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CKD Biomarkers

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162 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29636065/urinary-mir-196a-predicts-disease-progression-in-patients-with-chronic-kidney-disease
#1
Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen, Zhihong Liu
BACKGROUND: Urinary miRNAs may potentially serve as noninvasive biomarkers in various kidney diseases to reflect disease activity, severity and progression, especially those correlated with the pathogenesis of kidney diseases. This study demonstrates that urinary miR-196a, a kidney-enriched miRNA, can predict progression of chronic kidney disease (CKD). METHODS: Focal segmental glomerulosclerosis (FSGS) cohorts were used as the representative example of CKD. First, correlation of miR-196a with disease activity was analyzed using paired urine and plasma samples from FSGS patients with nephrotic-range proteinuria (FSGS-A), complete remission (FSGS-CR) and normal controls (NCs)...
April 10, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28931521/pgc1%C3%AE-in-the-kidney
#2
Matthew R Lynch, Mei T Tran, Samir M Parikh
Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal effects of PGC1α make it a prime target for therapeutics aimed at ameliorating AKI, forms of chronic kidney disease (CKD), and their intersection...
January 1, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29621752/fibroblast-growth-factor-23-a-biomarker-of-kidney-function-decline
#3
David A Drew, Ronit Katz, Stephen Kritchevsky, Joachim H Ix, Michael G Shlipak, Anne B Newman, Andy Hoofnagle, Linda Fried, Mark J Sarnak, Orlando M Gutierrez
BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Previous studies have shown FGF-23 to be a risk factor for incident end-stage renal disease; however, there are less data on the association of FGF-23 with earlier kidney-related outcomes. METHODS: Serum FGF-23 was assayed using an intact ELISA assay in 2,496 participants of the Healthy Aging and Body Composition Study, a cohort of well-functioning older adults...
April 5, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29602396/lipidomics-and-biomarker-discovery-in-kidney-disease
#4
REVIEW
Farsad Afshinnia, Thekkelnaycke M Rajendiran, Stefanie Wernisch, Tanu Soni, Adil Jadoon, Alla Karnovsky, George Michailidis, Subramaniam Pennathur
Technological advances in mass spectrometry-based lipidomic platforms have provided the opportunity for comprehensive profiling of lipids in biological samples and shown alterations in the lipidome that occur in metabolic disorders. A lipidomic approach serves as a powerful tool for biomarker discovery and gaining insight to molecular mechanisms of disease, especially when integrated with other -omics platforms (ie, transcriptomics, proteomics, and metabolomics) in the context of systems biology. In this review, we describe the workflow commonly applied to the conduct of lipidomic studies including important aspects of study design, sample preparation, biomarker identification and quantification, and data processing and analysis, as well as crucial considerations in clinical applications...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29332011/examining-the-utility-of-cystatin-c-as-a-confirmatory-test-of-chronic-kidney-disease-across-the-age-range-in-middle-aged-and-older-community-dwelling-adults
#5
Mark Canney, Donal J Sexton, Neil O'Leary, Martin Healy, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha
BACKGROUND: Cystatin C has been proposed as a confirmatory test of chronic kidney disease (CKD). This is most applicable to older individuals with CKD, the majority of whom have a creatinine-based estimated glomerular filtration rate (eGFR) of 45-59 mL/min/1.73 m2 (CKD stage 3a). We sought to examine the utility of cystatin C as a confirmatory test of CKD across the age range in the general population of older adults. METHODS: Cross-sectional analysis of 5386 participants from The Irish Longitudinal Study on Ageing, a cluster-sampled national cohort of community-dwelling adults aged ≥50 years...
