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Pancreatic adenoca. Highlights.

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17 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27770346/long-term-outcomes-of-98-surgically-resected-metastatic-tumors-in-the-pancreas
#1
Shin-Rong Lee, Georgios Gemenetzis, Michol Cooper, Ammar A Javed, John L Cameron, Christopher L Wolfgang, Frederick E Eckhauser, Jin He, Matthew J Weiss
PURPOSE: The goal of this study was to assess the outcomes and characteristics of patients who underwent pancreatectomy for metastatic disease to the pancreas. METHODS: Patients who underwent surgical resection of metastatic disease to the pancreas from 1988 to 2016 were identified using a prospectively maintained database. Data on clinicopathological features and outcomes of these patients were analyzed. Cox proportional hazard models were employed to identify patient-specific risk factors that influence survival...
October 21, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27013374/pancreatic-neoplasms
#2
Nicholas J Petrelli
No abstract text is available yet for this article.
April 2016: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27049786/carbohydrate-antigen-19-9-elevation-in-anatomically-resectable-early-stage-pancreatic-cancer-is-independently-associated-with-decreased-overall-survival-and-an-indication-for-neoadjuvant-therapy-a-national-cancer-database-study
#3
John R Bergquist, Carlos A Puig, Christopher R Shubert, Ryan T Groeschl, Elizabeth B Habermann, Michael L Kendrick, David M Nagorney, Rory L Smoot, Michael B Farnell, Mark J Truty
BACKGROUND: Patient triage in anatomically resectable, early stage pancreatic ductal adenocarcinoma (PDAC) with elevated carbohydrate antigen 19-9 (CA 19-9) remains unclear. We hypothesized that any CA 19-9 elevation indicates biologically borderline resectability. STUDY DESIGN: The National Cancer Data Base (NCDB 2010 to 2012) was reviewed for PDAC patients with reported CA 19-9. Nonsecretors were analyzed separately. Early stage (I/II) patients were stratified by CA 19-9 above or below normal (37 U/mL)...
July 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26923296/pancreatic-adenocarcinoma
#4
REVIEW
Mariam F Eskander, Lindsay A Bliss, Jennifer F Tseng
No abstract text is available yet for this article.
March 2016: Current Problems in Surgery
https://www.readbyqxmd.com/read/27048934/synchronous-resections-of-hepatic-oligometastatic-pancreatic-cancer-disputing-a-principle-in-a-time-of-safe-pancreatic-operations-in-a-retrospective-multicenter-analysis
#5
Michael Tachezy, Florian Gebauer, Monika Janot, Waldemar Uhl, Alessandro Zerbi, Marco Montorsi, Julie Perinel, Mustapha Adham, Christos Dervenis, Christos Agalianos, Giuseppe Malleo, Laura Maggino, Alexander Stein, Jakob R Izbicki, Maximilian Bockhorn
BACKGROUND: The prognosis of patients with liver metastasis is generally considered dismal, and combined resections of the primary tumor and metastasectomies are not recommended. In highly selected patients, however, resections are performed. The evidence for this indication is limited. The aim of the current study was to assess the operative and oncologic outcomes of patients with combined pancreatic and liver resections of synchronous liver metastases. METHODS: In a retrospective analysis of 6 European pancreas centers, we identified 69 patients with pancreatic ductal adenocarcinoma and synchronous liver metastasis who underwent simultaneous pancreas and liver metastasis resections...
July 2016: Surgery
https://www.readbyqxmd.com/read/26751142/which-is-the-best-surgical-approach-for-the-pancreatic-cancer-a-classification-of-pancreatic-cancer-to-guide-operative-decisions-is-needed
#6
Min Wang, Feng Zhu, Renyi Qin, Shuyou Peng
No abstract text is available yet for this article.
