collection
MENU ▼
Read by QxMD icon Read
search

Clinical Trials

shared collection
10 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27711966/an-argument-for-fewer-clinical-trials
#1
Kirstin Borgerson
The volume of clinical research is increasing exponentially-far beyond our ability to process and absorb the results. Given this situation, it may be beneficial to consider reducing the flow at its source. In what follows, I will motivate and critically evaluate the following proposal: researchers should conduct fewer clinical trials. More specifically, I c onsider whether researchers should be permitted to conduct only clinical research of very high quality and, in turn, whether research ethics committees (RECs) should prohibit all other, lower-quality research, even when it might appear to meet some minimal ethical standard...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/24383418/minimal-clinically-important-differences-in-pharmacological-trials
#2
REVIEW
Paul W Jones, Kai M Beeh, Kenneth R Chapman, Marc Decramer, Donald A Mahler, Jadwiga A Wedzicha
The concept of a minimal clinically important difference (MCID) is well established. Here, we review the evidence base and methods used to define MCIDs as well as their strengths and limitations. Most MCIDs in chronic obstructive pulmonary disease (COPD) are empirically derived estimates applying to populations of patients. Validated MCIDs are available for many commonly used outcomes in COPD, including lung function (100 ml for trough FEV1), dyspnea (improvement of ≥ 1 unit in the Transition Dyspnea Index total score or 5 units in the University of California, San Diego Shortness of Breath Questionnaire), health status (reduction of 4 units in the St George's Respiratory Questionnaire total score), and exercise capacity (47...
February 1, 2014: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26183298/strengths-and-limitations-of-industry-vs-academic-randomized-controlled-trials
#3
REVIEW
P-F Laterre, B François
Clinical research has evolved substantially over the last two decades, but industry-sponsored research is still substantially superior to academic research in preparing, organizing and monitoring studies. Academics have to realize that conducting clinical research has become a real job with professionalism requirements. The primary objectives of research and development clearly differ between industry and academics. In the first case, new drug development is expected to generate profit, whereas in the latter case, research is aimed at understanding mechanisms of disease, promoting evidence-based medicine, and improving public health and care...
October 2015: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/26203354/the-whole-truth-and-nothing-but-the-truth-the-need-for-full-reporting-of-randomised-trials
#4
Rupert M Pearse
The use of cardiac output monitoring to guide fluid and inotropic therapy in surgical patients has remained a controversial topic for more than 40 years. The reasons for this are numerous and complex, but key amongst them is the interplay between poor research methodology and the likely selective reporting of randomised trials. In this issue of Perioperative Medicine, we find a very unusual report, one which describes a randomised trial stopped for futility after the recruitment of only a small proportion of the target patient sample (Jammer et al...
2015: Perioperative Medicine
https://www.readbyqxmd.com/read/26092289/research-and-clinical-practice-how-to-better-answer-the-needs-of-patient-care
#5
COMMENT
Chris van Weel
This article analyzes the translation of research to clinical practice. Clinical practice is focused on a concrete context in which patients are encountered. This follows from the population under care in terms of their health status, socioeconomic circumstances, cultural and religious features, and social determinants of health but also from the actual function in which the encounter between patient and professional takes place. An understanding of this contextual complexity is as important in the translation of research into practice, as is an understanding of research...
October 2015: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/26132938/placebo-effects-in-medicine
#6
Ted J Kaptchuk, Franklin G Miller
Placebo effects are often considered the effects of an "inert substance," but that characterization is misleading. In a broad sense, placebo effects are improvements in patients' symptoms that are attributable to their participation in the therapeutic encounter, with its rituals, symbols, and..
July 2, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26113127/risk-and-regulation-in-research
#7
Julian Savulescu
No abstract text is available yet for this article.
July 2015: Journal of Medical Ethics
https://www.readbyqxmd.com/read/26096984/editorial-statement-on-negative-findings
#8
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 2015: Journal of Health Economics
https://www.readbyqxmd.com/read/26093842/a-guideline-for-reviewing-a-clinical-research-paper
#9
Lyndon V Hernandez, Lauren B Gerson
No abstract text is available yet for this article.
August 2015: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/25883410/participants-understanding-of-informed-consent-in-clinical-trials-over-three-decades-systematic-review-and-meta-analysis
#10
REVIEW
Nguyen Thanh Tam, Nguyen Tien Huy, Le Thi Bich Thoa, Nguyen Phuoc Long, Nguyen Thi Huyen Trang, Kenji Hirayama, Juntra Karbwang
OBJECTIVE: To estimate the proportion of participants in clinical trials who understand different components of informed consent. METHODS: Relevant studies were identified by a systematic review of PubMed, Scopus and Google Scholar and by manually reviewing reference lists for publications up to October 2013. A meta-analysis of study results was performed using a random-effects model to take account of heterogeneity. FINDINGS: The analysis included 103 studies evaluating 135 cohorts of participants...
March 1, 2015: Bulletin of the World Health Organization
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"