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CKD Biomarkers

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287 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/30639583/micrornas-in-chronic-kidney-disease
#1
REVIEW
Hui Zhao, Shi-Xing Ma, You-Quan Shang, Huan-Qiao Zhang, Wei Su
Chronic kidney disease (CKD) results in high morbidity and mortality worldwide causing a huge socioeconomic burden. MicroRNA (miRNA) exert critical regulatory functions by targeting downstream genes and have been associated with many pathophysiologic processes including CKD. In fact, many studies have shown that the expression of various miRNAs was significantly changed in CKD. Current investigations have focused on revealing the relationship between miRNAs and CKD states including diabetic nephropathy, lupus nephritis, focal segmental glomerulosclerosis and IgA nephropathy...
January 10, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30636243/a-pilot-study-urinary-uromodulin-creatinine-ratio-as-a-potential-clinical-biomarker-for-ckd-patients-with-gout
#2
Chien-Hsing Wu, Chih-Chao Yang, Hsueh-Wen Chang, Bin Huang, Chung-Jen Chen, Eton I-Cheng Lin, Chien-Yi Wu, Yueh-Hua Chung, Yu-Han Hsu, Chien-Te Lee, Feng-Rong Chuang
OBJECTIVE: Recent studies have reported that reduced excretion of urinary uromodulin (uUMOD) was associated with renal tubular function and risks of progressive kidney disease. Gouty nephropathy is usually seen in patients with gout. Patients with chronic gouty nephropathy are characterized by the deposition of monosodium urate crystals primarily involving the collecting ducts in the medulla. We postulated that this correlation may be specific to gout, and may serve as a useful biomarker for CKD...
January 13, 2019: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/30632676/urinary-proteomics-and-precision-medicine-for-chronic-kidney-disease-current-status-and-future-perspectives
#3
REVIEW
Frederik Persson, Peter Rossing
Precision medicine is since long an ongoing refinement of classical medicine, integrating improved and more detailed pathophysiological understanding with rapid technological advances. In the heterogenous are of chronic kidney disease there seems to be a high potential for improvement in treatment and prognosis for several causes, with new technologies under development, that have yet to be introduced in clinical practice. As in other medical disciplines, investigation of abundant peptide patterns (proteomics) has gained recent interest...
January 11, 2019: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/30633126/neuropeptide-y-predicts-cardiovascular-events-in-chronic-kidney-disease-patients-a-cohort-study
#4
Carmine Zoccali, Graziella D'Arrigo, Patrizia Pizzini, Maurizio Postorino, Giovanni Tripepi, Francesca Mallamaci
BACKGROUND: Neuropeptide Y (NPY) is a multifaceted sympathetic neurotransmitter regulating reflex cardiovascular control, myocardial cell growth, inflammation and innate immunity. Circulating NPY levels predict cardiovascular mortality in patients with end stage kidney disease on dialysis but this relationship has never been tested in predialysis chronic kidney disease (CKD) patients. METHODS: We investigated the relationship between circulating NPY and the risk for cardiovascular events (Fine & Gray competing risks model) in a cohort of 753 stages 2-5 CKD patients over a median follow-up of 36 months...
January 9, 2019: Journal of Hypertension
https://www.readbyqxmd.com/read/30629206/plasma-kidney-injury-molecule-1-p-kim-1-levels-and-deterioration-of-kidney-function-over-16-years
#5
Christina-Alexandra Schulz, Gunnar Engström, Jan Nilsson, Peter Almgren, Marinka Petkovic, Anders Christensson, Peter M Nilsson, Olle Melander, Marju Orho-Melander
Background: The kidney injury molecule-1 (KIM-1) has previously been associated with kidney function in rodents and humans. Yet its role as a predictive marker for future decline in kidney function has remained less clear. Methods: At baseline (1991-1994), fasting plasma KIM-1 (p-KIM-1) was measured in 4739 participants of the population-based Malmö Diet and Cancer Study. Creatinine and cystatin C were used to calculate estimated glomerular filtration rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Collaboration 2012 creatinine-cystatin C equation at baseline and follow-up examination (2007-2012)...
January 9, 2019: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30607777/thsd7a-as-a-marker-for-paraneoplastic-membranous-nephropathy
#6
LETTER
Tao Wang, Yan Zhang, MaoDong Liu, Xi Kang, Lin Kang, Hui Zhang
No abstract text is available yet for this article.
January 3, 2019: International Urology and Nephrology
https://www.readbyqxmd.com/read/30610470/effect-of-renal-function-on-homeostasis-of-asymmetric-dimethylarginine-adma-studies-in-donors-and-recipients-of-renal-transplants
#7
M Yusof Said, Rianne M Douwes, Marco van Londen, Isidor Minović, Anne-Roos Frenay, Martin H de Borst, Else van den Berg, M Rebecca Heiner-Fokkema, Arslan Arinc Kayacelebi, Alexander Bollenbach, Harry van Goor, Gerjan Navis, Dimitrios Tsikas, Stephan J L Bakker
Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy humans. Here, we measured plasma concentrations and urinary excretion of ADMA using GC-MS/MS in 130 living kidney donors before and at 1.6 (1.6-1.9) months after donation. We additionally analyzed 201 stable renal transplant recipients (RTR) that were included > 1 year after transplantation, as a model for kidney disease in the context of single kidney state...
