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Liver mets

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23 papers 25 to 100 followers
E Van Cutsem, A Cervantes, R Adam, A Sobrero, J H Van Krieken, D Aderka, E Aranda Aguilar, A Bardelli, A Benson, G Bodoky, F Ciardiello, A D'Hoore, E Diaz-Rubio, J-Y Douillard, M Ducreux, A Falcone, A Grothey, T Gruenberger, K Haustermans, V Heinemann, P Hoff, C-H Köhne, R Labianca, P Laurent-Puig, B Ma, T Maughan, K Muro, N Normanno, P Österlund, W J G Oyen, D Papamichael, G Pentheroudakis, P Pfeiffer, T J Price, C Punt, J Ricke, A Roth, R Salazar, W Scheithauer, H J Schmoll, J Tabernero, J Taïeb, S Tejpar, H Wasan, T Yoshino, A Zaanan, D Arnold
Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers...
August 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Maxime Ronot, Ashley Kieran Clift, Valérie Vilgrain, Andrea Frilling
Functional imaging encompasses techniques capable of assessing physiological parameters of tissues, and offers useful clinical information in addition to that obtained from morphological imaging. Such techniques may include magnetic resonance imaging with diffusion-weighted sequences or hepatobiliary contrast agents, perfusion imaging, or molecular imaging with radiolabelled tracers. The liver is of major importance in oncological practice; not only is hepatocellular carcinoma one of the malignancies with steadily rising incidence worldwide, but hepatic metastases are regularly observed with a range of solid neoplasms...
July 6, 2016: Journal of Hepatology
Yu-Long Cai, Pei-Pei Song, Wei Tang, Nan-Sheng Cheng
The main obstacle to achieving an R0 resection after a major hepatectomy is inability to preserve an adequate future liver remnant (FLR) to avoid postoperative liver failure (PLF). Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting tumors that were previously considered unresectable, and this technique results in a vast increase in the volume of the FLR in a short period of time. However, this technique continues to provoke heated debate because of its high mortality and morbidity...
June 2016: Medicine (Baltimore)
J Hallet, A Sa Cunha, R Adam, D Goéré, P Bachellier, D Azoulay, A Ayav, E Grégoire, F Navarro, P Pessaux
BACKGROUND: Data on recurrence patterns following hepatectomy for colorectal liver metastases (CRLMs) and their impact on long-term outcomes are limited in the setting of modern multimodal management. This study sought to characterize the patterns of, factors associated with, and survival impact of recurrence following initial hepatectomy for CRLMs. METHODS: A retrospective cohort study of patients undergoing initial hepatectomy for CRLMs at 39 institutions (2006-2013) was conducted...
September 2016: British Journal of Surgery
Marcel Autran C Machado, Rodrigo C Surjan, Tiago Basseres, Erik Schadde, Frederico P Costa, Fábio F Makdissi
OBJECTIVE: This study compares the Glissonian approach with the standard approach to laparoscopic liver resection for safety and efficacy. BACKGROUND: The standard laparoscopic approach to anatomic liver resection is the dissection of the elements of the Glissonian pedicle below the hilar plate. In contrast, the Glissonian approach identifies the intrahepatic pedicles by tentative clamping. Concerns have been raised about the safety of the Glissonian approach in laparoscopic liver surgery...
September 2016: Surgery
Takeo Nomi, David Fuks, Satoshi Ogiso, Yoshiyuki Nakajima, Christophe Louvet, Brice Gayet
No abstract text is available yet for this article.
May 2016: Annals of Surgery
Robert P Jones, Graeme J Poston
No abstract text is available yet for this article.
February 2016: Annals of Surgical Oncology
Lauren M Postlewait, Malcolm H Squires, David A Kooby, Sharon M Weber, Charles R Scoggins, Kenneth Cardona, Clifford S Cho, Robert C G Martin, Emily R Winslow, Shishir K Maithel
BACKGROUND: Data are lacking on long-term outcomes of patients undergoing major hepatectomy requiring bile duct resection (BDR) for the treatment of colorectal cancer liver metastases. METHODS: Patients who underwent major hepatectomy (≥3 segments) for metastatic colorectal cancer from 2000-2010 at three US academic institutions were included. The primary outcome was disease-specific survival (DSS). RESULTS: Of 429 patients, nine (2.1%) underwent BDR, which was associated with pre-operative portal vein embolization (25...
October 2015: Journal of Surgical Oncology
Daniel L Chan, Nayef A Alzahrani, David L Morris, Terence C Chua
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) has been shown to be beneficial in the management of unresectable colorectal liver metastases (CRLM). This systematic review evaluates the potential role of HAIC as a neoadjuvant downstaging therapy, prior to hepatic resection with curative intent for initially unresectable CRLM. METHODS: A literature search was conducted using Pubmed, EMBASE and Medline databases from January 2000 to November 2013. Studies adopting HAIC as a neoadjuvant bridging therapy for hepatic resection for CRLM were included...
September 2015: Surgical Oncology
Renato M Lupinacci, Julie Agostini, Mircea Chirica, Pierre Balladur, Najim Chafaï, Yann Parc, Emmanuel Tiret, François Paye
BACKGROUND: Stoma reversal can be performed during liver resection (LR) in patients with colorectal liver metastases (CRCLM) whose primary colorectal tumor has been previously resected with a diverting loop ileostomy. This combined procedure is reputed to be associated with an increased morbidity. This study investigates the impact of simultaneous loop ileostomy closure (LIC) on the postoperative outcome of LR for CRCLM. METHODS: From November 1996 to April 2012, 408 patients who underwent LR for CRCLM were retrospectively studied from a prospective database...
