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Gastroenterology

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88 papers 100 to 500 followers
https://www.readbyqxmd.com/read/28395507/pantoprazole-does-not-reduce-the-antiplatelet-effect-of-clopidogrel-a-randomized-controlled-trial-in-korea
#1
Yoon Jin Choi, Nayoung Kim, In-Jin Jang, Joo-Youn Cho, Ryoung Hee Nam, Ji Hyun Park, Hyun Jin Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyun Chae Jung
Background/Aims: Concerns that proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel could hamper the appropriate prescription of PPIs. We evaluated the influence of pantoprazole on the antiplatelet effect of clopidogrel compared with ranitidine, which is regarded as safe, after stratification of the population according to the presence of a cytochrome (CYP) 2C19 polymorphism in Korea. Methods: Forty patients who underwent dual antiplatelet therapy were randomized to receive pantoprazole (n=20) or ranitidine (n=20)...
April 11, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28494576/diverticular-disease-an-update-on-pathogenesis-and-management
#2
REVIEW
Mona Rezapour, Saima Ali, Neil Stollman
Diverticular disease is one of the most common conditions in the Western world and one of the most common findings identified at colonoscopy. Recently, there has been a significant paradigm shift in our understanding of diverticular disease and its management. The pathogenesis of diverticular disease is thought to be multifactorial and include both environmental and genetic factors in addition to the historically accepted etiology of dietary fiber deficiency. Symptomatic uncomplicated diverticular disease (SUDD) is currently considered a type of chronic diverticulosis that is perhaps akin to irritable bowel syndrome...
May 12, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28164856/the-gut-microbiome-in-irritable-bowel-syndrome-and-other-functional-bowel-disorders
#3
REVIEW
Yehuda Ringel
Emerging data from epidemiologic, microbiome, and physiology research in patients with functional bowel disorders (FBDs) provide evidence for a linkage between alterations in the intestinal microbiota and FBDs. However, currently most of the data is based on association studies, and the causality role of the microbiota in these disorders is not established. Growing evidence for compositional changes and the increasing recognition of the association between the intestinal microbiota and gut-brain functions that are relevant to the pathophysiology and/or clinical symptoms of FBDs have led to increased interest in manipulating the intestinal microbiota for the treatment of these disorders...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28331567/what-is-the-best-algorithm-for-investigation-of-acute-lower-gastrointestinal-haemorrhage
#4
Ainkaran Santhirasekaram, Sherif Latif, Easha Arooj, Kamran Rostami, Sauid Ishaq
An 81-year-old male presented with multiple episode of severe PR bleeding over 2 days. CTA done prior to catheter angiography that enabled successful intervention. This case emphasises the importance of CTA prior to catheter angiography in acute LGIB.
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28316536/gas-and-bloating
#5
William L Hasler
Gaseous symptoms including eructation, flatulence, and bloating occur as a consequence of excess gas production, altered gas transit, or abnormal perception of normal amounts of gas within the gastrointestinal tract. There are many causes of gas and bloating including aerophagia, luminal obstructive processes, carbohydrate intolerance syndromes, small intestinal bacterial overgrowth, diseases of gut motor activity, and functional bowel disorders including irritable bowel syndrome (IBS). Because of the prominence of gaseous complaints in IBS, recent investigations have focused on new insights into pathogenesis and novel therapies of bloating...
September 2006: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28331479/the-current-use-of-proton-pump-inhibitor-therapy-in-clinical-gi-practice
#6
Philip O Katz
No abstract text is available yet for this article.
December 2006: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28508867/bloating-and-abdominal-distension-old-misconceptions-and-current-knowledge
#7
REVIEW
Juan R Malagelada, Anna Accarino, Fernando Azpiroz
Bloating, as a symptom and abdominal distension, as a sign, are both common functional-type complaints and challenging to manage effectively. Individual patients may weight differently the impact of bloating and distension on their well-being. Complaints may range from chronic highly distressing pain to simply annoying and unfashionable protrusion of the abdomen. To avoid mishaps, organic bloating, and distension should always be considered first and appropriated assessed. Functional bloating and distension often present in association with other manifestations of irritable bowel syndrome or functional dyspepsia and in that context patients tend to regard them as most troublesome...
May 16, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28456631/global-prevalence-of-helicobacter-pylori-infection-systematic-review-and-meta-analysis
#8
James K Y Hooi, Wan Ying Lai, Wee Khoon Ng, Michael M Y Suen, Fox E Underwood, Divine Tanyingoh, Peter Malfertheiner, David Y Graham, Vincent W S Wong, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung, Gilaad G Kaplan, Siew C Ng
BACKGROUND & AIMS: The epidemiology of Helicobacter pylori infection has changed with improvements in sanitation and methods of eradication. We performed a systematic review and meta-analysis to evaluate changes in the global prevalence of H pylori infection. METHODS: We performed a systematic search of the MEDLINE and EMBASE databases for studies of the prevalence of H pylori infection published from January 1, 1970 through January 1, 2016. We analyzed data based on United Nations geoscheme regions and individual countries...
April 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28452210/functional-dyspepsia-advances-in-diagnosis-and-therapy
#9
REVIEW
Nicholas J Talley
Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; comprising early satiety or meal-related fullness) and epigastric pain syndrome. Symptoms of gastroesophageal reflux disease overlap with FD more than expected by chance; a subset has pathological acid reflux...
