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GU pathology

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By Sean Williamson Urologic Surgical Pathologist
T Maubon, N Branger, C Bastide, G Lonjon, K-A Harvey-Bryan, P Validire, S Giusiano, D Rossi, X Cathelineau, F Rozet
BACKGROUND: To assess the impact of the degree of extraprostatic extension (EPE) on biochemical recurrence (BCR) and utility of the original Epstein's criteria to define EPE in a cohort of pT3aN0 without positive surgical margin (PSM). METHODS: A two-center retrospective analysis was performed on data from 490 pT3aN0 patients who underwent radical prostatectomy between 2000 and 2012. Patients with neoadjuvant and/or adjuvant therapy, detectable PSA and PSM were excluded...
September 2016: Prostate Cancer and Prostatic Diseases
Bruce J Trock, Helen Fedor, Bora Gurel, Robert B Jenkins, B S Knudsen, Samson W Fine, Jonathan W Said, H Ballentine Carter, Tamara L Lotan, Angelo M De Marzo
Men who enter active surveillance because their biopsy exhibits only Gleason grade 3 (G3) frequently have higher grade tumor missed by biopsy. Thus, biomarkers are needed that, when measured on G3 tissue, can predict the presence of higher grade tumor in the whole prostate. We evaluated whether PTEN loss, chromosome 8q gain (MYC) and/or 8p loss (LPL) measured only on G3 cores is associated with un-sampled G4 tumor. A tissue microarray was constructed of prostatectomy tissue from patients whose prostates exhibited only Gleason score 3+3, only 3+4 or only 4+3 tumor (n=50 per group)...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Ikuma Kato, Yasuhiro Iribe, Yoji Nagashima, Naoto Kuroda, Reiko Tanaka, Yukio Nakatani, Hisashi Hasumi, Masahiro Yao, Mitsuko Furuya
Birt-Hogg-Dubé syndrome (BHD) is a familial disorder associated with a germline mutation of FLCN that is a tumor suppressor gene. Patients with BHD have high risks for developing multiple renal cell carcinomas (RCCs). The frequent histological types are hybrid oncocytic/chromophobe tumors (HOCTs) and chromophobe RCCs. The morphology of HOCTs could alert pathologists to the possibility of BHD. On the other hand, chromophobe RCCs occurring in BHD patients demonstrate positive immunostaining for cytokeratin-7, CD82, and Ksp-cadherin similar to their sporadic counterparts...
June 2016: Human Pathology
Evita T Sadimin, Jonathan I Epstein
Prostatic stromal tumor of uncertain malignant potential (STUMP) is a distinct entity which includes several different patterns. Four patterns of STUMP have been described including stroma with (1) degenerative atypia, (2) hypercellular spindle cells, (3) myxoid spindle cells, and (4) phyllodes-like pattern. The current study identified a novel round cell pattern. We searched our database from 1999 to 2015 and identified 7 patients with round cell pattern out of a total number of 98 patients with STUMP. All 7 cases showed mildly increased stromal cellularity with rounded nuclei, diagnosed on core biopsies in 5 cases, transurethral resection in 1 case, and radical prostatectomy in 1 case...
June 2016: Human Pathology
Rajal B Shah, Ming Zhou
Since its initial description in 1966 by Dr Donald Gleason, Gleason grading has become the cornerstone in the management of prostate cancer (PCa). With widespread use of Prostate Specific Antigen (PSA) screening and needle core biopsy, the diagnosis and management of PCa have dramatically evolved. In addition, better understanding of the morphological spectrum of prostate cancer and its clinical significance have prompted the refinement of the grading criteria and reporting guidelines commensurate to contemporary practice...
May 2016: Pathology International
Pedram Argani, Minghao Zhong, Victor E Reuter, John T Fallon, Jonathan I Epstein, George J Netto, Cristina R Antonescu
Xp11 translocation cancers include Xp11 translocation renal cell carcinoma (RCC), Xp11 translocation perivascular epithelioid cell tumor (PEComa), and melanotic Xp11 translocation renal cancer. In Xp11 translocation cancers, oncogenic activation of TFE3 is driven by the fusion of TFE3 with a number of different gene partners; however, the impact of individual fusion variant on specific clinicopathologic features of Xp11 translocation cancers has not been well defined. In this study, we analyze 60 Xp11 translocation cancers by fluorescence in situ hybridization using custom bacterial artificial chromosome probes to establish their TFE3 fusion gene partner...
