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CKD Biomarkers

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245 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Chia-Wen Kuo, Hsiao-Ling Chen, Min-Yu Tu, Chuan-Mu Chen
Extracellular superoxide dismutase (SOD3), one member of the antioxidant defense system and a superoxide scavenger, has been noted to be downregulated in the kidneys of diabetic mice and is characterized by a heparin-binding domain that can anchor the protein to the endothelium and extracellular matrix. The association of the serum and urinary SOD3 levels with diabetic nephropathy in different stages has never been evaluated. It remains unclear how urinary SOD3 changes in different renal diseases. We recruited 98 Taiwanese patients with type 2 diabetes and 10 patients with early chronic kidney disease (CKD) into this study...
October 10, 2018: American Journal of Physiology. Renal Physiology
Pavan K Bhatraju, Leila R Zelnick, Michael Shlipak, Ronit Katz, Bryan Kestenbaum
BACKGROUND: TNF receptor-1 (TNFR-1), which plays a causative role in endothelial cell dysfunction and inflammation, is expressed on the cell surface in glomerular and peritubular capillary endothelium of the kidneys. Higher soluble TNF receptor-1 (sTNFR-1) concentrations are associated with kidney disease progression among persons with established diabetic kidney disease. However, no studies have assessed sTNFR-1's role in long-term kidney function changes in a multiethnic population without cardiovascular disease at baseline...
October 4, 2018: Journal of the American Society of Nephrology: JASN
Robert Davies
Chronic kidney disease (CKD) is a growing burden on people and on healthcare for which the diagnostics are niether disease-specific nor indicative of progression. Biomarkers are sought to enable clinicians to offer more appropriate patient-centred treatments, which could come to fruition by using a metabolomics approach. This mini-review highlights the current literature of metabolomics and CKD, and suggests additional factors that need to be considered in this quest for a biomarker, namely the diet and the gut microbiome, for more meaningful advances to be made...
October 2018: Clinical Kidney Journal
Stephen Zewinger, Thomas Rauen, Michael Rudnicki, Giuseppina Federico, Martina Wagner, Sarah Triem, Stefan J Schunk, Ioannis Petrakis, David Schmit, Stefan Wagenpfeil, Gunnar H Heine, Gert Mayer, Jürgen Floege, Danilo Fliser, Hermann-Josef Gröne, Thimoteus Speer
BACKGROUND: The individual course of CKD may vary, and improved methods for identifying which patients will experience short-term eGFR loss are needed. Assessing urinary Dickkopf-3 (DKK3), a stress-induced tubular epithelia-derived profibrotic glycoprotein, may provide information about ongoing tubulointerstitial fibrosis and short-term eGFR loss. METHODS: To investigate urinary DKK3's potential as a biomarker of short-term eGFR loss (over 12 months), we prospectively assessed eGFR and urinary DKK3 levels in patients with CKD of various etiologies at baseline and annual follow-ups...
October 2, 2018: Journal of the American Society of Nephrology: JASN
Signe Holm Nielsen, Daniel Guldager Kring Rasmussen, Susanne Brix, Anthony Fenton, Mark Jesky, Charles J Ferro, Morten Karsdal, Federica Genovese, Paul Cockwell
BACKGROUND: Patients with chronic kidney disease (CKD) have increased risk of development of end-stage renal disease (ESRD) and early mortality. Fibrosis is the central pathogenic process in CKD and is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 chain (LAMC1) is a core structural protein present in the basement membrane of several organs, including the kidneys. We hypothesized that dysregulation of LAMC1 remodeling could be associated with a higher risk of adverse clinical outcomes in patients with CKD...
2018: PloS One
Mary B Nabity
Traditional biomarkers of renal disease have a number of limitations, whether evaluating veterinary patients or performing preclinical toxicity studies. Serum creatinine and urea nitrogen are affected by nonrenal influences that limit their usefulness for detecting small but significant decreases in glomerular filtration rate (GFR) in veterinary patients. These nonrenal influences can be more controlled in preclinical studies than in clinical patients; however, because of its high functional reserve, these estimates of GFR are insensitive for detecting kidney injury prior to loss of a substantial proportion of functioning nephrons...