September 2015: American Journal of Surgery
Simon Ulyett, Matthew G Wiggans, Matthew J Bowles, Somaiah Aroori, Christopher D Briggs, Paul Erasmus, Gary Minto, David A Stell
BACKGROUND: Liver resection is associated with significant morbidity, and assessment of risk is an important part of preoperative consultations. Objective methods exist to assess operative risk, including cardiopulmonary exercise testing (CPX). Subjective assessment is also made in clinic, and patients perceived to be high-risk are referred for CPX at our institution. This article addresses clinicians' ability to identify patients with a higher risk of surgical complications after hepatectomy, using selection for CPX as a surrogate marker for increased operative risk...
September 2015: Journal of Surgical Research
Rachel Wong, Peter Gibbs
No abstract text is available yet for this article.
August 2015: JAMA Surgery
Alexander Massmann, Thomas Rodt, Steffen Marquardt, Roland Seidel, Katrina Thomas, Frank Wacker, Götz M Richter, Hans U Kauczor, Arno Bücker, Philippe L Pereira, Christof M Sommer
BACKGROUND: Transarterial liver-directed therapies are currently not recommended as a standard treatment for colorectal liver metastases. Transarterial chemoembolization (TACE), however, is increasingly used for patients with liver-dominant colorectal metastases after failure of surgery or systemic chemotherapy. The limited available data potentially reveals TACE as a valuable option for pre- and post-operative downsizing, minimizing time-to-surgery, and prolongation of overall survival after surgery in patients with colorectal liver only metastases...
August 2015: Langenbeck's Archives of Surgery
Gaya Spolverato, Alessandro Vitale, Aslam Ejaz, David Cosgrove, Darren Cowzer, Umberto Cillo, Timothy M Pawlik
BACKGROUND: We sought to estimate the cost-effectiveness of hepatic resection (HR) (strategy A) relative to surveillance plus 6 months of additional systemic chemotherapy (sCT) (strategy B) for patients with colorectal disappearing liver metastases (DLM). METHODS: A Markov model was developed using data from a systematic literature review. Three base cases were evaluated: (1) a 60-year-old patient with three lesions in the right hemi-liver who underwent 6 months of sCT, had normalized carcinoembryonic antigen (CEA), and was diagnosed with DLM through a computed tomography (CT) scan; (2) a 60-year-old patient with three lesions in the right hemi-liver who underwent 6 months of sCT, had normalized CEA, and was diagnosed with DLM through a magnetic resonance imaging (MRI) scan; and (3) a 60-year-old patient with three lesions in the right hemi-liver who underwent 6 months of sCT plus hepatic artery infusion (HAI), had normalized CEA, and was diagnosed with DLM through a MRI scan...
September 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Fausto Petrelli, Andrea Coinu, Mary Cabiddu, Mara Ghilardi, Karen Borgonovo, Veronica Lonati, Sandro Barni
BACKGROUND: Resection of liver metastases from gastric cancer (GC) is rarely performed, and the outcome after hepatic surgery has not been systematically evaluated in the literature. The aim of this study was to perform a systematic review of outcome and prognostic factors for survival after liver metastasectomy for GC. METHODS: We performed a meta-analysis of published studies that focused on long-term outcomes (5-year overall survival [OS]) after surgical management of liver metastases from GC, and included more than 10 patients each...
June 2015: Journal of Surgical Oncology
Kathryn J Fowler, Nael E Saad, David Linehan
Liver imaging is a highly evolving field with new imaging contrast agents and modalities. Knowledge of the different imaging options and what they have to offer in primary and metastatic liver disease is essential for appropriate diagnosis, staging, and prognosis in patients. This review summarizes the major imaging modalities in liver neoplasms and provides specific discussion of imaging hepatocellular carcinoma, cholangiocarcinoma, and colorectal liver metastases. The final sections provide an overview of presurgical imaging relevant to planning hepatectomies and ablative procedures...
January 2015: Surgical Oncology Clinics of North America
Clifford S Cho
Staging systems are an attempt to incorporate the biology and therapy for cancer in a way that enables categorization and prediction of oncologic outcomes. Because of unusual disease biology and complexities related to treatment intervention, efforts to develop reliable staging systems for hepatic malignancies have been challenging. This article discusses the ways in which improved understanding of these diseases has informed the evolution of prognostication systems as applied to hepatocellular carcinoma, cholangiocarcinoma, and hepatic colorectal adenocarcinoma...
January 2015: Surgical Oncology Clinics of North America
Maria C Russell
As the number of liver resections in the United States has increased, operations are more commonly performed on older patients with multiple comorbidities. The advent of effective chemotherapy and techniques such as portal vein embolization, have compounded the number of increasingly complex resections taking up to 75% of healthy livers. Four potentially devastating complications of liver resection include postoperative hemorrhage, venous thromboembolism, bile leak, and post-hepatectomy liver failure. The risk factors and management of these complications are herein explored, stressing the importance of identifying preoperative factors that can decrease the risk for these potentially fatal complications...
January 2015: Surgical Oncology Clinics of North America
François Cauchy, Jacques Belghiti
No abstract text is available yet for this article.
April 2014: Annals of Surgical Oncology
Svein Dueland, Tormod K Guren, Morten Hagness, Bengt Glimelius, Pål-Dag Line, Per Pfeiffer, Aksel Foss, Kjell M Tveit
OBJECTIVE: The primary objective was to compare overall survival (OS) in patients with colorectal cancer (CRC) with nonresectable liver-only metastases treated by liver transplantation or chemotherapy. BACKGROUND: CRC is the third most common cancer worldwide. About 50% of patients will develop metastatic disease primarily to the liver and the lung. The majority of patients with liver metastases receive palliative chemotherapy, with a median OS of trial patients of about 2 years, and less than 10% are alive at 5 years...
May 2015: Annals of Surgery
2015-04-23 11:36:18
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