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14 papers 0 to 25 followers
Elske Sitsen, Erik Olofsen, Agnes Lesman, Albert Dahan, Jaap Vuyk
BACKGROUND: Neuraxial blockade reduces the dose requirements of sedative agents. It is unclear whether neuraxial blockade affects the pharmacokinetics and/or the pharmacodynamics of IV hypnotics. We therefore studied the influence of epidural blockade on the pharmacokinetics of propofol in patients scheduled for general surgery. METHODS: Twenty-eight patients were randomly divided into 4 groups, in a double-blind manner, to receive 0, 50, 100, or 150 mg epidural ropivacaine...
May 2016: Anesthesia and Analgesia
Praveen Maheshwari, Bradley Kelsheimer, Parul Maheshwari
No abstract text is available yet for this article.
April 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Colin S Goodchild, Juliet M Serrao, Anton Kolosov, Ben J Boyd
BACKGROUND: Alphaxalone is a neuroactive steroid anesthetic that is poorly water soluble. It was formulated in 1972 as Althesin® using Cremophor® EL, a nonionic surfactant additive. The product was a versatile short-acting IV anesthetic used in clinical practice in many countries from 1972 to 1984. It was withdrawn from clinical practice because of hypersensitivity to Cremophor EL. In the investigations reported here, we compared the properties of 3 anesthetics: a new aqueous solution of alphaxalone dissolved in 7-sulfobutyl-ether-β-cyclodextrin (SBECD, a water-soluble molecule with a lipophilic cavity that enables drug solubilization in water); a Cremophor EL preparation of alphaxalone; and propofol...
May 2015: Anesthesia and Analgesia
Daisuke Okada, Nobuyasu Komasawa, Shunsuke Fujiwara, Toshiaki Minami
BACKGROUND: Previous studies have shown the utility of indirect glottis viewing videolaryngoscopes for tracheal intubation during chest compression, but the efficacy of a videolaryngoscope with tube guide has not been sufficiently validated. We compared the utility of two videolaryngoscopes, the KingVISION(®) (KingV) with or without tube guide blade and Pentax-AWS Airwayscope(®) (AWS), which contain tube guide function, during chest compressions on an adult manikin. METHODS: Twenty-five novice doctors and 22 experienced anesthesiologists performed tracheal intubation on an adult manikin using the AWS and KingV with or without chest compressions...
June 2015: Journal of Anesthesia
Pattara Rattanawong, Tachapong Ngarmukos, Treechada Wisaratapong
No abstract text is available yet for this article.
June 2015: Journal of Anesthesia
H J Shin, Y H Kim, H W Lee
Meralgia paresthetica (MP) is generally caused by entrapment of the lateral femoral cutaneous nerve (LFCN), and presents with pain and paresthesia in the anterolateral thigh. This paper describes a patient who had MP-like symptoms as a result of continuous epidural analgesia after total knee arthroplasty. The patient with pre-existing left foraminal stenosis at L3-L4 and disc herniations at L4-5 did not complain of paresthesia or pain during the combined spinal-epidural anesthetic procedure. However, during epidural analgesia on the second post-operative day, he complained of paresthesia and pain in the anterolateral thigh of the contralateral leg...
November 2014: Acta Anaesthesiologica Scandinavica
Peter Van de Putte, Anahi Perlas
BACKGROUND: Gastric ultrasonography allows qualitative and quantitative assessment of gastric contents and volume in nonobese subjects. In this study, we sought to determine the feasibility of gastric ultrasound in severely obese patients (body mass index [BMI] ≥35 kg/m). We defined feasibility as the ability to identify a full cross section of the gastric antrum in at least 80% of subjects when imaged in the right lateral decubitus position. METHODS: This was a prospective cohort study on fasted surgical patients with BMI >35 kg/m...
November 2014: Anesthesia and Analgesia
Arnaud Foucrier, Reitze Rodseth, Mohamed Aissaoui, Cristina Ibanes, Jean-Pierre Goarin, Paul Landais, Pierre Coriat, Yannick Le Manach
BACKGROUND: Acute cardiac events are a frequent cause of morbidity after vascular surgery. The impact of early evidence-based treatment for patients with an acute cardiac event after vascular surgery on long-term postoperative outcomes has not been extensively studied. We hypothesized that providing appropriate evidence-based treatment to patients with elevated postoperative cardiac troponin levels may limit long-term mortality. METHODS: We conducted a study of 667 consecutive major vascular surgery patients with an elevated postoperative troponin I level...
November 2014: Anesthesia and Analgesia
D Payen
No abstract text is available yet for this article.
November 2014: British Journal of Anaesthesia
K Ker, D Prieto-Merino, I Roberts
BACKGROUND: Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of the reduction in blood loss and how it relates to the dose of TXA is unclear. METHODS: A systematic review of randomized trials was performed. Data were extracted on blood loss from trials comparing intravenous TXA with no TXA or placebo in surgical patients. A Bayesian linear regression was used to describe the relationship between the reduction in blood loss with TXA and the extent of bleeding as measured by the mean blood loss in the control group...
September 2013: British Journal of Surgery
Guilermo E Umpierez
Many patients admitted to the hospital have diabetes mellitus-diagnosed or undiagnosed-and others develop hyperglycemia from the stress of hospitalization. This paper discusses the prevalence, outcomes, and evidence for best management of hyperglycemia and diabetes in hospitalized patients outside the critical care setting.
June 2011: Cleveland Clinic Journal of Medicine
Richard Hall, C David Mazer
In the normal course of the delivery of care, anesthesiologists encounter many patients who are receiving drugs that affect platelet function as a fundamental part of primary and secondary management of atherosclerotic thrombotic disease. There are several antiplatelet drugs available for use in clinical practice and several under investigation. Aspirin and clopidogrel (alone and in combination) have been the most studied and have the most favorable risk-benefit profiles of drugs currently available. Prasugrel was recently approved for patients with acute coronary syndrome undergoing percutaneous interventions...
February 2011: Anesthesia and Analgesia
Daniel Chappell, Matthias Jacob, Klaus Hofmann-Kiefer, Peter Conzen, Markus Rehm
Replacement of assumed preoperative deficits, in addition to generous substitution of an unsubstantiated increased insensible perspiration and third space loss, plays an important role in current perioperative fluid regimens. The consequence is a positive fluid balance and weight gain of up to 10 kg, which may be related to severe complications. Because the intravascular blood volume remains unchanged and insensible perspiration is negligible, the fluid must accumulate inside the body. This concept brings into question common liberal infusion regimens...
October 2008: Anesthesiology
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