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By Kyla L Yett Vitiligo Study.
Hermes Taylor-Weiner, Joshua Graff Zivin
In recent decades, there has been tremendous hope that stem-cell–based technologies would introduce a new era of regenerative medicine, revolutionizing the treatment of disease. These hopes have been stoked by reports that often emphasize promising findings without adequately acknowledging the many..
September 10, 2015: New England Journal of Medicine
Padmaja Kunapuli, Robert Somerville, Ivan H Still, John K Cowell
A highly specific t(8;13)(p11;q12) translocation has been consistently identified in bone marrow cells from patients with an atypical myeloproliferative disease that is associated with peripheral blood eosinophila and T- or B-cell leukemias. In all patients analysed to date, the translocation event results in a chimeric gene in which the atypical zinc-finger domain of ZNF198 is fused to the N-terminal end of the catalytic domain of the FGFR1 receptor tyrosine kinase. To understand more about the consequences of this rearrangement we have investigated the normal function of the ZNF198 gene...
May 29, 2003: Oncogene
E David Litwack, Elizabeth Mansfield, Jeffrey Shuren
To the Editor: Evans et al. express concern about the potential of Food and Drug Administration (FDA) premarket review to stifle genomic testing in the United States. Although we agree with several of their points, we disagree that the FDA will chill innovation because it lacks the correct set of..
June 4, 2015: New England Journal of Medicine
Robert C Green, Denise Lautenbach, Amy L McGuire
In 2008, after 13 years of advocacy by the genetics community and U.S. lawmakers, the Genetic Information Nondiscrimination Act (GINA) was signed into law. GINA is the first U.S. federal antidiscrimination statute crafted to address an area where there was no well-documented history of widespread..
January 29, 2015: New England Journal of Medicine
Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F Urban, Thomas A Wynn, William C Gause
Helminths induce potent T helper 2 (TH2)-type immune responses that can mediate worm expulsion, but the role of this response in controlling the acute tissue damage caused by migrating multicellular parasites through vital tissues remains uncertain. We used a helminth infection model in which parasitic nematode larvae migrate transiently through the lung, resulting in hemorrhage and inflammation. We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage...
February 2012: Nature Medicine
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