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Liver mets

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27 papers 25 to 100 followers
https://www.readbyqxmd.com/read/28187043/difficulty-of-laparoscopic-liver-resection-proposal-for-a-new-classification
#1
Yoshikuni Kawaguchi, David Fuks, Norihiro Kokudo, Brice Gayet
OBJECTIVE: We propose an objective and practical classification system to predict difficulty of different laparoscopic liver resections (LLRs). BACKGROUND: Surgical difficulty is highly subjective and is not influenced only by surgical factors. Consequently, few series have described the degree of difficulty of LLR or attempted to objectively assess the surgical difficulty. METHODS: From a prospectively maintained database between 1995 and 2015, patients undergoing LLR without simultaneous procedures were selected, and LLR procedures were divided into 3 groups according to scores based on operative time (< or ≥190 minutes), blood loss (< or ≥100 mL), and conversion rate (< or ≥4...
February 9, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28109616/hammer-versus-swiss-army-knife-developing-a-strategy-for-the-management-of-bilobar-colorectal-liver-metastases
#2
REVIEW
Jordan M Cloyd, Thomas A Aloia
For patients with bilobar colorectal liver metastases, the recent increase in surgical approaches has resulted in more opportunities to extend the benefits of surgery to patients who were previously deemed unresectable. Surgical options now include anatomic hepatectomy, 1-stage parenchymal sparing hepatectomy, traditional 2-stage hepatectomy with or without portal vein embolization, associated liver partition and portal vein ligation for staged hepatectomy, local ablative techniques, and hepatic arterial infusion therapy...
January 18, 2017: Surgery
https://www.readbyqxmd.com/read/28146608/neuroendocrine-liver-metastasis-the-chance-to-be-cured-after-liver-surgery
#3
Fabio Bagante, Gaya Spolverato, Katiuscha Merath, Lauren McLendon Postlewait, George A Poultsides, Matthew G Mullen, Todd W Bauer, Ryan C Fields, Jorge Lamelas, Hugo P Marques, Luca Aldrighetti, Thuy Tran, Shishir K Maithel, Timothy M Pawlik
BACKGROUND AND OBJECTIVE: Neuroendocrine liver metastasis tumors (NELM) are a heterogeneous group of neoplasms with varied histologic features and a wide range of clinical behaviors. We aimed to identify the fraction of patients cured after liver surgery for NELM. METHODS: Cure fraction models were used to analyze 376 patients who underwent hepatectomy with curative intent for NELM. RESULTS: The median and 5-year disease-free survival (DFS) were 4...
February 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28002060/embryonic-origin-of-primary-colon-cancer-predicts-pathologic-response-and-survival-in-patients-undergoing-resection-for-colon-cancer-liver-metastases
#4
Suguru Yamashita, Kristoffer Watten Brudvik, Scott E Kopetz, Dipen Maru, Callisia N Clarke, Guillaume Passot, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: The aim of this study was to determine the prognostic value of embryonic origin in patients undergoing resection after chemotherapy for colon cancer liver metastases (CCLM). METHODS: We identified 725 patients with primary colon cancer and known RAS mutation status who underwent hepatic resection after preoperative chemotherapy for CCLM (1990 to 2015). Survival after resection of CCLM from midgut origin (n = 238) and hindgut origin (n = 487) was analyzed...
December 19, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27380959/esmo-consensus-guidelines-for-the-management-of-patients-with-metastatic-colorectal-cancer
#5
E Van Cutsem, A Cervantes, R Adam, A Sobrero, J H Van Krieken, D Aderka, E Aranda Aguilar, A Bardelli, A Benson, G Bodoky, F Ciardiello, A D'Hoore, E Diaz-Rubio, J-Y Douillard, M Ducreux, A Falcone, A Grothey, T Gruenberger, K Haustermans, V Heinemann, P Hoff, C-H Köhne, R Labianca, P Laurent-Puig, B Ma, T Maughan, K Muro, N Normanno, P Österlund, W J G Oyen, D Papamichael, G Pentheroudakis, P Pfeiffer, T J Price, C Punt, J Ricke, A Roth, R Salazar, W Scheithauer, H J Schmoll, J Tabernero, J Taïeb, S Tejpar, H Wasan, T Yoshino, A Zaanan, D Arnold
Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers...
August 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27395013/functional-imaging-in-liver-tumours
#6
REVIEW
Maxime Ronot, Ashley Kieran Clift, Valérie Vilgrain, Andrea Frilling
Functional imaging encompasses techniques capable of assessing physiological parameters of tissues, and offers useful clinical information in addition to that obtained from morphological imaging. Such techniques may include magnetic resonance imaging with diffusion-weighted sequences or hepatobiliary contrast agents, perfusion imaging, or molecular imaging with radiolabelled tracers. The liver is of major importance in oncological practice; not only is hepatocellular carcinoma one of the malignancies with steadily rising incidence worldwide, but hepatic metastases are regularly observed with a range of solid neoplasms...