January 5, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/26663252/meta-analysis-of-benefits-of-portal-superior-mesenteric-vein-resection-in-pancreatic-resection-for-ductal-adenocarcinoma
#7
REVIEW
F Giovinazzo, G Turri, M H Katz, N Heaton, I Ahmed
BACKGROUND: Pancreatic ductal adenocarcinoma has a poor prognosis without surgery. No standard treatment has yet been accepted for patients with portal-superior mesenteric vein (PV-SMV) infiltration. The present meta-analysis aimed to compare the results of pancreatic resection with PV-SMV resection for suspected infiltration with the results of surgery without PV-SMV resection. METHODS: A systematic search was performed of PubMed, Embase and the Cochrane Library in accordance with PRISMA guidelines from the time of inception to 2013...
February 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26661409/outcomes-of-a-clinical-pathway-for-borderline-resectable-pancreatic-cancer
#8
Omar M Rashid, Jose M Pimiento, Andrew W Gamenthaler, Phuong Nguyen, Tin T Ha, Tai Hutchinson, Gregory Springett, Sarah Hoffe, Ravi Shridhar, Pamela J Hodul, Brad L Johnson, Karl Illig, Paul A Armstrong, Barbara A Centeno, William J Fulp, Dung-Tsa Chen, Mokenge P Malafa
BACKGROUND: Without prospective data establishing a consensus multimodality approach to borderline resectable pancreatic adenocarcinoma, institutional treatment regimens vary. This study investigated the outcomes of the clinical pathway at the author's institution, which consists of neoadjuvant gemcitabine, docetaxel, capecitabine, and stereotactic radiotherapy followed by surgery. METHODS: The study reviewed all cases that met the National Comprehensive Cancer Network (NCCN) diagnostic criteria for borderline resectable pancreatic adenocarcinoma from 1 January 2006, to 31 December 2013...
April 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26589594/original-scientific-reports-clinicopathological-findings-of-remnant-pancreatic-cancers-in-survivors-following-curative-resections-of-pancreatic-cancers
#9
Shuji Suzuki, Toru Furukawa, Nana Oshima, Wataru Izumo, Kyoko Shimizu, Masakazu Yamamoto
BACKGROUND: This retrospective study aimed to evaluate clinicopathological findings of remnant pancreatic cancers in survivors of invasive ductal adenocarcinomas of the pancreas (PDAC). METHODS: A group of 23 patients out of 826 who had curative resections for PDAC between 1980 and 2011 was identified and treated for metachronous pancreatic cancer. RESULTS: The following tubular adenocarcinomas were found at the first surgery: 3 well differentiated, 17 moderately differentiated, 1 papillary, and 1 poorly differentiated...
April 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26363649/multidisciplinary-management-of-locally-advanced-pancreatic-ductal-adenocarcinoma
#10
REVIEW
Farzad Alemi, Adnan Alseidi, W Scott Helton, Flavio G Rocha
No abstract text is available yet for this article.
September 2015: Current Problems in Surgery
https://www.readbyqxmd.com/read/26314780/cancer-of-the-pancreas-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#11
M Ducreux, A Sa Cuhna, C Caramella, A Hollebecque, P Burtin, D Goéré, T Seufferlein, K Haustermans, J L Van Laethem, T Conroy, D Arnold
No abstract text is available yet for this article.
September 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26153355/the-indolent-nature-of-pulmonary-metastases-from-ductal-adenocarcinoma-of-the-pancreas
#12
COMPARATIVE STUDY
Stephanie Downs-Canner, Mazen Zenati, Brian A Boone, Patrick R Varley, Jennifer Steve, Melissa E Hogg, Amer Zureikat, Herbert J Zeh, Kenneth K W Lee
BACKGROUND AND OBJECTIVES: The natural history of pulmonary metastases from pancreatic ductal adenocarcinoma (PDAC) is not well studied. Limited evidence suggests patients with isolated pulmonary metastases from PDAC follow a more benign clinical course than those with other sites of metastases. METHODS: We performed a retrospective review of all patients with pulmonary metastases from PDAC from 2000 to 2010 and analyzed survival utilizing the Kaplan-Meier method based upon location of first metastasis (lung first, intra-abdominal first, or synchronous intra-abdominal and lung metastases)...