May 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28395784/acute-mesenteric-ischemia-part-i-incidence-etiologies-and-how-to-improve-early-diagnosis
#10
REVIEW
Jussi M Kärkkäinen, Stefan Acosta
Acute mesenteric ischemia (AMI) is generally thought to be a rare disease, but in fact, it is more common cause of acute abdomen than appendicitis or ruptured abdominal aortic aneurysm in patients over 75 years of age. In occlusive AMI, surgical treatment without revascularization is associated with as high as 80% overall mortality. It has been shown that early diagnosis with contrast-enhanced computed tomography and revascularization can reduce the overall mortality in AMI by up to 50%. However, only a minority of patients with AMI are being treated actively with revascularization in the United States, and the situation is very likely similar in Europe as well...
February 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28427116/current-trends-in-the-management-of-gastroesophageal-reflux-disease
#11
REVIEW
Dalbir S Sandhu, Ronnie Fass
Gastroesophageal reflux disease (GERD) characterized by heartburn and/or regurgitation symptoms is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians. There has been an increase in GERD prevalence, particularly in North America and East Asia. Over the past three decades proton pump inhibitors (PPIs) have been the mainstay of medical therapy for GERD. However, recently there has been an increasing awareness amongst physicians and patients regarding the side effects of the PPI class of drugs...
April 24, 2017: Gut and Liver
https://www.readbyqxmd.com/read/27914657/ulcerative-colitis
#12
REVIEW
Ryan Ungaro, Saurabh Mehandru, Patrick B Allen, Laurent Peyrin-Biroulet, Jean-Frédéric Colombel
Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Patients with ulcerative colitis have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. Ulcerative colitis usually presents with bloody diarrhoea and is diagnosed by colonoscopy and histological findings...
April 29, 2017: Lancet
https://www.readbyqxmd.com/read/27273496/adverse-effects-of-proton-pump-inhibitors-in-chronic-kidney-disease
#13
Ruben Poesen, Björn Meijers, Pieter Evenepoel
No abstract text is available yet for this article.
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/17722704/proton-pump-inhibitors-and-the-kidney-critical-review
#14
REVIEW
U C Brewster, M A Perazella
Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal disorders due to excessive acid production. While effective and safe, adverse renal effects have been described. Most concerning is the ever increasing number of cases of acute interstitial nephritis (AIN) associated with PPI therapy. It appears to be a class effect as all PPIs have been documented to cause AIN. Several adverse drug event registries now note PPIs as the most common cause of drug-induced AIN. While most patients recover kidney function, many are left with some level of chronic kidney disease...
August 2007: Clinical Nephrology
https://www.readbyqxmd.com/read/10848649/review-article-potential-gastrointestinal-effects-of-long-term-acid-suppression-with-proton-pump-inhibitors
#15
REVIEW
L Laine, D Ahnen, C McClain, E Solcia, J H Walsh
This review examines the evidence for the development of adverse effects due to prolonged gastric acid suppression with proton pump inhibitors. Potential areas of concern regarding long-term proton pump inhibitor use have included: carcinoid formation; development of gastric adenocarcinoma (especially in patients with Helicobacter pylori infection); bacterial overgrowth; enteric infections; and malabsorption of fat, minerals, and vitamins. Prolonged proton pump inhibitor use may lead to enterochromaffin-like cell hyperplasia, but has not been demonstrated to increase the risk of carcinoid formation...
June 2000: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/10597119/safety-profile-of-the-proton-pump-inhibitors
#16
REVIEW
J P Reilly
The adverse effect profile of proton-pump inhibitors is presented. The proton-pump inhibitors are a well-tolerated class of drugs. The most common adverse events of headache, diarrhea, and nausea have been reported in fewer than 5% of patients treated with lansoprazole or omeprazole. The frequency of these adverse events with the two proton-pump inhibitors is comparable to that of placebo and histamine H2-receptor antagonists. Few clinically important interactions have been observed between proton-pump inhibitors and other drugs metabolized by the cytochrome P-450 system...
December 1, 1999: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28433613/association-between-early-ercp-and-mortality-in-patients-with-acute-cholangitis
#17
Ming Tan, Ove B Schaffalitzky de Muckadell, Stig B Laursen
BACKGROUND AND AIMS: Acute cholangitis (AC) is associated with high mortality of up to 10%. The association between timing of ERCP and mortality in AC patients remains unclear. The aim of this study was to investigate if early ERCP within 24 hours was associated with improved survival. METHODS: All AC patients that underwent ERCP at Odense University Hospital, Denmark, between March 2009 and September 2016 were identified using a prospective ERCP database. Clinical data were collected from medical records...
April 19, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28411763/is-timing-everything-in-the-management-of-acute-upper-gi-bleeding
#18
EDITORIAL
John C T Wong, James Y W Lau
No abstract text is available yet for this article.
May 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27273495/adverse-effects-of-proton-pump-inhibitors-in-chronic-kidney-disease
#19
Pan Zhao, Zhenman Wei, Jin Han
No abstract text is available yet for this article.
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27273498/adverse-effects-of-proton-pump-inhibitors-in-chronic-kidney-disease
#20
Francesco Iannuzzella, Mattia Corradini, Sonia Pasquali
No abstract text is available yet for this article.
June 1, 2016: JAMA Internal Medicine
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