collection
MENU ▼
Read by QxMD icon Read
search

Pancreatic cancer

shared collection
158 papers 25 to 100 followers Pancreatic cancer
https://www.readbyqxmd.com/read/29493784/propensity-score-matched-comparison-of-oncological-outcomes-between-laparoscopic-and-open-distal-pancreatic-resection
#1
M Raoof, P H G Ituarte, Y Woo, S G Warner, G Singh, Y Fong, L Melstrom
BACKGROUND: Selected studies have reported improved outcomes in laparoscopic compared with open distal pancreatic resection. Concerns regarding failure to achieve proper oncological resection and compromised long-term outcomes remain. This study investigated whether postoperative outcomes and long-term survival after laparoscopic distal pancreatectomy are comparable to those after an open procedure. METHODS: This retrospective case-control study included patients who underwent distal pancreatectomy for resectable pancreatic adenocarcinoma between 2010 and 2013, identified from the National Cancer Database...
April 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29363018/surgical-anatomy-of-the-superior-mesenteric-vessels-related-to-pancreaticoduodenectomy-a-systematic-review-and-meta-analysis
#2
Ionut Negoi, Mircea Beuran, Sorin Hostiuc, Ruxandra Irina Negoi, Yosuke Inoue
BACKGROUND AND PURPOSE: Mesopancreas dissection with central vascular ligation and the superior mesenteric artery (SMA)-first approach represent the cornerstone of current principles for radical resection for pancreatic head cancer. The surgeon dissecting around the SMV and SMA should be aware regarding the anatomical variants in this area. The aims of this systematic review and meta-analysis are to detail the surgical anatomy of the superior mesenteric vessels and to propose a standardized terminology with impact in pancreatic cancer surgery...
May 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29334562/is-a-pathological-complete-response-following-neoadjuvant-chemoradiation-associated-with-prolonged-survival-in-patients-with-pancreatic-cancer
#3
Jin He, Alex B Blair, Vincent P Groot, Ammar A Javed, Richard A Burkhart, Georgios Gemenetzis, Ralph H Hruban, Kevin M Waters, Justin Poling, Lei Zheng, Daniel Laheru, Joseph M Herman, Martin A Makary, Matthew J Weiss, John L Cameron, Christopher L Wolfgang
OBJECTIVES: To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA-PDAC) who have a pathologic complete response (pCR) following neoadjuvant chemoradiation. BACKGROUND: Patients with BR/LA-PDAC are often treated with neoadjuvant chemoradiation in an attempt to downstage the tumor. Uncommonly, a pCR may result. METHODS: A retrospective review of a prospectively maintained database was performed at a single institution...
July 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29249649/systematic-review-on-the-impact-of-pancreatoduodenectomy-on-quality-of-life-in-patients-with-pancreatic-cancer
#4
REVIEW
Sven M van Dijk, Hanne D Heerkens, Dorine S J Tseng, Martijn Intven, I Quintus Molenaar, Hjalmar C van Santvoort
BACKGROUND: Patients undergoing pancreatoduodenectomy for pancreatic cancer have a high risk of major postoperative complications and a low survival rate. Insight in the impact of pancreatoduodenectomy on quality of life (QoL) is therefore of great importance. The aim of this systematic review was to assess QoL after pancreatoduodenectomy for pancreatic cancer. METHODS: A systematic review of the literature was performed according to the PRISMA guidelines. A systematic search of all the English literature available in PubMed and Medline was performed...
March 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29307511/acinar-cell-density-at-the-pancreatic-resection-margin-is-associated-with-post-pancreatectomy-pancreatitis-and-the-development-of-postoperative-pancreatic-fistula
#5
Christopher B Nahm, Kai M Brown, Philip J Townend, Emily Colvin, Viive M Howell, Anthony J Gill, Saxon Connor, Jaswinder S Samra, Anubhav Mittal
BACKGROUND: There has been recent evidence supporting post-pancreatectomy pancreatitis as a factor in the development of postoperative pancreatic fistula (POPF). The aims of this study were to evaluate: (i) the correlation of the acinar cell density at the pancreatic resection margin with the intra-operative amylase concentration (IOAC) of peri-pancreatic fluid, postoperative pancreatitis, and POPF; and (ii) the association between postoperative pancreatitis on the first postoperative day and POPF...
