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BIDMC interdisciplinary breast rotation

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17 papers 0 to 25 followers
Charles E Rutter, Henry S Park, Brigid K Killelea, Suzanne B Evans
BACKGROUND: Ductal carcinoma-in situ (DCIS) is a preinvasive form of breast cancer associated with excellent outcomes after either mastectomy or breast conservation therapy. Previous studies have demonstrated declining rates of mastectomy. However, it is unclear how this pattern has changed in recent years. METHODS: Women with DCIS were identified within the National Cancer Data Base. Patients treated with lumpectomy with or without radiotherapy were compared to women treated with mastectomy on the basis of demographic, clinicopathologic, and reporting facility details using χ (2) tests and multivariable logistic regression modeling to identify factors that may influence surgical choice...
July 2015: Annals of Surgical Oncology
B Fisher, J P Costantino, D L Wickerham, C K Redmond, M Kavanah, W M Cronin, V Vogel, A Robidoux, N Dimitrov, J Atkins, M Daly, S Wieand, E Tan-Chiu, L Ford, N Wolmark
BACKGROUND: The finding of a decrease in contralateral breast cancer incidence following tamoxifen administration for adjuvant therapy led to the concept that the drug might play a role in breast cancer prevention. To test this hypothesis, the National Surgical Adjuvant Breast and Bowel Project initiated the Breast Cancer Prevention Trial (P-1) in 1992. METHODS: Women (N=13388) at increased risk for breast cancer because they 1) were 60 years of age or older, 2) were 35-59 years of age with a 5-year predicted risk for breast cancer of at least 1...
September 16, 1998: Journal of the National Cancer Institute
L M Marshall, D J Hunter, J L Connolly, S J Schnitt, C Byrne, S J London, G A Colditz
Epidemiological studies using the histological classification of Page for benign breast disease consistently demonstrate a positive association between atypical hyperplasia and the subsequent development of breast cancer. However, atypical hyperplasia is of either lobular or ductal types, and breast cancer risk in relation to type of atypical hyperplasia has not been studied extensively. Thus, we investigated prospectively the risk of breast cancer associated with histological subtypes of benign proliferative breast disease, including the types of atypical hyperplasia, among participants in the Nurses' Health Study who had biopsy-confirmed benign breast disease...
May 1997: Cancer Epidemiology, Biomarkers & Prevention
Timothy W Jacobs, James L Connolly, Stuart J Schnitt
Large core needle biopsies using stereotactic mammography or ultrasound guidance are now commonly performed as the initial diagnostic approach to nonpalpable breast lesions. Although the subsequent management of patients with invasive cancer, ductal carcinoma in situ, and most benign lesions diagnosed on core needle biopsy specimens is straightforward, certain nonmalignant lesions pose dilemmas with regard to the most appropriate clinical management following core needle biopsy. The purpose of this article is to review the available data regarding several nonmalignant breast lesions, which when encountered in core needle biopsy specimens raise repeated management questions...
September 2002: American Journal of Surgical Pathology
Monica Morrow, Stuart J Schnitt, Larry Norton
High-risk breast lesions, which comprise benign lesions and in situ carcinomas (lobular carcinoma in situ and ductal carcinoma in situ), are clinically, morphologically, and biologically heterogeneous and are associated with an increased risk of invasive breast cancer development, albeit to varying degrees. Recognition and proactive management of such lesions can help to prevent progression to invasive disease, and might, therefore, reduce breast cancer incidence, morbidity, and mortality. However, this opportunity comes with the possibility of overdiagnosis and overtreatment, necessitating risk-based intervention...
April 2015: Nature Reviews. Clinical Oncology
Faina Nakhlis, Nasim Ahmadiyeh, Susan Lester, Sughra Raza, Parisa Lotfi, Mehra Golshan
BACKGROUND: Intraductal papillomas (IPs) are commonly seen breast lesions with variable clinical presentation. For a palpable lesion and/or evidence of cellular atypia and/or pathologic nipple discharge, excision is warranted to rule out adjacent carcinoma, while for asymptomatic IPs lacking atypia current data for excision vs. observation are controversial. We reviewed outcomes of IPs diagnosed at our institution. METHODS: With IRB approval, we reviewed consecutive patients with IPs seen on core biopsy (CBx) between 2005 and 2013...