January 4, 2019: Amino Acids
https://www.readbyqxmd.com/read/30604232/evolution-of-protein-bound-uremic-toxins-indoxyl-sulphate-and-p-cresyl-sulphate-in-acute-kidney-injury
#8
Laurens Veldeman, Jill Vanmassenhove, Wim Van Biesen, Ziad A Massy, Sophie Liabeuf, Griet Glorieux, Raymond Vanholder
BACKGROUND: There is a gradual increase in serum concentrations of protein-bound colon-derived uremic toxins indoxyl sulphate (IxS) and p-cresyl sulphate (pCS) as chronic kidney disease (CKD) progresses. In acute kidney injury (AKI), up till now, the retention pattern has not been studied. METHODS: In this study, 194 adult patients admitted with sepsis to the intensive care unit were included. IxS, pCS and serum creatinine (sCrea) were quantified at inclusion (D0) and at day 4, unless follow-up ended earlier (Dend )...
January 2, 2019: International Urology and Nephrology
https://www.readbyqxmd.com/read/30602020/robust-clinical-marker-identification-for-diabetic-kidney-disease-with-ensemble-feature-selection
#9
Xing Song, Lemuel R Waitman, Yong Hu, Alan S L Yu, David Robins, Mei Liu
Objective: Diabetic kidney disease (DKD) is one of the most frequent complications in diabetes associated with substantial morbidity and mortality. To accelerate DKD risk factor discovery, we present an ensemble feature selection approach to identify a robust set of discriminant factors using electronic medical records (EMRs). Material and Methods: We identified a retrospective cohort of 15 645 adult patients with type 2 diabetes, excluding those with pre-existing kidney disease, and utilized all available clinical data types in modeling...
January 2, 2019: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/30598193/emerging-role-of-myostatin-and-its-inhibition-in-the-setting-of-chronic-kidney-disease
#10
REVIEW
Daniela Verzola, Chiara Barisione, Daniela Picciotto, Giacomo Garibotto, Laetitia Koppe
The past two decades have witnessed tremendous progress in our understanding of the mechanisms underlying wasting and cachexia in chronic kidney disease (CKD) and in other chronic illnesses, such as cancer and heart failure. In all these conditions wasting is an effect of the activation of protein degradation in muscle, a response that increases the risk of morbidity and mortality. Major recent advances in our knowledge on how CKD and inflammation affect cellular signaling include the identification of the myostatin (MSTN)/activin system, and its related transcriptional program that promotes protein degradation...
December 28, 2018: Kidney International
https://www.readbyqxmd.com/read/30595681/the-correlation-of-serum-osteoprotegerin-with-non-traditional-cardiovascular-risk-factors-and-arterial-stiffness-in-patients-with-pre-dialysis-chronic-kidney-disease-results-from-the-know-ckd-study
#11
Seung Yun Chae, WooKyung Chung, Yeong Hoon Kim, Yun Kyu Oh, Joongyub Lee, Kyu Hun Choi, Curie Ahn, Yong-Soo Kim
Background: Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD...
December 31, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/30574040/urinary-proteomics-in-biomarker-discovery-of-kidney-related-disorders-diabetic-nephropathy-and-drug-induced-nephrotoxicity-in-chronic-headache
#12
Elisa Bellei, Emanuela Monari, Stefania Bergamini, Luigi Alberto Pini, Tomasi Aldo, Tomris Ozben
Objective: Urinary proteomics is primarily applied to the study of renal and urogenital tract disorders. Here are reported two distinct successful examples of this approach for the discovery of early urinary biomarkers of kidney-related dysfunctions: diabetic nephropathy (DN), a well-known complication of diabetes frequently leading to dialysis, and drug-induced nephrotoxicity, a possible condition caused by medication-overuse headache (MOH). Early detection of kidney disorders based on selective biomarkers could permit to diagnose patients at the initial stage of the disease, where the therapy may be suspended or prevent disease advancement...
December 2018: EJIFCC
https://www.readbyqxmd.com/read/30575177/urotensin-ii-in-the-development-and-progression-of-chronic-kidney-disease-following-5-6-nephrectomy-in-the-rat
#13
Heather J Eyre, Thomas Speight, Jocelyn D Glazier, David M Smith, Nick Ashton
NEW FINDINGS: What is the central question of this study? Urotensin II is upregulated in patients in the later stages of chronic kidney disease (CKD), particularly in individuals requiring dialysis. However, studies in animals have been limited to the early stages of CKD. What is the main finding and its importance? Expression of urotensin II and its receptor increased, extending into cortical structures as CKD progressed towards end-stage renal failure in the rat. Sub-chronic treatment with a urotensin receptor antagonist slowed but did not prevent progression of CKD...
