to end-stage renal failure and cardiovascular events. Neutrophil to lymphocyte ratio (NLR) is a surrogate marker of inflammation and has been widely studied in malignancies, hypertension, heart diseases, and vascular diseases. In this study, we aimed to investigate if NLR represents renal reserve and function after partial or radical nephrectomy. METHODS: We conducted a retrospective study consists of patients who had undergone radical/partial nephrectomy in our hospital and/or who admitted to urology and nephrology clinics as an outpatient...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29581246/the-association-of-neutrophil-to-lymphocyte-ratio-mean-platelet-volume-and-platelet-distribution-width-with-diabetic-retinopathy-and-nephropathy-a-meta-analysis
#5
Juxiang Liu, Xingguang Liu, Youpeng Li, Jinxing Quan, Suhong Wei, Siqin An, Ruifei Yang, Jing Liu
The aim of this study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to 01 December 2017. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. A total of 48 studies were included in our meta-analysis. Compared to patients with type Ⅱ diabetes mellitus (T2DM) and without DR, NLR, MPV and PDW was higher in patients with DR (SMD = 0...
March 26, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29556749/mean-platelet-volume-can-estimate-the-current-vasculitis-activity-of-microscopic-polyangiitis
#6
Ho Jae Kim, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Mean platelet volume (MPV) was known to be associated with the inflammatory burdens in various diseases, but not microscopic polyangiitis (MPA) yet. In this study, we investigated the association between MPV and Birmingham vasculitis activity score (BVAS) in 88 patients with MPA. We retrospectively reviewed the medical records of 88 patients with MPA. Clinical and laboratory data at diagnosis and partially at follow-up were collected. Linear regression analyses were used to clarify the association between MPV and BVAS...
March 19, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29226160/the-significance-of-changes-in-platelet-concentration-during-the-early-phase-after-severe-burn-injury-in-a-chinese-mass-casualty
#7
Beiming Shou, Junqiang Li, Chenqi Tang, Qian Tan, Dongfeng Zheng, Binwei Sun, Lanjun Nie, Hongwei Zhang, Yanan Jiang, Chunming Wang, Yanwen Wu
Background: Changes in platelet concentration are common in severe burn patients. Platelets play a key role in the course of disease. This study aims to explore the significance of platelet concentration during the course of the disease in victims of a mass burn casualty. Methods: A total of 180 patients were involved in the "8.2" Kunshan explosion accident in China. The examined data included age, gender, total burn area (% TBSA), third-degree burn area (% TBSA), and platelet concentration within the first 5 days after the burn injury...
2017: Burns and trauma
https://www.readbyqxmd.com/read/29227977/red-blood-cell-distribution-width-is-an-independent-predictor-of-aki-and-mortality-in-patients-in-the-coronary-care-unit
#8
Yugang Hu, Huilan Liu, Shuai Fu, Jing Wan, Xiaoning Li
BACKGROUND/AIMS: We investigated the hypothesis that RDW is an independent predictor of acute kidney injury (AKI) and mortality in patients in the coronary care unit (CCU). METHODS: In this prospective, observational study, we screened 412 adults admitted to the CCU at Zhongnan Hospital of Wuhan University from January 1, 2014 to June 1, 2015. AKI was defined based on the KDIGO-AKI criteria. The survivors were followed up for up to 2 years after hospital discharge...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29141483/red-blood-cell-distribution-width-as-a-marker-of-cerebral-infarction-in-hemodialysis-patients
#9
Liyi Mo, Yuanhan Chen, Zhilian Li, Lixia Xu, Wei Dong, Li Zhang, Huaban Liang, Ruizhao Li, Yiming Tao, Wei Shi, Xinling Liang
BACKGROUND: Red blood cell distribution width (RDW) is a cardiovascular biomarker. We evaluated the association between RDW and cerebral stroke risk in hemodialysis patients. METHODS: A cohort of 442 adult patients on hemodialysis was studied. Strokes were defined according to ICD-10 diagnosis codes. Routine complete blood counts, evaluated every 3-6 months, were used for RDW values. RESULTS: Among 442 hemodialysis patients, during the 50-month follow-up, there were 62 cases (14...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/29130984/lymphocyte-cell-ratios-and-mortality-among-incident-hemodialysis-patients
#10