June 2016: American Journal of Surgical Pathology
Sara M Falzarano, Jesse K McKenney, Rodolfo Montironi, John N Eble, Adeboye O Osunkoya, Juan Guo, Shengmei Zhou, Hong Xiao, Saravana M Dhanasekaran, Sudhanshu Shukla, Rohit Mehra, Cristina Magi-Galluzzi
Renal cell carcinoma (RCC) associated with neuroblastoma (NB) was included as a distinct entity in the 2004 World Health Organization classification of kidney tumors. A spectrum of RCC subtypes has been reported in NB survivors. We herein describe a series of 8 RCCs diagnosed in 7 patients with a history of NB. Microscopic evaluation, immunohistochemical staining for PAX8, cathepsin K, and succinate dehydrogenase subunit B (SDHB), and fluorescence in situ hybridization (FISH) for TFE3 and TFEB were performed...
July 2016: American Journal of Surgical Pathology
Guang-Qian Xiao, Faqian Li, Pamela D Unger, Hani Katerji, Qi Yang, Loralee McMahon, David E Burstein
Although the function of zinc finger and BTB domain containing 16 (ZBTB16) in spermatogenesis is well documented, expression of ZBTB16 in germ cell tumors has not yet been studied. The aim of this study was to investigate the immunohistochemical expression and diagnostic utility of ZBTB16 in germ cell tumors. A total of 67 adult germ cell tumors were studied (62 testicular germ cell tumors, 2 ovarian yolk sac tumors, 1 mediastinal yolk sac tumor, and 2 retroperitoneal metastatic yolk sac tumors). The 62 testicular primary germ cell tumors are as follows: 34 pure germ cell tumors (20 seminomas, 8 embryonal carcinomas, 2 teratomas, 1 choriocarcinoma, 1 carcinoid, and 2 spermatocytic tumors) and 28 mixed germ cell tumors (composed of 13 embryonal carcinomas, 15 yolk sac tumors, 15 teratomas, 7 seminomas, and 3 choriocarcinomas in various combinations)...
June 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Martin J Magers, Aaron M Udager, Arul M Chinnaiyan, Diana French, Jeffrey L Myers, Jeffrey M Jentzen, Jonathan B McHugh, Amer Heider, Rohit Mehra
The immunophenotype of a normal testis and the excretory duct system has not been studied comprehensively in fetal and adult patients without testicular disease or hormonal manipulation so far. In addition, testicular (TA) and epididymal (EA) appendages are frequent paratesticular structures without previously reported comprehensive immunophenotypic studies. Immunohistochemistry for multiple markers, including the androgen receptor (AR), the estrogen receptor (ER), the progesterone receptor (PR), the prostate-specific antigen, the prostate-specific membrane antigen, PAX8, WT1, calretinin, CK7, CK20, OCT4, SALL4, and CD117, was performed on full sections of testicular/paratesticular tissue from a large cohort of adult and fetal autopsy patients...
August 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Gladell P Paner, Antonio Lopez-Beltran, Deepika Sirohi, Mahul B Amin
Since the publication of the World Health Organization "blue book" in 2004, several recent studies have provided new insights on the pathologic aspects of urachal neoplasms. The proposed updates include modified criteria for the diagnosis of urachal carcinoma. A uniform nomenclature for cystic tumors was lacking, and it is recommended that urachal mucinous cystic tumors should be separated and classified in a manner similar to ovarian mucinous neoplasms. The spectrum includes mucinous cystadenoma, mucinous cystic tumor of low malignant potential, mucinous cystic tumor of low malignant potential with intraepithelial carcinoma, and microscopically or frankly invasive mucinous cystadenocarcinoma, with 65% of cystic tumors classified as mucinous cystic tumor of low malignant potential...
March 2016: Advances in Anatomic Pathology
Hironori Kusano, Yuki Togashi, Jun Akiba, Fukuko Moriya, Katsuyoshi Baba, Naomi Matsuzaki, Yoshiaki Yuba, Yusuke Shiraishi, Hiroshi Kanamaru, Naoto Kuroda, Seiji Sakata, Kengo Takeuchi, Hirohisa Yano
Anaplastic lymphoma kinase (ALK) translocation renal cell carcinomas (RCCs) have been reported by several independent groups in recent times. The clinical behavior and histopathologic characteristics of these carcinomas are not fully understood because of the paucity of cases reported. Here, we describe 2 cases of RCC harboring a novel striatin (STRN)-ALK fusion. The first case was a 33-year-old woman with no sickle cell trait who underwent nephrectomy for right renal mass and had late recurrence in para-aortic lymph nodes twice 10 and 12 years after initial surgery...
