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Hypothermia and TBI: fever control is the goal!!!!!

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3 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/26449873/temperature-management-after-cardiac-arrest-an-advisory-statement-by-the-advanced-life-support-task-force-of-the-international-liaison-committee-on-resuscitation-and-the-american-heart-association-emergency-cardiovascular-care-committee-and-the-council-on-cardiopulmonary
#1
Michael W Donnino, Lars W Andersen, Katherine M Berg, Joshua C Reynolds, Jerry P Nolan, Peter T Morley, Eddy Lang, Michael N Cocchi, Theodoros Xanthos, Clifton W Callaway, Jasmeet Soar
For more than a decade, mild induced hypothermia (32 °C-34 °C) has been standard of care for patients remaining comatose after resuscitation from out-of-hospital cardiac arrest with an initial shockable rhythm, and this has been extrapolated to survivors of cardiac arrest with initially nonshockable rhythms and to patients with in-hospital cardiac arrest. Two randomized trials published in 2002 reported a survival and neurological benefit with mild induced hypothermia. One recent randomized trial reported similar outcomes in patients treated with targeted temperature management at either 33 °C or 36 °C...
January 2016: Resuscitation
https://www.readbyqxmd.com/read/26434495/temperature-management-after-cardiac-arrest-an-advisory-statement-by-the-advanced-life-support-task-force-of-the-international-liaison-committee-on-resuscitation-and-the-american-heart-association-emergency-cardiovascular-care-committee-and-the-council-on-cardiopulmonary
#2
REVIEW
Michael W Donnino, Lars W Andersen, Katherine M Berg, Joshua C Reynolds, Jerry P Nolan, Peter T Morley, Eddy Lang, Michael N Cocchi, Theodoros Xanthos, Clifton W Callaway, Jasmeet Soar
For more than a decade, mild induced hypothermia (32 °C-34 °C) has been standard of care for patients remaining comatose after resuscitation from out-of-hospital cardiac arrest with an initial shockable rhythm, and this has been extrapolated to survivors of cardiac arrest with initially nonshockable rhythms and to patients with in-hospital cardiac arrest. Two randomized trials published in 2002 reported a survival and neurological benefit with mild induced hypothermia. One recent randomized trial reported similar outcomes in patients treated with targeted temperature management at either 33 °C or 36 °C...
December 22, 2015: Circulation
https://www.readbyqxmd.com/read/25099730/prolonged-mild-therapeutic-hypothermia-versus-fever-control-with-tight-hemodynamic-monitoring-and-slow-rewarming-in-patients-with-severe-traumatic-brain-injury-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Tsuyoshi Maekawa, Susumu Yamashita, Seigo Nagao, Nariyuki Hayashi, Yasuo Ohashi
Although mild therapeutic hypothermia is an effective neuroprotective strategy for cardiac arrest/resuscitated patients, and asphyxic newborns, recent randomized controlled trials (RCTs) have equally shown good neurological outcome between targeted temperature management at 33 °C versus 36 °C, and have not shown consistent benefits in patients with traumatic brain injury (TBI). We aimed to determine the effect of therapeutic hypothermia, while avoiding some limitations of earlier studies, which included patient selection based on Glasgow coma scale (GCS), delayed initiation of cooling, short duration of cooling, inter-center variation in patient care, and relatively rapid rewarming...
April 1, 2015: Journal of Neurotrauma
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