Christina Catabay, Yoshitsugu Obi, Elani Streja, Melissa Soohoo, Christina Park, Connie M Rhee, Csaba P Kovesdy, Takayuki Hamano, Kamyar Kalantar-Zadeh
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been previously suggested as oncologic prognostication markers. These are associated with malnutrition and inflammation, and hence, may provide benefit in predicting mortality among hemodialysis patients. METHODS: Among 108,548 incident hemodialysis patients in a large U.S. dialysis organization (2007-2011), we compared the mortality predictability of NLR and PLR with baseline and time-varying covariate Cox models using the receiver operating characteristic curve (AUROC), net reclassification index (NRI), and adjusted R2...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29128485/neutrophil-lymphocyte-and-platelet-counts-and-acute-kidney-injury-after-cardiovascular-surgery
#11
Chang-Hoon Koo, Dhong Eun Jung, Yoon Sang Park, Jungil Bae, Youn Joung Cho, Won Ho Kim, Jae-Hyon Bahk
OBJECTIVE: Postoperative low platelet count and perioperative high neutrophil/lymphocyte (N/L) ratio are associated with acute kidney injury (AKI) and mortality after cardiac surgery. The authors investigated whether (1) their combination neutrophil/lymphocyte × platelet (N/LP) ratio is an independent predictor of AKI and postoperative mortality and (2) whether the N/LP ratio increases predictive ability compared with the N/L ratio or platelet nadir. DESIGN: This was a retrospective and observational study...
August 24, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29026786/the-relationship-between-type-2-diabetes-and-platelet-indicators
#12
Xiangyu Chen, Le Fang, Hongbo Lin, Peng Shen, Tao Zhang, Hui Li, Xiaoyong Li, Min Yu, Chunxiao Xu, Jie Zhang, Feng Lu, Xiaofu DU, Ruying Hu, Jieming Zhong
BACKGROUND: Currently, the studies on the relationship between type 2 diabetes and platelets indicators were carried out on a selective small sample population generally. Large sample studies in this area are rare, especially in Chinese population. In this study, we aimed to investigate the relationship between type 2 diabetes and the mean platelet volume (MPV), platelet count (PLT) and platelet distribution width (PDW). METHODS: This is a cross-sectional analysis of the routine health examination data from 20128 participants with complete baseline data in Yinzhou District 2013...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28882170/prognostic-value-of-platelet-to-lymphocyte-ratios-among-critically-ill-patients-with-acute-kidney-injury
#13
Chen-Fei Zheng, Wen-Yue Liu, Fang-Fang Zeng, Ming-Hua Zheng, Hong-Ying Shi, Ying Zhou, Jing-Ye Pan
BACKGROUND: Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value of the PLR in predicting the outcomes of critically ill patients with AKI. METHODS: Patient data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care Database III version 1...
September 8, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28721136/mean-platelet-volume-changes-before-and-after-glycated-hemoglobin-hba1c-improvement-in-a-large-study-population
#14
Yasar Sertbas, Meltem Sertbas, Nalan Okuroglu, Mehmet Akif Ozturk, Kerem Yigit Abacar, Ali Ozdemir
INTRODUCTION: Diabetes mellitus (DM) is a metabolic disorder associated with both microvascular and macrovascular complications. Mean platelet volume (MPV) is a marker of platelet activity, which plays a major role in the development of vascular complications of DM. The aim of this study is to compare the MPV levels before and after the decrease of glycated hemoglobin (HbA1c) levels in a large diabetic population. MATERIAL AND METHODS: This was a retrospective study conducted on type 2 diabetic patients from the outpatient clinic for 1 year between 2014 and 2015 with the participation of 595 diabetic patients...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28756545/single-emergency-room-measurement-of-neutrophil-lymphocyte-ratio-for-early-detection-of-acute-kidney-injury-aki
#15
Mohsen Abu Alfeilat, Itzchak Slotki, Linda Shavit
Neutrophil-to-lymphocyte ratio (NLR) is considered a readily available biomarker of systemic inflammation. An association between elevated NLR and adverse outcomes in a variety of medical and surgical conditions including CKD has been demonstrated in several studies. In this study, we evaluated the accuracy of single Emergency Department (ED) measurement of NLR for early diagnosis of acute kidney injury (AKI). We prospectively studied 294 patients aged 71.6 ± 17. We measured NLR at presentation to the ED...
