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Diabetes complications

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8 papers 0 to 25 followers
By Ehud Ur Professor and Head, Endocrinology, UBC, Vancouver
https://www.readbyqxmd.com/read/28365411/effects-of-intensive-glucose-control-on-microvascular-outcomes-in-patients-with-type-2-diabetes-a-meta-analysis-of-individual-participant-data-from-randomised-controlled-trials
#1
Sophia Zoungas, Hisatomi Arima, Hertzel C Gerstein, Rury R Holman, Mark Woodward, Peter Reaven, Rodney A Hayward, Timothy Craven, Ruth L Coleman, John Chalmers
BACKGROUND: Intensive glucose control is understood to prevent complications in adults with type 2 diabetes. We aimed to more precisely estimate the effects of more intensive glucose control, compared with less intensive glucose control, on the risk of microvascular events. METHODS: In this meta-analysis, we obtained de-identified individual participant data from large-scale randomised controlled trials assessing the effects of more intensive glucose control versus less intensive glucose control in adults with type 2 diabetes, with at least 1000 patient-years of follow-up in each treatment group and a minimum of 2 years average follow-up on randomised treatment...
March 29, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28298470/genetically-driven-hyperglycemia-increases-risk-of-coronary-artery-disease-separately-from-type-2-diabetes
#2
Jordi Merino, Aaron Leong, Daniel C Posner, Bianca Porneala, Lluís Masana, Josée Dupuis, Jose C Florez
OBJECTIVE: This study tested the hypothesis that genetically raised hyperglycemia increases coronary artery disease (CAD) risk separately from the risk conferred by type 2 diabetes as a whole. RESEARCH DESIGN AND METHODS: We conducted a Mendelian randomization (MR) analysis using summary-level statistics from the largest published meta-analyses of genome-wide association studies (GWAS) for fasting glucose (FG) (n = 133,010 participants free of diabetes) and CAD (n = 63,746 case subjects and 130,681 control subjects) of predominantly European ancestry...
March 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28001453/insulin-resistance-is-associated-with-smaller-cortical-bone-size-in-non-diabetic-men-at-the-age-of-peak-bone-mass
#3
Charlotte Verroken, Hans-Georg Zmierczak, Stefan Goemaere, Jean-Marc Kaufman, Bruno Lapauw
CONTEXT: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be explained by insulin resistance affecting bone structure and/or material properties, few studies have investigated the association between insulin resistance and bone geometry. OBJECTIVE: We aimed to explore this association in a cohort of non-diabetic men at the age of peak bone mass. DESIGN, SETTING AND PARTICIPANTS: 996 non-diabetic men aged 25-45 years were recruited in a cross-sectional, population-based sibling-pair study at a university research center...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27881565/low-dose-aspirin-for-primary-prevention-of-cardiovascular-events-in-patients-with-type-2-diabetes-mellitus-10-year-follow-up-of-a-randomized-controlled-trial
#4
Yoshihiko Saito, Sadanori Okada, Hisao Ogawa, Hirofumi Soejima, Mio Sakuma, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Takeshi Morimoto
BACKGROUND: The long-term efficacy and safety of low-dose aspirin for primary prevention of cardiovascular events in patients with type 2 diabetes mellitus are still inconclusive. METHODS: The JPAD trial (Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes) was a randomized, open-label, standard care-controlled trial examining whether low-dose aspirin affected cardiovascular events in 2539 Japanese patients with type 2 diabetes mellitus and without preexisting cardiovascular disease...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/26822326/nine-year-effects-of-3-7-years-of-intensive-glycemic-control-on-cardiovascular-outcomes
#5
(no author information available yet)
OBJECTIVE: In the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, ∼4 years of intensive versus standard glycemic control in participants with type 2 diabetes and other cardiovascular risk factors had a neutral effect on the composite cardiovascular outcome, increased cardiovascular and total mortality, and reduced nonfatal myocardial infarction. Effects of the intervention during prolonged follow-up were analyzed. RESEARCH DESIGN AND METHODS: All surviving ACCORD participants were invited to participate in the ACCORD Follow-on (ACCORDION) study, during which participants were treated according to their health care provider's judgment...
May 2016: Diabetes Care
https://www.readbyqxmd.com/read/26571120/impaired-glucose-tolerance-or-newly-diagnosed-diabetes-mellitus-diagnosed-during-admission-adversely-affects-prognosis-after-myocardial-infarction-an-observational-study
#6
Anish George, Raghav T Bhatia, Gill L Buchanan, Anne Whiteside, Robert S Moisey, Stephen F Beer, Sudipta Chattopadhyay, Thozhukat Sathyapalan, Joseph John
OBJECTIVE: To investigate the prognostic effect of newly diagnosed diabetes mellitus (NDM) and impaired glucose tolerance (IGT) post myocardial infarction (MI). RESEARCH DESIGN AND METHODS: Retrospective cohort study of 768 patients without preexisting diabetes mellitus post-MI at one centre in Yorkshire between November 2005 and October 2008. Patients were categorised as normal glucose tolerance (NGT n = 337), IGT (n = 279) and NDM (n = 152) on pre- discharge oral glucose tolerance test (OGTT)...
2015: PloS One
https://www.readbyqxmd.com/read/26407587/the-impact-of-nocturnal-hypoglycemia-on-sleep-in-subjects-with-type-2-diabetes
#7
RANDOMIZED CONTROLLED TRIAL
Poul Jennum, Kirstine Stender-Petersen, Rasmus Rabøl, Niklas Rye Jørgensen, Pei-Ling Chu, Sten Madsbad
OBJECTIVE: The aim of this trial was to investigate the impact of nocturnal hypoglycemia on sleep patterns (assessed by polysomnography) and counterregulatory hormones. RESEARCH DESIGN AND METHODS: In this single-blinded, crossover trial, 26 subjects with type 2 diabetes attended two experimental night visits (one normoglycemic and one hypoglycemic) in randomized order. Plasma glucose (PG) levels were controlled by hyperinsulinemic glucose clamping. On the hypoglycemic night, hypoglycemia was induced after reaching sleep stage N2 by turning off glucose infusion until the PG target of 2...
November 2015: Diabetes Care
https://www.readbyqxmd.com/read/25871838/differential-gene-expression-in-diabetic-nephropathy-in-individuals-with-type-1-diabetes
#8
M Luiza Caramori, Youngki Kim, Allison B Goldfine, Jason H Moore, Stephen S Rich, Josyf C Mychaleckyj, David Kirkpatrick, Helen Nickerson, Andrzej S Krolewski, Michael Mauer
CONTEXT: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) in the United States. OBJECTIVE: The aim of this study was to determine whether there were skin fibroblast gene expression differences between subjects with type 1 diabetes (T1D) with or without DN. SETTING: This was a cross-sectional study conducted in the University of Minnesota. PATIENTS: Study volunteers were 100 former participants of Genetics of Kidneys in Diabetes: 40 were diabetic nephropathy (DN) Controls, normoalbuminuric after ≥ 15 years of T1D; and 60 were DN Cases, 25 with proteinuria and 35 with ESRD...
June 2015: Journal of Clinical Endocrinology and Metabolism
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