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CKD Biomarkers

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96 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/27904596/association-of-adiponectin-with-peripheral-arterial-disease-and-mortality-in-nondiabetic-hemodialysis-patients-long-term-follow-up-data-of-7-years
#1
Yijun Zhou, Jiwei Zhang, Weiming Zhang, Zhaohui Ni
BACKGROUND: The relationships between adiponectin and clinical outcomes in hemodialysis (HD) patients remain highly controversial. Meanwhile, the association between adiponectin and the peripheral artery disease (PAD) has not been well studied in HD patients without diabetic mellitus. MATERIALS AND METHODS: The ankle-brachial index was measured in HD patients. Adiponectin levels in 105 HD patients were measured by Enzyme-Linked Immunosorbant Assay. RESULTS: 105 HD patients were enrolled; 14 (13%) patients had PAD...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27893762/circulating-angiopoietin-2-and-its-soluble-receptor-tie-2-concentrations-are-related-to-renal-function-in-two-population-based-cohorts
#2
Anna Hennings, Anke Hannemann, Rainer Rettig, Marcus Dörr, Matthias Nauck, Henry Völzke, Markus M Lerch, Wolfgang Lieb, Nele Friedrich
BACKGROUND: An intact angiopoietin/Tie-2 ligand receptor system is indispensable for life. High circulating angiopoietin-2 (Ang-2) concentrations are strongly associated with kidney disease involving the progressive loss of glomerular filtration. The aim of our study was to investigate the associations between renal function and serum Ang-2 or serum Tie-2 concentrations in the general population. METHODS: Data of 3081 and 4088 subjects from two population-based studies, the Study of Health in Pomerania (SHIP-1) and SHIP-Trend, were used...
2016: PloS One
https://www.readbyqxmd.com/read/27907168/are-urinary-tubular-injury-markers-useful-in-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#3
Le-Ting Zhou, Lin-Li Lv, Ming-Ming Pan, Yu-Han Cao, Hong Liu, Ye Feng, Hai-Feng Ni, Bi-Cheng Liu
BACKGROUND: Adverse outcome of chronic kidney disease, such as end stage renal disease, is a significant burden on personal health and healthcare costs. Urinary tubular injury markers, such as NGAL, KIM-1 and NAG, could provide useful prognostic value for the early identification of high-risk patients. However, discrepancies between recent large prospective studies have resulted in controversy regarding the potential clinical value of these markers. Therefore, we conducted the first meta-analysis to provide a more persuasive argument to this debate...
2016: PloS One
https://www.readbyqxmd.com/read/27898524/uromodulin-in-kidney-health-and-disease
#4
Pranav S Garimella, Mark J Sarnak
PURPOSE OF REVIEW: Although uromodulin or Tamm-Horsfall protein was discovered over 60 years ago, its functional role in humans remains unclear. This review highlights new studies elucidating the clinical correlates of uromodulin, its association with kidney function decline, nephrolithiasis and urinary host defense. RECENT FINDINGS: Uromodulin is evolutionarily conserved and has multiple functional roles. In large population studies, higher levels of uromodulin are associated with higher estimated glomerular filtration rate (eGFR) and kidney size, possibly indicating greater kidney functional reserve...
November 24, 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27872172/urea-a-true-uremic-toxin-the-empire-strikes-back
#5
REVIEW
Wei Ling Lau, Nosratola D Vaziri
Blood levels of urea rise with progressive decline in kidney function. Older studies examining acute urea infusion suggested that urea was well-tolerated at levels 8-10× above normal values. More recent in vitro and in vivo work argue the opposite and demonstrate both direct and indirect toxicities of urea, which probably promote the premature aging phenotype that is pervasive in chronic kidney disease (CKD). Elevated urea at concentrations typically encountered in uremic patients induces disintegration of the gut epithelial barrier, leading to translocation of bacterial toxins into the bloodstream and systemic inflammation...
January 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27758121/kidney-injury-molecule-1-in-kidney-disease
#6
Caixia Yin, Ningning Wang
Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome...
