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https://www.readbyqxmd.com/read/28553678/population-study-confirms-serum-proteins-change-and-reveals-diagnostic-values-in-congenital-ventricular-septal-defect
#1
Jinghua Long, Shun Liu, Xiaoyun Zeng, Xiaoyun Yang, Hui Huang, Yongbo Zhang, Jiehua Chen, Yang Xu, Dongping Huang, Xiaoqiang Qiu
This study was designed to validate thrombospondin 1 (TSP-1), vascular endothelial-cadherin complex (VE-cad), insulin-like growth factor 2 (IGF-2), and amyloid precursor protein (APP) and assess their diagnostic value in ventricular septal defect (VSD). We investigated the serum levels of TSP-1, VE-cad, IGF-2, and APP by enzyme-linked immunosorbent assay in a hospital-based case-control study that included 40 VSD children and 40 healthy controls. Logistic regression analysis was applied to evaluate the relationship of the proteins and VSD, and receiver operating characteristic (ROC) curve was used to assess the diagnostic value of the significant proteins...
May 29, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28512184/effect-of-intensive-blood-pressure-lowering-on-left-ventricular-hypertrophy-in-patients-with-hypertension-the-systolic-blood-pressure-intervention-sprint-trial
#2
Elsayed Z Soliman, Walter T Ambrosius, William C Cushman, Zhu-Ming Zhang, Jeffrey T Bates, Javier A Neyra, Thaddeus Y Carson, Leonardo Tamariz, Lama Ghazi, Monique E Cho, Brian P Shapiro, Jiang He, Lawrence J Fine, Cora E Lewis
Background -It is currently unknown whether intensive blood pressure (BP) lowering beyond that recommended would lead to more lowering of the risk of Left ventricular hypertrophy (LVH) in patients with hypertension, and whether reducing the risk of LVH explains the reported cardiovascular disease (CVD) benefits of intensive BP lowering in this population. Methods -This analysis included 8,164 participants (mean age 67.9 years, 35.3% women, 31.2% blacks) with hypertension but no diabetes from the Systolic Blood Pressure Intervention (SPRINT) Trial; 4,086 randomly assigned to intensive BP lowering (target systolic BP<120mmHg) and 4,078 assigned to standard BP lowering (target systolic BP <140mmHg)...
May 16, 2017: Circulation
https://www.readbyqxmd.com/read/28401252/evaluation-of-ventricular-septal-defect-with-special-reference-to-the-spontaneous-closure-rate-subaortic-ridge-and-aortic-valve-prolapse-ii
#3
Ayse Guler Eroglu, Sezen Ugan Atik, Esma Sengenc, Gulnaz Cig, Irfan Levent Saltik, Funda Oztunc
The medical records of 2283 patients with ventricular septal defect (VSD) were reviewed to determine spontaneous closure, left ventricular-to-right atrial shunt, subaortic ridge, and aortic valve prolapse. One thousand eight hundred and twenty-three patients had been followed 1 month to 26 years (median 4 years) by echocardiography. Most of 460 patients could not be followed due to transportation of the institution. VSD was perimembranous in 68.8% (1255), trabecular muscular in 21.7% (395), muscular outlet in 6% (109), muscular inlet in 2...
April 12, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/21357825/best-practices-in-managing-transition-to-adulthood-for-adolescents-with-congenital-heart-disease-the-transition-process-and-medical-and-psychosocial-issues-a-scientific-statement-from-the-american-heart-association
#4
Craig Sable, Elyse Foster, Karen Uzark, Katherine Bjornsen, Mary M Canobbio, Heidi M Connolly, Thomas P Graham, Michelle Z Gurvitz, Adrienne Kovacs, Alison K Meadows, Graham J Reid, John G Reiss, Kenneth N Rosenbaum, Paul J Sagerman, Arwa Saidi, Rhonda Schonberg, Sangeeta Shah, Elizabeth Tong, Roberta G Williams
No abstract text is available yet for this article.
April 5, 2011: Circulation
https://www.readbyqxmd.com/read/28286222/2017-acc-aha-hrs-guideline-for-the-evaluation-and-management-of-patients-with-syncope-executive-summary-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines-and-the-heart-rhythm-society
#5
Win-Kuang Shen, Robert S Sheldon, David G Benditt, Mitchell I Cohen, Daniel E Forman, Zachary D Goldberger, Blair P Grubb, Mohamed H Hamdan, Andrew D Krahn, Mark S Link, Brian Olshansky, Satish R Raj, Roopinder Kaur Sandhu, Dan Sorajja, Benjamin C Sun, Clyde W Yancy
No abstract text is available yet for this article.