May 2015: Annals of Surgical Oncology
Kelly Metcalfe, Shelley Gershman, Parviz Ghadirian, Henry T Lynch, Carrie Snyder, Nadine Tung, Charmaine Kim-Sing, Andrea Eisen, William D Foulkes, Barry Rosen, Ping Sun, Steven A Narod
OBJECTIVE: To compare the survival rates of women with BRCA associated breast cancer who did and did not undergo mastectomy of the contralateral breast. DESIGN: Retrospective analysis. SETTING: 12 cancer genetics clinics. PARTICIPANTS: 390 women with a family history of stage I or II breast cancer who were carriers of BRCA1 and BRCA2 mutations and initially treated with unilateral or bilateral mastectomy. 181 patients had mastectomy of the contralateral breast...
February 11, 2014: BMJ: British Medical Journal
Fergus J Couch, Steven N Hart, Priyanka Sharma, Amanda Ewart Toland, Xianshu Wang, Penelope Miron, Janet E Olson, Andrew K Godwin, V Shane Pankratz, Curtis Olswold, Seth Slettedahl, Emily Hallberg, Lucia Guidugli, Jaime I Davila, Matthias W Beckmann, Wolfgang Janni, Brigitte Rack, Arif B Ekici, Dennis J Slamon, Irene Konstantopoulou, Florentia Fostira, Athanassios Vratimos, George Fountzilas, Liisa M Pelttari, William J Tapper, Lorraine Durcan, Simon S Cross, Robert Pilarski, Charles L Shapiro, Jennifer Klemp, Song Yao, Judy Garber, Angela Cox, Hiltrud Brauch, Christine Ambrosone, Heli Nevanlinna, Drakoulis Yannoukakos, Susan L Slager, Celine M Vachon, Diana M Eccles, Peter A Fasching
PURPOSE: Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing of patients. We assessed the frequency of mutations in 17 predisposition genes, including BRCA1 and BRCA2, in a large cohort of patients with triple-negative breast cancer (TNBC) unselected for family history of breast or ovarian cancer to determine the utility of germline genetic testing for those with TNBC. PATIENTS AND METHODS: Patients with TNBC (N = 1,824) unselected for family history of breast or ovarian cancer were recruited through 12 studies, and germline DNA was sequenced to identify mutations...
February 1, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Soonmyung Paik, Steven Shak, Gong Tang, Chungyeul Kim, Joffre Baker, Maureen Cronin, Frederick L Baehner, Michael G Walker, Drew Watson, Taesung Park, William Hiller, Edwin R Fisher, D Lawrence Wickerham, John Bryant, Norman Wolmark
BACKGROUND: The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures. METHODS: We tested whether the results of a reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of 21 prospectively selected genes in paraffin-embedded tumor tissue would correlate with the likelihood of distant recurrence in patients with node-negative, tamoxifen-treated breast cancer who were enrolled in the National Surgical Adjuvant Breast and Bowel Project clinical trial B-14...
December 30, 2004: New England Journal of Medicine
S Darby, P McGale, C Correa, C Taylor, R Arriagada, M Clarke, D Cutter, C Davies, M Ewertz, J Godwin, R Gray, L Pierce, T Whelan, Y Wang, R Peto
BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. METHODS: We undertook a meta-analysis of individual patient data for 10,801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease...
November 12, 2011: Lancet
Reshma Jagsi, Jing Jiang, Adeyiza O Momoh, Amy Alderman, Sharon H Giordano, Thomas A Buchholz, Steven J Kronowitz, Benjamin D Smith
PURPOSE: Concerns exist regarding breast cancer patients' access to breast reconstruction, which provides important psychosocial benefits. PATIENTS AND METHODS: Using the MarketScan database, a claims-based data set of US patients with employment-based insurance, we identified 20,560 women undergoing mastectomy for breast cancer from 1998 to 2007. We evaluated time trends using the Cochran-Armitage test and correlated reconstruction use with plastic-surgery workforce density and other treatments using multivariable regression...