December 21, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30575924/serum-sclerostin-as-a-potential-novel-biomarker-for-heart-valve-calcification-in-patients-with-chronic-kidney-disease
#14
Y-Q Ji, L-N Guan, S-X Yu, P-Y Yin, X-Q Shen, Z-W Sun, J Liu, W Lv, G-P Yu, C Ren
OBJECTIVE: To explore the correlation between change in sclerostin level and heart valve calcification in patients with chronic kidney disease (CKD) in stages 3-5, as well as the possible underlying mechanism, which could provide a clinical reference for the diagnosis and treatment of cardiovascular disease (CVD). PATIENTS AND METHODS: 110 patients were divided into a healthy control group and three groups of patients with CKD stages 3, 4, and 5 according to CKD staging guidelines...
December 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30560270/-transforming-growth-factor-%C3%AE-and-renal-fibrosis
#15
Xiao-Ming Meng, Hui-Yao Lan
Transforming growth factor-β (TGF-β) is a driving force of renal fibrosis, which may lead to chronic kidney diseases and even end stage renal diseases. By activating canonical and non-canonical signaling pathways, TGF-β promotes the synthesis of extracellular matrix while preventing their degradation. In the injured kidney, TGF-β induces apoptosis, proliferation and fibrotic response of renal cells including epithelial cells, endothelial cells, podocytes, fibroblasts, pericytes and macrophages, and it also promotes transdifferentiation, activation and proliferation of myofibroblasts...
December 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/30560274/-urinary-biomarkers-for-chronic-kidney-disease-a-focus-on-gene-transcript
#16
Lin-Li Lyu, Bi-Cheng Liu
Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. This review will discuss the recent advances in biomarker study from urine sediment, urine supernatant and urinary extracellular vesicles with special interest in gene transcript (miRNA, mRNA) biomarkers...
December 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/30545708/use-of-measures-of-inflammation-and-kidney-function-for-prediction-of-atherosclerotic-vascular-disease-events-and-death-in-patients-with-ckd-findings-from-the-cric-study
#17
Richard L Amdur, Harold I Feldman, Elizabeth A Dominic, Amanda H Anderson, Srinivasan Beddhu, Mahboob Rahman, Myles Wolf, Muredach Reilly, Akinlolu Ojo, Raymond R Townsend, Alan S Go, Jiang He, Dawei Xie, Sally Thompson, Matthew Budoff, Scott Kasner, Paul L Kimmel, John W Kusek, Dominic S Raj
RATIONALE & OBJECTIVE: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 2,399 Chronic Renal Insufficiency Cohort (CRIC) Study participants without a history of cardiovascular disease at study entry...
December 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/30525316/adropin-and-irisin-new-biomarkers-of-cardiac-status-in-patients-with-end-stage-renal-disease-a-preliminary-study
#18
Małgorzata Kałużna, Krzysztof Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Magdalena Człapka-Matyasik, Aisha Yusuf Ibrahim, Nadia Sawicka-Gutaj, Andrzej Minczykowski, Katarzyna Ziemnicka, Andrzej Oko, Marek Ruchała
BACKGROUND: The new polypeptide hormones adropin and irisin have a broad impact on human metabolism and energy homeostasis. They could be potential biomarkers of cardiac injury. In end-stage renal disease (ESRD), the clinical importance of adropin and irisin is yet to be investigated. OBJECTIVES: The aim of this study was to determine the relationship between these peptides and cardiac status in ESRD patients. MATERIAL AND METHODS: Seventy-nine ESRD patients on hemodialysis (HD), peritoneal dialysis (PD) or after renal transplantation (Tx), and 40 healthy, ageand sex-matched controls (CON) were included in this study...
December 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30529606/identification-of-salivary-peptidomic-biomarkers-in-chronic-kidney-disease-patients-undergoing-haemodialysis
#19
Peiyuan Tong, Chao Yuan, Xiangyu Sun, Qi Yue, Xiaoling Wang, Shuguo Zheng
BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem. To detect discriminating salivary peptide profiles between CKD patients undergoing haemodialysis (HD) and healthy controls (HCs) and to screen candidate biomarkers for CKD, we preliminarily explored the diagnostic potentiality of saliva. METHODS: Saliva samples from 30 CKD HD patients and 35 HCs were analysed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads...
December 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30521014/increased-urinary-mir-196a-level-predicts-the-progression-of-renal-injury-in-patients-with-diabetic-nephropathy
#20
Yu An, Changming Zhang, Feng Xu, Wei Li, Caihong Zeng, Lu Xie, Zhihong Liu
Background: Recent data suggest that miR-196a is predominantly expressed in the kidney and plays an inhibitory role in the progress of renal interstitial fibrosis (IF). However, the predictive value of miR-196a in diabetic nephropathy (DN) remains unknown. We validated the role of urinary miR-196a in the progression of renal injury in a cohort of patients with type 2 diabetes mellitus. Methods: Our study included 209 patients with biopsy-proven DN. The mean follow-up time was 54...
December 5, 2018: Nephrology, Dialysis, Transplantation
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