collection
MENU ▼
Read by QxMD icon Read
search

GBM

shared collection
20 papers 0 to 25 followers
https://www.readbyqxmd.com/read/24981259/brain-cancer-intratumoural-heterogeneity-in-primary-glioblastoma
#1
(no author information available yet)
No abstract text is available yet for this article.
August 2014: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/2720563/prognostic-factors-and-results-of-therapy-for-adult-thalamic-and-brainstem-tumors
#2
P W Grigsby, D M Garcia, J R Simpson, B B Fineberg, H G Schwartz
This report is a retrospective analysis of 83 adults (greater than 16 years of age) with histologically proven or presumed primary neoplasms of the thalamus, hypothalamus, midbrain, pons, and medulla. Patients were treated with combined surgery and postoperative irradiation or with irradiation alone at the Washington University Medical Center (St. Louis, MO) from January 1950 through December 1984. Histologic analysis confirmed the diagnosis of tumor in 21, including nine with well-differentiated astrocytoma, four with astrocytoma with anaplasia, and eight with glioblastoma multiforme...
June 1, 1989: Cancer
https://www.readbyqxmd.com/read/9202774/thalamic-gliomas-a-clinicopathologic-analysis-of-20-cases-with-reference-to-patient-age
#3
S Nishio, T Morioka, S Suzuki, I Takeshita, M Fukui
Twenty patients (M 11, F9; ranging from 1-77 years old) with histologically proven glial tumours in the thalamic region, treated from 1979 until 1994 at Kyushu University Hospital were retrospectively reviewed and analysed in order to elucidate their clinical and neuropathological characteristics. The initial common clinical manifestations were those of increased intracranial pressure or motor weakness. The histological diagnosis of the tumour was pilocytic astrocytoma in 2 patients, fibrillary astrocytoma in 7, anaplastic astrocytoma in 7, and glioblastoma multiforme in 4...
1997: Acta Neurochirurgica
https://www.readbyqxmd.com/read/2984910/surgical-approach-to-large-thalamic-gliomas
#4
B Prakash
Fifteen cases of large thalamic gliomas were treated by laser surgery and CUSA under X8 magnification and subsequently they were subjected to radiotherapy. More than 50% of the tumours were located in the dominant hemisphere and therefore an interhemispheric approach was carried out to avoid disturbances of speech and field defects. Nine patients had astrocytomas grade II and the remaining six had astrocytomas grades III-IV. The quality and survival has been gratifying in the less malignant gliomas. The operative technique and use of Laser and CUSA is highlighted...
1985: Acta Neurochirurgica
https://www.readbyqxmd.com/read/11214625/thalamic-astrocytomas-surgical-anatomy-and-results-of-a-pilot-series-using-maximum-microsurgical-removal
#5
H J Steiger, C Götz, R Schmid-Elsaesser, W Stummer
Deep-seated astrocytomas within the basal ganglia and the thalamus are considered unfavourable for microsurgical removal since the circumferential neighbourhood of critical structures limits radical resection. On closer assessment, the thalamus has a unique configuration within the basal ganglia. Its tetrahedric shape has 3 free surfaces and only the ventrolateral border is in contact with vital and critical functional structures, e.g. the subthalamic nuclei and the internal capsule. The purpose of the present study was to investigate the feasibility of maximum microsurgical removal in a series of intrinsic thalamic astrocytomas...
2000: Acta Neurochirurgica
https://www.readbyqxmd.com/read/2537807/multivariate-analysis-of-prognostic-factors-in-pediatric-and-adult-thalamic-and-brainstem-tumors
#6
P W Grigsby, P R Thomas, H G Schwartz, B B Fineberg
A multivariate analysis of prognostic variables was performed on a retrospective review of 136 patients with presumed or histologically proven primary lesions of the thalamus and brainstem treated by combined surgery and post-operative irradiation or by irradiation alone from January 1950 through December 1983. Overall survival for all patients at 5 and 10 years was 34.4 and 27.8%, respectively. Follow-up of 33 living patients ranged from 3 to 22 years. Prognostic variables analyzed by univariate analysis and found to be of significance (p less than 0...
March 1989: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/16951965/thalamic-gliomas-in-children-an-extensive-clinical-neuroradiological-and-pathological-study-of-14-cases
#7
Carla Fernandez, André Maues de Paula, Carole Colin, Benoît Quilichini, Corinne Bouvier-Labit, Nadine Girard, Didier Scavarda, Gabriel Lena, Dominique Figarella-Branger
OBJECT: Thalamic tumors represent only 1 to 5% of brain neoplasms but frequently affect children. However, pediatric series are rare and go back to several years in spite of recent advances in the neuroradiological, pathological, and molecular fields. METHODS: We report a series of 14 pediatric thalamic gliomas with clinical, neuroradiological, and pathological studies including p53 immunostaining in 11 cases and 1p19q status in three cases. RESULTS: Our series included five pilocytic astrocytomas, seven oligodendrogliomas, and two glioblastomas...