July 2015: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26062046/characteristics-of-10-year-survivors-of-pancreatic-ductal-adenocarcinoma
#13
Alessandro Paniccia, Patrick Hosokawa, William Henderson, Richard D Schulick, Barish H Edil, Martin D McCarter, Csaba Gajdos
IMPORTANCE: To our knowledge, this study reports on the largest cohort of long-term survivors (LTSs) (≥10 years) following a diagnosis of pancreatic ductal adenocarcinoma (PADC) and identifies the characteristics associated with LTS. OBJECTIVE: To determine patient, tumor, surgical, and sociodemographic characteristics associated with LTS. DESIGN, SETTING, AND PARTICIPANTS: A nationwide retrospective cohort study of patients with invasive PADC (International Classification of Diseases for Oncology, Third Edition codes 8140/3, 8500/3, 8021/3, and 8035/3) was conducted using data collected in the National Cancer Database (NCDB)...
August 2015: JAMA Surgery
https://www.readbyqxmd.com/read/26065868/folfirinox-induction-therapy-for-stage-3-pancreatic-adenocarcinoma
#14
Eran Sadot, Alexandre Doussot, Eileen M O'Reilly, Maeve A Lowery, Karyn A Goodman, Richard Kinh Gian Do, Laura H Tang, Mithat Gönen, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, William R Jarnagin, Peter J Allen
BACKGROUND: Reports show that FOLFIRINOX therapy for pancreatic ductal adenocarcinoma (PDAC) results in objective response rates two to threefold higher than those of other regimens. This study aimed to assess response and resection rates for locally unresectable (stage 3) patients initially treated with induction FOLFIRINOX. METHODS: The institutional cancer database was queried for patients treated with induction FOLFIRINOX therapy between 2010 and 2013. Patients were included in the study if they were treated at the authors' institution for stage 3 PDAC (locally unresectable) that had been adjudicated at a weekly multidisciplinary tumor board...
October 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25905586/safety-and-biologic-response-of-pre-operative-autophagy-inhibition-in-combination-with-gemcitabine-in-patients-with-pancreatic-adenocarcinoma
#15
MULTICENTER STUDY
Brian A Boone, Nathan Bahary, Amer H Zureikat, A James Moser, Daniel P Normolle, Wen-Chi Wu, Aatur D Singhi, Phillip Bao, David L Bartlett, Lance A Liotta, Virginia Espina, Patricia Loughran, Michael T Lotze, Herbert J Zeh
PURPOSE: Autophagy is a cell survival mechanism that plays a critical role in pancreatic carcinogenesis. Murine studies have previously demonstrated that treatment with the late-autophagy inhibitor chloroquine in combination with chemotherapy limited tumor growth. METHODS: In this phase 1/2 trial, we examined treatment with hydroxychloroquine (HCQ) and gemcitabine for patients with pancreatic adenocarcinoma. The primary endpoints were safety and tolerability, evaluated by Storer's dose escalation design...
December 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25925237/impact-total-psoas-volume-on-short-and-long-term-outcomes-in-patients-undergoing-curative-resection-for-pancreatic-adenocarcinoma-a-new-tool-to-assess-sarcopenia
#16
Neda Amini, Gaya Spolverato, Rohan Gupta, Georgios A Margonis, Yuhree Kim, Doris Wagner, Neda Rezaee, Matthew J Weiss, Christopher L Wolfgang, Martin M Makary, Ihab R Kamel, Timothy M Pawlik
BACKGROUND: While sarcopenia is typically defined using total psoas area (TPA), characterizing sarcopenia using only a single axial cross-sectional image may be inadequate. We sought to evaluate total psoas volume (TPV) as a new tool to define sarcopenia and compare patient outcomes relative to TPA and TPV. METHOD: Sarcopenia was assessed in 763 patients who underwent pancreatectomy for pancreatic adenocarcinoma between 1996 and 2014. It was defined as the TPA and TPV in the lowest sex-specific quartile...
September 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/25207767/pancreatic-adenocarcinoma
#17
REVIEW
David P Ryan, Theodore S Hong, Nabeel Bardeesy
New England Journal of Medicine, Volume 371, Issue 11, Page 1039-1049, September 2014.
September 11, 2014: New England Journal of Medicine
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