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Thirod function test within the normal range and risk of CHD death

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Bjørn O Åsvold, Lars J Vatten, Trine Bjøro, Douglas C Bauer, Alexandra Bremner, Anne R Cappola, Graziano Ceresini, Wendy P J den Elzen, Luigi Ferrucci, Oscar H Franco, Jayne A Franklyn, Jacobijn Gussekloo, Giorgio Iervasi, Misa Imaizumi, Patricia M Kearney, Kay-Tee Khaw, Rui M B Maciel, Anne B Newman, Robin P Peeters, Bruce M Psaty, Salman Razvi, José A Sgarbi, David J Stott, Stella Trompet, Mark P J Vanderpump, Henry Völzke, John P Walsh, Rudi G J Westendorp, Nicolas Rodondi
IMPORTANCE: Some experts suggest that serum thyrotropin levels in the upper part of the current reference range should be considered abnormal, an approach that would reclassify many individuals as having mild hypothyroidism. Health hazards associated with such thyrotropin levels are poorly documented, but conflicting evidence suggests that thyrotropin levels in the upper part of the reference range may be associated with an increased risk of coronary heart disease (CHD). OBJECTIVE: To assess the association between differences in thyroid function within the reference range and CHD risk...
June 2015: JAMA Internal Medicine
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