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Mild cognitive impairment

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3 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26027811/mild-cognitive-impairment-at-the-crossroad-of-neurodegeneration-and-vascular-dysfunction
#1
REVIEW
Satoshi Saito, Yumi Yamamoto, Masafumi Ihara
The concept of mild cognitive impairment (MCI) was first introduced for the purpose of identifying individuals in an intermediate state between no cognitive impairment and Alzheimer's disease (AD). Recently, the heterogeneity of MCI has attracted attention as it has become clear that other diseases, such as cerebrovascular disease and Parkinson disease can also cause mild cognitive deficits, prompting a redefinition of MCI. Heterogeneity of MCI has been confirmed by neuropathological examinations. Most MCI patients not only possess amyloid plaques and neurofibrillary tau tangles, but also cerebral vascular pathology such as arteriosclerosis and cerebral amyloid angiopathy (CAA)...
2015: Current Alzheimer Research
https://www.readbyqxmd.com/read/26079417/the-effect-of-white-matter-hyperintensities-on-neurodegeneration-in-mild-cognitive-impairment
#2
Giuseppe Tosto, Molly E Zimmerman, Jamie L Hamilton, Owen T Carmichael, Adam M Brickman
INTRODUCTION: It is unclear whether white matter hyperintensities (WMHs), magnetic resonance imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and associated clinical decline in Alzheimer's disease (AD), or simply co-occur with recognized pathogenic processes. METHODS: In 169 patients with mild cognitive impairment, followed for 3 years, we examined the association of (1) baseline regional WMH and cerebral spinal fluid-derived t-tau (total tau) with entorhinal cortex atrophy rates, as a marker of AD-related neurodegeneration, and conversion to AD; and (2) baseline regional WMH with change in t-tau level...
December 2015: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/25514304/the-diagnosis-and-management-of-mild-cognitive-impairment-a-clinical-review
#3
REVIEW
Kenneth M Langa, Deborah A Levine
IMPORTANCE: Cognitive decline is a common and feared aspect of aging. Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage on the continuum of cognitive decline, characterized by objective impairment in cognition that is not severe enough to require help with usual activities of daily living. OBJECTIVE: To present evidence on the diagnosis, treatment, and prognosis of MCI and to provide physicians with an evidence-based framework for caring for older patients with MCI and their caregivers...
December 17, 2014: JAMA: the Journal of the American Medical Association
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