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Gaetano Gorgone, Monica CurrĂ², Nadia Ferlazzo, Giulia Parisi, Lucilla Parnetti, Vincenzo Belcastro, Nicola Tambasco, Aroldo Rossi, Francesco Pisani, Paolo Calabresi, Riccardo Ientile, Daniela Caccamo
There is evidence that increased homocysteine (Hcy) levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects. Homocysteine neurotoxicity mainly relies on redox state alterations. The present work was aimed at investigating the relationships between plasma Hcy concentrations and percent content of oxidized versus total Coenzyme Q10 (%CoQ10) in 60 PD patients and 82 healthy subjects. Both groups were screened for plasma levels of Hcy, vitamin B12, folate, %CoQ10 and C677T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism...
March 2012: Neuromolecular Medicine
Nicolas A Crossley, Jessica Scott, Ian Ellison-Wright, Andrea Mechelli
BACKGROUND: It is unclear to what extent the traditional distinction between neurological and psychiatric disorders reflects biological differences. AIMS: To examine neuroimaging evidence for the distinction between neurological and psychiatric disorders. METHOD: We performed an activation likelihood estimation meta-analysis on voxel-based morphometry studies reporting decreased grey matter in 14 neurological and 10 psychiatric disorders, and compared the regional and network-level alterations for these two classes of disease...
November 2015: British Journal of Psychiatry: the Journal of Mental Science
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