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26 papers 0 to 25 followers A bucket of SIDS theories that leaves me wanting the "right one".
By Joe Weatherly FM/Hospitalist-CoFounder of QuestioningMedicine and PCRAP contributor.
https://www.readbyqxmd.com/read/25757662/the-role-of-the-sodium-current-complex-in-a-nonreferred-nationwide-cohort-of-sudden-infant-death-syndrome
#1
Bo Gregers Winkel, Lei Yuan, Morten S Olesen, Golnaz Sadjadieh, Yinman Wang, Bjarke Risgaard, Reza Jabbari, Stig Haunsø, Anders Gaarsdal Holst, Mads Vilhelm Hollegaard, Jacob Tfelt-Hansen, Thomas Jespersen
BACKGROUND: Sudden infant death syndrome (SIDS) is the most common cause of death in infants between the age of 1 month and 1 year. Rare variants in Nav1.5 encoded by SCN5A are known to play a role in SIDS; however, the combined role of the sodium current complex is unknown. OBJECTIVE: The purpose of this study was to investigate the role of the sodium current complex in a nonreferred nationwide cohort of SIDS cases. METHODS: DNA was extracted from dried blood spot samples from the Danish Neonatal Screening Biobank...
June 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/25748025/ambient-heat-and-sudden-infant-death-a-case-crossover-study-spanning-30-years-in-montreal-canada
#2
Nathalie Auger, William D Fraser, Audrey Smargiassi, Tom Kosatsky
BACKGROUND: Climate change may lead to more severe and extreme heat waves in the future, but its potential impact on sudden infant death-a leading cause of infant mortality-is unclear. OBJECTIVES: We sought to determine whether risk of sudden infant death syndrome (SIDS) is elevated during hot weather. METHODS: We undertook a case-crossover analysis of all sudden infant deaths during warm periods in metropolitan Montreal, Quebec, Canada, from 1981 through 2010...
July 2015: Environmental Health Perspectives
https://www.readbyqxmd.com/read/25746481/-management-of-sudden-unexpected-infant-death-syndrome-suids-in-reference-centers-in-france-in-2013
#3
MULTICENTER STUDY
K Levieux, H Patural, I Harrewijn, M Hanf, C Gras Leguen
In France, nearly 500 infants still die unexpectedly every year. In 2009, the French Institute for Public Health Surveillance published a survey showing great heterogeneity in the management of sudden unexpected infant death (SUID) cases. The aim of this study was to evaluate the actual diagnostic approach to SUID in the different reference centers in France and to determine the degree to which the 2007 recommendations of the French National Authority for Health (Haute Autorité de santé [HAS]) are applied...
April 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/25699563/sudden-unexpected-death-in-infancy-aetiology-pathophysiology-epidemiology-and-prevention-in-2015
#4
REVIEW
Peter J Fleming, Peter S Blair, Anna Pease
Despite the fall in numbers of unexpected infant deaths that followed the 'Back to Sleep' campaigns in the early 1990 s in the UK and many other countries, such deaths remain one of the largest single groups of deaths in the postneonatal period in many Western countries. Changes in the ways in which unexpected infant deaths are categorised by pathologists and coroners, and increasing reluctance to use the term 'sudden infant death syndrome', make assessment of nationally and internationally collected data on incidence potentially inaccurate and confusing...
October 2015: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/25695895/the-alteration-of-neonatal-raphe-neurons-by-prenatal-perinatal-nicotine-meaning-for-sudden-infant-death-syndrome
#5
Verónica J Cerpa, María de la Luz O Aylwin, Sebastián Beltrán-Castillo, Eduardo U Bravo, Isabel R Llona, George B Richerson, Jaime L Eugenín
Nicotine may link maternal cigarette smoking with respiratory dysfunctions in sudden infant death syndrome (SIDS). Prenatal-perinatal nicotine exposure blunts ventilatory responses to hypercapnia and reduces central respiratory chemoreception in mouse neonates at Postnatal Days 0 (P0) to P3. This suggests that raphe neurons, which are altered in SIDS and contribute to central respiratory chemoreception, may be affected by nicotine. We therefore investigated whether prenatal-perinatal nicotine exposure affects the activity, electrical properties, and chemosensitivity of raphe obscurus (ROb) neurons in mouse neonates...
