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Gastroenterology

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By Jeff Bank Internal Medicine R2 at the University of Utah
https://www.readbyqxmd.com/read/29981753/water-exchange-colonoscopy-increases-adenoma-detection-rate-a-systematic-review-with-network-meta-analysis-of-randomized-controlled-studies
#1
REVIEW
Lorenzo Fuccio, Leonardo Frazzoni, Cesare Hassan, Marina La Marca, Valentina Paci, Veronica Smania, Nicola De Bortoli, Franco Bazzoli, Alessandro Repici, Douglas Rex, Sergio Cadoni
BACKGROUND AND AIMS: Water-aided colonoscopy techniques (water immersion, WI; water exchange, WE) have shown different results regarding adenoma detection rate (ADR). We determined the impact of WI and WE on ADR and other procedural outcomes versus gas (air, AI; carbon dioxide, CO2 ) insufflation colonoscopy. METHODS: Systematic search of multiple databases for randomized controlled trials comparing WI and/or WE with AI and/or CO2 and reporting ADR. A network meta-analysis with mixed comparisons was performed...
July 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29990592/adding-value-to-the-conversation-about-colorectal-cancer-screening-practical-pearls-for-gastroenterologists
#2
Jennifer K Maratt, Keith Naylor, Sameer D Saini
No abstract text is available yet for this article.
July 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29981436/microscopic-colitis-a-rare-cause-of-pseudomembranes
#3
Robert J Schenck, Greg S Cohen, Maryam K Pezhouh
No abstract text is available yet for this article.
July 4, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29949497/prophylaxis-against-upper-gastrointestinal-bleeding-in-hospitalized-patients
#4
REVIEW
Deborah Cook, Gordon Guyatt
New England Journal of Medicine, Volume 378, Issue 26, Page 2506-2516, June 2018.
June 28, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29888239/medical-therapy-of-gastroesophageal-reflux-disease-beyond-proton-pump-inhibitors-where-are-we-heading
#5
REVIEW
Herbert Koop
Proton pump inhibitors (PPI) have greatly improved the treatment of gastroesophageal reflux disease. However, recent investigations have revealed that reflux symptoms persist in a substantial number of patients. Therefore, treatment strategies beyond PPI are urgently required. One such strategy may involve more reliable acid suppression, e.g., with new acid inhibitory drugs. Furthermore, the rapid appearance of an acidic compartment in the proximal stomach after a meal, which is largely responsible for postprandial heartburn, requires a specific kind of therapy in addition to PPI which still needs to be established...
April 2018: Visceral Medicine
https://www.readbyqxmd.com/read/29935326/effects-of-electronic-chromoendoscopy-on-detection-of-adenomas-during-colonoscopy
#6
Trilokesh D Kidambi, Jonathan P Terdiman, Najwa El-Nachef, Aparajita Singh, Michael G Kattah, Jeffrey K Lee
BACKGROUND & AIMS: I-scan is an electronic chromoendoscopy technology that improves resolution of epithelial and mucosal surfaces and vessels. We performed a randomized controlled trial to compare detection of adenomas by i-scan vs standard high-definition white-light (HDWL) colonoscopy. METHODS: From February 1 through December 31, 2017, 740 outpatients (50-75 years old) undergoing screening and surveillance for colorectal neoplasia were randomly assigned to groups that received colonoscopies with i-scan 1 (surface and contrast enhancement) or HDWL...
June 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29944926/effect-of-accelerated-infliximab-induction-on-short-and-long-term-outcomes-of-acute-severe-ulcerative-colitis-a-retrospective-multi-center-study-and-meta-analysis
#7
Niharika Nalagatla, Katherine Falloon, Gloria Tran, Nienke Z Borren, Danny Avalos, Jay Luther, Francis Colizzo, John Garber, Hamed Khalili, Joanna Melia, Matthew Bohm, Ashwin N Ananthakrishnan
BACKGROUND & AIMS: In patients with acute severe ulcerative colitis (ASUC), standard infliximab induction therapy has modest efficacy. There are limited data on the short-term or long-term efficacy of accelerated infliximab induction therapy for these patients. METHODS: In a retrospective study, we collected data from 213 patients with steroid refractory ASUC who received infliximab rescue therapy at 3 centers, from 2005 through 2017. Patients were classified that received standard therapy (5 mg/kg infliximab at weeks 0, 2, and 6) or accelerated therapy (>5 mg/kg infliximab at shorter intervals)...
June 23, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29935628/treatment-of-thrombocytopenic-patients-with-gi-bleeding
#8
EDITORIAL
Loren Laine
No abstract text is available yet for this article.
