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Clinical blood levels

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2 papers 0 to 25 followers
Le-Ben Wan, Cara F Levitch, Andrew M Perez, Jess W Brallier, Dan V Iosifescu, Lee C Chang, Alexandra Foulkes, Sanjay J Mathew, Dennis S Charney, James W Murrough
OBJECTIVE: Ketamine has demonstrated rapid antidepressant effects in patients with treatment-resistant depression (TRD); however, the safety and tolerability of ketamine in this population have not been fully described. Herein we report the largest study to date of the safety, tolerability, and acceptability of ketamine in TRD. METHOD: Data from 205 intravenous (IV) ketamine infusions (0.5 mg/kg over 40 minutes) in 97 participants with DSM-IV-defined major depressive disorder (MDD) were pooled from 3 clinical trials conducted between 2006 and 2012 at 2 academic medical centers...
March 2015: Journal of Clinical Psychiatry
Viktor Voros, Peter Osvath, Sandor Fekete, Tamas Tenyi
Introduction. Elevated serum CK levels often occur in psychiatric in-patient practice. Although the majority of cases are benign and temporary, it is important to recognize and treat these conditions. Aims. To discuss the etiology, the clinical significance and the management of elevated creatine kinase levels in psychiatric in-patient practice, focusing on antipsychotic-induced rhabdomyolysis. To compare the pathogenesis and the clinical features of rhabdomyolysis and neuroleptic malignant syndrome. Methods...
2008: International Journal of Psychiatry in Clinical Practice
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