July 29, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28714524/simple-platelet-markers-mean-platelet-volume-and-congestive-heart-failure-coexistent-with-periodontal-disease-pilot-studies
#16
Maciej R Czerniuk, Zbigniew Bartoszewicz, Iwona Dudzik-Niewiadomska, Tomasz Pilecki, Renata Górska, Krzysztof J Filipiak
BACKGROUND: Conducted pilot study concerning mean platelet volume parameter among patients suffering from congestive heart failure and periodontal disease. METHODS: Examination of dynamic changes of platelet and periodontal markers in group of 50 patients before and an average of 6 months subsequent to professional periodontal treatment. RESULTS: Both platelet and periodontal parameters decreased after periodontal treatment, what is more, the decrease of mean platelet volume (MPV) value due to periodontal disease/mm improvement was shown to be statistically significant (p = 0...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28580812/platelet-reactivity-in-stable-cardiovascular-patients-with-chronic-kidney-disease
#17
Thomas A Mavrakanas, Ahsan Alam, Jean-Luc Reny, Pierre Fontana
The study aimed to evaluate antiplatelet drug responsiveness in stable outpatients with cardiovascular disease and chronic kidney disease (CKD) and examine whether impaired antiplatelet drug responsiveness is associated with worse clinical outcomes in this population. Stable cardiovascular patients (n = 771) were enrolled at least one month after an acute ischemic atherothrombotic event. Antiplatelet drug responsiveness was assessed with specific assays (serum TxA2 for aspirin, the VASP assay for clopidogrel) and other aggregation-based assays using different agonists...
June 5, 2017: Platelets
https://www.readbyqxmd.com/read/28422358/is-mean-platelet-volume-a-better-biomarker-in-pre-eclampsia
#18
Gustavo Vilchez, Moraima Lagos, Komal Kumar, Pedro Argoti
AIM: Platelet activation and destruction is a well recognized feature of pre-eclampsia, but the current literature is contradictory regarding the role of mean platelet volume (MPV) in the diagnosis of this condition. We investigated whether MPV, compared with other routine laboratory markers such as platelet count, is a more significant biomarker of pre-eclampsia, giving special attention to the intrapartum period. METHODS: Biochemical and hematological markers along pregnancy including MPV were compared retrospectively between pre-eclampsia and matched controls...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28403540/monocyte-lymphocyte-ratio-as-a-better-predictor-of-cardiovascular-and-all-cause-mortality-in-hemodialysis-patients-a-prospective-cohort-study
#19
Fangfang Xiang, Rongyi Chen, Xuesen Cao, Bo Shen, Zhonghua Liu, Xiao Tan, Xiaoqiang Ding, Jianzhou Zou
INTRODUCTION: Patients with chronic kidney disease, especially those with end-stage renal disease, have an increased risk of death. Previous studies have suggested neutrophil/lymphocyte ratio (NLR) was related to worse outcome in patients undergoing hemodialysis (HD). However, monocyte/lymphocyte ratio (MLR) has not been evaluated in HD patients. In this study, we prospectively studied the predictive value of MLR for all-cause and cardiovascular mortality in HD patients and compared it with NLR...
April 12, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28385106/association-between-hemogram-parameters-and-survival-of-critically-ill-patients
#20
Ibrahim Karagoz, Gulali Aktas, Hamit Yoldas, Isa Yildiz, Muhammet Nur Ogun, Murat Bilgi, Abdullah Demirhan
AIM: Recently, hemogram parameters, such as mean platelet volume (MPV), had been proposed as novel inflammatory and prognostic factors. In present retrospective analysis, we aimed to determine and compare MPV of survived and dead patients whom admitted to intensive care unit (ICU) of our institution. METHODS: We recorded hemogram parameters and other laboratory data and demographic characteristics of patients treated in ICU. Patients are divided into 2 groups-dead patients and survived patients...
January 1, 2017: Journal of Intensive Care Medicine
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