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Osteoporosis

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127 papers 25 to 100 followers
https://www.readbyqxmd.com/read/30535289/comparison-of-denosumab-vs-bisphosphonates-in-osteoporosis-patients-a-meta-analysis-of-randomized-controlled-trials
#1
Houchen Lyu, Bakr Jundi, Chang Xu, Sara K Tedeschi, Kazuki Yoshida, Sizheng Zhao, Sagar U Nigwekar, Benjamin Z Leder, Daniel H Solomon
Background: Among the currently available osteoporosis therapeutics, bisphosphonates and denosumab are widely used. However, it remains uncertain which therapy is more effective. Objective: To determine whether the use of denosumab increases bone mineral density (BMD) and reduces the risk of fractures more than bisphosphonates in patients with low BMD or osteoporosis. Data Sources: We searched PubMed, Embase and the Cochrane Library through Nov 2018...
December 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30400332/vitamin-d-nutrient-hormone-and-immunomodulator
#2
REVIEW
Francesca Sassi, Cristina Tamone, Patrizia D'Amelio
The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and control bone metabolism. However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. These observations, together with experimental studies, suggest a critical role for vitamin D in the modulation of immune function. This leads to the hypothesis of a disease-specific alteration of vitamin D metabolism and reinforces the role of vitamin D in maintaining a healthy immune system...
November 3, 2018: Nutrients
https://www.readbyqxmd.com/read/30402097/irisin-a-novel-metabolic-biomarker-present-knowledge-and-future-directions
#3
REVIEW
Ilse Yessabel Martinez Munoz, Eneida Del Socorro Camarillo Romero, Jose de Jesus Garduno Garcia
The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/30408611/use-it-or-lose-it-to-age-a-review-of-bone-and-muscle-communication
#4
Lynda Bonewald
Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism. A relatively new concept is that muscle, especially contracted muscle, acts as a secretory organ, regulating metabolism. An even newer concept is that bone, especially the osteocytes in bone, act as endocrine cells targeting other organs such as kidney and more recently, muscle. These two new concepts logically led to the third concept: that muscle and bone communicate via soluble factors...
November 5, 2018: Bone
https://www.readbyqxmd.com/read/30273092/a-not-so-new-treatment-for-old-bones
#5
Clifford J Rosen
No abstract text is available yet for this article.
October 1, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30237785/advances-and-unmet-needs-in-the-therapeutics-of-bone-fragility
#6
REVIEW
Sabashini K Ramchand, Ego Seeman
The prevalence of fragility fractures increases as longevity increases the proportion of the elderly in the community. Until recently, the majority of studies have targeted women with osteoporosis defined as a bone mineral density (BMD) T score of < -2.5 SD, despite evidence that the population burden of fractures arises from women with osteopenia. Antiresorptive agents reduce vertebral and hip fracture risk by ~50 percent during 3 years but efficacy against non-vertebral fractures, 80% of all fractures in the community, is reported in few studies, and of those, the risk reduction is only 20-30%...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30087947/osteoanabolic-agents-for-osteoporosis
#7
REVIEW
Andrea V Haas, Meryl S LeBoff
Medications for osteoporosis are classified as either antiresorptive or anabolic. Whereas antiresorptive agents prevent bone resorption, anabolic agents promote new bone formation. Anabolics should be considered in individuals with severe osteoporosis, failure of alternative osteoporosis agents, intolerability or contraindications to other osteoporosis agents, and glucocorticoid-induced osteoporosis. There are currently two approved anabolic therapies, teriparatide and abaloparatide, and a third anabolic agent, romozosumab, is under review by the US Food and Drug Administration...
August 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/30060226/primary-hyperparathyroidism
#8
John P Bilezikian
Background: Primary hyperparathyroidism (PHPT), the most common cause of hypercalcemia, is most often identified in postmenopausal women. The clinical presentation of PHPT has evolved over the past 40 years to include three distinct clinical phenotypes, each of which has been studied in detail and has led to evolving concepts about target organ involvement, natural history, and management. Methods: In the present review, I provide an evidence-based summary of this disorder as it has been studied worldwide, citing key concepts and data that have helped to shape our concepts about this disease...
November 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30048523/factors-affecting-development-of-medication-related-osteonecrosis-of-the-jaw-in-cancer-patients-receiving-high-dose-bisphosphonate-or-denosumab-therapy-is-tooth-extraction-a-risk-factor
#9
Sakiko Soutome, Saki Hayashida, Madoka Funahara, Yuki Sakamoto, Yuka Kojima, Souichi Yanamoto, Masahiro Umeda
Methods for preventing medication-related osteonecrosis of the jaw (MRONJ) in cancer patients who have received high-dose bisphosphonate (BP) or denosumab (Dmab) have not yet been established. Tooth extraction after starting medication has been believed to be a major risk factor for MRONJ, and therefore this procedure tends to be avoided. This study investigated the risk factors for MRONJ, with a special reference to the correlation between tooth extraction and development of MRONJ. One hundred and thirty-five cancer patients who were administrated high-dose BP or Dmab were enrolled in the study...
