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VEGF

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3 papers 0 to 25 followers
By Xx Liu
https://www.readbyqxmd.com/read/25417109/neurons-limit-angiogenesis-by-titrating-vegf-in-retina
#1
Keisuke Okabe, Sakiko Kobayashi, Toru Yamada, Toshihide Kurihara, Ikue Tai-Nagara, Takeshi Miyamoto, Yoh-suke Mukouyama, Thomas N Sato, Toshio Suda, Masatsugu Ema, Yoshiaki Kubota
Vascular and nervous systems, two major networks in mammalian bodies, show a high degree of anatomical parallelism and functional crosstalk. During development, neurons guide and attract blood vessels, and consequently this parallelism is established. Here, we identified a noncanonical neurovascular interaction in eye development and disease. VEGFR2, a critical endothelial receptor for VEGF, was more abundantly expressed in retinal neurons than in endothelial cells, including endothelial tip cells. Genetic deletion of VEGFR2 in neurons caused misdirected angiogenesis toward neurons, resulting in abnormally increased vascular density around neurons...
October 23, 2014: Cell
https://www.readbyqxmd.com/read/24332926/extracellular-regulation-of-vegf-isoforms-proteolysis-and-vascular-patterning
#2
REVIEW
Prakash Vempati, Aleksander S Popel, Feilim Mac Gabhann
The regulation of vascular endothelial growth factor A (VEGF) is critical to neovascularization in numerous tissues under physiological and pathological conditions. VEGF has multiple isoforms, created by alternative splicing or proteolytic cleavage, and characterized by different receptor-binding and matrix-binding properties. These isoforms are known to give rise to a spectrum of angiogenesis patterns marked by differences in branching, which has functional implications for tissues. In this review, we detail the extensive extracellular regulation of VEGF and the ability of VEGF to dictate the vascular phenotype...
February 2014: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/20811158/retinopathy-of-prematurity-understanding-ischemic-retinal-vasculopathies-at-an-extreme-of-life
#3
REVIEW
Przemyslaw Sapieha, Jean-Sebastien Joyal, José Carlos Rivera, Elsa Kermorvant-Duchemin, Florian Sennlaub, Pierre Hardy, Pierre Lachapelle, Sylvain Chemtob
Retinopathy of prematurity (ROP) is a major complication of preterm birth. It encompasses a spectrum of pathologies that affect vision, from mild disease that resolves spontaneously to severe disease that causes retinal detachment and subsequent blindness. The pathologies are characterized by an arrest in normal retinal vascular development associated with microvascular degeneration. The resulting ischemia and retinal hypoxia lead to excessive abnormal compensatory blood vessel growth. However, this neovascularization can lead to fibrous scar formation and culminate in retinal detachment...
September 2010: Journal of Clinical Investigation
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