March 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Béatrice Lauby-Secretan, Chiara Scoccianti, Dana Loomis, Lamia Benbrahim-Tallaa, Véronique Bouvard, Franca Bianchini, Kurt Straif
In November 2014, experts from 16 countries met at the International Agency for Research on Cancer (IARC) to assess the cancer-preventive and adverse effects of different methods of screening for breast cancer. (The members of the working group for volume 15 of the IARC Handbook are listed at the..
June 11, 2015: New England Journal of Medicine
Lynn C Hartmann, Thomas A Sellers, Marlene H Frost, Wilma L Lingle, Amy C Degnim, Karthik Ghosh, Robert A Vierkant, Shaun D Maloney, V Shane Pankratz, David W Hillman, Vera J Suman, Jo Johnson, Cassann Blake, Thea Tlsty, Celine M Vachon, L Joseph Melton, Daniel W Visscher
BACKGROUND: Benign breast disease is an important risk factor for breast cancer. We studied a large group of women with benign breast disease to obtain reliable estimates of this risk. METHODS: We identified all women who received a diagnosis of benign breast disease at the Mayo Clinic between 1967 and 1991. Breast-cancer events were obtained from medical records and questionnaires. To estimate relative risks, we compared the number of observed breast cancers with the number expected on the basis of the rates of breast cancer in the Iowa Surveillance, Epidemiology, and End Results registry...
July 21, 2005: New England Journal of Medicine
Gad Rennert, Shantih Bisland-Naggan, Ofra Barnett-Griness, Naomi Bar-Joseph, Shiyu Zhang, Hedy S Rennert, Steven A Narod
BACKGROUND: Some features of breast cancer in women with a BRCA1 mutation suggest that hereditary breast cancer has a poor outcome. We conducted a national population-based study of Israeli women to determine the influence, if any, of a BRCA1 or a BRCA2 mutation on the prognosis in breast cancer. METHODS: We obtained data on all incident cases of invasive breast cancer that were diagnosed from January 1, 1987, to December 31, 1988, and recorded in the Israel National Cancer Registry...
July 12, 2007: New England Journal of Medicine
Sarah M Friedewald, Elizabeth A Rafferty, Stephen L Rose, Melissa A Durand, Donna M Plecha, Julianne S Greenberg, Mary K Hayes, Debra S Copit, Kara L Carlson, Thomas M Cink, Lora D Barke, Linda N Greer, Dave P Miller, Emily F Conant
IMPORTANCE: Mammography plays a key role in early breast cancer detection. Single-institution studies have shown that adding tomosynthesis to mammography increases cancer detection and reduces false-positive results. OBJECTIVE: To determine if mammography combined with tomosynthesis is associated with better performance of breast screening programs in the United States. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of screening performance metrics from 13 academic and nonacademic breast centers using mixed models adjusting for site as a random effect...
June 25, 2014: JAMA: the Journal of the American Medical Association
Cristina O'Donoghue, Martin Eklund, Elissa M Ozanne, Laura J Esserman
BACKGROUND: Controversy exists over how often and at what age mammography screening should be implemented. Given that evidence supports less frequent screening, the cost differences among advocated screening policies should be better understood. OBJECTIVE: To estimate the aggregate cost of mammography screening in the United States in 2010 and compare the costs of policy recommendations by professional organizations. DESIGN: A model was developed to estimate the cost of mammography screening in 2010 and 3 screening strategies: annual (ages 40 to 84 years), biennial (ages 50 to 69 years), and U...
February 4, 2014: Annals of Internal Medicine
Gary H Lyman, Armando E Giuliano, Mark R Somerfield, Al B Benson, Diane C Bodurka, Harold J Burstein, Alistair J Cochran, Hiram S Cody, Stephen B Edge, Sharon Galper, James A Hayman, Theodore Y Kim, Cheryl L Perkins, Donald A Podoloff, Visa Haran Sivasubramaniam, Roderick R Turner, Richard Wahl, Donald L Weaver, Antonio C Wolff, Eric P Winer
PURPOSE: To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer. METHODS: An American Society of Clinical Oncology (ASCO) Expert Panel conducted a systematic review of the literature available through February 2004 on the use of SNB in early-stage breast cancer. The panel developed a guideline for clinicians and patients regarding the appropriate use of a sentinel lymph node identification and sampling procedure from hereon referred to as SNB...
October 20, 2005: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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