October 19, 2016: Renal Failure
https://www.readbyqxmd.com/read/27701453/plasma-pentosidine-and-its-association-with-mortality-in-patients-with-chronic-kidney-disease
#7
Anna Machowska, Jia Sun, Abdul Rashid Qureshi, Naohito Isoyama, Paul Leurs, Björn Anderstam, Olof Heimburger, Peter Barany, Peter Stenvinkel, Bengt Lindholm
BACKGROUND: Circulating advanced glycated end-products (AGEs) including pentosidine accumulating in chronic kidney disease (CKD) patients due to retention and increased formation are thought to contribute to cardiovascular disease (CVD). Here we evaluated factors linked to increased plasma pentosidine and its association with mortality in patients with different stages of CKD and undergoing different treatments. METHODS: Plasma pentosidine, biomarkers of inflammation, oxidative stress and nutritional status were investigated in CKD 1-2 (n = 37), CKD 3-4 (n = 54), CKD 5 non-dialyzed (CKD5-ND; n = 386), peritoneal dialysis (PD; n = 74) and hemodialysis (HD; n = 195) patients...
2016: PloS One
https://www.readbyqxmd.com/read/27667892/proteomic-biomarkers-panel-new-insights-in-chronic-kidney-disease
#8
Simona Mihai, Elena Codrici, Ionela Daniela Popescu, Ana-Maria Enciu, Elena Rusu, Diana Zilisteanu, Radu Albulescu, Gabriela Anton, Cristiana Tanase
Chronic kidney disease, despite being a "silent epidemic" disease, represents one of the main causes of mortality in general population, along with cardiovascular disease, which is the leading cause of poor prognosis for these patients. The specific objective of our study was to characterize the relationship between the inflammatory status, the bone disorders markers, and kidney failure in chronic kidney disease patient stages 2-4, in order to design a novel biomarker panel that improves early disease diagnosis and therapeutic response, thus being further integrated into clinical applications...
2016: Disease Markers
https://www.readbyqxmd.com/read/27586401/urinary-c-type-natriuretic-peptide-excretion-a-promising-biomarker-to-detect-underlying-renal-injury-and-remodeling-both-acutely-and-chronically
#9
Peng Hu, Si Yan Liu, Dong Dong Zhang, Yao Xu, Xun Xia
Acute kidney injury (AKI) refers to a sudden decline in renal function. A growing body of evidence demonstrates that AKI is a risk factor for the future development or accelerated progression of chronic kidney disease (CKD), whereas the actual distinction between AKI and CKD remains unknown. CNP is predominantly present in the kidney and possesses multiple renoprotective properties. Urinary CNP excretion tends to be high in AKI, whereas back to the baseline in CKD. The dynamic changes in urinary CNP excretion may help detect underlying renal injury and remodeling both acutely and chronically...
September 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27636000/metabolomic-signatures-of-chronic-kidney-disease-of-diverse-etiologies-in-the-rats-and-humans
#10
Zhi-Hao Zhang, Hua Chen, Nosratola D Vaziri, Jia-Rong Mao, Li Zhang, Xu Bai, Ying-Yong Zhao
Chronic kidney disease (CKD) has emerged as a major public health problem worldwide. It frequently progresses to end-stage renal disease, which is related to very high cost and mortality. Novel biomarkers can provide insight into the novel mechanism, facilitate early detection, and monitor progression of CKD and its response to therapeutic interventions. To identify potential biomarkers, we applied an UPLC-HDMS together with univariate and multivariate statistical analyses using plasma samples from patients with CKD of diverse etiologies (100 sera in discovery set and 120 sera in validation set) and two different rat models of CKD...