November 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27311006/an-updated-systematic-review-of-the-evolution-of-alpps-and-evaluation-of-its-advantages-and-disadvantages-in-accordance-with-current-evidence
#7
REVIEW
Yu-Long Cai, Pei-Pei Song, Wei Tang, Nan-Sheng Cheng
The main obstacle to achieving an R0 resection after a major hepatectomy is inability to preserve an adequate future liver remnant (FLR) to avoid postoperative liver failure (PLF). Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting tumors that were previously considered unresectable, and this technique results in a vast increase in the volume of the FLR in a short period of time. However, this technique continues to provoke heated debate because of its high mortality and morbidity...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27306949/factors-influencing-recurrence-following-initial-hepatectomy-for-colorectal-liver-metastases
#8
J Hallet, A Sa Cunha, R Adam, D Goéré, P Bachellier, D Azoulay, A Ayav, E Grégoire, F Navarro, P Pessaux
BACKGROUND: Data on recurrence patterns following hepatectomy for colorectal liver metastases (CRLMs) and their impact on long-term outcomes are limited in the setting of modern multimodal management. This study sought to characterize the patterns of, factors associated with, and survival impact of recurrence following initial hepatectomy for CRLMs. METHODS: A retrospective cohort study of patients undergoing initial hepatectomy for CRLMs at 39 institutions (2006-2013) was conducted...
September 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26948499/the-laparoscopic-glissonian-approach-is-safe-and-efficient-when-compared-with-standard-laparoscopic-liver-resection-results-of-an-observational-study-over-7%C3%A2-years
#9
Marcel Autran C Machado, Rodrigo C Surjan, Tiago Basseres, Erik Schadde, Frederico P Costa, Fábio F Makdissi
OBJECTIVE: This study compares the Glissonian approach with the standard approach to laparoscopic liver resection for safety and efficacy. BACKGROUND: The standard laparoscopic approach to anatomic liver resection is the dissection of the elements of the Glissonian pedicle below the hilar plate. In contrast, the Glissonian approach identifies the intrahepatic pedicles by tentative clamping. Concerns have been raised about the safety of the Glissonian approach in laparoscopic liver surgery...
September 2016: Surgery
https://www.readbyqxmd.com/read/26641255/second-and-third-laparoscopic-liver-resection-for-patients-with-recurrent-colorectal-liver-metastases
#10
Takeo Nomi, David Fuks, Satoshi Ogiso, Yoshiyuki Nakajima, Christophe Louvet, Brice Gayet
No abstract text is available yet for this article.
May 2016: Annals of Surgery
https://www.readbyqxmd.com/read/26631387/decision-making-around-optimal-management-of-liver-limited-metastatic-colorectal-cancer
#11
EDITORIAL
Robert P Jones, Graeme J Poston
No abstract text is available yet for this article.
February 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26496211/a-multi-institutional-analysis-of-429-patients-undergoing-major-hepatectomy-for-colorectal-cancer-liver-metastases-the-impact-of-concomitant-bile-duct-resection-on-survival
#12
MULTICENTER STUDY
Lauren M Postlewait, Malcolm H Squires, David A Kooby, Sharon M Weber, Charles R Scoggins, Kenneth Cardona, Clifford S Cho, Robert C G Martin, Emily R Winslow, Shishir K Maithel
BACKGROUND: Data are lacking on long-term outcomes of patients undergoing major hepatectomy requiring bile duct resection (BDR) for the treatment of colorectal cancer liver metastases. METHODS: Patients who underwent major hepatectomy (≥3 segments) for metastatic colorectal cancer from 2000-2010 at three US academic institutions were included. The primary outcome was disease-specific survival (DSS). RESULTS: Of 429 patients, nine (2.1%) underwent BDR, which was associated with pre-operative portal vein embolization (25...
October 2015: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26133575/systematic-review-and-meta-analysis-of-hepatic-arterial-infusion-chemotherapy-as-bridging-therapy-for-colorectal-liver-metastases
#13
REVIEW
Daniel L Chan, Nayef A Alzahrani, David L Morris, Terence C Chua
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) has been shown to be beneficial in the management of unresectable colorectal liver metastases (CRLM). This systematic review evaluates the potential role of HAIC as a neoadjuvant downstaging therapy, prior to hepatic resection with curative intent for initially unresectable CRLM. METHODS: A literature search was conducted using Pubmed, EMBASE and Medline databases from January 2000 to November 2013. Studies adopting HAIC as a neoadjuvant bridging therapy for hepatic resection for CRLM were included...
September 2015: Surgical Oncology
https://www.readbyqxmd.com/read/26105801/combined-stoma-reversal-and-liver-resection-a-matched-case-control-study
#14
Renato M Lupinacci, Julie Agostini, Mircea Chirica, Pierre Balladur, Najim Chafaï, Yann Parc, Emmanuel Tiret, François Paye
BACKGROUND: Stoma reversal can be performed during liver resection (LR) in patients with colorectal liver metastases (CRCLM) whose primary colorectal tumor has been previously resected with a diverting loop ileostomy. This combined procedure is reputed to be associated with an increased morbidity. This study investigates the impact of simultaneous loop ileostomy closure (LIC) on the postoperative outcome of LR for CRCLM. METHODS: From November 1996 to April 2012, 408 patients who underwent LR for CRCLM were retrospectively studied from a prospective database...