March 9, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28289069/omega-3-polyunsaturated-fatty-acid-fish-oil-supplementation-and-the-prevention-of-clinical-cardiovascular-disease-a-science-advisory-from-the-american-heart-association
#6
REVIEW
David S Siscovick, Thomas A Barringer, Amanda M Fretts, Jason H Y Wu, Alice H Lichtenstein, Rebecca B Costello, Penny M Kris-Etherton, Terry A Jacobson, Mary B Engler, Heather M Alger, Lawrence J Appel, Dariush Mozaffarian
Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid plus docosahexaenoic acid (omega-3 polyunsaturated fatty acids, commonly called fish oils) on the occurrence of clinical cardiovascular diseases. Although the effects of supplementation for the primary prevention of clinical cardiovascular events in the general population have not been examined, RCTs have assessed the role of supplementation in secondary prevention among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prevalent coronary heart disease...
April 11, 2017: Circulation
https://www.readbyqxmd.com/read/28137935/meal-timing-and-frequency-implications-for-cardiovascular-disease-prevention-a-scientific-statement-from-the-american-heart-association
#7
REVIEW
Marie-Pierre St-Onge, Jamy Ard, Monica L Baskin, Stephanie E Chiuve, Heather M Johnson, Penny Kris-Etherton, Krista Varady
Eating patterns are increasingly varied. Typical breakfast, lunch, and dinner meals are difficult to distinguish because skipping meals and snacking have become more prevalent. Such eating styles can have various effects on cardiometabolic health markers, namely obesity, lipid profile, insulin resistance, and blood pressure. In this statement, we review the cardiometabolic health effects of specific eating patterns: skipping breakfast, intermittent fasting, meal frequency (number of daily eating occasions), and timing of eating occasions...
February 28, 2017: Circulation
https://www.readbyqxmd.com/read/28077506/clinical-guidelines-for-the-management-of-patients-with-transposition-of-the-great-arteries-with-intact-ventricular-septum
#8
George E Sarris, Christian Balmer, Pipina Bonou, Juan V Comas, Eduardo da Cruz, Luca Di Chiara, Roberto M Di Donato, José Fragata, Tuula Eero Jokinen, George Kirvassilis, Irene Lytrivi, Milan Milojevic, Gurleen Sharland, Matthias Siepe, Joerg Stein, Emanuela Valsangiacomo Büchel, Pascal R Vouhé
No abstract text is available yet for this article.
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28082385/management-of-pregnancy-in-patients-with-complex-congenital-heart-disease-a-scientific-statement-for-healthcare-professionals-from-the-american-heart-association
#9
REVIEW
Mary M Canobbio, Carole A Warnes, Jamil Aboulhosn, Heidi M Connolly, Amber Khanna, Brian J Koos, Seema Mital, Carl Rose, Candice Silversides, Karen Stout
Today, most female children born with congenital heart disease will reach childbearing age. For many women with complex congenital heart disease, carrying a pregnancy carries a moderate to high risk for both the mother and her fetus. Many such women, however, do not have access to adult congenital heart disease tertiary centers with experienced reproductive programs. Therefore, it is important that all practitioners who will be managing these women have current information not only on preconception counseling and diagnostic evaluation to determine maternal and fetal risk but also on how to manage them once they are pregnant and when to refer them to a regional center with expertise in pregnancy management...
February 21, 2017: Circulation
https://www.readbyqxmd.com/read/27567407/2016-esc-eas-guidelines-for-the-management-of-dyslipidaemias
#10
Alberico L Catapano, Ian Graham, Guy De Backer, Olov Wiklund, M John Chapman, Heinz Drexel, Arno W Hoes, Catriona S Jennings, Ulf Landmesser, Terje R Pedersen, Željko Reiner, Gabriele Riccardi, Marja-Riita Taskinen, Lale Tokgozoglu, W M Monique Verschuren, Charalambos Vlachopoulos, David A Wood, Jose Luis Zamorano
No abstract text is available yet for this article.