October 7, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27636773/biomarkers-for-predicting-outcomes-in-chronic-kidney-disease
#11
Lekha Tummalapalli, Girish N Nadkarni, Steven G Coca
PURPOSE OF REVIEW: Current biomarkers for chronic kidney disease (CKD) are limited by lack of sensitivity and inability to prognosticate CKD progression. Significant recent research has better characterized novel biomarker candidates that are associated with CKD progression and cardiovascular mortality in CKD. This review discusses the most significant advances within the past year. RECENT FINDINGS: We discuss biomarkers for outcomes in CKD under two categories: emerging (defined as having been validated in an independent cohort), which include serum cystatin C, serum β-trace protein, β2-microglobulin, soluble urokinase-type plasminogen activator receptor, soluble tumor necrosis factor receptors 1/2, urinary monocyte chemotactic protein-1, neutrophil gelatin-associated lipocalin, kidney injury molecule-1, and fibroblast growth factor-23; and novel (which have shown associations in smaller observational studies but have not been validated yet), which include indoxyl sulfate, p-cresyl sulfate, trimethylamine-N-oxide, IL-18, Klotho, markers of endothelial dysfunction, vimentin, and procollagen type III N-terminal propeptide...
November 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27624489/matrix-metalloproteinase-7-is-a-urinary-biomarker-and-pathogenic-mediator-of-kidney-fibrosis
#12
Dong Zhou, Yuan Tian, Ling Sun, Lili Zhou, Liangxiang Xiao, Roderick J Tan, Jianwei Tian, Haiyan Fu, Fan Fan Hou, Youhua Liu
Matrix metalloproteinase-7 (MMP-7), a secreted zinc- and calcium-dependent endopeptidase, is a transcriptional target of canonical Wnt/β-catenin signaling. Because Wnt/β-catenin is activated in diseased kidney, we hypothesized that urinary MMP-7 level may be used as a noninvasive surrogate biomarker for fibrotic lesions. To test this hypothesis, we conducted a cross-sectional study, measuring urinary MMP-7 levels in a cohort of 102 patients with CKD. Compared with normal subjects, patients with various kidney disorders had markedly elevated urinary levels of MMP-7...
September 13, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27401687/high-level-of-fasting-plasma-proenkephalin-a-predicts-deterioration-of-kidney-function-and-incidence-of-ckd
#13
Christina-Alexandra Schulz, Anders Christensson, Ulrika Ericson, Peter Almgren, George Hindy, Peter M Nilsson, Joachim Struck, Andreas Bergmann, Olle Melander, Marju Orho-Melander
High levels of proenkephalin-A (pro-ENK) have been associated with decreased eGFR in an acute setting. Here, we examined whether pro-ENK levels predict CKD and decline of renal function in a prospective cohort of 2568 participants without CKD (eGFR>60 ml/min per 1.73 m(2)) at baseline. During a mean follow-up of 16.6 years, 31.7% of participants developed CKD. Participants with baseline pro-ENK levels in the highest tertile had significantly greater yearly mean decline of eGFR (Ptrend<0.001) and rise of cystatin C (Ptrend=0...
July 8, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27313827/dna-damage-in-chronic-kidney-disease-evaluation-of-clinical-biomarkers
#14
REVIEW
Nicole Schupp, Helga Stopper, August Heidland
Patients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a healthy control population. To be able to estimate the cancer risk of the patients and to assess the impact of interventional therapies thereon, it is of particular interest to measure the patients' burden of genomic damage. Chromosomal abnormalities, reduced DNA repair, and DNA lesions were found indeed in cells of patients with CKD. Biomarkers for DNA damage measurable in easily accessible cells like peripheral blood lymphocytes are chromosomal aberrations, structural DNA lesions, and oxidatively modified DNA bases...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27288367/urinary-chemoattractant-protein-1-a-new-biomarker-of-renal-fibrosis
#15
Richard J Glassock
No abstract text is available yet for this article.