May 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29240007/alternative-fistula-risk-score-for-pancreatoduodenectomy-a-frs-design-and-international-external-validation
#6
Timothy H Mungroop, L Bengt van Rijssen, David van Klaveren, F Jasmijn Smits, Victor van Woerden, Ralph J Linnemann, Matteo de Pastena, Sjors Klompmaker, Giovanni Marchegiani, Brett L Ecker, Susan van Dieren, Bert Bonsing, Olivier R Busch, Ronald M van Dam, Joris Erdmann, Casper H van Eijck, Michael F Gerhards, Harry van Goor, Erwin van der Harst, Ignace H de Hingh, Koert P de Jong, Geert Kazemier, Misha Luyer, Awad Shamali, Salvatore Barbaro, Thomas Armstrong, Arjun Takhar, Zaed Hamady, Joost Klaase, Daan J Lips, I Quintus Molenaar, Vincent B Nieuwenhuijs, Coen Rupert, Hjalmar C van Santvoort, Joris J Scheepers, George P van der Schelling, Claudio Bassi, Charles M Vollmer, Ewout W Steyerberg, Mohammed Abu Hilal, Bas Groot Koerkamp, Marc G Besselink
OBJECTIVE: The aim of this study was to develop an alternative fistula risk score (a-FRS) for postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, without blood loss as a predictor. BACKGROUND: Blood loss, one of the predictors of the original-FRS, was not a significant factor during 2 recent external validations. METHODS: The a-FRS was developed in 2 databases: the Dutch Pancreatic Cancer Audit (18 centers) and the University Hospital Southampton NHS...
December 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29265404/randomized-clinical-trial-of-duct-to-mucosa-versus-invagination-pancreaticojejunostomy-after-pancreatoduodenectomy
#7
RANDOMIZED CONTROLLED TRIAL
Y Senda, Y Shimizu, S Natsume, S Ito, K Komori, T Abe, K Matsuo, T Sano
BACKGROUND: The postoperative pancreatic fistula (POPF) rate for duct-to-mucosa and invagination anastomosis after pancreatoduodenectomy is still debated. The aim of this RCT was to investigate the POPF rate for duct-to-mucosa versus invagination pancreaticojejunostomy. METHODS: Patients were stratified by pancreatic texture and diameter of the main pancreatic duct and randomized to the duct-to-mucosa or invagination group. The primary endpoint was the rate of clinically relevant POPF (defined as grade B or C)...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29119533/18-fluorodeoxyglucose-positron-emission-tomography-predicts-recurrence-in-resected-pancreatic-ductal-adenocarcinoma
#8
Kyohei Ariake, Fuyuhiko Motoi, Hideo Shimomura, Masamichi Mizuma, Shimpei Maeda, Chiaki Terao, Yasuko Tatewaki, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Tatsuyuki Takadate, Takeshi Naitoh, Yasuyuki Taki, Michiaki Unno
BACKGROUND: We aimed to determine whether treatment should be stratified according to 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake values (SUVmax ) in pancreatic ductal adenocarcinoma. METHODS: Patients who underwent preoperative 18F-FDG PET/CT between 2006 and 2014 (n = 138) were stratified into high (≥ 4.85) and low (< 4.85) PET groups. The clinicopathological characteristics and prognostic outcomes were analyzed retrospectively...
February 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29103084/reinforced-staplers-for-distal-pancreatectomy
#9
Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Sohei Satoi, Hiroaki Yanagimoto, Masanori Kon, Yoshiaki Murakami, Naru Kondo, Masayuki Sho, Takahiro Akahori, Hirochika Toyama, Takumi Fukumoto, Tsutomu Fujii, Ippei Matsumoto, Hidetoshi Eguchi, Hisashi Ikoma, Yutaka Takeda, Jiro Fujimoto, Hiroki Yamaue
PURPOSE: The safety and efficacy of reinforced staplers during distal pancreatectomy (DP) remain controversial because of the small sample size. This multicenter single-arm prospective study aims to evaluate the safety and efficacy of reinforced staplers with bioabsorbable material during DP. METHODS: Between October 2014 and August 2015, 121 patients scheduled for DP were enrolled in this study at 11 institutions in Japan. The primary endpoint was the incidence of clinically relevant pancreatic fistula...