June 2016: American Journal of Surgical Pathology
Robert H Young, Jennifer N Stall, Henri Sevestre
No abstract text is available yet for this article.
March 2016: International Journal of Gynecological Pathology
Hany Osman, Liang Cheng, Thomas M Ulbright, Muhammad T Idrees
We identified 109 testicular tumors, including pure and mixed germ cell tumors and sex cord-stromal tumors, and conducted immunohistochemical staining for CDX2, DOG1, and GATA3 to address the potential utility of these readily available and commonly used markers in the evaluation of testicular tumors. Their expression has not been previously thoroughly examined in testicular germ cell tumors. The distribution, percentage, and intensity of positivity were assessed. CDX2 was positive in all yolk sac tumors, 25% of choriocarcinomas, 9% of seminomas, and 4% of embryonal carcinomas (sensitivity for yolk sac tumor, 100%; specificity, 89% [teratomas excluded])...
February 2016: Human Pathology
Pedram Argani, Justin Lee, George J Netto, Gang Zheng, Ming Tseh-Lin, Ben Ho Park
No abstract text is available yet for this article.
May 2016: American Journal of Surgical Pathology
Seung-Hyun Jung, Sun Shin, Min Sung Kim, In-Pyo Baek, Ji Youl Lee, Sung Hak Lee, Tae-Min Kim, Sug Hyung Lee, Yeun-Jun Chung
BACKGROUND: Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN remain unknown. OBJECTIVE: Identification of the genomic landscape of HGPIN and the genomic differences between HGPIN and PCA that may drive the progression to PCA. DESIGN, SETTINGS, AND PARTICIPANTS: We analyzed 20 regions of paired HGPIN and PCA from six patients using whole-exome sequencing and array-comparative genomic hybridization...
May 2016: European Urology
Hari P Dhakal, Jesse K McKenney, Li Yan Khor, Jordan P Reynolds, Cristina Magi-Galluzzi, Christopher G Przybycin
Clear cell papillary renal cell carcinoma (CCPRCC) was recently included in the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia as a subtype of RCC that is morphologically, immunohistochemically, and genetically distinct from both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma. In our clinical practice we have observed tumors with overlapping histologic features of CCPRCC and CCRCC; therefore, our aim was to describe the morphologic, immunohistochemical, and clinical characteristics of these tumors...
February 2016: American Journal of Surgical Pathology
Oleksandr N Kryvenko, Jonathan I Epstein
Since 1966, when Donald Gleason, MD, first proposed grading prostate cancer based on its histologic architecture, there have been numerous changes in clinical and pathologic practices relating to prostate cancer. Patterns 1 and 2, comprising more than 30% of cases in the original publications by Gleason, are no longer reported on biopsy and are rarely diagnosed on radical prostatectomy. Many of these cases may even have been mimickers of prostate cancer that were described later with the use of contemporary immunohistochemistry...
October 2016: Archives of Pathology & Laboratory Medicine
Murali Varma, Fouad S Alchami, David F R Griffiths
No abstract text is available yet for this article.
August 2016: Histopathology
Lauren E Schwartz, Francesca Khani, Justin A Bishop, Russell Vang, Jonathan I Epstein
Uterine cervical carcinoma secondarily involving the genitourinary tract is rarely documented histologically. These tumors present a unique diagnostic challenge as they can appear morphologically similar to urothelial carcinoma as well as primary squamous cell carcinoma and primary adenocarcinoma of the bladder. Genitourinary consult cases at the Johns Hopkins Hospital from 1984 to the present were searched for cases in which the differential diagnosis was primary bladder carcinoma versus secondary involvement by cervical carcinoma...
January 2016: American Journal of Surgical Pathology
Jamie Stanhiser, Haider Mahdi, Gabriela Rosa, Holly Harper, Dale Shepard, Peter G Rose, Andres A Roma
We report our experience with prostatic-type tissue in ovarian teratomas, and in particular we highlight a case of prostatic-type adenocarcinoma arising within a mature cystic ovarian teratoma in a 32-yr-old woman. On gross examination, the cyst consisted of typical features of a dermoid cyst. Closer examination revealed a single 1.5-cm solid nodule within the cyst. Microscopically, it was composed of a small cyst-like structure lined by urothelium and to one side glandular and stromal tissue consistent with prostate parenchyma...
March 2016: International Journal of Gynecological Pathology
2015-09-26 01:28:57
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