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3 papers 25 to 100 followers
By Andres Munoz-Ramos M.D.; Nephtology and Internal Medicine on Mexico City.
Paul A James, Suzanne Oparil, Barry L Carter, William C Cushman, Cheryl Dennison-Himmelfarb, Joel Handler, Daniel T Lackland, Michael L LeFevre, Thomas D MacKenzie, Olugbenga Ogedegbe, Sidney C Smith, Laura P Svetkey, Sandra J Taler, Raymond R Townsend, Jackson T Wright, Andrew S Narva, Eduardo Ortiz
Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. Patients want to be assured that blood pressure (BP) treatment will reduce their disease burden, while clinicians want guidance on hypertension management using the best scientific evidence. This report takes a rigorous, evidence-based approach to recommend treatment thresholds, goals, and medications in the management of hypertension in adults...
February 5, 2014: JAMA: the Journal of the American Medical Association
Maria-Eleni Roumelioti, Mark Unruh
No abstract text is available yet for this article.
July 1, 2014: Annals of Internal Medicine
Cees G M Kallenberg, Peter Heeringa, Coen A Stegeman
Wegener's granulomatosis and microscopic polyangiitis are idiopathic systemic vasculitides strongly associated with antineutrophil cytoplasmic autoantibodies (ANCA). In Wegener's granulomatosis, ANCA are mostly directed against proteinase 3 (PR3), whereas in microscopic polyangiitis ANCA are directed against myeloperoxidase; increases in levels of these autoantibodies precede or coincide with clinical relapses in many cases. In vitro, ANCA can further activate primed neutrophils to release reactive oxygen species and lytic enzymes, and, in conjunction with neutrophils, can damage and lyse endothelial cells...
December 2006: Nature Clinical Practice. Rheumatology
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