April 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29590173/soluble-klotho-as-a-marker-of-renal-fibrosis-and-podocyte-injuries-in-human-kidneys
#6
Nam-Jun Cho, Dong-Jae Han, Ji-Hye Lee, Si-Hyong Jang, Jeong Suk Kang, Hyo-Wook Gil, Samel Park, Eun Young Lee
Klotho deficiency is relevant to renal fibrosis and podocyte injury in vivo and in vitro. We examined whether histological findings of renal biopsy specimens were associated with the levels of soluble klotho in humans. We investigated renal biopsy specimens of 67 patients and detailed microscopic findings were reviewed. Soluble serum/urinary klotho and urinary angiotensinogen were assessed by enzyme-linked immunosorbent assays, and tissue klotho expression was assessed by immunohistochemical staining. The median age of the study participants was 35...
2018: PloS One
https://www.readbyqxmd.com/read/29561187/increased-urinary-angiotensin-converting-enzyme-2-ace2-and-neprilysin-nep-in-type-2-diabetic-patients
#7
Sridevi Gutta, Nadja Grobe, Meenasri Kumbaji, Hassan Osman, Mohammad Saklayen, Gengxin Li, Khalid M Elased
ACE2 and NEP are metalloproteases which are highly expressed in the renal proximal tubules. ACE2 and NEP generate renoprotective angiotensin (1-7) from angiotensin II (Ang II) and Ang I, respectively, and therefore could have a major role in chronic kidney disease (CKD). Recent data demonstrated increased urinary ACE2 in diabetic patients with CKD and kidney transplants. We tested the hypothesis that urinary ACE2, NEP and ADAM17 are increased and could be risk predictors of CKD in diabetic patients. Urinary and plasma ACE2, NEP, and ADAM17 were investigated in twenty healthy nondiabetics (ND), and forty diabetic patients with normoalbuminuria (Dnormo), microalbuminuria (Dmicro) and macroalbuminuria (Dmacro) using ELISA, Western blot, fluorogenic and novel mass spectrometric-based enzyme assays...
March 21, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29539618/non-proximal-renal-tubule-derived-urinary-exosomal-mir-200b-as-a-biomarker-of-renal-fibrosis
#8
Yanting Yu, Feng Bai, Nan Qin, Wenjin Liu, Qi Sun, Yang Zhou, Junwei Yang
BACKGROUND: Renal fibrosis is a common outcome of nearly all kinds of chronic kidney disease (CKD) and eventually progresses to end-stage renal disease. The identification of an optimal biomarker of renal fibrosis to replace the invasive renal biopsy will have important clinical implications. METHODS: We isolated urinary exosomes from 50 participants and examined the exosomal protein content and particle number in 38 CKD patients with different degrees of renal fibrosis and in 12 normal individuals...
March 14, 2018: Nephron
https://www.readbyqxmd.com/read/29503020/prediction-of-tubulointerstitial-injury-in-chronic-kidney-disease-using-a-non-invasive-model-combination-of-renal-sonography-and-laboratory-biomarkers
#9
Wen-Qi Yang, Shan Mou, Li Xu, Feng-Hua Li, Hong-Li Li
The goal of the study described here was to evaluate the degree of tubulointerstitial injury in patients with chronic kidney disease (CKD) using a more accurate model that combines renal sonographic parameters and laboratory biomarkers. A total of 308 patients were enrolled. The study protocol included conventional ultrasound, contrast-enhanced ultrasonography and renal biopsy. CKD patients were divided into normal and mild (≤25%), moderate (26%-50%) and severe (>50%) tubulointerstitial injury groups. We created a model comprising peak intensity, time to peak, urinary retinol-binding protein and β2 -microglobulin that could discriminate severe (>50%) tubulointerstitial injury...
March 1, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29471407/plasma-copeptin-as-a-predictor-of-kidney-disease
#10
Sofia Enhörning, Anders Christensson, Olle Melander
Background: Plasma copeptin, a marker of vasopressin, is associated with renal function decline in the general population. Our aim was to study the links between elevated copeptin and future risk of kidney disease. Methods: Copeptin was measured in a sample of the Malmö Preventive Project (MPP) Reinvestigation (n = 5158) and in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC) (n = 5162). According to national registers, 89 subjects in MPP and 180 in MDC-CC developed chronic kidney disease (CKD) during follow-up (8...
