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Single Ventricle Trials

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3 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26396116/outcomes-in-patients-with-persistent-ventricular-dysfunction-after-stage-i-palliation-for-hypoplastic-left-heart-syndrome
#1
Emilie Jean-St-Michel, Devin Chetan, Steven M Schwartz, Glen S Van Arsdell, Alejandro A Floh, Osami Honjo, Jennifer Conway
We sought to describe the clinical course for patients with hypoplastic left heart syndrome and persistent ventricular dysfunction and identify risk factors for death or transplantation before stage II palliation. 138 children undergoing stage I palliation from 2004 to 2011 were reviewed. Twenty-two (16 %) patients (seven Hybrid, 15 Norwood) with two consecutive echocardiograms reporting at least moderate dysfunction were included and compared to case-matched controls. Eleven of the 22 patients with dysfunction (50 %) underwent stage II, seven (32 %) were transplanted, and four (18 %) died prior to stage II...
February 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/21798429/a-multicenter-randomized-trial-comparing-heparin-warfarin-and-acetylsalicylic-acid-as-primary-thromboprophylaxis-for-2-years-after-the-fontan-procedure-in-children
#2
RANDOMIZED CONTROLLED TRIAL
Paul Monagle, Andrew Cochrane, Robin Roberts, Cedric Manlhiot, Robert Weintraub, Barbara Szechtman, Marina Hughes, Maureen Andrew, Brian W McCrindle
OBJECTIVES: The purpose of this study was to compare the safety and efficacy of acetylsalicylic acid (ASA) and warfarin for thromboprophylaxis after the Fontan procedure. BACKGROUND: Fontan surgery is the definitive palliation for children with single-ventricle physiology. Thrombosis is an important complication; the optimal thromboprophylaxis strategy has not been determined. METHODS: We performed a multicenter international randomized trial of primary prophylactic anticoagulation after Fontan surgery...
August 2, 2011: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/20625111/enalapril-in-infants-with-single-ventricle-results-of-a-multicenter-randomized-trial
#3
RANDOMIZED CONTROLLED TRIAL
Daphne T Hsu, Victor Zak, Lynn Mahony, Lynn A Sleeper, Andrew M Atz, Jami C Levine, Piers C Barker, Chitra Ravishankar, Brian W McCrindle, Richard V Williams, Karen Altmann, Nancy S Ghanayem, Renee Margossian, Wendy K Chung, William L Border, Gail D Pearson, Mario P Stylianou, Seema Mital
BACKGROUND: Angiotensin-converting enzyme inhibitor therapy improves clinical outcome and ventricular function in adults with heart failure. Infants with single-ventricle physiology have poor growth and are at risk for abnormalities in ventricular systolic and diastolic function. The ability of angiotensin-converting enzyme inhibitor therapy to preserve ventricular function and improve somatic growth and outcomes in these infants is unknown. METHODS AND RESULTS: The Pediatric Heart Network conducted a double-blind trial involving 230 infants with single-ventricle physiology randomized to receive enalapril (target dose 0...
July 27, 2010: Circulation
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