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Breast cancer

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22 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27014653/lack-of-association-between-mthfr-c677t-polymorphism-and-breast-cancer-risk-in-ahvaz-west-south-iran
#1
Ghorban Mohammadzadeh, Maryam Karimi, Mohammad Bazyar, Seyed-Mohammad Hosseini
BACKGROUND: Association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism and DNA methylation, and breast cancer risk are inconsistent. We investigated in a case-control study, possible effect of the common MTHFR C677T polymorphism on breast cancer risk in a sample of Iranian patients. MATERIALS AND METHODS: The study subjects comprised of 123 breast cancer cases and 110 cancer-free control, who were matched for age and body mass index (BMI)...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27173331/role-of-mthfr-c677t-and-mtr-a2756g-polymorphisms-in-thyroid-and-breast-cancer-development
#2
T Zara-Lopes, A P A Gimenez-Martins, C H V Nascimento-Filho, M M U Castanhole-Nunes, A L S Galbiatti-Dias, J A Padovani-Júnior, J V Maniglia, J L E Francisco, E C Pavarino, E M Goloni-Bertollo
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer. Polymerase chain reaction-restriction fragment length technique was used to determine the specific genotypes in the genes of interest...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26897124/serum-betaine-but-not-choline-is-inversely-associated-with-breast-cancer-risk-a-case-control-study-in-china
#3
Yu-Feng Du, Fang-Yu Lin, Wei-Qing Long, Wei-Ping Luo, Bo Yan, Ming Xu, Xiong-Fei Mo, Cai-Xia Zhang
PURPOSE: Choline and betaine are important for DNA methylation and synthesis, and may affect tumor carcinogenesis. To our knowledge, no previous study has examined the association between serum choline and betaine and breast cancer risk. This study aimed to examine whether serum choline and betaine were inversely associated with breast cancer risk among Chinese women. METHODS: This hospital-based case-control study consecutively recruited 510 breast cancer cases and 518 frequency-matched (age and residence) controls, and blood samples were available for 500 cases and 500 controls...
February 20, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/26537580/the-association-between-methylenetetrahydrofolate-reductase-gene-c677t-polymorphisms-and-breast-cancer-risk-in-chinese-population
#4
Yadong Wang, Haiyan Yang, Huiyan Gao, Haiyu Wang
With great interest, we read the recent article entitled "Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies" published online in Tumor Biology, 2014, 35: 1695-1701. This article suggests that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism was significantly associated with breast cancer risk in Chinese population. The result is encouraging. Nevertheless, three key issues in this meta-analysis are worth noticing...
December 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26073487/11-keto-boswellic-acid-derived-amides-and-monodesmosidic-saponins-induce-apoptosis-in-breast-and-cervical-cancers-cells
#5
René Csuk, Anja Barthel-Niesen, Alexander Barthel, Renate Schäfer, Ahmed Al-Harrasi
Beta-boswellic acids are considered the main bioactive components of frankincense. Their potential to act as cytotoxic agents, as well as that of their derivatives remained unexploited so far. In this study we were able to prepare derivatives of 11-keto-β-boswellic acid (KBA) that showed lower IC50 values as determined by a sulphorhodamine B (SRB) assay using several different human tumour cell lines. Monodesmosidic saponins of KBA are as cytotoxic as 3-acetyl-KBA. The presence of a free hydroxyl group at position C-3 seems to lower cytotoxicity while the presence of an amide function at C-24 improves cytotoxicity...
July 15, 2015: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/24269837/chemoprevention-of-rat-mammary-carcinogenesis-by-spirulina
#6
Allal Ouhtit, Mohammed F Ismail, Amira Othman, Augusta Fernando, Mohamed E Abdraboh, Attalla F El-Kott, Yahia A Azab, Sherif H Abdeen, Rajiv L Gaur, Ishita Gupta, Somya Shanmuganathan, Yahya M Al-Farsi, Hamad Al-Riyami, Madhwa H G Raj
Spirulina (SP) (Arthrospira platensis; previously Spirulina platensis) is a filamentous blue-green microalga (cyanobacterium) with potent dietary phytoantioxidant and anticancerous properties. We investigated the chemopreventive effect of SP against 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat breast carcinogenesis, and further studied its underlying mechanisms of action in vitro. Remarkably, SP cleared DMBA-induced rat mammary tumors, which was clearly confirmed by morphological and histological methods...
