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By Maryd Almaradh Intrested things that could help sick people and difficult cases management
Pooja Ghatalia, Youjin Je, Paul L Nguyen, Quoc-Dien Trinh, Toni K Choueiri, Guru Sonpavde
A trial-level meta-analysis of randomized phase II/III controlled trials in renal cell carcinoma (RCC) and other malignancies was conducted to systematically determine the relative risk (RR) of fatigue, a common side effect associated with single agent therapy with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) and mammalian target of rapamycin inhibitors (mTORi). The RR of all grade fatigue and high grade fatigue in 7304 patients from 19 trials was 1.35 (95% CI 1.22-1...
August 2015: Critical Reviews in Oncology/hematology
Qian Wang-Lopez, Nassera Chalabi, Catherine Abrial, Nina Radosevic-Robin, Xavier Durando, Marie-Ange Mouret-Reynier, Kheir-Eddine Benmammar, Sharif Kullab, Mohun Bahadoor, Philippe Chollet, Frédérique Penault-Llorca, Jean-Marc Nabholtz
Breast cancer is heterogeneous in clinical, morphological, immunohistochemical and biological features, as reflected by several different prognostic subgroups. Neoadjuvant approaches are currently used for the "in vivo" efficacy assessment of treatments. Pathological complete response (pCR) has been reported as a reliable predictive factor of survival in that setting. However, pCR remains a subject of controversy in terms of definition and its evaluation methods. In addition, its predictive value for patient outcome in various breast cancer biological subtypes has been under debate...
July 2015: Critical Reviews in Oncology/hematology
Artrish Jefferson, Valerie E Cadet, Abigail Hielscher
The use of oncolytic viruses for the treatment of cancer is an emerging field of cancer research and therapy. Oncolytic viruses are designed to induce tumor specific immunity while replicating selectively within cancer cells to cause lysis of the tumor cells. While there are several forms of oncolytic viruses, the use of vaccinia viruses for oncolysis may be more beneficial than other forms of oncolytic viruses. For example, vaccinia viruses have been shown to exert their anti-tumor effects through genetic engineering strategies which enhance their therapeutic efficacy...
September 2015: Critical Reviews in Oncology/hematology
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