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CKD Biomarkers

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224 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Viktor Rotbain Curovic, Tine W Hansen, Mie K Eickhoff, Bernt Johan von Scholten, Henrik Reinhard, Peter Karl Jacobsen, Frederik Persson, Hans-Henrik Parving, Peter Rossing
AIMS: Urinary levels of kidney injury molecule 1 (u-KIM-1) and neutrophil gelatinase-associated lipocalin (u-NGAL) reflect proximal tubular pathophysiology and have been proposed as risk markers for development of complications in patients with type 2 diabetes (T2D). We clarify the predictive value of u-KIM-1 and u-NGAL for decline in eGFR, cardiovascular events (CVE) and all-cause mortality in patients with T2D and persistent microalbuminuria without clinical cardiovascular disease. METHODS: This is a prospective study that included 200 patients...
August 14, 2018: Acta Diabetologica
Anna Pieniazek, Lukasz Gwozdzinski, Pawel Hikisz, Krzysztof Gwozdzinski
Indoxyl sulfate (IS) is a uremic toxin that has been associated with inflammation, oxidative stress as well as with the progression of chronic kidney disease (CKD). Indoxyl sulfate is a protein metabolite that is concentrated in the serum of CKD patients. IS is a well-known uremic toxin but there are very few reports on the effect of IS on cells including mononuclear cells (MNCs). We hypothesized that a high concentration of IS in CKD patients may induce changes in redox balance in the in vitro cells exposed...
August 15, 2018: Chemical Research in Toxicology
Kyoko Okada, Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Taiga Ichinomiya, Hiroaki Murata, Takuji Maekawa, Masaharu Nishikido, Kiyoyuki Eishi, Tetsuya Hara
BACKGROUND: Intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, has been reported to be a diagnostic marker of intestinal ischemia and a prognostic marker in critically ill patients. However, the kinetics of I-FABP in renal failure patients is unknown. We sought to identify I-FABP levels in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) on hemodialysis (HD) and to identify the manner in which the I-FABP levels change. MATERIALS AND METHODS: Adult patients who were admitted for elective cardiac surgery with either normal renal function (NRF), CKD, or ESKD on HD were enrolled...
October 2018: Journal of Surgical Research
Vanesa Palau, Marta Riera, Xavier Duran, José Manuel Valdivielso, Angels Betriu, Elvira Fernández, Julio Pascual, Maria José Soler
Background: A disintegrin and metalloproteinase (ADAM) 17, also known as tumour necrosis factor α-converting enzyme (TACE), is a metalloproteinase that releases the ectodomains of most growth factors, cytokines, receptors and enzymes and has been associated with the presence of chronic kidney disease (CKD) and cardiovascular (CV) disease. The role of circulating ADAMs in the progression of renal function and CV events in CKD patients is unknown. Methods: A total of 2570 subjects from an observational and multicentre study with CKD Stages 3-5, CKD Stage 5D and controls without any history of CV disease were studied...
August 8, 2018: Nephrology, Dialysis, Transplantation
Hengzhong Lun, Weihua Yang, Shuping Zhao, Meijie Jiang, Mingjie Xu, Fenfen Liu, Yunshan Wang
The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease (CKD) and healthy controls (HC) and search for better microbial biomarkers associated with CKD. The 16S rRNA gene sequencing approach was used to investigate the differences in gut microbiota between the CKD and HC groups. The study found that 12 phylotypes were overrepresented in the CKD group and 19 in the HC group at the genus level. Furthermore, genera Lachnospira and Ruminococcus_gnavus performed the best in differentiating between HC and CKD populations...
August 7, 2018: MicrobiologyOpen
Yi-Sha Huang, Jian-Bo Lai, Sheng-Fa Li, Ting Wang, Ying-Nan Liu, Qing-Xia Zhang, Shu-Yuan Zhang, Chun-Han Sun, Nan Hu, Xin-Zhou Zhang
The relationship between the levels of renalase and changes in proteinuria, hypertension, renal function, renal tubular epithelial cell apoptosis and B-cell lymphoma-2 (Bcl-2) expression was investigated in patients (chronic nephritis, primary nephrotic syndrome or other kidney disease) that underwent renal biopsy. The study group comprised 72 patients undergoing renal biopsy. Patient profiles and renal function were collected. Concentrations of renalase and Bcl-2 were measured by immunohistochemistry. Tubular injury was detected by periodic acid Schiff staining (PAS) and renal tubular epithelial cell apoptosis was assessed by TUNEL assay...