October 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27702773/clinical-outcomes-in-3343-children-and-adults-with-rheumatic-heart-disease-from-14-low-and-middle-income-countries-two-year-follow-up-of-the-global-rheumatic-heart-disease-registry-the-remedy-study
#11
MULTICENTER STUDY
Liesl Zühlke, Ganesan Karthikeyan, Mark E Engel, Sumathy Rangarajan, Pam Mackie, Blanche Cupido-Katya Mauff, Shofiqul Islam, Rezeen Daniels, Veronica Francis, Stephen Ogendo, Bernard Gitura, Charles Mondo, Emmy Okello, Peter Lwabi, Mohammed M Al-Kebsi, Christopher Hugo-Hamman, Sahar S Sheta, Abraham Haileamlak, Wandimu Daniel, Dejuma Yadeta Goshu, Senbeta G Abdissa, Araya G Desta, Bekele A Shasho, Dufera M Begna, Ahmed ElSayed, Ahmed S Ibrahim, John Musuku, Fidelia Bode-Thomas, Christopher C Yilgwan, Ganiyu A Amusa, Olukemi Ige, Basil Okeahialam, Christopher Sutton, Rajeev Misra, Azza Abul Fadl, Neil Kennedy, Albertino Damasceno, Mahmoud U Sani, Okechukwu S Ogah, Taiwo OlunugaHuda H M Elhassan, Ana Olga Mocumbi, Abiodun M Adeoye, Phindile Mntla, Dike Ojji, Joseph Mucumbitsi, Koon Teo, Salim Yusuf, Bongani M Mayosi
BACKGROUND: There are few contemporary data on the mortality and morbidity associated with rheumatic heart disease or information on their predictors. We report the 2-year follow-up of individuals with rheumatic heart disease from 14 low- and middle-income countries in Africa and Asia. METHODS: Between January 2010 and November 2012, we enrolled 3343 patients from 25 centers in 14 countries and followed them for 2 years to assess mortality, congestive heart failure, stroke or transient ischemic attack, recurrent acute rheumatic fever, and infective endocarditis...
November 8, 2016: Circulation
https://www.readbyqxmd.com/read/27091847/mortality-and-complications-in-3495-children-with-isolated-ventricular-septal-defects
#12
MULTICENTER STUDY
Jarle Jortveit, Elisabeth Leirgul, Leif Eskedal, Gottfried Greve, Tatiana Fomina, Gaute Døhlen, Grethe S Tell, Sigurd Birkeland, Nina Øyen, Henrik Holmstrøm
BACKGROUND: Ventricular septal defects (VSDs) are the most common congenital heart defects (CHDs). Previous studies indicate an increased risk of endocarditis, aortic regurgitation, left ventricular outflow tract obstructions, pulmonary hypertension, arrhythmias and sudden death in patients with isolated VSDs. The present nationwide cohort study reports mortality and cardiac complications requiring hospitalisation or intervention in children with isolated VSDs. METHODS AND RESULTS: Medical information concerning all 943 871 live births in Norway in 1994-2009 was retrieved from the Medical Birth Registry of Norway, the Cardiovascular Disease in Norway project, the Oslo University Hospital's Clinical Registry of Congenital Heart Defects and the Norwegian Cause of Death Registry...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/24226806/prevention-and-treatment-of-thrombosis-in-pediatric-and-congenital-heart-disease-a-scientific-statement-from-the-american-heart-association
#13
Therese M Giglia, M Patricia Massicotte, James S Tweddell, Robyn J Barst, Mary Bauman, Christopher C Erickson, Timothy F Feltes, Elyse Foster, Kathleen Hinoki, Rebecca N Ichord, Jacqueline Kreutzer, Brian W McCrindle, Jane W Newburger, Sarah Tabbutt, Jane L Todd, Catherine L Webb
No abstract text is available yet for this article.
December 17, 2013: Circulation
https://www.readbyqxmd.com/read/8152445/progression-of-aortic-dilatation-and-the-benefit-of-long-term-beta-adrenergic-blockade-in-marfan-s-syndrome
#14
RANDOMIZED CONTROLLED TRIAL
J Shores, K R Berger, E A Murphy, R E Pyeritz
BACKGROUND: The aortic root enlarges progressively in Marfan's syndrome, and this enlargement is associated with aortic regurgitation and dissection. Long-term treatment with beta-adrenergic blockade, by reducing the impulse (i.e., the rate of pressure change in the aortic root) of left ventricular ejection and the heart rate, may protect the aortic root. METHODS: We conducted an open-label, randomized trial of propranolol in adolescent and adult patients with classic Marfan's syndrome (32 treated and 38 untreated [control] patients)...
May 12, 1994: New England Journal of Medicine
https://www.readbyqxmd.com/read/26508439/hypertension-in-late-adolescence-and-cardiovascular-mortality-in-midlife-a-cohort-study-of-2-3-million-16-to-19-year-old-examinees
#15
Adi Leiba, Gilad Twig, Hagai Levine, Nehama Goldberger, Arnon Afek, Ari Shamiss, Estela Derazne, Dorit Tzur, Ziona Haklai, Jeremy D Kark
BACKGROUND: The effect of early hypertension on midlife cardiovascular (CV) mortality remains controversial. We assessed the association of established hypertension in late adolescence with subsequent CV mortality. METHODS: Of 2,298,130 Israeli adolescents (60% males; age 17.4 ± 0.3 years) who underwent a compulsory medical examination prior to military service between 1967 and 2010, 8720 teenagers (0.4%) were formally diagnosed with persistent hypertension...