September 2015: American Journal of Surgery
https://www.readbyqxmd.com/read/26095422/clinical-assessment-before-hepatectomy-identifies-high-risk-patients
#15
Simon Ulyett, Matthew G Wiggans, Matthew J Bowles, Somaiah Aroori, Christopher D Briggs, Paul Erasmus, Gary Minto, David A Stell
BACKGROUND: Liver resection is associated with significant morbidity, and assessment of risk is an important part of preoperative consultations. Objective methods exist to assess operative risk, including cardiopulmonary exercise testing (CPX). Subjective assessment is also made in clinic, and patients perceived to be high-risk are referred for CPX at our institution. This article addresses clinicians' ability to identify patients with a higher risk of surgical complications after hepatectomy, using selection for CPX as a surrogate marker for increased operative risk...
September 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/26107888/less-surgery-improved-survival-from-stage-iv-colorectal-cancer
#16
LETTER
Rachel Wong, Peter Gibbs
No abstract text is available yet for this article.
August 2015: JAMA Surgery
https://www.readbyqxmd.com/read/26088872/transarterial-chemoembolization-tace-for-colorectal-liver-metastases-current-status-and-critical-review
#17
REVIEW
Alexander Massmann, Thomas Rodt, Steffen Marquardt, Roland Seidel, Katrina Thomas, Frank Wacker, Götz M Richter, Hans U Kauczor, Arno Bücker, Philippe L Pereira, Christof M Sommer
BACKGROUND: Transarterial liver-directed therapies are currently not recommended as a standard treatment for colorectal liver metastases. Transarterial chemoembolization (TACE), however, is increasingly used for patients with liver-dominant colorectal metastases after failure of surgery or systemic chemotherapy. The limited available data potentially reveals TACE as a valuable option for pre- and post-operative downsizing, minimizing time-to-surgery, and prolongation of overall survival after surgery in patients with colorectal liver only metastases...
August 2015: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/26077902/hepatic-resection-for-disappearing-liver-metastasis-a-cost-utility-analysis
#18
Gaya Spolverato, Alessandro Vitale, Aslam Ejaz, David Cosgrove, Darren Cowzer, Umberto Cillo, Timothy M Pawlik
BACKGROUND: We sought to estimate the cost-effectiveness of hepatic resection (HR) (strategy A) relative to surveillance plus 6 months of additional systemic chemotherapy (sCT) (strategy B) for patients with colorectal disappearing liver metastases (DLM). METHODS: A Markov model was developed using data from a systematic literature review. Three base cases were evaluated: (1) a 60-year-old patient with three lesions in the right hemi-liver who underwent 6 months of sCT, had normalized carcinoembryonic antigen (CEA), and was diagnosed with DLM through a computed tomography (CT) scan; (2) a 60-year-old patient with three lesions in the right hemi-liver who underwent 6 months of sCT, had normalized CEA, and was diagnosed with DLM through a magnetic resonance imaging (MRI) scan; and (3) a 60-year-old patient with three lesions in the right hemi-liver who underwent 6 months of sCT plus hepatic artery infusion (HAI), had normalized CEA, and was diagnosed with DLM through a MRI scan...
September 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26082326/hepatic-resection-for-gastric-cancer-liver-metastases-a-systematic-review-and-meta-analysis
#19
REVIEW
Fausto Petrelli, Andrea Coinu, Mary Cabiddu, Mara Ghilardi, Karen Borgonovo, Veronica Lonati, Sandro Barni
BACKGROUND: Resection of liver metastases from gastric cancer (GC) is rarely performed, and the outcome after hepatic surgery has not been systematically evaluated in the literature. The aim of this study was to perform a systematic review of outcome and prognostic factors for survival after liver metastasectomy for GC. METHODS: We performed a meta-analysis of published studies that focused on long-term outcomes (5-year overall survival [OS]) after surgical management of liver metastases from GC, and included more than 10 patients each...
June 2015: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25444467/imaging-approach-to-hepatocellular-carcinoma-cholangiocarcinoma-and-metastatic-colorectal-cancer
#20
REVIEW
Kathryn J Fowler, Nael E Saad, David Linehan
Liver imaging is a highly evolving field with new imaging contrast agents and modalities. Knowledge of the different imaging options and what they have to offer in primary and metastatic liver disease is essential for appropriate diagnosis, staging, and prognosis in patients. This review summarizes the major imaging modalities in liver neoplasms and provides specific discussion of imaging hepatocellular carcinoma, cholangiocarcinoma, and colorectal liver metastases. The final sections provide an overview of presurgical imaging relevant to planning hepatectomies and ablative procedures...
January 2015: Surgical Oncology Clinics of North America
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