July 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29935143/a-randomized-controlled-trial-comparing-efficacy-of-early-video-capsule-endoscopy-with-standard-of-care-in-the-approach-to-non-hematemesis-gastrointestinal-bleeding-with-videos
#9
Neil B Marya, Salmaan Jawaid, Anne Foley, Samuel Han, Krunal Patel, Louise Maranda, Daniel Kaufman, Kanishka Bhattacharya, Christopher Marshall, Joseph Tennyson, David R Cave
OBJECTIVE: Patients presenting with non-hematemesis GI bleeding represent a diagnostic challenge for physicians. We performed a randomized controlled trial to assess the benefits of deployment of a video capsule soon after admission in the management of patients presenting with melena, hematochezia, or severe anemia compared with standard of care management. DESIGN: Patients admitted with non-hematemesis GI bleeding were randomized and placed into one of 2 study groups...
June 20, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29935329/incidence-and-prevalence-of-pediatric-eosinophilic-esophagitis-in-utah-based-on-a-5-year-population-based-study
#10
Jacob Robson, Molly O'Gorman, Amber McClain, Krishna Mutyala, Cassandra Davis, Carlos Barbagelata, Justin Wheeler, Rafael Firszt, Ken Smith, Raza Patel, Kathryn Peterson, Amy Lowichik, Stephen Guthery
BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is often detected in children and is considered to be a rare disease, with prevalence values reported to be below 60 cases per 100,000 persons. To determine whether the incidence of EoE in children in Utah exceeds estimates from regional reports, we calculated incidence and prevalence values over a 5-year period. METHODS: Using consensus guidelines for the diagnosis of EoE, we reviewed pathology records from in the Intermountain Healthcare pathology database, from July 1, 2011 through June 31, 2016...
June 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29867180/how-i-approach-it-improving-nutritional-status-in-patients-with-cirrhosis
#11
Jennifer C Lai, Puneeta Tandon
No abstract text is available yet for this article.
June 5, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29915405/wheat-intolerance-and-chronic-gastrointestinal-symptoms-in-an-australian-population-based-study-association-between-wheat-sensitivity-celiac-disease-and-functional-gastrointestinal-disorders
#12
Michael D E Potter, Marjorie M Walker, Michael P Jones, Natasha A Koloski, Simon Keely, Nicholas J Talley
OBJECTIVES: Wheat avoidance in the absence of celiac disease (CD) is common but occurrence of concurrent functional gastrointestinal disorders (FGIDs) in this group is uncertain. The aims of this study were to determine the prevalence of self-reported wheat or gluten sensitivity and doctor diagnosed CD in an Australian population, define the associated gastrointestinal (GI) symptoms and FGIDs, and determine the relationship between self-reported wheat sensitivity, demographic and medical factors...
June 19, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29904156/contrasting-effectiveness-and-cost-effectiveness-of-colorectal-cancer-screening-under-commercial-insurance-vs-medicare
#13
Uri Ladabaum, Ajitha Mannalithara, Joel V Brill, Zachary Levin, M Kate Bundorf
OBJECTIVES: Most cost-effectiveness analyses of colorectal cancer (CRC) screening assume Medicare payment rates and a lifetime horizon. Our aims were to examine the implications of differential payment levels and time horizons for commercial insurers vs. Medicare on the cost-effectiveness of CRC screening. METHODS: We used our validated Markov cohort simulation of CRC screening in the average risk US population to examine CRC screening at ages 50-64 under commercial insurance, and at ages 65-80 under Medicare, using a health-care sector perspective...
June 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29904158/association-between-ultra-processed-food-consumption-and-functional-gastrointestinal-disorders-results-from-the-french-nutrinet-sant%C3%A3-cohort
#14
Laure Schnabel, Camille Buscail, Jean-Marc Sabate, Michel Bouchoucha, Emmanuelle Kesse-Guyot, Benjamin Allès, Mathilde Touvier, Carlos A Monteiro, Serge Hercberg, Robert Benamouzig, Chantal Julia
OBJECTIVES: Ultra-processed foods (UPF) consumption has increased over the last decades and is raising concerns about potential adverse health effects. Our objective was to assess the association between UPF consumption and four functional gastrointestinal disorders (FGIDs): irritable bowel syndrome (IBS), functional constipation (FC), functional diarrhea (FDh), and functional dyspepsia (FDy), in a large sample of French adults. METHODS: We analyzed dietary data of 33,343 participants from the web-based NutriNet-Santé cohort, who completed at least three 24 h food records, prior to a Rome III self-administered questionnaire...