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27241541/comparison-of-asymmetric-dimethylarginine-levels-between-stages-three-four-and-five-non-dialysis-of-chronic-kidney-disease
#16
Tri P Asmarawati, Widodo, M Thaha, Aditiawardana, Nunuk Mardiana, Ardityo R Ardhany, Artaria Tjempakasari, Djoko Santoso, Pranawa, Chandra Irwanadi
AIM: to determine the differences of ADMA level between stages 3, 4, and 5 non-dialysis of chronic kidney disease (CKD) patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital. METHODS: a cross-sectional study was conducted on stage 3, 4, and 5 non-dialysis CKD patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital, Surabaya from January to February 2015. Stages of CKD were determined based on GFR estimation according to 4-variable MDRD formula. Statistical analysis of differences in the levels of ADMA in three subject groups use one-way ANOVA test...
January 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27189318/association-of-urinary-biomarkers-of-inflammation-injury-and-fibrosis-with-renal-function-decline-the-accord-trial
#17
Girish N Nadkarni, Veena Rao, Faramarz Ismail-Beigi, Vivian A Fonseca, Sudhir V Shah, Michael S Simonson, Lloyd Cantley, Prasad Devarajan, Chirag R Parikh, Steven G Coca
BACKGROUND AND OBJECTIVES: Current measures for predicting renal functional decline in patients with type 2 diabetes with preserved renal function are unsatisfactory, and multiple markers assessing various biologic axes may improve prediction. We examined the association of four biomarker-to-creatinine ratio levels (monocyte chemotactic protein-1, IL-18, kidney injury molecule-1, and YKL-40) with renal outcome. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used a nested case-control design in the Action to Control Cardiovascular Disease Trial by matching 190 participants with ≥40% sustained eGFR decline over the 5-year follow-up period to 190 participants with ≤10% eGFR decline in a 1:1 fashion on key characteristics (age within 5 years, sex, race, baseline albumin-to-creatinine ratio within 20 μg/mg, and baseline eGFR within 10 ml/min per 1...
August 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27194714/the-proximal-tubule-is-the-primary-target-of-injury-and-progression-of-kidney-disease-role-of-the-glomerulotubular-junction
#18
REVIEW
Robert L Chevalier
There is an alarming global increase in the incidence of end-stage kidney disease, for which early biomarkers and effective treatment options are lacking. Largely based on the histology of the end-stage kidney and on the model of unilateral ureteral obstruction, current investigation is focused on the pathogenesis of renal interstitial fibrosis as a central mechanism in the progression of chronic kidney disease (CKD). It is now recognized that cumulative episodes of acute kidney injury (AKI) can lead to CKD, and, conversely, CKD is a risk factor for AKI...
July 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27108839/tgf-%C3%AE-the-master-regulator-of-fibrosis
#19
REVIEW
Xiao-Ming Meng, David J Nikolic-Paterson, Hui Yao Lan
Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its downstream signalling pathways substantially limits renal fibrosis in a wide range of disease models whereas overexpression of TGF-β1 induces renal fibrosis. TGF-β1 can induce renal fibrosis via activation of both canonical (Smad-based) and non-canonical (non-Smad-based) signalling pathways, which result in activation of myofibroblasts, excessive production of extracellular matrix (ECM) and inhibition of ECM degradation...
June 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/26962815/plasma-uromodulin-correlates-with-kidney-function-and-identifies-early-stages-in-chronic-kidney-disease-patients
#20
Dominik Steubl, Matthias Block, Victor Herbst, Wolfgang Andreas Nockher, Wolfgang Schlumberger, Robin Satanovskij, Susanne Angermann, Anna-Lena Hasenau, Lynne Stecher, Uwe Heemann, Lutz Renders, Jürgen Scherberich
Uromodulin, released from tubular cells of the ascending limb into the blood, may be associated with kidney function. This work studies the relevance of plasma uromodulin as a biomarker for kidney function in an observational cohort of chronic kidney disease (CKD) patients and subjects without CKD (CKD stage 0). It should be further evaluated if uromodulin allows the identification of early CKD stages.Plasma uromodulin, serum creatinine, cystatin C, blood-urea-nitrogen (BUN) concentrations, and estimated glomerular filtration rate (eGFR CKD-EPIcrea-cystatin) were assessed in 426 individuals of whom 71 were CKD stage 0 and 355 had CKD...
March 2016: Medicine (Baltimore)
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