December 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29099399/minimally-invasive-versus-open-distal-pancreatectomy-for-ductal-adenocarcinoma-diploma-a-pan-european-propensity-score-matched-study
#10
Jony van Hilst, Thijs de Rooij, Sjors Klompmaker, Majd Rawashdeh, Francesca Aleotti, Bilal Al-Sarireh, Adnan Alseidi, Zeeshan Ateeb, Gianpaolo Balzano, Frederik Berrevoet, Bergthor Björnsson, Ugo Boggi, Olivier R Busch, Giovanni Butturini, Riccardo Casadei, Marco Del Chiaro, Sophia Chikhladze, Federica Cipriani, Ronald van Dam, Isacco Damoli, Susan van Dieren, Safi Dokmak, Bjørn Edwin, Casper van Eijck, Jean-Marie Fabre, Massimo Falconi, Olivier Farges, Laureano Fernández-Cruz, Antonello Forgione, Isabella Frigerio, David Fuks, Francesca Gavazzi, Brice Gayet, Alessandro Giardino, Koerkamp Bas Groot, Thilo Hackert, Matthias Hassenpflug, Irfan Kabir, Tobias Keck, Igor Khatkov, Masa Kusar, Carlo Lombardo, Giovanni Marchegiani, Ryne Marshall, Krish V Menon, Marco Montorsi, Marion Orville, Matteo de Pastena, Andrea Pietrabissa, Ignaci Poves, John Primrose, Raffaele Pugliese, Claudio Ricci, Keith Roberts, Bård Røsok, Mushegh A Sahakyan, Santiago Sánchez-Cabús, Per Sandström, Lauren Scovel, Leonardo Solaini, Zahir Soonawalla, F Régis Souche, Robert P Sutcliffe, Guido A Tiberio, Aleš Tomazic, Roberto Troisi, Ulrich Wellner, Steven White, Uwe A Wittel, Alessandro Zerbi, Claudio Bassi, Marc G Besselink, Mohammed Abu Hilal
OBJECTIVE: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC. METHODS: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29068800/the-impact-of-positive-resection-margins-on-survival-and-recurrence-following-resection-and-adjuvant-chemotherapy-for-pancreatic-ductal-adenocarcinoma
#11
Paula Ghaneh, Jorg Kleeff, Christopher M Halloran, Michael Raraty, Richard Jackson, James Melling, Owain Jones, Daniel H Palmer, Trevor F Cox, Chloe J Smith, Derek A O'Reilly, Jakob R Izbicki, Andrew G Scarfe, Juan W Valle, Alexander C McDonald, Ross Carter, Niall C Tebbutt, David Goldstein, Robert Padbury, Jennifer Shannon, Christos Dervenis, Bengt Glimelius, Mark Deakin, Alan Anthoney, Markus M Lerch, Julia Mayerle, Attila Oláh, Charlotte L Rawcliffe, Fiona Campbell, Oliver Strobel, Markus W Büchler, John P Neoptolemos
OBJECTIVE AND BACKGROUND: Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies. METHODS: Analyses were carried out to assess the association between clinical characteristics and margin involvement as well as the effects of individual margin involvement on site of recurrence and overall and recurrence-free survival using individual patient data from the European Study Group for Pancreatic Cancer (ESPAC)-3 randomized controlled trial...
October 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28943396/pancreatectomy-combined-with-multivisceral-resection-for-pancreatic-malignancies-is-it-justified-results-of-a-systematic-review
#12
REVIEW
Niccolò Petrucciani, Tarek Debs, Giuseppe Nigri, Giulia Giannini, Elena Sborlini, Radwan Kassir, Imed Ben Amor, Antonio Iannelli, Stefano Valabrega, Francesco D'Angelo, Jean Gugenheim, Giovanni Ramacciato
BACKGROUND: Multivisceral resections combined with pancreatectomy have been proposed in selected patients with tumor invasion into adjacent organs, in order to allow complete tumor resection. Some authors have also reported multivisceral resection combined with metastasectomy in very selected cases. The utility of this practice is debated. The aim of the review is to compare the postoperative results and survival of pancreatectomies combined with multivisceral resections with those of standard pancreatectomies...
January 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28849366/is-adjuvant-therapy-necessary-for-all-patients-with-localized-pancreatic-cancer-who-have-received-neoadjuvant-therapy
#13
Chad A Barnes, Ashley N Krepline, Mohammed Aldakkak, Callisia N Clarke, Kathleen K Christians, Abdul H Khan, Bryan C Hunt, Paul S Ritch, Ben George, William A Hall, Beth A Erickson, Douglas B Evans, Susan Tsai
BACKGROUND: Among patients with localized pancreatic cancer (PC), the benefit of adjuvant therapy after neoadjuvant therapy and surgery is unknown. METHODS: Patients with localized PC who completed all intended neoadjuvant therapy and surgery were categorized based on the receipt of adjuvant therapy and by pathologic lymph node status (LN- /LN+ ). RESULTS: Data was available from 234 consecutive patients, 121 (52%) with resectable and 113 (48%) with borderline resectable PC...
November 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28885506/the-theory-and-practice-of-pancreatic-surgery-in-france
#14
Olivier Farges, Noelle Bendersky, Stéphanie Truant, Jean Robert Delpero, François René Pruvot, Alain Sauvanet
OBJECTIVE: Measure the caseload of pancreatectomies that influences their short-term outcome, at a national level, and assess the applicability of a centralization policy. BACKGROUND: There is agreement that pancreatectomies should be centralized. However, previous studies have failed to accurately define a "high-volume" center. METHODS: French healthcare databases were screened to identify all adult patients who had elective pancreatectomies between 2007 and 2012...
