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Cohort studies using EHR

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9 papers 0 to 25 followers Examples of cohort studies utilising Electronic Health Records
https://www.readbyqxmd.com/read/25866264/bmi-and-risk-of-dementia-in-two-million-people-over-two-decades-a-retrospective-cohort-study
#1
Nawab Qizilbash, John Gregson, Michelle E Johnson, Neil Pearce, Ian Douglas, Kevin Wing, Stephen J W Evans, Stuart J Pocock
BACKGROUND: Dementia and obesity are increasingly important public health issues. Obesity in middle age has been proposed to lead to dementia in old age. We investigated the association between BMI and risk of dementia. METHODS: For this retrospective cohort study, we used a cohort of 1,958,191 individuals derived from the United Kingdom Clinical Practice Research Datalink (CPRD) which included people aged 40 years or older in whom BMI was recorded between 1992 and 2007...
June 2015: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/26033947/risk-of-bladder-cancer-in-patients-with-diabetes-a-retrospective-cohort-study
#2
Maria E Goossens, Maurice P Zeegers, Marloes T Bazelier, Marie L De Bruin, Frank Buntinx, Frank de Vries
OBJECTIVE: The objective of this study was to examine the association between diabetes, and both urinary bladder cancer (UBC) risk and mortality. METHODS: We conducted a retrospective cohort study using data from the UK Clinical Practice Research Datalink (CPRD) linked to the Office of National Statistics (ONS). Patients diagnosed with diabetes mellitus type 1 or 2, or using antidiabetic drugs (ADDs), were compared to matched non-diabetic controls. Cox proportional hazards models were used to estimate the risk and mortality of UBC...
June 1, 2015: BMJ Open
https://www.readbyqxmd.com/read/25352213/prevalence-and-incidence-rates-of-cardiovascular-autoimmune-and-other-diseases-in-patients-with-psoriatic-or-psoriatic-arthritis-a-retrospective-study-using-clinical-practice-research-datalink
#3
E Edson-Heredia, B Zhu, C Lefevre, M Wang, A Barrett, C J Bushe, A Cox, J J Wu, T Maeda-Chubachi
BACKGROUND: Previous studies have demonstrated that patients with psoriasis have higher rates of comorbidities compared to the general population. Despite the clinical and economic burden of psoriatic disease, there have been few large-scale observational studies focused on this condition. OBJECTIVE: To assess rates of cardiovascular, autoimmune, infectious and other conditions in patients with psoriasis or psoriatic arthritis (PSA). METHODS: The data for this retrospective study were obtained from the Clinical Practice Research Datalink (CRPD)...
May 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/25249162/antibiotic-treatment-failure-in-four-common-infections-in-uk-primary-care-1991-2012-longitudinal-analysis
#4
Craig J Currie, Ellen Berni, Sara Jenkins-Jones, Chris D Poole, Mario Ouwens, Stefan Driessen, Hanka de Voogd, Christopher C Butler, Christopher Ll Morgan
OBJECTIVE: To characterise failure of antibiotic treatment in primary care in the United Kingdom in four common infection classes from 1991 to 2012. DESIGN: Longitudinal analysis of failure rates for first line antibiotic monotherapies associated with diagnoses for upper and lower respiratory tract infections, skin and soft tissue infections, and acute otitis media. SETTING: Routine primary care data from the UK Clinical Practice Research Datalink (CPRD)...
September 23, 2014: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/25165032/increased-risk-of-vascular-disease-associated-with-gout-a-retrospective-matched-cohort-study-in-the-uk-clinical-practice-research-datalink
#5
Lorna E Clarson, Samantha L Hider, John Belcher, Carl Heneghan, Edward Roddy, Christian D Mallen
OBJECTIVES: To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studies in primary care. METHODS: A retrospective cohort study was performed using data from the Clinical Practice Research Datalink (CPRD). Risk of incident CHD, CVD and PVD was compared in 8386 patients with an incident diagnosis of gout, and 39 766 age, sex and registered general practice-matched controls, all aged over 50 years and with no prior vascular history, in the 10 years following incidence of gout, or matched index date (baseline)...
April 2015: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25041462/can-people-with-type-2-diabetes-live-longer-than-those-without-a-comparison-of-mortality-in-people-initiated-with-metformin-or-sulphonylurea-monotherapy-and-matched-non-diabetic-controls
#6
COMPARATIVE STUDY
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie
AIMS: Clinical and observational studies have shown an increased risk of cardiovascular events and death associated with sulphonylureas versus metformin. However, it has never been determined whether this was due to the beneficial effects of metformin or detrimental effects of sulphonylureas. The objective of this study was therefore to compare all-cause mortality in diabetic patients treated first-line with either sulphonylurea or metformin monotherapy with that in matched individuals without diabetes...
November 2014: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/25022519/statins-and-the-risk-of-type-2-diabetes-mellitus-cohort-study-using-the-uk-clinical-practice-pesearch-datalink
#7
Ana Filipa Macedo, Ian Douglas, Liam Smeeth, Harriet Forbes, Shah Ebrahim
BACKGROUND: There is strong evidence of reductions in major vascular events from statins across all cardiovascular risk categories. However, trials of statin therapy have provided conflicting results regarding statin use and type 2 diabetes (T2DM). We aimed to assess the effect of statins on T2DM development. METHOD: We carried out a population-based cohort study using the Clinical Practice Research Datalink (CPRD), a database of computerized clinical records. Every patient aged 30-85 years old starting a statin between 1989 and 2009 was matched with up to five non-statin users...
July 15, 2014: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/24468720/population-based-cohort-study-of-warfarin-treated-patients-with-atrial-fibrillation-incidence-of-cardiovascular-and-bleeding-outcomes
#8
Arlene M Gallagher, Tjeerd P van Staa, Tarita Murray-Thomas, Nils Schoof, Andreas Clemens, Diana Ackermann, Dorothee B Bartels
OBJECTIVES: Atrial fibrillation (AF) is the most common cardiac rhythm disorder with a significant health burden. The aim of this study was to characterise patients with recently diagnosed AF and to estimate the rates of comorbidities and outcome events requiring hospitalisation in routine clinical practice. DESIGN: Pharmacoepidemiological cohort study using observational data. METHODS/SETTING: This study included 16 513 patients with a first diagnosis of AF between 1 January 2005 and 28 February 2010 (newly diagnosed patients) using data from the UK Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and the Office for National Statistics mortality data...
January 27, 2014: BMJ Open
https://www.readbyqxmd.com/read/24302508/primary-prevention-of-diabetic-retinopathy-with-fibrates-a-retrospective-matched-cohort-study
#9
Christopher Ll Morgan, David R Owens, Patrick Aubonnet, Emma S M Carr, Sara Jenkins-Jones, Chris D Poole, Craig J Currie
OBJECTIVES: To compare the progression of diabetic retinopathy (DR) in people with type 2 diabetes treated with fibrates with that of non-exposed controls. DESIGN: Retrospective, matched cohort study. SETTING: UK Clinical Practice Research Datalink (CPRD). PARTICIPANTS: 5038 people with type 2 diabetes with a history of fibrate exposure but without evidence of DR were identified. Three thousand one hundred and seventy-six (63%) people could be randomly matched to one non-exposed control; of these, 2599 (81...
2013: BMJ Open
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