December 2006: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/24285547/h3f3a-k27m-mutations-in-thalamic-gliomas-from-young-adult-patients
#8
Koki Aihara, Akitake Mukasa, Kengo Gotoh, Kuniaki Saito, Genta Nagae, Shingo Tsuji, Kenji Tatsuno, Shogo Yamamoto, Shunsaku Takayanagi, Yoshitaka Narita, Soichiro Shibui, Hiroyuki Aburatani, Nobuhito Saito
INTRODUCTION: Mutations in H3F3A, which encodes histone H3.3, commonly occur in pediatric glioblastoma. Additionally, H3F3A K27M substitutions occur in gliomas that arise at midline locations (eg, pons, thalamus, spine); moreover, this substitution occurs mainly in tumors in children and adolescents. Here, we sought to determine the association between H3F3A mutations and adult thalamic glioma. METHODS: Genomic H3F3A was sequenced from 20 separate thalamic gliomas...
January 2014: Neuro-oncology
https://www.readbyqxmd.com/read/27157931/the-2016-world-health-organization-classification-of-tumors-of-the-central-nervous-system-a-summary
#9
REVIEW
David N Louis, Arie Perry, Guido Reifenberger, Andreas von Deimling, Dominique Figarella-Branger, Webster K Cavenee, Hiroko Ohgaki, Otmar D Wiestler, Paul Kleihues, David W Ellison
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M-mutant; RELA fusion-positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumour with multilayered rosettes, C19MC-altered...
June 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/26830009/therapeutic-options-in-recurrent-glioblastoma-an-update
#10
REVIEW
Katharina Seystahl, Wolfgang Wick, Michael Weller
INTRODUCTION: Standards of care are not yet defined in recurrent glioblastoma. METHODS: We reviewed the literature on clinical trials for recurrent glioblastoma available in PubMed and American Society of Clinical Oncology (ASCO) abstracts until June 2015. RESULTS: Evidence is limited due to the paucity of randomized controlled studies. Second surgery or re-irradiation are options for selected patients. Alkylating chemotherapy such as nitrosoureas or temozolomide and the vascular endothelial growth factor (VEGF) antibody, bevacizumab, exhibit comparable single agent activity...
March 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26851183/immunotherapy-and-oncogenic-pathways-the-pten-connection
#11
Naiyer A Rizvi, Timothy A Chan
Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma. These results shed light on the intricate interplay between oncogenic pathways and antitumor immune response.
February 2016: Cancer Discovery
https://www.readbyqxmd.com/read/26573230/transmembrane-protein-cd9-is-glioblastoma-biomarker-relevant-for-maintenance-of-glioblastoma-stem-cells
#12
Neža Podergajs, Helena Motaln, Uroš Rajčević, Urška Verbovšek, Marjan Koršič, Nina Obad, Heidi Espedal, Miloš Vittori, Christel Herold-Mende, Hrvoje Miletic, Rolf Bjerkvig, Tamara Lah Turnšek
The cancer stem cell model suggests that glioblastomas contain a subpopulation of stem-like tumor cells that reproduce themselves to sustain tumor growth. Targeting these cells thus represents a novel treatment strategy and therefore more specific markers that characterize glioblastoma stem cells need to be identified. In the present study, we performed transcriptomic analysis of glioblastoma tissues compared to normal brain tissues revealing sensible up-regulation of CD9 gene. CD9 encodes the transmembrane protein tetraspanin which is involved in tumor cell invasion, apoptosis and resistance to chemotherapy...
January 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/26552043/commentary-combining-5-aminolevulinic-acid-fluorescence-and-intraoperative-magnetic-resonance-imaging-in-glioblastoma-surgery-a-histology-based-evaluation
#13
COMMENT
https://www.readbyqxmd.com/read/15325097/molecular-genetic-analysis-of-deep-seated-glioblastomas
#14
REVIEW
Yutaka Hayashi, Junkoh Yamashita, Takuya Watanabe
Glioblastoma can be divided into genetic subsets. The most prominent criterion for dividing glioblastomas into subsets is the dichotomy between TP53 mutation and EGFR amplification, two genetic alterations that almost never coincide in the same tumor. Approximately one third of glioblastomas have TP53 mutations, one third have EGFR amplification, and one third have neither. When viewed in terms of tumor progression, secondary glioblastomas have a much higher incidence of TP53 mutations than do primary glioblastomas...