2018: PloS One
https://www.readbyqxmd.com/read/30007343/a-mediterranean-like-dietary-pattern-with-vitamin-d3-10-%C3%A2%C2%B5g-d-supplements-reduced-the-rate-of-bone-loss-in-older-europeans-with-osteoporosis-at-baseline-results-of-a-1-y-randomized-controlled-trial
#10
Amy Jennings, Kevin D Cashman, Rachel Gillings, Aedin Cassidy, Jonathan Tang, William Fraser, Kirsten G Dowling, George L J Hull, Agnes A M Berendsen, Lisette C P G M de Groot, Barbara Pietruszka, Elzbieta Wierzbicka, Rita Ostan, Alberto Bazzocchi, Giuseppe Battista, Elodie Caumon, Nathalie Meunier, Corinne Malpuech-Brugère, Claudio Franceschi, Aurelia Santoro, Susan J Fairweather-Tait
Background: The Mediterranean diet (MD) is widely recommended for the prevention of chronic disease, but evidence for a beneficial effect on bone health is lacking. Objective: The aim of this study was to examine the effect of a Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe)] on indexes of inflammation with a number of secondary endpoints, including bone mineral density (BMD) and biomarkers of bone and collagen degradation in a 1-y multicenter randomized controlled trial (RCT; NU-AGE) in elderly Europeans...
July 11, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29951870/current-understanding-of-epidemiology-pathophysiology-and-management-of-atypical-femur-fractures
#11
REVIEW
Jessica Starr, Yu Kwang Donovan Tay, Elizabeth Shane
PURPOSE OF REVIEW: To summarize reports published since the 2013 American Society of Bone and Mineral Research Task Force Report on atypical femoral fractures (AFF). RECENT FINDINGS: The absolute incidence of AFFs remains low. AFFs are primarily associated with prolonged bisphosphonate (BP) exposure, but have also been reported in unexposed patients and those receiving denosumab for osteoporosis and metastatic bone disease. Asians may be more susceptible to AFFs...
August 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29931216/a-phase-iii-randomized-placebo-controlled-trial-to-evaluate-efficacy-and-safety-of-romosozumab-in-men-with-osteoporosis
#12
E Michael Lewiecki, Tomasz Blicharski, Stefan Goemaere, Kurt Lippuner, Paul D Meisner, Paul D Miller, Akimitsu Miyauchi, Judy Maddox, Li Chen, Stephane Horlait
Context: Globally, one in five men aged >50 years is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming agents for men, new osteoporosis treatments are needed. Objective: To evaluate the safety and efficacy of romosozumab in men with osteoporosis. Design: Phase III randomized BRIDGE study (placebo-controlled double-blind study evaluating the efficacy and safety of romosozumab in treating men with osteoporosis; ClinicalTrials...
September 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29690515/acid-balance-dietary-acid-load-and-bone-effects-a-controversial-subject
#13
REVIEW
Lynda Frassetto, Tanushree Banerjee, Neil Powe, Anthony Sebastian
Modern Western diets, with higher contents of animal compared to fruits and vegetable products, have a greater content of acid precursors vs. base precursors, which results in a net acid load to the body. To prevent inexorable accumulation of acid in the body and progressively increasing degrees of metabolic acidosis, the body has multiple systems to buffer and titrate acid, including bone which contains large quantities of alkaline salts of calcium. Both in vitro and in vivo studies in animals and humans suggest that bone base helps neutralize part of the dietary net acid load...
April 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29662314/pretreatment-of-daily-teriparatide-enhances-the-increase-of-bone-mineral-density-in-cortical-bones-by-denosumab-therapy
#14
Mikio Kamimura, Akira Taguchi, Yukio Nakamura, Hidefumi Koiwai, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
Background: While it is well known that teriparatide (TPTD) increases bone mineral density (BMD) in osteoporotic patients, it is unknown whether TPTD pretreatment affects BMD after denosumab (DMAb) therapy. Methods: Fifty-seven patients in TPTD-pretreated group and 35 patients in DMAb-alone group had been further analyzed, all of whom were treated by DMAb for 1.5 years. Vitamin D (400 IU) and Ca (600 mg) supplementation was used in all patients. The BMD of lumbar 1-4 vertebrae (L-BMD), bilateral total hips (H-BMD), and bilateral femoral neck (FN-BMD) was quantified at first visit, and at 4, 8, 12, and 18 months after daily TPTD treatment following four times DMAb treatment...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29573473/frame-study-the-foundation-effect-of-building-bone-with-1-year-of-romosozumab-leads-to-continued-lower-fracture-risk-after-transition-to-denosumab
#15
Felicia Cosman, Daria B Crittenden, Serge Ferrari, Aliya Khan, Nancy E Lane, Kurt Lippuner, Toshio Matsumoto, Cassandra E Milmont, Cesar Libanati, Andreas Grauer
Romosozumab is a bone-forming agent with a dual effect of increasing bone formation and decreasing bone resorption. In FRActure study in postmenopausal woMen with ostEoporosis (FRAME), postmenopausal women with osteoporosis received romosozumab 210 mg s.c. or placebo once monthly for 12 months, followed by denosumab 60 mg s.c. once every 6 months in both groups for 12 months. One year of romosozumab increased spine and hip BMD by 13% and 7%, respectively, and reduced vertebral and clinical fractures with persistent fracture risk reduction upon transition to denosumab over 24 months...