April 2018: Current medical science
M Yang, Y-H Bai, J-S Wang, H-Y Jiang, S-L Hu
OBJECTIVE: Elderly uremia frequently refers to the end stage of various chronic kidney diseases that threats the patients' health seriously. Enteral nutrition can reduce complications, while the molecular mechanism is still unclear. Mitochondrial protein Bim plays an essential role in regulating inflammation, restraining oxidative stress, and maintaining the balance of the mitochondrial membrane potential and energy production. This study aims to investigate the effect of Bim on the early diagnosis and prognosis of the elderly uremia with gastrointestinal nutrition combined with dialysis...
July 2018: European Review for Medical and Pharmacological Sciences
Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Jianhong Ching, Jean-Paul Kovalik, Tsze Yin Tan, Su Chi Lim
Context: Metabolites in tricarboxylic acid (TCA) cycle are not only involved in energy metabolism but also play important roles in non-energy production activities. Objective: To study whether baseline urine key TCA cycle metabolites (lactate, pyruvate, citrate, alpha-ketoglutaric acid, succinate, fumarate and malate) may independently predict risk of chronic kidney disease (CKD) progression (fast eGFR decline) in individuals with type 2 diabetes mellitus (T2DM)...
July 27, 2018: Journal of Clinical Endocrinology and Metabolism
T Takada, T Yamamoto, H Matsuo, J K Tan, K Ooyama, M Sakiyama, H Miyata, Y Yamanashi, Y Toyoda, T Higashino, A Nakayama, A Nakashima, N Shinomiya, K Ichida, H Ooyama, S Fujimori, H Suzuki
Chronic kidney disease (CKD) patients accumulate uremic toxins in the body, potentially require dialysis, and can eventually develop cardiovascular disease. CKD incidence has increased worldwide, and preventing CKD progression is one of the most important goals in clinical treatment. In this study, we conducted a series of in vitro and in vivo experiments and employed a metabolomics approach to investigate CKD. Our results demonstrated that ATP-binding cassette transporter subfamily G member 2 (ABCG2) is a major transporter of the uremic toxin indoxyl sulfate...
July 24, 2018: Scientific Reports
Grzegorz Piecha, Agata Kujawa-Szewieczek, Piotr Kuczera, Katarzyna Skiba, Ewelina Sikora-Grabka, Andrzej Wiecek
Experimental data have shown increased plasma levels of marinobufagenin in kidney failure. In this case-controlled retrospective analysis we evaluated plasma marinobufagenin immunoreactivity in hemodialysis patients compared to subjects with normal kidney function. Sixty eight adult hemodialysis patients with chronic kidney disease (34 females and 34 males) as well as 68 age-, gender-, and blood pressure-matched subjects without chronic kidney disease were enrolled. Patients on stable hemodialysis regimen for at least 3 months prior to the study were included...
July 25, 2018: American Journal of Physiology. Renal Physiology
Takehiro Suzuki, Takaaki Abe
Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein...
August 2018: Kidney International
Dominika Klimczak-Tomaniak, Tomasz Pilecki, Dorota Żochowska, Damian Sieńko, Maciej Janiszewski, Leszek Pączek, Marek Kuch
BACKGROUND/AIMS: Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients. METHODS: This single-center observational study involved 90 stable CKD stage 1-5 patients (including 33 renal transplant recipients) and 25 healthy age- and sex-matched control subjects...
2018: Cardiorenal Medicine
Y Ding, L-M Nie, Y Pang, W-J Wu, Y Tan, F Yu, M-H Zhao
Objective This study aimed to evaluate the clinical value of urinary biomarkers including kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis. Methods A total of 109 biopsy-proven lupus nephritis patients were included and 50 healthy individuals were used as normal controls. Urinary KIM-1, NGAL, and MCP-1 levels were measured by ELISA and their correlations with clinical and histological features were assessed...
July 18, 2018: Lupus
Katharina Neubauer, Björn Neubauer, Maximilian Seidl, Barbara Zieger
Chronic kidney disease (CKD) is characterized by the loss of nephrons and worsening organ-fibrosis that leads to deterioration and ultimately the total breakdown of kidney function. Renal fibrosis has become a major public health problem worldwide and necessitates hemodialysis and kidney transplantation in affected patients. CKD is mainly characterized by the activation and proliferation of interstitial fibroblasts and by excessive synthesis and accumulation of extracellular matrix components, causing the disruption of the normal tissue architecture of the kidney...