August 2004: Cancer Genetics and Cytogenetics
https://www.readbyqxmd.com/read/25728810/high-grade-astrocytoma-glioblastoma-multiforme-in-an-atlantic-spotted-dolphin-stenella-frontalis
#15
J Díaz-Delgado, S Sacchini, A Suárez-Bonnet, E Sierra, M Arbelo, A Espinosa, E Rodríguez-Grau Bassas, B Mompeo, L Pérez, A Fernández
This report describes the gross, microscopical and immunohistochemical features of a high-grade astrocytoma (glioblastoma multiforme) in an adult male Atlantic spotted dolphin (Stenella frontalis). On necropsy examination, a 5 × 2.5 × 2 cm, poorly demarcated, red, friable and locally expansile mass effaced the thalamus and the left periventricular region and extended to the left lateral ventricle of the brain. Microscopically, the mass consisted of haphazardly arranged bundles and rows of interweaving polygonal to spindle-shaped cells...
February 2015: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/25895711/immunobiology-and-immunotherapeutic-targeting-of-glioma-stem-cells
#16
REVIEW
Mecca Madany, Tom M Thomas, Lincoln Edwards, John S Yu
For decades human brain tumors have confounded our efforts to effectively manage and treat patients. In adults, glioblastoma multiforme is the most common malignant brain tumor with a patient survival of just over 14 months. In children, brain tumors are the leading cause of solid tumor cancer death and gliomas account for one-fifth of all childhood cancers. Despite advances in conventional treatments such as surgical resection, radiotherapy, and systemic chemotherapy, the incidence and mortality rates for gliomas have essentially stayed the same...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25895710/chemoresistance-and-chemotherapy-targeting-stem-like-cells-in-malignant-glioma
#17
REVIEW
Mia Dahl Sørensen, Sigurd Fosmark, Sofie Hellwege, Dagmar Beier, Bjarne Winther Kristensen, Christoph Patrick Beier
Glioblastoma remains a tumor with a dismal prognosis because of failure of current treatment. Glioblastoma cells with stem cell (GSC) properties survive chemotherapy and give rise to tumor recurrences that invariably result in the death of the patients. Here we summarize the current knowledge on chemoresistance of malignant glioma with a strong focus on GSC. Chemoresistant GSC are the most likely cause of tumor recurrence, but it remains controversial if GSC and under which conditions GSC are more chemoresistant than non-GSC within the tumor...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25886608/peritumoral-edema-shown-by-mri-predicts-poor-clinical-outcome-in-glioblastoma
#18
Chen-Xing Wu, Guo-Shi Lin, Zhi-Xiong Lin, Jian-Dong Zhang, Shui-Yuan Liu, Chang-Fu Zhou
BACKGROUND: Magnetic resonance imaging (MRI) plays an irreplaceable role in the preoperative diagnosis of glioma, and its imaging features are the base of making treatment decisions in patients with glioma, but it is still controversial whether peritumoral edema shown by MRI from preoperative routine scans are associated with patient survival. The aim of this study was to assess the prognostic value of preoperative MRI features in patients with glioblastoma. METHODS: A retrospective review of 87 patients with newly diagnosed supratentorial glioblastoma was performed using medical records and MRI data from routine scans...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25885250/adult-classical-glioblastoma-with-a-braf-v600e-mutation
#19
Yoshinobu Takahashi, Toshiaki Akahane, Takahiro Sawada, Hidetoshi Ikeda, Akira Tempaku, Shigeru Yamauchi, Hiroshi Nishihara, Shinya Tanaka, Kazumi Nitta, Wataru Ide, Ikuo Hashimoto, Hajime Kamada
The B-Raf proto-oncogene serine/threonine kinase (B-Raf) is a member of the Raf kinase family. The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma, ganglioglioma, and pilocytic astrocytoma, and less frequently in epithelioid and giant cell glioblastoma. BRAF V600E mutation in these cases has been canonically detected using Sanger sequencing or immunohistochemistry but not with next-generation sequencing (NGS). Moreover, to our knowledge, there is no detailed report of the BRAF V600E mutation in an adult glioblastoma with classical histologic features (c-GBM)...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25731774/identification-and-functional-prediction-of-mitochondrial-complex-iii-and-iv-mutations-associated-with-glioblastoma
#20
Rhiannon E Lloyd, Kathleen Keatley, D Timothy J Littlewood, Brigitte Meunier, William V Holt, Qian An, Samantha C Higgins, Stavros Polyzoidis, Katie F Stephenson, Keyoumars Ashkan, Helen L Fillmore, Geoffrey J Pilkington, John E McGeehan
BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment is hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how mitochondrial DNA (mtDNA) mutations contribute to GBM biology and therapeutic response remains poorly described. We sought to determine the spectrum of functional complex III and IV mtDNA mutations in GBM. METHODS: The complete mitochondrial genomes of 10 GBM cell lines were obtained using next-generation sequencing and combined with another set obtained from 32 GBM tissues...
July 2015: Neuro-oncology
label_collection
label_collection
4724
1
2
2015-05-31 06:16:20
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"