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49 papers 25 to 100 followers Centered on para-clinic ways of diagnosis or follow up
By Mohammad Mahdi Salem Otolaryngologist and head and neck surgen
Amber M Leaver, Anna Seydell-Greenwald, Josef P Rauschecker
Tinnitus is a widespread auditory disorder affecting approximately 10-15% of the population, often with debilitating consequences. Although tinnitus commonly begins with damage to the auditory system due to loud-noise exposure, aging, or other etiologies, the exact neurophysiological basis of chronic tinnitus remains unknown. Many researchers point to a central auditory origin of tinnitus; however, a growing body of evidence also implicates other brain regions, including the limbic system. Correspondingly, we and others have proposed models of tinnitus in which the limbic and auditory systems both play critical roles and interact with one another...
April 2016: Hearing Research
G D Searchfield, K Kobayashi, K Proudfoot, H Tevoitdale, S Irving
BACKGROUND: A software-based method for assessing and tinnitus in three-dimensional (3D) 'virtual' auditory space is described and tested. NEW METHOD: Phase I was a proof-of-concept evaluation of tinnitus localization in the horizontal plane in 19 participants. Phase II assessed the reliability of software developed from phase I findings in 34 participants. The software used interaural timing and level differences and an average Head Related Transfer Function (HRTF) to match tinnitus in the horizontal and vertical plane...
December 30, 2015: Journal of Neuroscience Methods
Dirk De Ridder, Kathleen Joos, Sven Vanneste
Tinnitus can be distressful, and tinnitus distress has been linked to increased beta oscillatory activity in the dorsal anterior cingulate cortex (dACC). The amount of distress is linked to alpha activity in the medial temporal lobe (amygdala and parahippocampal area), as well as the subgenual (sg)ACC and insula, and the functional connectivity between the parahippocampal area and the sgACC at 10 and 11.5 Hz. The authors describe 2 patients with very severely distressing intractable tinnitus who underwent transcranial magnetic stimulation (TMS) with a double-cone coil targeting the dACC and subsequent implantation of electrodes on the dACC...
April 2016: Journal of Neurosurgery
Chul Won Yang, Junyang Jung, Sang Hoon Kim, Jae Yong Byun, Moon Suh Park, Seung Geun Yeo
CONCLUSION: Discomfort from bilateral tinnitus was more frequent and severe than that from unilateral tinnitus. Also, patients with bilateral tinnitus were significantly older and tended to have a longer duration of tinnitus than those with unilateral tinnitus. Background and subjects: Although bilateral tinnitus differs from unilateral tinnitus, their treatment is identical. Clinical characteristics associated with tinnitus, including tinnitograms, were retrospectively examined in 105 patients with unilateral tinnitus and 102 with bilateral tinnitus evaluated in the center between January 2012 and January 2014...
2015: Acta Oto-laryngologica
Calvin Wu, David T Martel, Susan E Shore
The cochlear nucleus (CN) is the first site of multisensory integration in the ascending auditory pathway. The principal output neurons of the dorsal cochlear nucleus (DCN), fusiform cells, receive somatosensory information relayed by the CN granule cells from the trigeminal and dorsal column pathways. Integration of somatosensory and auditory inputs results in long-term enhancement or suppression in a stimulus-timing-dependent manner. Here, we demonstrate that stimulus-timing-dependent plasticity (STDP) can be induced in DCN fusiform cells using paired auditory and transcutaneous electrical stimulation of the face and neck to activate trigeminal and dorsal column pathways to the CN, respectively...
2015: Frontiers in Systems Neuroscience
Takashi Ueyama, Tomohiro Donishi, Satoshi Ukai, Yuta Yamamoto, Takuya Ishida, Shunji Tamagawa, Muneki Hotomi, Kazuhiro Shinosaki, Noboru Yamanaka, Yoshiki Kaneoke
Tinnitus is the perception of phantom sound without an external auditory stimulus. Using neuroimaging techniques, such as positron emission tomography, electroencephalography, magnetoencephalography, and functional magnetic resonance imaging (fMRI), many studies have demonstrated that abnormal functions of the central nervous system are closely associated with tinnitus. In our previous research, we reported using resting-state fMRI that several brain regions, including the rectus gyrus, cingulate gyrus, thalamus, hippocampus, caudate, inferior temporal gyrus, cerebellar hemisphere, and medial superior frontal gyrus, were associated with tinnitus distress and loudness...