July 18, 2018: Cytoskeleton
Ran Luo, Shui-Ming Guo, Yue-Qiang Li, Yi Yang, Meng-Lan Li, Min Han, Xiao-Feng He, Shu-Wang Ge, Gang Xu
Background: A recognized noninvasive biomarker to improve risk stratification of immunoglobulin A nephropathy (IgAN) patients is scarce. Fractalkine has been shown to play a key role in glomerular disease as chemoattractant, adhesion and even fibrosis factor. The current study assessed the possibility of plasma fractalkine as a novel biomarker in IgAN patients. Methods: Plasma fractalkine was measured in 229 patients with renal biopsy consistent IgAN from 2012 to 2014, and clinical, pathological and prognostic relationships were analyzed...
July 12, 2018: Nephrology, Dialysis, Transplantation
Seyed Mostafa Parizadeh, Maryam Ghandehari, Mohammad Reza Parizadeh, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan, Seyed Mahdi Hassanian
Copeptin is a glycosylated peptide derived from the cleavage of the precursor of arginine-vasopressin. In contrast to arginine-vasopressin, copeptin is a stable molecule and can easily be measured using a simple rapid assay. The serum concentration of copeptin is increased in several clinical conditions, including hypertension, chronic kidney disease, and, of special interest in this review, in cardiovascular diseases. The diagnostic and prognostic value of copeptin in different cardiovascular diseases (acute coronary syndrome, stable coronary artery disease, congestive heart failure, and acute ischemic stroke) has been reviewed in this article, to provide an understanding of how its measurement may be applied to improve the management of these conditions...
July 16, 2018: Journal of Cellular Biochemistry
Crina Claudia Rusu, Simona Racasan, Diana Moldovan, Alina Potra, Dacian Tirinescu, Cristian Budurea, Remus Orasan, Ioan Mihai Patiu, Cosmina Bondor, Dan Vladutiu, Dan Delean, Alexandra Danu, Ina Maria Kacso
PURPOSE: Exogenous ghrelin is associated with cardiovascular protection in experimental and human studies. Nevertheless ESRD patients have increased ghrelin levels and severe cardiovascular comorbidities. This study aims to elucidate the metabolic factors influencing endogenous ghrelin/acyl ghrelin levels and to analyze the relation between endogenous ghrelin/acyl ghrelin levels and cardiac and vascular function markers in hemodialysis patients. METHODS: The cross-sectional study was conducted in hemodialysis patients (n = 88); 50 of them were men, mean age 61...
July 13, 2018: International Urology and Nephrology
Ray El Boustany, Irina Tasevska, Esther Meijer, Lyanne M Kieneker, Sofia Enhörning, Guillaume Lefèvre, Kamel Mohammedi, Michel Marre, Frédéric Fumeron, Beverley Balkau, Nadine Bouby, Lise Bankir, Stephan Jl Bakker, Ronan Roussel, Olle Melander, Ron T Gansevoort, Gilberto Velho
BACKGROUND: The prevalence of chronic kidney disease (CKD) is increasing worldwide. The identification of factors contributing to its progression is important for designing preventive measures. Previous studies have suggested that chronically high vasopressin is deleterious to renal function. Here, we evaluated the association of plasma copeptin, a surrogate of vasopressin, with the incidence of CKD in the general population. METHODS: We studied 3 European cohorts: DESIR (n = 5,047; France), MDCS-CC (n = 3,643; Sweden), and PREVEND (n = 7,684; the Netherlands)...
July 12, 2018: JCI Insight
Ming-Shi Chang, Yu-Hsiang Hsu
Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure...
July 12, 2018: Journal of Leukocyte Biology
Cristina Beltrami, Kate Simpson, Mark Jesky, Alexa Wonnacott, Christopher Carrington, Peter Holmans, Lucy Newbury, Robert Jenkins, Thomas Ashdown, Colin Dayan, Simon Satchell, Peter Corish, Paul Cockwell, Donald Fraser, Timothy Bowen
Effective diabetic kidney disease (DKD) biomarkers remain elusive, and urinary miRNAs represent a potential source of novel noninvasive disease sentinels. We profiled 754 miRNAs in pooled urine samples from DKD patients (n = 20), detecting significantly increased miR-126, miR-155, and miR-29b compared with controls (n = 20). These results were confirmed in an independent cohort of 89 DKD patients, 62 diabetic patients without DKD, and 41 controls: miR-126 (2.8-fold increase; P < 0.0001), miR-155 (1.8-fold increase; P < 0...
July 6, 2018: American Journal of Pathology
2018-07-11 09:54:33
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