October 2015: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/25689231/undiagnosed-metabolic-dysfunction-and-sudden-infant-death-syndrome-a-case-control-study
#6
Ning An Rosenthal, Robert J Currier, Rebecca J Baer, Lisa Feuchtbaum, Laura L Jelliffe-Pawlowski
BACKGROUND: Decades of research has yielded few clues about causes of sudden infant death syndrome (SIDS). While some studies have shown a link to inborn errors of metabolism (IEMs), few have examined the link in a large population-based sample. This population-based case-control study assessed the association between undiagnosed IEMs and SIDS. METHODS: Children born in California during 2005-08 who died from SIDS were obtained from death records and linked to the newborn screening, birth certificate, and hospital discharge databases...
March 2015: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/25665709/occurrence-of-specific-environmental-risk-factors-in-brain-tissues-of-sudden-infant-death-and-sudden-intrauterine-unexpected-death-victims-assessed-with-gas-chromatography-tandem-mass-spectrometry
#7
Veronica Termopoli, Giorgio Famiglini, Pierangela Palma, Laura Magrini, Achille Cappiello
Sudden infant death syndrome (SIDS) and sudden intrauterine unexpected death syndrome (SIUDS) are an unresolved teaser in the social-medical and health setting of modern medicine and are the result of multifactorial interactions. Recently, prenatal exposure to environmental contaminants has been associated with negative pregnancy outcomes, and verification of their presence in fetal and newborn tissues is of crucial importance. A gas chromatography-tandem mass spectrometry (MS/MS) method, using a triple quadrupole analyzer, is proposed to assess the presence of 20 organochlorine pesticides, two organophosphate pesticides, one carbamate (boscalid), and a phenol (bisphenol A) in human brain tissues...
March 2015: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/25656219/updated-swedish-advice-on-reducing-the-risk-of-sudden-infant-death-syndrome
#8
REVIEW
Göran Wennergren, Kerstin Nordstrand, Bernt Alm, Per Möllborg, Anna Öhman, Anita Berlin, Miriam Katz-Salamon, Hugo Lagercrantz
UNLABELLED: This article reviews updated advice and factual material from the Swedish National Board of Health and Welfare on reducing the risk of sudden infant death syndrome. Issues covered by the guidance for parents and healthcare professionals include sleeping positions, smoking, breastfeeding, bed sharing and using pacifiers. CONCLUSION: The guidelines conclude that infants under three months of age are safest sleeping in their own cot and that a pacifier can be used when they are going to sleep...
May 2015: Acta Paediatrica
https://www.readbyqxmd.com/read/25609764/association-of-prone-position-with-sudden-unexpected-death-in-epilepsy
#9
REVIEW
Jennifer A Liebenthal, Shasha Wu, Sandra Rose, John S Ebersole, James X Tao
OBJECTIVE: To examine the association between prone position and sudden unexpected death in epilepsy (SUDEP). METHODS: We conducted a systematic review and meta-analysis based on a literature search from databases PubMed, Web of Science, and Scopus, using keywords "SUDEP" or "sudden unexpected death in epilepsy" or "sudden unexplained death syndromes in epilepsy." Twenty-five publications met the inclusion and exclusion criteria and were enrolled in this study. RESULTS: Body positions were documented in 253 cases of SUDEP...
February 17, 2015: Neurology
https://www.readbyqxmd.com/read/25596542/developmental-nicotine-exposure-adversely-effects-respiratory-patterning-in-the-barbiturate-anesthetized-neonatal-rat
#10
Santiago Barreda, Ian J Kidder, Jordan A Mudery, E Fiona Bailey
Neonates at risk for sudden infant death syndrome (SIDS) are hospitalized for cardiorespiratory monitoring however, monitoring is costly and generates large quantities of averaged data that serve as poor predictors of infant risk. In this study we used a traditional autocorrelation function (ACF) testing its suitability as a tool to detect subtle alterations in respiratory patterning in vivo. We applied the ACF to chest wall motion tracings obtained from rat pups in the period corresponding to the mid-to-end of the third trimester of human pregnancy...