October 1, 2018: Toxicologic Pathology
Anna Levin, Deepika Nair, Abdul Rashid Qureshi, Peter Bárány, Olof Heimburger, Björn Anderstam, Peter Stenvinkel, Annette Bruchfeld, Johanna S Ungerstedt
BACKGROUND: Inflammation and oxidative stress play important roles in the pathogenesis and progression of chronic kidney disease (CKD) and in its complications, in particular cardiovascular disease, a major cause of death among patients undergoing dialysis treatment. We recently described that Glutaredoxin1 (Grx), an intracellular antioxidant, catalyzes oxidoreductase reactions also extracellularly, and that serum Grx levels correlate to disease severity in type 2 diabetes. AIM: In the current study we assess Grx as a potential clinical marker of oxidative stress in CKD...
September 25, 2018: Nephron
Bancha Satirapoj, Rattanawan Dispan, Piyanuch Radinahamed, Chagriya Kitiyakara
BACKGROUND: Increased monocyte chemoattractant protein-1 (MCP-1) and decreased epidermal growth factor (EGF) are promising biomarkers to predict progressive decline in kidney function in non-diabetic kidney diseases. We aimed to evaluate the performance of urinary EGF, MCP-1 or their ratio in predicting rapid decline of GFR in a cohort of Type 2 diabetic patients (T2DM) with diabetic kidney disease (DKD). METHODS: T2DM patients (n = 83) with DKD at high risk for renal progression were followed up prospectively...
September 21, 2018: BMC Nephrology
Qi Wu, Robert A Fenton
Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to detect alterations in protein abundances and/or post-translational modifications in plasma, urine or tissue. Such approaches can provide a large unbiased database to facilitate identification of potential biomarkers. In the diagnosis of kidney diseases, urine is usually a more favorable specimen than plasma and kidney tissue due to its non-invasive collection and simplicity of processing...
September 19, 2018: American Journal of Physiology. Renal Physiology
Ruth F Dubin, Suzanne Judd, Rebecca Scherzer, Michael Shlipak, David G Warnock, Mary Cushman, Mark Sarnak, Chirag Parikh, Michael Bennett, Neil Powe, Carmen A Peralta
Introduction: Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury. In persons with reduced estimated glomerular filtration rate (eGFR) and albuminuria who are at high risk for end-stage renal disease (ESRD) and death, the associations of these urinary markers with incident ESRD or death is an area of active investigation. Methods: Among 1472 black and white participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study with eGFR ≤60 ml/min per 1...
September 2018: KI Reports
Terumasa Hayashi, Keiko Yasuda, Tomonori Kimura, Koichi Sasaki, Karin Shimada, Nobuhiro Hashimoto, Yoshitaka Isaka
BACKGROUND: It is unclear whether asymptomatic elevation of brain natriuretic peptide (BNP) is associated with cardiovascular events (CVEs) or heart failure (HF) in predialysis chronic kidney disease (CKD) patients. METHODS: We measured BNP in 482 asymptomatic predialysis patients with CKD stages 2-5 at nephrology referral between August 2004 and October 2010, and followed them prospectively to investigate the prognostic significance of BNP using Cox models and receiver operating characteristic (ROC) analyses...
2018: American Journal of Nephrology
Andreana De Mauri, Matteo Vidali, Doriana Chiarinotti, Giorgio Bellomo, Roberta Rolla
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is a serine lipase that enhances the instability of the atherosclerotic plaques. While in the general and cardiac population Lp-PLA2 is recognized as an important determinant of cardiovascular (CV) accidents, no data are available for the renal population. The aim of this study was to evaluate the relationship between Lp-PLA2 and acute CV events in hemodialyzed patients. METHODS: We enrolled 102 dialyzed patients, 63% male, age 71 years (59-78), 35% with diabetes, 54% hypertension, 40% coronary artery disease and 31% peripheral vascular disease...
August 27, 2018: Journal of Nephrology
P Prabu, S Rome, C Sathishkumar, C Gastebois, E Meugnier, V Mohan, M Balasubramanyam
AIMS: MicroRNAs (miRNAs) from extracellular vesicles (EVs) have been proposed as promising biomarkers for a number of diseases. In this study, their potential as urine-based biomarkers of diabetic nephropathy (DN) was assessed. METHODS: MiRNAs were profiled in urinary EVs from 160 fasting subjects with normal glucose tolerance (NGT) and in T2DM patients with either microalbumininuria (MIC) or macroalbuminuria (MAC). RESULTS: A total of 73 miRNAs detected in urinary EVs (NGT) were predicted to target important functions for kidney homoeostasis, thereby validating their use as indicators of kidney dysfunction...