February 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29398328/relation-of-asymmetrical-dimethylarginine-levels-with-renal-outcomes-in-hypertensive-patients-with-and-without-type-2-diabetes-mellitus
#11
Cristina B Triches, Marie Quinto, Saurus Mayer, Marcelo Batista, Maria Teresa Zanella
AIM: The aim of the study was to evaluate the association between high plasma ADMA levels, a biomarker of endothelial dysfunction, with the progression of albuminuria and chronic kidney disease (CKD) in hypertensive patients, with and without type 2 diabetes mellitus. METHODS: We successfully contacted 213 of 644 patients who had been evaluated between 2004 and 2005 and for whom basal data were available. After the exclusion of 51 patients, 162 hypertensive patients who were free from albuminuria were stratified into the following 4 groups according to the presence of diabetes and plasma ADMA percentiles: general hypertensive patients with high levels of plasma ADMA (>P4 or ADMA > 0...
December 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29339356/kidney-biomarkers-and-decline-in-egfr-in-patients-with-type-2-diabetes
#12
Katherine G Garlo, William B White, George L Bakris, Faiez Zannad, Craig A Wilson, Stuart Kupfer, Muthiah Vaduganathan, David A Morrow, Christopher P Cannon, David M Charytan
BACKGROUND AND OBJECTIVES: Biomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. However, available biomarkers remain incompletely validated for risk stratification and prediction modeling. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined serum cystatin C, urinary kidney injury molecule-1 (uKIM-1), and urinary neutrophil gelatinase-associated lipocalin (UNGAL) in 5367 individuals with type 2 diabetes mellitus and recent acute coronary syndromes enrolled in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial...
March 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29333147/novel-filtration-markers-for-gfr-estimation
#13
Amy B Karger, Lesley A Inker, Josef Coresh, Andrew S Levey, John H Eckfeldt
Creatinine-based glomerular filtration rate estimation (eGFRcr ) has been improved and refined since the 1970s through both the Modification of Diet in Renal Disease (MDRD) Study equation in 1999 and the CKD Epidemiology Collaboration (CKD-EPI) equation in 2009, with current clinical practice dependent primarily on eGFR for accurate assessment of GFR. However, researchers and clinicians have recognized limitations of relying on creatinine as the only filtration marker, which can lead to inaccurate GFR estimates in certain populations due to the influence of non-GFR determinants of serum or plasma creatinine...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29281176/the-impact-of-the-glomerular-filtration-rate-on-the-human-plasma-proteome
#14
Anders Christensson, Jessica A Ash, Robert K DeLisle, Fraser W Gaspar, Rachel Ostroff, Anders Grubb, Veronica Lindström, Laila Bruun, Steve A Williams
PURPOSE: The application of proteomics in chronic kidney disease (CKD) can potentially uncover biomarkers and pathways that are predictive of disease. EXPERIMENTAL DESIGN: Within this context, this study examines the relationship between the human plasma proteome and glomerular filtration rate (GFR) as measured by iohexol clearance in a cohort from Sweden (n = 389; GFR range: 8-100 mL min-1 /1.73 m2 ). A total of 2893 proteins are quantified using a modified aptamer assay...
December 27, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29240457/urinary-peptidomics-in-kidney-disease-and-drug-research
#15
Magdalena Krochmal, Joost P Schanstra, Harald Mischak
Due to its close connection with the renal system, urine is considered a valuable source of information in kidney disease research. Peptidomics methods focus on the discovery of endogenous peptides, given their wide range of biological functions and diagnostic and therapeutic potential. Representing a non-invasive and sensitive method, technological prospects of urinary peptidomics should be evaluated in the context of drug discovery and research. Areas covered: This review describes urinary peptidomics with focus on its application in drug research in the field of kidney diseases...