January 2014: American Journal of Pathology
https://www.readbyqxmd.com/read/26090795/associations-between-genetic-variation-in-one-carbon-metabolism-and-line-1-dna-methylation-in-histologically-normal-breast-tissues
#7
Adana A M Llanos, Catalin Marian, Theodore M Brasky, Ramona G Dumitrescu, Zhenhua Liu, Joel B Mason, Kepher H Makambi, Scott L Spear, Bhaskar V S Kallakury, Jo L Freudenheim, Peter G Shields
Genome-wide DNA hypomethylation is an early event in the carcinogenic process. Percent methylation of long interspersed nucleotide element-1 (LINE-1) is a biomarker of genome-wide methylation and is a potential biomarker for breast cancer. Understanding factors associated with percent LINE-1 DNA methylation in histologically normal tissues could provide insight into early stages of carcinogenesis. In a cross-sectional study of 121 healthy women with no prior history of cancer who underwent reduction mammoplasty, we examined associations between plasma and breast folate, genetic variation in one-carbon metabolism, and percent LINE-1 methylation using multivariable regression models (adjusting for race, oral contraceptive use, and alcohol use)...
2015: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/26081619/association-between-the-mthfr-c677t-polymorphism-and-risk-of-cancer-evidence-from-446-case-control-studies
#8
Shu-Zhe Xie, Zhi-Zhong Liu, Jun-hua Yu, Li Liu, Wei Wang, Dao-Lin Xie, Jiang-Bo Qin
Many molecular epidemiological studies have been performed to explore the association between MTHFR C677T polymorphism and cancer risk in diverse populations. However, the results were inconsistent. Hence, we performed a meta-analysis to investigate the association between cancer risk and MTHFR C677T (150,086 cases and 200,699 controls from 446 studies) polymorphism. Overall, significantly increased cancer risk was found when all eligible studies were pooled into the meta-analysis. In the further stratified and sensitivity analyses, significantly increased breast cancer risk was found in Asians and Indians, significantly decreased colon cancer risk was found, significantly decreased colorectal cancer risk was found in male population, significantly increased gastric cancer risk was found in Caucasians and Asians, significantly increased hepatocellular cancer risk was found in Asians, significantly decreased adult acute lymphoblastic leukemia (AALL) risk was found in Caucasians, significantly decreased childhood acute lymphoblastic leukemia (CALL) risk was found in Asians, and significantly increased multiple myeloma and NHL risk was found in Caucasians...
November 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26071793/association-between-tamoxifen-treatment-and-the-development-of-different-stages-of%C3%A2-nonalcoholic-fatty-liver-disease-among-breast-cancer-patients
#9
Hsiang-Ju Pan, Hong-Tai Chang, Chien-Hung Lee
BACKGROUND/PURPOSE: For estrogen-receptor positive breast cancer cases, tamoxifen has been the most important adjuvant hormonal therapy for the purpose of reducing recurrence rates and prolonging disease free survival. However, several side effects have been noticed, and fatty liver is one of the most common side effects among them. Since fatty liver is a common problem in the general population, we wanted to examine the effects of tamoxifen under pre-existing fatty liver conditions and evaluate the prevalence of tamoxifen-related impaired liver function...
June 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/26072091/xrcc1-polymorphism-associated-with-late-toxicity-after-radiation-therapy-in-breast-cancer-patients
#10
Petra Seibold, Sabine Behrens, Peter Schmezer, Irmgard Helmbold, Gillian Barnett, Charlotte Coles, John Yarnold, Christopher J Talbot, Takashi Imai, David Azria, C Anne Koch, Alison M Dunning, Neil Burnet, Judith M Bliss, R Paul Symonds, Tim Rattay, Tomo Suga, Sarah L Kerns, Celine Bourgier, Katherine A Vallis, Marie-Luise Sautter-Bihl, Johannes Claßen, Juergen Debus, Thomas Schnabel, Barry S Rosenstein, Frederik Wenz, Catharine M West, Odilia Popanda, Jenny Chang-Claude
PURPOSE: To identify single-nucleotide polymorphisms (SNPs) in oxidative stress-related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy. METHODS AND MATERIALS: Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes were evaluated in the replication phase in up to 1883 breast cancer patients from 6 cohorts identified through the Radiogenomics Consortium...
