Kateřina Zdráhalová, Jaroslav Štěrba, Jiří Domanský, Bohumír Blažek, Hana Ptoszková, Vladimír Mihál, Zbyněk Novák, Jiří Hak, Daniela Procházková, Zdena Černá, Pavel Timr, Yahia Jabali, Petr Sedláček, Petr Smíšek, Zuzana Zemanová, Marie Jarošová, Alena Houdková, Ester Mejstříková, Ondřej Hrušák, Jan Zuna, Iveta Janotová, Jan Trka, Jan Starý
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most frequent childhood malignancy. Treatment has been unified in the middle of 1980 in the Czech Republic. In 2002-2007 children and adolescents with acute lymphoblastic leukemia were treated in an international randomized trial ALL-IC BFM 2002 in the Czech Republic. 291 patients aged 1-18 years were enrolled; infants below 1 year entered a separate trial. METHODS AND RESULTS: Patients were stratified into three risk groups according to their age, initial leukocyte count, prednisone response, presence of fusion genes BCR/ABL or MLL/AF4, bone marrow D+15 and remission status D+33...
2015: Casopís Lékar̆ů C̆eských