March 2015: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/25556016/gestational-age-at-birth-affects-maturation-of-baroreflex-control
#11
Karinna L Fyfe, Stephanie R Yiallourou, Flora Y Wong, Alexsandria Odoi, Adrian M Walker, Rosemary S C Horne
OBJECTIVES: To assess the effect of prone sleeping, the major risk factor for sudden infant death syndrome, in the control of blood pressure (BP) in preterm infants born across a range of gestational ages. STUDY DESIGN: Daytime polysomnography was performed at 2-4 weeks, 2-3 months, and 5-6 months postterm age. The participants were 21 very preterm (mean gestation 29.4 ± 0.3 weeks), 14 preterm (mean gestation 33.1 ± 0.3 weeks), and 17 term (mean gestation 40.1 ± 0...
March 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/25504652/human-connexin43e42k-mutation-from-a-sudden-infant-death-victim-leads-to-impaired-ventricular-activation-and-neonatal-death-in-mice
#12
Indra Lübkemeier, Felicitas Bosen, Jung-Sun Kim, Philipp Sasse, Daniela Malan, Bernd K Fleischmann, Klaus Willecke
BACKGROUND: Sudden infant death syndrome (SIDS) describes the sudden, unexplained death of a baby during its first year of age and is the third leading cause of infant mortality. It is assumed that ≤20% of all SIDS cases are because of cardiac arrhythmias resulting from mutations in ion channel proteins. Besides ion channels also cardiac gap junction channels are important for proper conduction of cardiac electric activation. In the mammalian heart Connexin43 (Cx43) is the major gap junction protein expressed in ventricular cardiomyocytes...
February 2015: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/25441371/infectious-causes-of-sudden-infant-death-syndrome
#13
REVIEW
Mohammad Alfelali, Gulam Khandaker
Investigators have long suspected the role of infection in sudden infant death syndrome (SIDS). Evidence of infectious associations with SIDS is accentuated through the presence of markers of infection and inflammation on autopsy of SIDS infants and isolates of some bacteria and viruses. Several observational studies have looked into the relation between seasonality and incidence of SIDS, which often showed a winter peak. These all may suggest an infectious aetiology of SIDS. In this review we have summarised the current literature on infectious aetiologies of SIDS by looking at viral, bacterial, genetic and environmental factors which are believed to be associated with SIDS...
December 2014: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/25304427/neurochemical-abnormalities-in-the-brainstem-of-the-sudden-infant-death-syndrome-sids
#14
REVIEW
Rita Machaalani, Karen A Waters
The brainstem has been a focus in Sudden Infant Death Syndrome (SIDS) research for 30 years. Physiological and animal model data show that cardiorespiratory, sleep, and arousal mechanisms are abnormal after exposure to SIDS risk factors or in infants who subsequently die from SIDS. As the brainstem houses the regulatory centres for these functions, it is the most likely site to find abnormalities. True to this hypothesis, data derived over the last 30 years shows that the brainstem of infants who died from SIDS exhibits abnormalities in a number of major neurotransmitter and receptor systems including: catecholamines, neuropeptides, acetylcholinergic, indole amines (predominantly serotonin and its receptors), amino acids (predominantly glutamate), brain derived neurotrophic growth factor (BDNF), and some cytokines...
December 2014: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/24951305/gut-microbiome-in-sudden-infant-death-syndrome-sids-differs-from-that-in-healthy-comparison-babies-and-offers-an-explanation-for-the-risk-factor-of-prone-position
#15
Amanda R Highet, Anne M Berry, Karl A Bettelheim, Paul N Goldwater
The role of bacteria in the causation of sudden infant death syndrome (SIDS) is gaining acceptance. Mainstream research favouring respiratory compromise has failed to provide a plausible pathogenetic mechanism despite many years of investigation and thousands of research papers. Bacterial colonisation of the colon of the human infant is influenced by many factors including age, mode of delivery, diet, environment, and antibiotic exposure. The gut microbiome influences development of the immune system. The gut microflora could be important in protection against the bacteria and/or their toxins purportedly involved in SIDS pathogenesis...