August 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26064880/morphine-promotes-tumor-angiogenesis-and-increases-breast-cancer-progression
#11
Sabrina Bimonte, Antonio Barbieri, Domenica Rea, Giuseppe Palma, Antonio Luciano, Arturo Cuomo, Claudio Arra, Francesco Izzo
Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to better dissect the role of morphine in cancer cell growth and angiogenesis we performed in vitro studies on ER-negative human breast carcinoma cells, MDA.MB231 and in vivo studies on heterotopic mouse model of human triple negative breast cancer, TNBC...
2015: BioMed Research International
https://www.readbyqxmd.com/read/23638402/dealing-with-the-unexpected-consumer-responses-to-direct-access-brca-mutation-testing
#12
Uta Francke, Cheri Dijamco, Amy K Kiefer, Nicholas Eriksson, Bianca Moiseff, Joyce Y Tung, Joanna L Mountain
Background. Inherited BRCA gene mutations convey a high risk for breast and ovarian cancer, but current guidelines limit BRCA mutation testing to women with early-onset cancer and relatives of mutation-positive cases. Benefits and risks of providing this information directly to consumers are unknown. Methods. To assess and quantify emotional and behavioral reactions of consumers to their 23andMe Personal Genome Service(®) report of three BRCA mutations that are common in Ashkenazi Jews, we invited all 136 BRCA1 and BRCA2 mutation-positive individuals in the 23andMe customer database who had chosen to view their BRCA reports to participate in this IRB-approved study...
2013: PeerJ
https://www.readbyqxmd.com/read/26053433/non-coding-rnas-derived-from-an-alternatively-spliced-rest-transcript-rest-003-regulate-breast-cancer-invasiveness
#13
Nan Sook Lee, Oleg V Evgrafov, Tade Souaiaia, Adrineh Bonyad, Jennifer Herstein, Joo Yeun Lee, Jihong Kim, Yan Ning, Marcos Sixto, Andrew C Weitz, Heinz-Josef Lenz, Kai Wang, James A Knowles, Michael F Press, Paul M Salvaterra, K Kirk Shung, Robert H Chow
RE1-Silencing Transcription factor (REST) has a well-established role in regulating transcription of genes important for neuronal development. Its role in cancer, though significant, is less well understood. We show that REST downregulation in weakly invasive MCF-7 breast cancer cells converts them to a more invasive phenotype, while REST overexpression in highly invasive MDA-MB-231 cells suppresses invasiveness. Surprisingly, the mechanism responsible for these phenotypic changes does not depend directly on the transcriptional function of REST protein...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26053551/a-common-cancer-risk-associated-allele-in-the-htert-locus-encodes-a-dominant-negative-inhibitor-of-telomerase
#14
Anagha Killedar, Michael D Stutz, Alexander P Sobinoff, Christopher G Tomlinson, Tracy M Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R Reddel, Hilda A Pickett
The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690, have been identified within the hTERT gene. The minor allele (A) at rs10069690 creates an additional splice donor site in intron 4 of hTERT, and is associated with an elevated risk of multiple cancers including breast and ovarian carcinomas. We previously demonstrated that the presence of this allele resulted in co-production of full length (FL)-hTERT and an alternatively spliced, INS1b, transcript...
June 2015: PLoS Genetics
https://www.readbyqxmd.com/read/26026723/size-at-birth-and-risk-of-breast-cancer-update-from-a-prospective-population-based-study
#15
Marie Søfteland Sandvei, Pagona Lagiou, Pål Richard Romundstad, Dimitrios Trichopoulos, Lars Johan Vatten
Birth size variables (birth weight, birth length and head circumference) have been reported to be positively associated with adult breast cancer risk, whereas a possible association of placental weight has not been adequately studied. It has also been suggested that maternal height may modify the association of birth size with adult breast cancer risk, but this has not been studied in detail. We updated a long-term follow-up of 22,931 Norwegian women (average of 51 years of follow up during which 870 women were diagnosed with breast cancer) and assessed placental weight in relation to breast cancer risk, in addition to providing updated analyses on breast cancer risk in relation to birth weight, birth length and head circumference...