2015: PloS One
Rodney C Diaz
No abstract text is available yet for this article.
October 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
Natassja Pal, Raphael Maire, Marianne A Stephan, François R Herrmann, David H Benninger
BACKGROUND: Tinnitus is an often disabling condition for which there is no effective therapy. Current research suggests that tinnitus may develop due to maladaptive plastic changes and altered activity in the auditory and prefrontal cortex. Transcranial direct current stimulation (tDCS) modulates brain activity and has been shown to transiently suppress tinnitus in trials. OBJECTIVE: To investigate the efficacy and safety of tDCS in the treatment of chronic subjective tinnitus...
November 2015: Brain Stimulation
Michael D Seidman, Syed F Ahsan
PURPOSE OF REVIEW: The purpose of this review is to describe our experience with management of chronic tinnitus and to review the recent literature on the best treatment options available for treating patients who are troubled by their tinnitus. In addition, we want to highlight our experience and approach to this very common problem. RECENT FINDINGS: Treatment options for patients are based on the severity of the tinnitus and any associated problems. The use of nutritional supplements has a place in the treatment of mild-to-moderate tinnitus...
October 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
Fan-Gang Zeng, Hamid Djalilian, Harrison Lin
PURPOSE OF REVIEW: Electric stimulation is a potent means of neuromodulation that has been used to restore hearing and minimize tremor, but its application on tinnitus symptoms has been limited. We examine recent evidence to identify the knowledge gaps in the use of electric stimulation for tinnitus treatment. RECENT FINDINGS: Recent studies using electric stimulation to suppress tinnitus in humans are categorized according to their points of attacks. First, noninvasive, direct current stimulation uses an active electrode in the ear canal, tympanic membrane, or temporal scalp...
October 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
Kuo-Wei Wang, Hsiao-Huang Chang, Chuan-Chih Hsu, Kuang-Chao Chen, Jen-Chuen Hsieh, Lieber Po-Hung Li, Po-Lei Lee, An-Suey Shiao
BACKGROUND: Auditory steady-state response (ASSR) induced by repetitive auditory stimulus is commonly used for audiometric testing. ASSR can be measured using electro-encephalography (EEG) and magnetoencephalography (MEG), referred to as steady-state auditory evoked potential (SSAEP) and steady-state auditory evoked field (SSAEF), respectively. However, the signal level of SSAEP and SSAEF are weak so that signal processing technique is required to increase its signal-to-noise ratio. In this study, a complementary ensemble empirical mode decomposition (CEEMD)-based approach is proposed in MEG study and the extraction of SSAEF has been demonstrated in normal subjects and tinnitus patients...
2015: Biomedical Engineering Online
H Schaaf, G Hesse
BACKGROUND: Inpatient treatment of chronic complex tinnitus can be necessary for patients with a high symptomatic strain, mostly accompanied by a corresponding mental comorbidity, and/or for patients that can only perceive their psychogenic suffering through somatization into tinnitus. METHODS: We report the results of 368 consecutively treated inpatients with chronic complex tinnitus. Patients' audiometric data were collected, and at the beginning and end of treatment, the Mini-Tinnitus Questionnaire (Mini-TQ12; Hiller und Goebel) was completed, as was the German version of the Hospitality Anxiety and Depression Score (HADS)...
August 2015: HNO
Francesco Martines, Antonella Ballacchino, Federico Sireci, Marianna Mucia, Eleonora La Mattina, Serena Rizzo, Pietro Salvago
The objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS; we compared the audiologic profile with the severity of OSAS to detect early signs of cochlear damage. One hundred-sixty patients underwent overnight polysomnography, micro-otoscopy, multi-frequency audiometry, acufenometry, TEOAE recording and d-ROMs test. All subjects were divided in four groups, based on presence/absence of AHI (simple snoring without OSAS, mild OSAS, moderate OSAS, severe OSAS)...