August 27, 2018: Diabetes & Metabolism
Hermine I Brunner, Gaurav Gulati, Marisa S Klein-Gitelman, Kelly A Rouster-Stevens, Lori Tucker, Stacey P Ardoin, Karen B Onel, Rylie Mainville, Jessica Turnier, Pinar Ozge Avar Aydin, David Witte, Bin Huang, Michael R Bennett, Prasad Devarajan
OBJECTIVES: To delineate urine biomarkers that reflect kidney structural damage and predict renal functional decline in pediatric lupus nephritis (LN). METHODS: In this prospective study, we evaluated kidney biopsies and urine samples of 89 patients with pediatric LN. Urinary levels of 10 biomarkers [adiponectin, ceruloplasmin, kidney injury molecule-1, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, osteopontin, transforming growth factor-ß (TGFß), vitamin-D binding protein, liver fatty acid binding protein (LFABP), and transferrin] were measured...
August 29, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski
Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92...
2018: Mediators of Inflammation
Qinglian Wang, Wenyan Su, Zhenwei Shen, Rong Wang
Objective: Over decades, numerous inconsistent studies are reported on the relationship between soluble α -Klotho and renal function in patients with chronic kidney disease (CKD). This study aims to perform a meta-analysis to figure out the correlations between soluble α -Klotho and renal function in patients with CKD. Materials and Methods: We searched medical and scientific literature databases, PubMed and EMBASE (from the inception to October 2017), for publications that reported studies on associations between soluble α -Klotho and renal function in patients with CKD...
2018: BioMed Research International
S Benito, A Sánchez-Ortega, N Unceta, F Andrade, L Aldámiz-Echevarria, M A Goicolea, R J Barrio
Pediatric chronic kidney disease (CKD) is a clinical syndrome characterized by renal hypofunction occurring due to gradual and irreversible kidney damage that can further progress over time. New biomarkers may help early diagnosis of pediatric patients suffering from CKD and improve the outcome. Untargeted metabolomics based on LC-QTOF-MS has been used to find new biomarkers for the early diagnosis of CKD in plasma from pediatric patients. In order to avoid any bias in the determination of statistically significant entities as a consequence of the data analysis method followed, two different chemometric approaches have been used, Mass Profiler Professional (MPP) software and Matlab R2015a software...
September 10, 2018: Analyst
Samuel N Uwaezuoke, Adaeze C Ayuk, Vivian U Muoneke, Ngozi R Mbanefo
Chronic kidney disease (CKD) in children contributes to the global health burden. The focus on using novel biomarkers to predict the onset and progression of the disease has increased tremendously over the past decade. Discovery of these biomarkers offers prospects for the early anticipation of the late stages of CKD, slowing down disease progression, and achieving better disease outcomes. The aim of this article is to classify and highlight the utility of these novel biomarkers in predicting disease-onset and progression...
July 2018: Saudi Journal of Kidney Diseases and Transplantation
Farsad Afshinnia, Lixia Zeng, Jaeman Byun, Stefanie Wernisch, Rajat Deo, Jing Chen, Lee Hamm, Edgar R Miller, Eugene P Rhee, Michael J Fischer, Kumar Sharma, Harold I Feldman, George Michailidis, Subramaniam Pennathur
Background: The clinical relevance of arachidonic acid (AA) metabolites in chronic kidney disease (CKD) progression is poorly understood. We aimed to compare the concentrations of 85 enzymatic pathway products of AA metabolism in patients with CKD who progressed to end-stage kidney disease (ESKD) versus patients who did not in a subcohort of Chronic Renal Insufficiency Cohort (CRIC) and to estimate the risk of CKD progression and major cardiovascular events by levels of AA metabolites and their link to enzymatic metabolic pathways...
July 25, 2018: Nephrology, Dialysis, Transplantation
Helen C Looker, Michael L Merchant, Madhavi J Rane, Robert G Nelson, Paul L Kimmel, Brad H Rovin, Jon B Klein, Michael Mauer, Ckd Biomarkers Consortium
We examined the association of urine inositol pentakisphosphate 2-kinase (IPP2K) with the presence and progression of diabetic kidney disease (DKD) lesions. Urine IPP2K was measured at baseline by quantitative liquid chromatography mass spectrometry in 215 participants from the Renin-Angiotensin System Study who had type 1 diabetes and were normoalbuminuric and normotensive with normal or increased glomerular filtration rate (GFR). Urine IPP2K was detectable in 166 participants. Participants with IPP2K below the limit of quantification (LOQ) were assigned concentrations of LOQ/√2...
August 22, 2018: American Journal of Physiology. Renal Physiology
2018-08-24 16:08:48
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