November 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28885510/pylorus-resection-does-not-reduce-delayed-gastric-emptying-after-partial-pancreatoduodenectomy-a-blinded-randomized-controlled-trial-propp-study-drks00004191
#15
Thilo Hackert, Pascal Probst, Phillip Knebel, Colette Doerr-Harim, Thomas Bruckner, Ulla Klaiber, Jens Werner, Lutz Schneider, Christoph W Michalski, Oliver Strobel, Alexis Ulrich, Markus K Diener, Markus W Büchler
OBJECTIVES: The aim of this study was to investigate the effect of pylorus resection on postoperative delayed gastric emptying (DGE) after partial pancreatoduodenectomy (PD). BACKGROUND: PD is the standard treatment for tumors of the pancreatic head. Preservation of the pylorus has been widely accepted as standard procedure. DGE is a common complication causing impaired oral intake, prolonged hospital stay, and postponed further treatment. Recently, pylorus resection has been shown to reduce DGE...
June 2018: Annals of Surgery
https://www.readbyqxmd.com/read/28852967/recent-advances-in-pancreatic-cancer-surgery
#16
REVIEW
Laura Maggino, Charles M Vollmer
Pancreatic cancer surgery is a continuously evolving field. Despite tremendous advances in perioperative outcomes, pancreatic resection is still associated with substantial morbidity, and mortality is not nil. Institutional caseload is a well-established determinant of patient outcomes, and centralization to experienced centers is essential to the safety and oncological appropriateness of the resection. Minimally invasive approaches are increasingly applied for pancreatic resection, even in cancer patients...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28770287/duodenal-invasion-by-pancreatic-adenocarcinoma-mdct-diagnosis-of-an-aggressive-imaging-phenotype-and-its-clinical-implications
#17
REVIEW
Bhavik N Patel, Eric W Olcott, R Brooke Jeffrey
Despite advances in oncologic and imaging technology, pancreatic ductal adenocarcinoma remains a highly deadly disease. The only curative option, pancreaticoduodenectomy or pancreatectomy, carries a significant morbidity. Current imaging plays a role in pre-operative staging to determine the probability of achieve disease-free margins. However, a small but not insignificant number of pancreatic cancers have a relatively higher aggressive biology, despite being resectable based on traditional criteria. Recently, imaging biomarkers that serve as a surrogate for tumors with such aggressive phenotype have been described...
February 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/28522378/a-comparative-study-of-risk-factors-for-pancreatic-fistula-after-pancreatoduodenectomy-or-distal-pancreatectomy
#18
COMPARATIVE STUDY
James M Halle-Smith, Eduardo Vinuela, Rachel M Brown, James Hodson, Zergham Zia, Simon R Bramhall, Ravi Marudanayagam, Robert P Sutcliffe, Darius F Mirza, Paolo Muiesan, John Isaac, Keith J Roberts
BACKGROUND: Evidence associates various biometric and histological variables such as steatosis and absence of fibrosis as risk factors for post-operative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). Following distal pancreatectomy (DP), the association between these factors and POPF is less clear. This study of patients, drawn from the same background population, undergoing PD or DP at a single centre is a comparative study of the risk factors for POPF after these two operations...
August 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28711377/pancreas-exocrine-replacement-therapy-is-associated-with-increased-survival-following-pancreatoduodenectomy-for-periampullary-malignancy
#19
Keith J Roberts, Harald Schrem, James Hodson, Roberta Angelico, Bobby V M Dasari, Chris A Coldham, Ravi Marudanayagam, Robert P Sutcliffe, Paolo Muiesan, John Isaac, Darius F Mirza
BACKGROUND: Although many patients undergoing pancreatoduodenectomy (PD) for cancer have pancreatic exocrine insufficiency, pancreatic enzyme replacement therapy (PERT) is not routinely used, and effects upon post-operative survival are unclear. METHODS: This review of patients undergoing PD for periampullary malignancy sought to test for an association between PERT and overall survival, with post-hoc subgroup analysis performed after stratifying patients by the year of surgery, pancreatic duct width and tumour type...
October 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28747265/pancreatic-adenocarcinoma-effects-of-neoadjuvant-therapy-on-post-pancreatectomy-outcomes-an-american-college-of-surgeons-national-surgical-quality-improvement-program-targeted-variable-review
#20
COMPARATIVE STUDY
Nicholas M Czosnyka, Andrew J Borgert, Travis J Smith
BACKGROUND: As the incidence of pancreatic adenocarcinoma increases, so has the utilization of neoadjuvant therapy. The objective of this study was to evaluate outcomes in patients undergoing neoadjuvant therapy or surgery first for pancreatic adenocarcinoma. METHODS: The ACS-NSQIP 2014-2015 targeted pancreatectomy variables were queried for patients with pancreatic adenocarcinoma who underwent resection. Outcomes of those receiving neoadjuvant therapy were compared to surgery first using a multivariate, logistic regression model...
October 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
label_collection
label_collection
4496
1
2
2017-08-19 03:16:53
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"