July 2014: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/24596401/long-qt-molecular-autopsy-in-sudden-infant-death-syndrome
#16
Joanna Moira Glengarry, Jackie Crawford, Paul Lowell Morrow, Simon Robert Stables, Donald Roy Love, Jonathan Robert Skinner
OBJECTIVE: To describe experience of long QT (LQT) molecular autopsy in sudden infant death syndrome (SIDS). DESIGN: Descriptive audit from two distinct periods: (1) A prospective, population-based series between 2006 and 2008 ('unselected'). (2) Before and after 2006-2008, with testing guided by a cardiac genetic service ('selected'). LQT genes 1, 2, 3, 5, 6 and 7 were sequenced. Next of kin were offered cardiac evaluation. SETTING: New Zealand...
July 2014: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/23735486/the-physiological-determinants-of-sudden-infant-death-syndrome
#17
REVIEW
Alfredo J Garcia, Jenna E Koschnitzky, Jan-Marino Ramirez
It is well-established that environmental and biological risk factors contribute to Sudden Infant Death Syndrome (SIDS). There is also growing consensus that SIDS requires the intersection of multiple risk factors that result in the failure of an infant to overcome cardio-respiratory challenges. Thus, the critical next steps in understanding SIDS are to unravel the physiological determinants that actually cause the sudden death, to synthesize how these determinants are affected by the known risk factors, and to develop novel ideas for SIDS prevention...
November 1, 2013: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/23623143/postmortem-review-and-genetic-analysis-in-sudden-infant-death-syndrome-an-11-year-review
#18
Angharad Evans, Richard D Bagnall, Johan Duflou, Christopher Semsarian
Sudden infant death syndrome (SIDS) is the unexpected death of a child younger than 1 year that remains unexplained after thorough evaluation. The possibility of an underlying primary arrhythmogenic disorder has been proposed as a potential cause of SIDS. This study sought to review SIDS deaths and to perform genetic analysis in key genes that may contribute to sudden death. From 2000 to 2010, all postmortem records from the Department of Forensic Medicine in Sydney, Australia, were reviewed. Cases that gave the cause of death as "SIDS" or "undetermined" but consistent with SIDS were included...
September 2013: Human Pathology
https://www.readbyqxmd.com/read/23439895/maternal-alcohol-use-and-sudden-infant-death-syndrome-and-infant-mortality-excluding-sids
#19
RANDOMIZED CONTROLLED TRIAL
Colleen M O'Leary, Peter J Jacoby, Anne Bartu, Heather D'Antoine, Carol Bower
BACKGROUND: Improvements in the rate of infant mortality (death in first year of life) have not occurred in recent years. This study investigates the association between maternal alcohol-use disorder and sudden infant death syndrome (SIDS) and infant mortality not classified as SIDS using linked, population-based health and mortality data. METHODS: Exposed mothers were identified through the presence of an International Classification of Diseases 9/10 alcohol diagnosis, a proxy for alcohol-use disorder, recorded on health, mental health, and/or drug and alcohol datasets (1983-2005)...
March 2013: Pediatrics
https://www.readbyqxmd.com/read/23391042/monoamine-oxidase-a-gene-polymorphism-and-the-pathogenesis-of-sudden-infant-death-syndrome
#20
Cornelius Courts, Melanie Grabmüller, Burkhard Madea
OBJECTIVES: To test the hypothesis that there is a significant association between functionally relevant allelic variants of the monoamine oxidase A (MAO-A) polymorphism and sudden infant death syndrome (SIDS). STUDY DESIGN: In a case-control study of 142 cases of SIDS and 280 sex-matched control cases, the distribution of allelic and genotype variants of a promoter polymorphism of the MAO-A gene was examined using polymerase chain reaction locus amplification and fluorescence based fragment length analysis...
July 2013: Journal of Pediatrics
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