June 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29908362/magnetic-resonance-vs-transient-elastography-analysis-of-patients-with-non-alcoholic-fatty-liver-disease-a-systematic-review-and-pooled-analysis-of-individual-participants
#15
Cynthia Hsu, Cyrielle Caussy, Kento Imajo, Jun Chen, Siddharth Singh, Kellee Kaulback, Minh-Da Le, Jonathan Hooker, Xin Tu, Ricki Bettencourt, Meng Yin, Claude B Sirlin, Richard L Ehman, Atsushi Nakajima, Rohit Loomba
BACKGROUND & AIMS: Magnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques for detection of liver fibrosis. Single-center studies have compared the diagnostic performance of MRE vs TE in patients with nonalcoholic fatty liver disease (NAFLD). We conducted a pooled analysis of individual participant data from published studies to compare the diagnostic performance of MRE vs TE for staging of liver fibrosis in patients with NAFLD, using liver biopsy as reference...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908364/non-alcoholic-steatohepatitis-is-the-fastest-growing-cause-of-hepatocellular-carcinoma-in-liver-transplant-candidates
#16
Zobair Younossi, Maria Stepanova, Janus P Ong, Ira M Jacobson, Elisabetta Bugianesi, Ajay Duseja, Yuichiro Eguchi, Vincent W Wong, Francesco Negro, Yusuf Yilmaz, Manuel Romero-Gomez, Jacob George, Aijaz Ahmed, Robert Wong, Issah Younossi, Mariam Ziayee, Arian Afendy
BACKGROUND: While hepatitis B and C have been the main drivers of hepatocellular carcinoma (HCC), non-alcoholic steatohepatitis (NASH) has recently become an important cause of HCC. The aim of this study was to assess the causes of HCC among liver transplant (LT) candidates in the U.S. METHODS: The Scientific Registry of Transplant Recipients (2002-2016) was used to estimate the trends in prevalence of HCC in LT candidates with the most common types of chronic liver disease: alcoholic liver disease (ALD), chronic hepatitis B (CHB), chronic hepatitis C, and NASH...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908178/new-generation-full-spectrum-endoscopy-versus-standard-forward-viewing-colonoscopy-a-multicenter-randomized-tandem-colonoscopy-trial-j-fuse-study
#17
Toyoki Kudo, Yutaka Saito, Hiroaki Ikematsu, Kinichi Hotta, Yoji Takeuchi, Masaaki Shimatani, Ken Kawakami, Naoto Tamai, Yuichi Mori, Yasuharu Maeda, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Kenichiro Imai, Sayo Ito, Kenta Hamada, Norimasa Fukata, Takuya Inoue, Hisao Tajiri, Kenichi Yoshimura, Hideki Ishikawa, Shin-Ei Kudo
OBJECTIVES: Although colonoscopy is the criterion standard for detection of colorectal adenomas, some adenomas are missed. Full-spectrum endoscopy (FUSE) allows for observation with a 330° angle of view, which is expected to decrease the miss rate. However, no consensus has been reached regarding the superiority of FUSE over standard forward-viewing colonoscopy (SFVC) for detection of adenomas; we therefore compared new-generation FUSE and SFVC regarding colorectal adenoma miss rate (AMR) in this, the first reported randomized control trial using new-generation FUSE...
June 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29880972/the-impact-of-albumin-use-on-resolution-of-hyponatremia-in-hospitalized-patients-with-cirrhosis
#18
Jasmohan S Bajaj, Puneeta Tandon, Jacqueline G O'Leary, Scott W Biggins, Florence Wong, Patrick S Kamath, Guadalupe Garcia-Tsao, Benedict Maliakkal, Jennifer C Lai, Michael Fallon, Paul Thuluvath, Hugo E Vargas, Ram M Subramanian, Leroy R Thacker, K Rajender Reddy
OBJECTIVES: Hyponatremia is associated with poor outcomes in cirrhosis independent of MELD. While intravenous albumin has been used in small series, its role in hyponatremia is unclear. The aim of this study is to determine the effect of albumin therapy on hyponatremia. METHODS: Hospitalized cirrhotic patients included in the NACSELD (North American Consortium for End-Stage Liver Disease) cohort with hyponatremia (Na <130mmol/L) were divided into those receiving intravenous albumin or not...
June 8, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29736167/mechanisms-and-management-of-acute-pancreatitis
#19
REVIEW
Ari Garber, Catherine Frakes, Zubin Arora, Prabhleen Chahal
Acute pancreatitis represents a disorder characterized by acute necroinflammatory changes of the pancreas and is histologically characterized by acinar cell destruction. Diagnosed clinically with the Revised Atlanta Criteria, and with alcohol and cholelithiasis/choledocholithiasis as the two most prominent antecedents, acute pancreatitis ranks first amongst gastrointestinal diagnoses requiring admission and 21st amongst all diagnoses requiring hospitalization with estimated costs approximating 2.6 billion dollars annually...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29859984/cirrhotic-patients-require-more-fecal-microbiota-capsules-to-cure-refractory-and-recurrent-clostridium-difficile-infection
#20
Patricia L Pringle, Mariam Torres Soto, Raymond T Chung, Elizabeth Hohmann
No abstract text is available yet for this article.
May 31, 2018: Clinical Gastroenterology and Hepatology
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