Aline R Borçoi, Camilla L Patti, Karina A Zanin, André W Hollais, Renan Santos-Baldaia, Liliane M B Ceccon, Laís F Berro, Raphael Wuo-Silva, Stephanie B Grapiglia, Luciana T C Ribeiro, Leonardo B Lopes-Silva, Roberto Frussa-Filho
BACKGROUND: Prenatal environmental adversities may affect brain development and are associated with increased risk for schizophrenia, an illness with 50% comorbidity with addiction. Maternal immune activation by poly-inosinic-citidilic acid (Poly(I:C)) exposure can promote behavioral alterations consistent with schizophrenia symptoms in rodents. OBJECTIVES: Considering the vulnerability to addiction in patients with schizophrenia, we evaluated the interactions between prenatal Poly(I:C) administration and addiction in two animal models (behavioral sensitization and conditioned place preference - CPP) in mice repeatedly treated with amphetamine (AMP)...
December 3, 2015: Progress in Neuro-psychopharmacology & Biological Psychiatry