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Hypertension

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4 papers 100 to 500 followers
By Andres Munoz-Ramos M.D.; Nephtology and Internal Medicine on Mexico City.
https://www.readbyqxmd.com/read/23121378/cardiorenal-end-points-in-a-trial-of-aliskiren-for-type-2-diabetes
#1
RANDOMIZED CONTROLLED TRIAL
Hans-Henrik Parving, Barry M Brenner, John J V McMurray, Dick de Zeeuw, Steven M Haffner, Scott D Solomon, Nish Chaturvedi, Frederik Persson, Akshay S Desai, Maria Nicolaides, Alexia Richard, Zhihua Xiang, Patrick Brunel, Marc A Pfeffer
BACKGROUND: This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS: In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level...
December 6, 2012: New England Journal of Medicine
https://www.readbyqxmd.com/read/24500308/paricalcitol-or-cinacalcet-centred-therapy-affects-markers-of-bone-mineral-disease-in-patients-with-secondary-hyperparathyroidism-receiving-haemodialysis-results-of-the-impact-shpt-study
#2
RANDOMIZED CONTROLLED TRIAL
Mario Cozzolino, Markus Ketteler, Kevin J Martin, Amit Sharma, David Goldsmith, Samina Khan
BACKGROUND: In this Phase 4 international study, efficacy and safety of paricalcitol-centred therapy were compared with that of cinacalcet-centred therapy for the treatment of chronic kidney disease (CKD)-associated secondary hyperparathyroidism (SHPT) in patients undergoing haemodialysis (ClinicalTrials.gov identifier NCT00977080). METHODS: Patients ≥ 18 years of age with Stage 5 CKD and SHPT [intact parathyroid hormone (iPTH) level of 300-800 pg/mL, calcium level of 8...
April 2014: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/24352759/updated-guidelines-for-management-of-high-blood-pressure-recommendations-review-and-responsibility
#3
EDITORIAL
Howard Bauchner, Phil B Fontanarosa, Robert M Golub
No abstract text is available yet for this article.
February 5, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/23984731/severe-sepsis-and-septic-shock
#4
REVIEW
Derek C Angus, Tom van der Poll
New England Journal of Medicine, Volume 369, Issue 9, Page 840-851, August 2013.
August 29, 2013: New England Journal of Medicine
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