June 2016: European Archives of Oto-rhino-laryngology
Hannah Brotherton, Christopher J Plack, Michael Maslin, Roland Schaette, Kevin J Munro
Naturally occurring stimuli can vary over several orders of magnitude and may exceed the dynamic range of sensory neurons. As a result, sensory systems adapt their sensitivity by changing their responsiveness or 'gain'. While many peripheral adaptation processes are rapid, slow adaptation processes have been observed in response to sensory deprivation or elevated stimulation. This adaptation process alters neural gain in order to adjust the basic operating point of sensory processing. In the auditory system, abnormally high neural gain may result in higher spontaneous and/or stimulus-evoked neural firing rates, and this may have the unintended consequence of presenting as tinnitus and/or sound intolerance, respectively...
2015: Audiology & Neuro-otology
Anchun Deng, Xiaojun Liang, Yuchen Sun, Yanghong Xiang, Junjie Yang, Jingjing Yan, Wei Sun
CONCLUSION: Scopolamine, a tropane alkaloid drug that mainly acts as an antagonist of muscarinic acetylcholine receptors, was found to reduce the local field potentials (LFP) of auditory cortex (AC) evoked by tone and gap-offsets whose effects may compensate the cortical hyperexcitability related to tinnitus. OBJECTIVE: To study the effects of scopolamine on the AC and the inferior colliculus (IC) of awake rats in order to understand scopolamine's effect on tinnitus and gap detection...
2015: Acta Oto-laryngologica
Patricia Simonetti, Jeanne Oiticica
Introduction Tinnitus is an abnormal perception of sound in the absence of an external stimulus. Chronic tinnitus usually has a high impact in many aspects of patients' lives, such as emotional stress, sleep disturbance, concentration difficulties, and so on. These strong reactions are usually attributed to central nervous system involvement. Neuroimaging has revealed the implication of brain structures in the auditory system. Objective This systematic review points out neuroimaging studies that contribute to identifying the structures involved in the pathophysiological mechanism of generation and persistence of various forms of tinnitus...
July 2015: International Archives of Otorhinolaryngology
Joo Hyun Park, Tae-Soo Noh, Jun Ho Lee, Seung-Ha Oh, June Sic Kim, Chun Kee Chung, Myung-Whan Suh
OBJECTIVE: We aimed to compare the treatment result between 6,000 and 12,000 pulses of low-frequency repetitive transcranial magnetic stimulation (rTMS) and to evaluate the correct location of rTMS in Korean brains compared with that of Caucasians. STUDY DESIGN: Controlled trial. SETTING: Tertiary referral center. PATIENTS: Fourteen patients with chronic essential tinnitus were treated with rTMS on the left auditory cortex (AC) and prefrontal cortex (FC)...
September 2015: Otology & Neurotology
Hanna Sahlsten, Johan Isohanni, Jorma Haapaniemi, Jaakko Salonen, Janika Paavola, Eliisa Löyttyniemi, Reijo Johansson, Satu K Jääskeläinen
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has shown potential in reducing tinnitus symptoms. We evaluated effects of electric field (E-field) navigated rTMS targeted neuroanatomically according to tinnitus pitch. DESIGN: In this open methodological pilot study, the patients received E-field navigated 1-Hz rTMS in daily treatment sessions to the left superior temporal gyrus, targeted according to tonotopic representation of their individual tinnitus pitch...
2015: International Journal of Audiology
Philippe Lavigne, François Lavigne, Issam Saliba
The objective of the study was to determine the evidence of intratympanic steroids injections (ITSI) for efficacy in the management of the following inner ear diseases: Ménière's disease, tinnitus, noise-induced hearing loss (NIHL) and idiopathic sudden sensorineural hearing loss (ISSNHL). The data sources were literature review from 1946 to December 2014, PubMed and Medline. A systematic review of the existing literature was performed. Databases were searched for all human prospective randomized clinical trials using ITSI in at least one treatment group...
September 2016: European Archives of Oto-rhino-laryngology
Dirk De Ridder, Sven Vanneste, Berthold Langguth, Rodolfo Llinas
Tinnitus is the perception of a sound in the absence of a corresponding external sound source. Pathophysiologically it has been attributed to bottom-up deafferentation and/or top-down noise-cancelling deficit. Both mechanisms are proposed to alter auditory -thalamocortical signal transmission, resulting in thalamocortical dysrhythmia (TCD). In deafferentation, TCD is characterized by a slowing down of resting state alpha to theta activity associated with an increase in surrounding gamma activity, resulting in persisting cross-frequency coupling between theta and gamma activity...
2015: Frontiers in Neurology
2015-06-26 13:28:15
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