David S Kotlyar, James D Lewis, Laurent Beaugerie, Ann Tierney, Colleen M Brensinger, Javier P Gisbert, Edward V Loftus, Laurent Peyrin-Biroulet, Wojciech C Blonski, Manuel Van Domselaar, Maria Chaparro, Sandipani Sandilya, Meenakshi Bewtra, Florian Beigel, Livia Biancone, Gary R Lichtenstein
BACKGROUND & AIMS: Thiopurine therapy for inflammatory bowel disease (IBD) has been associated with increased risk for lymphoma. We estimated the relative risk of lymphoma in patients with IBD exposed to thiopurines and compared relative risk values derived from population-based studies with those from referral center-based studies. We investigated whether active use increased risk compared with past use, and whether sex, age, or duration of use affects risk of lymphoma. METHODS: We searched MEDLINE, EMBASE, and Cochrane databases, as well as conference abstracts and international publications, for the terms "6-MP and lymphoma," "6-mercaptopurine and lymphoma," "thiopurines and lymphoma," "azathioprine and cancer and IBD," "azathioprine and malignancy and IBD," "azathioprine and lymphoma," and "lymphoproliferative and thiopurines...
May 2015: Clinical Gastroenterology and Hepatology