March 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29228604/bcl-3-is-a-novel-biomarker-of-renal-fibrosis-in-chronic-kidney-disease
#16
Ran Chen, Lunshan Wang, Sanhong Liu, Xi Chen, Yiming Hu, Hanshao Liu, Haohao Zhang, Yuhang Jiang, Qi Wang, Deji Ye, Lingling Li, Dandan Liu, Xiaorong Pan, Lixin Wei, Xuemei Li, Xiaoren Zhang
Progressive renal fibrosis in chronic kidney disease (CKD) greatly contributes to end-stage renal failure and is associated with high mortality. The identification of renal fibrosis biomarkers for the diagnosis and the monitoring of disease progression in CKD is urgently needed. Whole-transcriptomic analysis of renal tissues in a unilateral ureteral obstruction (UUO) mouse model revealed that the mRNA level of Bcl-3, an atypical member of the IκB family, was induced 6.3-fold 2 days after UUO. Compared with renal tissues in sham-operated mice, increases in Bcl-3 mRNA and protein in the renal tissues in the UUO model were accompanied with increases in other markers of renal fibrosis, including human epididymis protein 4 (HE4), a recently identified biomarker of renal fibrosis...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29234020/from-discovery-to-translation-characterization-of-c-mannosyltryptophan-and-pseudouridine-as-markers-of-kidney-function
#17
Peggy Sekula, Katja Dettmer, Franziska C Vogl, Wolfram Gronwald, Lisa Ellmann, Robert P Mohney, Kai-Uwe Eckardt, Karsten Suhre, Gabi Kastenmüller, Peter J Oefner, Anna Köttgen
Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges and to assess their fractional excretions (FE), and to assess the agreement with their non-targeted counterparts. In individuals without/with CKD, mean plasma and urine concentrations for C-mannosyltryptophan were 0...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229941/urinary-endotrophin-predicts-disease-progression-in-patients-with-chronic-kidney-disease
#18
Daniel Guldager Kring Rasmussen, Anthony Fenton, Mark Jesky, Charles Ferro, Peter Boor, Martin Tepel, Morten Asser Karsdal, Federica Genovese, Paul Cockwell
Renal fibrosis is the central pathogenic process in progression of chronic kidney disease (CKD). Collagen type VI (COL VI) is upregulated in renal fibrosis. Endotrophin is released from COL VI and promotes pleiotropic pro-fibrotic effects. Kidney disease severity varies considerably and accurate information regarding CKD progression may improve clinical decisions. We tested the hypothesis that urinary endotrophin derived during COL VI deposition in fibrotic human kidneys is a marker for progression of CKD in the Renal Impairment in Secondary Care (RIISC) cohort, a prospective observational study of 499 CKD patients...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208969/association-of-kidney-fibrosis-with-urinary-peptides-a-path-towards-non-invasive-liquid-biopsies
#19
Pedro Magalhães, Martin Pejchinovski, Katerina Markoska, Miroslaw Banasik, Marian Klinger, Dominika Švec-Billá, Ivan Rychlík, Merita Rroji, Arianna Restivo, Giovambattista Capasso, Flaviu Bob, Adalbert Schiller, Alberto Ortiz, Maria Vanessa Perez-Gomez, Pablo Cannata, Maria Dolores Sanchez-Niño, Radomir Naumovic, Voin Brkovic, Momir Polenakovic, William Mullen, Antonia Vlahou, Petra Zürbig, Lars Pape, Franco Ferrario, Colette Denis, Goce Spasovski, Harald Mischak, Joost P Schanstra
Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29190600/hyaluronic-acid-as-a-new-biomarker-to-differentiate-acute-kidney-injury-from-chronic-kidney-disease
#20
Davut Akin, Sehmus Ozmen, Mehmet Emin Yilmaz
INTRODUCTION: It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. MATERIALS AND METHODS: A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured...
November 2017: Iranian Journal of Kidney Diseases
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