March 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27297341/whole-grain-intake-and-mortality-from-all-causes-cardiovascular-disease-and-cancer-a-meta-analysis-of-prospective-cohort-studies
#16
Geng Zong, Alisa Gao, Frank B Hu, Qi Sun
BACKGROUND: Current findings on associations between whole grain (WG) intake and mortality are inconsistent and have not been summarized by meta-analysis. METHODS AND RESULTS: We searched for prospective cohort studies reporting associations between WG intake and mortality from all causes, cardiovascular disease (CVD), and cancer through February 2016 in Medline, Embase, and clinicaltrials.gov, and we further included unpublished results from National Health and Nutrition Examination Survey (NHANES) III and NHANES 1999 to 2004...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27297348/endemic-cardiovascular-diseases-of-the-poorest-billion
#17
REVIEW
Gene F Kwan, Bongani M Mayosi, Ana O Mocumbi, J Jaime Miranda, Majid Ezzati, Yogesh Jain, Gisela Robles, Emelia J Benjamin, S V Subramanian, Gene Bukhman
The poorest billion people are distributed throughout the world, though most are concentrated in rural sub-Saharan Africa and South Asia. Cardiovascular disease (CVD) data can be sparse in low- and middle-income countries beyond urban centers. Despite this urban bias, CVD registries from the poorest countries have long revealed a predominance of nonatherosclerotic stroke, hypertensive heart disease, nonischemic and Chagas cardiomyopathies, rheumatic heart disease, and congenital heart anomalies, among others...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27278630/screening-for-congenital-heart-disease-in-infants-with-down-syndrome-is-universal-echocardiography-necessary
#18
Soujanya Bogarapu, Nelangi M Pinto, Susan P Etheridge, Xiaoming Sheng, Kirk N Liesemer, Paul C Young, Elizabeth V Saarel
Current guidelines recommend that all neonates with Down syndrome (DS) be screened for congenital heart disease (CHD) with an echocardiogram. We sought to determine the effectiveness of a more accessible and less expensive screening strategy consisting of physical examination, electrocardiogram (ECG), and chest X-ray. The Intermountain Healthcare Enterprise Data Warehouse was used to identify infants with a positive karyotype for DS who were born between January 1, 2000, and June 30, 2012. Infants with the results of an echocardiogram, physical examination, ECG, and chest X-ray documented at age ≤6 months were included...
October 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26499357/prostaglandin-availability-and-association-with-outcomes-for-infants-with-congenital-heart-disease
#19
MULTICENTER STUDY
Brady S Moffett, Joshua M Garrison, Aimee Hang, Shaine A Morris, Rocky Tsang, Kimberly Dinh, Pamela Griffiths, Ronald Bronicki, Paul A Checchia
Data regarding availability of prostaglandin E1 (PGE) and its impact on the stabilization, transport, critical care course, and surgical outcome of infants with ductal-dependent congenital heart disease in the current pediatric healthcare environment are unknown. We sought to determine the proportion of hospitals in Texas that stock PGE and to investigate associations between PGE availability and clinical outcomes. All birth institutions listed with the Texas Department of Health and Human Services were contacted to determine PGE availability as of 2011...
February 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26483167/mitral-valve-disease-morphology-and-mechanisms
#20
REVIEW
Robert A Levine, Albert A Hagége, Daniel P Judge, Muralidhar Padala, Jacob P Dal-Bianco, Elena Aikawa, Jonathan Beaudoin, Joyce Bischoff, Nabila Bouatia-Naji, Patrick Bruneval, Jonathan T Butcher, Alain Carpentier, Miguel Chaput, Adrian H Chester, Catherine Clusel, Francesca N Delling, Harry C Dietz, Christian Dina, Ronen Durst, Leticia Fernandez-Friera, Mark D Handschumacher, Morten O Jensen, Xavier P Jeunemaitre, Hervé Le Marec, Thierry Le Tourneau, Roger R Markwald, Jean Mérot, Emmanuel Messas, David P Milan, Tui Neri, Russell A Norris, David Peal, Maelle Perrocheau, Vincent Probst, Michael Pucéat, Nadia Rosenthal, Jorge Solis, Jean-Jacques Schott, Ehud Schwammenthal, Susan A Slaugenhaupt, Jae-Kwan Song, Magdi H Yacoub
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates that the mitral valve is not a passive structure, but--even in adult life--remains dynamic and accessible for treatment. This concept motivates efforts to reduce the clinical progression of mitral valve disease through early detection and modification of underlying mechanisms. Discoveries of genetic mutations causing mitral valve elongation and prolapse have revealed that growth factor signalling and cell migration pathways are regulated by structural molecules in ways that can be modified to limit progression from developmental defects to valve degeneration with clinical complications...
December 2015: Nature Reviews. Cardiology
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