July 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29380013/bone-mineral-density-changes-after-1-year-of-denosumab-discontinuation-in-postmenopausal-women-with-long-term-denosumab-treatment-for-osteoporosis
#16
Albrecht Werner Popp, Nadshathra Varathan, Helene Buffat, Christoph Senn, Romain Perrelet, Kurt Lippuner
The aim of the present study was to document the changes in bone mineral density (BMD) 1 year after denosumab loss-of-effect following long-term treatment with subcutaneous denosumab 60 mg Q6M during 7 or 10 years and in the absence of any treatment with a bone active substance. All postmenopausal women with osteoporosis who participated to the randomized placebo-controlled FREEDOM core trial and its open-label extension at the University Hospital of Bern, Switzerland, and who accepted to undergo off-treatment follow-up during 1 year after discontinuation, were included (N = 12)...
July 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29304057/long-chain-omega-3-polyunsaturated-fatty-acid-dietary-intake-is-positively-associated-with-bone-mineral-density-in-normal-and-osteopenic-spanish-women
#17
Jesus Lavado-García, Raul Roncero-Martin, Jose M Moran, Maria Pedrera-Canal, Ignacio Aliaga, Olga Leal-Hernandez, Sergio Rico-Martin, Maria L Canal-Macias
The regular consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) results in general health benefits. The intake of LCO3-PUFAs has been reported to contribute to bone metabolism. We aimed to investigate the relationships between dietary intakes of LCO3-PUFAs and bone mineral density (BMD) in Spanish women aged 20-79 years old. A total of 1865 female subjects (20-79 years old) were enrolled, and lumbar (L2, L3, L3 and total spine), hip (femoral neck (FN), femoral trochanter (FT) and Ward's triangle (WT)) bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DXA)...
2018: PloS One
https://www.readbyqxmd.com/read/29188222/effects-of-3-year-denosumab-treatment-on-hip-structure-in-japanese-postmenopausal-women-and-men-with-osteoporosis
#18
Teruki Sone, Naohiro Kon, Kenneth W Gaither, Naoki Okubo, Taisuke Osakabe, Yutaka Nakayama, Masao Fukunaga, Masako Ito, Toshitaka Nakamura
Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients. However, there have been no data showing actions on Japanese bone architecture. Here we show that denosumab continuously improves several geometrical parameters calculated by hip structural analysis for 3 years. Compared to placebo, denosumab significantly increased bone mineral density, cortical thickness and cross sectional area in all of the three analyzed areas: the narrow neck, intertrochanter and femoral shaft...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29170905/irisin-in-metabolic-diseases
#19
REVIEW
Stergios A Polyzos, Athanasios D Anastasilakis, Zoe A Efstathiadou, Polyzois Makras, Nikolaos Perakakis, Jannis Kountouras, Christos S Mantzoros
INTRODUCTION: Irisin is a myokine/adipokine induced by the exercise in mice and humans, which is proposed to induce "browning" of white adipose tissue, its primary target, thus increasing thermogenesis and energy expenditure. Since its identification, irisin has been linked to favorable effects on metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), lipid metabolism and cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and metabolic bone diseases...
February 2018: Endocrine
https://www.readbyqxmd.com/read/29129460/the-association-of-novel-polymorphisms-with-stress-fracture-injury-in-elite-athletes-further-insights-from-the-sfea-cohort
#20
Ian Varley, David C Hughes, Julie P Greeves, Trent Stellingwerff, Craig Ranson, William D Fraser, Craig Sale
OBJECTIVES: To determine, in conjunction with a wider investigation, whether 11 genetic variants in the vicinity of vitamin D, collagen and Wnt signalling pathways were associated with stress fracture injury in the Stress Fracture Elite Athlete (SFEA) cohort. DESIGN: Genotype-phenotype association study. METHODS: Self-reported stress fracture history and demographic data were recorded in 518 elite athletes, 449 male and 69 female (mean age 24...
June 2018: Journal of Science and Medicine in Sport
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