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Cardiac Surgery

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9 papers 0 to 25 followers
Elizabeth H Stephens, David Odell, William Stein, Damien J LaPar, Walter F DeNino, Muhammad Aftab, Kathleen Berfield, Amanda L Eilers, Shawn Groth, John F Lazar, Michael P Robich, Asad A Shah, Danielle A Smith, Cameron Stock, Vakhtang Tchantchaleishvili, Carlos M Mery, Joseph W Turek, Jorge Salazar, Tom C Nguyen
BACKGROUND: During the past decade, cardiothoracic surgery (CTS) education has undergone tremendous change with the advent of new technologies and the implementation of integrated programs, to name a few. The goal of this study was to assess how residents' career paths, training, and perceptions changed during this period. METHODS: The 2006 to 2014 surveys accompanying the Thoracic Surgery Residents Association/Thoracic Surgery Directors' Association in-training examination taken by CTS residents were analyzed, along with a 2003 survey of graduating CTS residents...
October 2015: Annals of Thoracic Surgery
P J Devereaux, Marko Mrkobrada, Daniel I Sessler, Kate Leslie, Pablo Alonso-Coello, Andrea Kurz, Juan Carlos Villar, Alben Sigamani, Bruce M Biccard, Christian S Meyhoff, Joel L Parlow, Gordon Guyatt, Andrea Robinson, Amit X Garg, Reitze N Rodseth, Fernando Botto, Giovanna Lurati Buse, Denis Xavier, Matthew T V Chan, Maria Tiboni, Deborah Cook, Priya A Kumar, Patrice Forget, German Malaga, Edith Fleischmann, Mohammed Amir, John Eikelboom, Richard Mizera, David Torres, C Y Wang, Tomas VanHelder, Pilar Paniagua, Otavio Berwanger, Sadeesh Srinathan, Michelle Graham, Laura Pasin, Yannick Le Manach, Peggy Gao, Janice Pogue, Richard Whitlock, André Lamy, Clive Kearon, Colin Baigent, Clara Chow, Shirley Pettit, Susan Chrolavicius, Salim Yusuf
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a 2-by-2 factorial trial design, we randomly assigned 10,010 patients who were preparing to undergo noncardiac surgery and were at risk for vascular complications to receive aspirin or placebo and clonidine or placebo. The results of the aspirin trial are reported here...
April 17, 2014: New England Journal of Medicine
Muhammad Musa Salick, Irfan Qadir, Shazia Perveen, Shumaila Furnaz, Hasanat Sharif
BACKGROUND: improvements in nonsurgical revascularization have left a group of higher-risk patients presenting for operation in a later stage of coronary artery disease. We undertook this study to analyze temporal changes in demographic and clinical profiles and outcomes of cardiac surgical patients. METHODS: we identified and retrieved preoperative, intraoperative, and postoperative variables for 3064 consecutive patients who underwent myocardial revascularization at the Aga Khan University Hospital between 2006 and 2011...
August 2013: Asian Cardiovascular & Thoracic Annals
Naosumi Sekiya, Kimimasa Tobita, Sarah Beckman, Masaho Okada, Burhan Gharaibeh, Yoshiki Sawa, Robert L Kormos, Johnny Huard
Direct intracardiac cell injection for heart repair is hindered by numerous limitations including: cell death, poor spreading of the injected cells, arrhythmia, needle injury, etc. Tissue-engineered cell sheet implantation has the potential to overcome some of these limitations. We evaluated whether the transplantation of a muscle-derived stem cell (MDSC) sheet could improve the regenerative capacity of MDSCs in a chronic model of myocardial infarction. MDSC sheet-implanted mice displayed a reduction in left ventricle (LV) dilation and sustained LV contraction compared with the other groups...
March 2013: Molecular Therapy: the Journal of the American Society of Gene Therapy
Jullia Y Lee, Francis S Markland, Benedict R Lucchesi
BACKGROUND: An optimal strategy to improve reperfusion in patients with arterial occlusions is a recognized clinical need. We hypothesized that hirudin (thrombin inhibitor) and S18886 [S18, thromboxane A(2) receptor (TP) antagonist] would improve blood flow and reperfusion rates after thrombolysis with the direct-acting fibrinolytic enzyme alfimeprase. METHODS: In anesthetized beagles, carotid artery thrombosis was induced by electrolytic endothelial injury. After 30 minutes of occlusion, animals were administered vehicle, hirudin, and/or S18...
February 2013: Journal of Cardiovascular Pharmacology
Shunsuke Saito, Shigeru Miyagawa, Taichi Sakaguchi, Yukiko Imanishi, Hiroko Iseoka, Hiroyuki Nishi, Yasushi Yoshikawa, Satsuki Fukushima, Atsuhiro Saito, Tatsuya Shimizu, Teruo Okano, Yoshiki Sawa
BACKGROUND: Impairment of diastolic function and late remodeling are concerns after left ventricular restoration (LVR) for ischemic cardiomyopathy. This study aims to evaluate the effects of combined surgery of myoblast sheets (MS) implantation and LVR. METHODS: Rat myocardial infarction model was established 2 weeks after left anterior descending artery ligation. They were divided into three groups: sham operation (n=15; group sham), LVR by plicating the infracted area (n=15; group LVR), and MS implantation with LVR (n=15; group LVR+MS)...
June 15, 2012: Transplantation
Assad Haneya, Alois Philipp, Karla Lehle, Claudius Diez, Leopold Rupprecht, Reinhard Kobuch, Stephan W Hirt, York A Zausig, Christof Schmid, Thomas Puehler
In this case series, we describe our successful use of a reduced hirudin dosage as an anticoagulant during cardiac surgery using minimized extracorporeal circulation in patients with heparin-induced thrombocytopenia.
August 2011: Annals of Thoracic Surgery
Samuel C Siu, Candice K Silversides
Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect. While the BAV can be found in isolation, it is often associated with other congenital cardiac lesions. The most frequent associated finding is dilation of the proximal ascending aorta secondary to abnormalities of the aortic media. Changes in the aortic media are present independent of whether the valve is functionally normal, stenotic, or incompetent. Although symptoms often manifest in adulthood, there is a wide spectrum of presentations ranging from severe disease detected in utero to asymptomatic disease in old age...
June 22, 2010: Journal of the American College of Cardiology
Imran A Memon, Yoshiki Sawa, Norihide Fukushima, Goro Matsumiya, Shigeru Miyagawa, Satoshi Taketani, Satoru K Sakakida, Haruhiko Kondoh, Alexey N Aleshin, Tatsuya Shimizu, Teruo Okano, Hikaru Matsuda
OBJECTIVES: Autologous skeletal myoblast cell transplantation by means of the injection method is subject to the loss of intercellular communication, extracellular matrix, and cell numbers. We hypothesize that the implantation of skeletal myoblast cell sheets might be more advantageous in repairing the impaired heart by providing uniform and stable cell delivery with less cell loss and without disrupting the cell-cell microenvironment. METHODS: Left anterior descending coronary artery-ligated Lewis rat hearts (2 weeks, total n = 173) received 1 x 10(7) autologous skeletal myoblasts by means of cell transplantation either through myoblast injection or implantation of 2 monolayer-constructed myoblast sheets (5 x 10(6) cells per sheet) or through medium injection...
November 2005: Journal of Thoracic and Cardiovascular Surgery
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