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Medical renal pathology

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14 papers 25 to 100 followers
By Sean Williamson Urologic Surgical Pathologist
https://www.readbyqxmd.com/read/26848798/igg-subclass-staining-in-routine-renal-biopsy-material
#1
REVIEW
Jessica Hemminger, Gyongyi Nadasdy, Anjali Satoskar, Sergey V Brodsky, Tibor Nadasdy
Immunofluorescence staining plays a vital role in nephropathology, but the panel of antibodies used has not changed for decades. Further classification of immunoglobulin (Ig)G-containing immune-type deposits with IgG subclass staining (IgG1, IgG2, IgG3, and IgG4) has been shown to be of diagnostic utility in glomerular diseases, but their value in the evaluation of renal biopsies has not been addressed systematically in large renal biopsy material. Between January 2007 and June 2014, using direct immunofluorescence, we stained every renal biopsy for the IgG subclasses if there was moderate to prominent glomerular IgG staining and/or IgG-predominant or IgG-codominant glomerular staining...
May 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26759930/practical-applications-in-immunohistochemistry-evaluation-of-rejection-and-infection-in-organ-transplantation
#2
Megan L Troxell, Christian Lanciault
CONTEXT: -Immunohistochemical analysis of tissue biopsy specimens is a crucial tool in diagnosis of both rejection and infection in patients with solid organ transplants. In the past 15 years, the concept of antibody-mediated rejection has been refined, and diagnostic criteria have been codified in renal, heart, pancreas, and lung allografts (with studies ongoing in liver, small intestine, and composite grafts), all of which include immunoanalysis for the complement split product C4d...
September 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26210726/ajkd-atlas-of-renal-pathology-minimal-change-disease
#3
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26210729/ajkd-atlas-of-renal-pathology-focal-segmental-glomerulosclerosis
#4
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26210732/ajkd-atlas-of-renal-pathology-cellular-variant-of-focal-segmental-glomerulosclerosis
#5
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300202/ajkd-atlas-of-renal-pathology-c1q-nephropathy
#6
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300203/ajkd-atlas-of-renal-pathology-membranous-nephropathy
#7
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300204/ajkd-atlas-of-renal-pathology-membranoproliferative-glomerulonephritis
#8
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300205/ajkd-atlas-of-renal-pathology-dense-deposit-disease
#9
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26408241/ajkd-atlas-of-renal-pathology-glomerulonephritis-with-dominant-c3
#10
Mark A Lusco, Agnes B Fogo, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26408243/ajkd-atlas-of-renal-pathology-immunotactoid-glomerulopathy
#11
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26408244/ajkd-atlas-of-renal-pathology-postinfectious-glomerulonephritis
#12
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/25918035/reassessing-the-significance-of-intimal-arteritis-in-kidney-transplant-biopsy-specimens
#13
Israel D R Salazar, Maribel Merino López, Jessica Chang, Philip F Halloran
Intimal arteritis (the presence of v-lesions) in kidney transplant biopsy specimens is believed to have major prognostic and diagnostic significance. We assessed the relationship of v-lesions to prognosis in 703 indication biopsy specimens and used microarray-based molecular tests to re-examine the relationship of v-lesions to rejection. v-Lesions were noted in 49 specimens (7%) and were usually mild (v1). The presence of v-lesions had no effect on graft survival compared with the absence of v-lesions. Pathologists using current conventions almost always interpreted v-lesions as reflecting T cell-mediated rejection (TCMR), either pure or mixed with antibody-mediated rejection (ABMR)...
December 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25888387/distinguishing-age-related-from-disease-related-glomerulosclerosis-on-kidney-biopsy-the-aging-kidney-anatomy-study
#14
COMPARATIVE STUDY
Walter K Kremers, Aleksandar Denic, John C Lieske, Mariam P Alexander, Vidhu Kaushik, Hisham E Elsherbiny, Harini A Chakkera, Emilio D Poggio, Andrew D Rule
BACKGROUND: Global glomerulosclerosis is characteristic of chronic kidney disease and also occurs with normal aging. Our goal was to determine the upper limit of normal for number of globally sclerotic glomeruli. METHODS: Core-needle biopsies of the renal cortex were obtained at the time of living kidney transplantation at three centers between 1998 and 2011. The number of globally sclerotic glomeruli was averaged across two biopsy sections. Quantile regression was used to estimate the 95th percentile for globally sclerotic glomeruli as the upper reference limit...
December 2015: Nephrology, Dialysis, Transplantation
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