June 2015: European Journal of Epidemiology
https://www.readbyqxmd.com/read/26026075/whole-genome-linkage-analysis-and-sequence-analysis-of-candidate-loci-in-familial-breast-cancer
#16
Rajeshwari Marikkannu, Christos Aravidis, Johanna Rantala, Simone Picelli, Tatjana Adamovic, Markku Keihas, Tao Liu, Vinaykumar Kontham, Daniel Nilsson, Annika Lindblom
BACKGROUND: Known breast cancer-predisposing genes account for fewer than 25% of all familial breast cancer cases and further studies are required to find the remaining high- and moderate-risk genes. We set-out to couple linkage analysis using microsatellite marker data and sequence analysis of linked regions in 13 non-BRCA1/2 families in order to find novel susceptibility loci and high-penetrant genes. MATERIALS AND METHODS: Genotyping with 540 fluorescently-labeled microsatellite markers located on the 23 chromosomes at 7...
June 2015: Anticancer Research
https://www.readbyqxmd.com/read/26018078/all-trans-retinoic-acid-modulates-the-plasticity-and-inhibits-the-motility-of-breast-cancer-cells-role-of-notch1-and-transforming-growth-factor-tgf%C3%AE
#17
Adriana Zanetti, Roberta Affatato, Floriana Centritto, Maddalena Fratelli, Mami Kurosaki, Maria Monica Barzago, Marco Bolis, Mineko Terao, Enrico Garattini, Gabriela Paroni
All-trans-retinoic acid (ATRA) is a natural compound proposed for the treatment/chemoprevention of breast cancer. Increasing evidence indicates that aberrant regulation of epithelial-to-mesenchymal transition (EMT) is a determinant of the cancer cell invasive and metastatic behavior. The effects of ATRA on EMT are largely unknown. In HER2-positive SKBR3 and UACC812 cells, showing co-amplification of the ERBB2 and RARA genes, ATRA activates a RARα-dependent epithelial differentiation program. In SKBR3 cells, this causes the formation/reorganization of adherens and tight junctions...
July 17, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25873999/integrated-analysis-reveals-microrna-networks-coordinately-expressed-with-key-proteins-in-breast-cancer
#18
Miriam Ragle Aure, Sandra Jernström, Marit Krohn, Hans Kristian Moen Vollan, Eldri U Due, Einar Rødland, Rolf Kåresen, Prahlad Ram, Yiling Lu, Gordon B Mills, Kristine Kleivi Sahlberg, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Vessela N Kristensen
BACKGROUND: The role played by microRNAs in the deregulation of protein expression in breast cancer is only partly understood. To gain insight, the combined effect of microRNA and mRNA expression on protein expression was investigated in three independent data sets. METHODS: Protein expression was modeled as a multilinear function of powers of mRNA and microRNA expression. The model was first applied to mRNA and protein expression for 105 selected cancer-associated genes and to genome-wide microRNA expression from 283 breast tumors...
2015: Genome Medicine
https://www.readbyqxmd.com/read/25869796/joint-effects-between-urinary-selenium-and-polymorphisms-in-methylation-related-genes-on-breast-cancer-risk
#19
W Lin, Y L Cen, Y Lin, F X Su, B H Wu, L Y Tang, Z F Ren
The aim of this study was to explore the associations of urinary selenium and polymorphisms in methylation related genes with breast cancer risk and the interactions on the risk. The present study involved in 240 female patients with incident breast cancer and 246 age-matched controls in two affiliated hospitals of Sun Yat-sen University in Guangzhou, China, from October 2009 to July 2010. DNMT1 rs2228611, MTHFR rs1801133, and MTR rs1805087 were genotyped using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform...
2015: Neoplasma
https://www.readbyqxmd.com/read/25801246/breast-cancer-risk-associated-with-gene-expression-and-genotype-polymorphisms-of-the-folate-metabolizing-mthfr-gene-a-case-control-study-in-a-high-altitude-ecuadorian-mestizo-population
#20
Andrés López-Cortés, Carolina Echeverría, Fabián Oña-Cisneros, María Eugenia Sánchez, Camilo Herrera, Alejandro Cabrera-Andrade, Felipe Rosales, Malena Ortiz, César Paz-Y-Miño
Breast cancer (BC) is the leading cause of cancer-related death among women in 2014. Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and MTR reductase (MTRR) are enzymes that play an important role in folate metabolism. The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G, and MTRR A66G, alter plasmatic folate and homocysteine concentrations, causing problems during the repairment, synthesis, and methylation of the genetic material. Therefore, it is essential to know how BC risk is associated with histopathological and immunohistochemical characteristics, genotype polymorphisms, and gene expression in a high altitude Ecuadorian mestizo population...
August 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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