collection
https://read.qxmd.com/read/27811940/the-endocrine-manifestations-of-anorexia-nervosa-mechanisms-and-management
#1
REVIEW
Melanie Schorr, Karen K Miller
Anorexia nervosa is a psychiatric disorder characterized by altered body image, persistent food restriction and low body weight, and is associated with global endocrine dysregulation in both adolescent girls and women. Dysfunction of the hypothalamic-pituitary axis includes hypogonadotropic hypogonadism with relative oestrogen and androgen deficiency, growth hormone resistance, hypercortisolaemia, non-thyroidal illness syndrome, hyponatraemia and hypooxytocinaemia. Serum levels of leptin, an anorexigenic adipokine, are suppressed and levels of ghrelin, an orexigenic gut peptide, are elevated in women with anorexia nervosa; however, levels of peptide YY, an anorexigenic gut peptide, are paradoxically elevated...
March 2017: Nature Reviews. Endocrinology
https://read.qxmd.com/read/27222139/hormonal-factors-and-disturbances-in-eating-disorders
#2
REVIEW
Kristen M Culbert, Sarah E Racine, Kelly L Klump
This review summarizes the current state of the literature regarding hormonal correlates of, and etiologic influences on, eating pathology. Several hormones (e.g., ghrelin, CCK, GLP-1, PYY, leptin, oxytocin, cortisol) are disrupted during the ill state of eating disorders and likely contribute to the maintenance of core symptoms (e.g., dietary restriction, binge eating) and/or co-occurring features (e.g., mood symptoms, attentional biases). Some of these hormones (e.g., ghrelin, cortisol) may also be related to eating pathology via links with psychological stress...
July 2016: Current Psychiatry Reports
https://read.qxmd.com/read/25773226/application-of-the-research-domain-criteria-rdoc-framework-to-eating-disorders-emerging-concepts-and-research
#3
REVIEW
Jennifer E Wildes, Marsha D Marcus
The Research Domain Criteria (RDoC) project was initiated by the National Institute of Mental Health as a heuristic for addressing the limitations of categorical, symptom-based psychiatric diagnoses. RDoC is conceptualized as a matrix, with the rows representing dimensional constructs or domains implicated in the expression of psychiatric symptoms and the columns representing units of analysis that can be used to assess dimensional constructs (i.e., genes, molecules, cells, circuits, physiology, behavior, and self-reports)...
May 2015: Current Psychiatry Reports
https://read.qxmd.com/read/25745131/classification-of-eating-disorders-comparison-of-relative-prevalence-rates-using-dsm-iv-and-dsm-5-criteria
#4
COMPARATIVE STUDY
Serafino G Mancuso, J Richard Newton, Peter Bosanac, Susan L Rossell, Julian B Nesci, David J Castle
DSM-5 contains substantial changes to eating disorder diagnoses. We examined relative prevalence rates of DSM-IV and DSM-5 eating disorder diagnoses using Eating Disorder Examination-Questionnaire diagnostic algorithms in 117 community out-patients. DSM-5 criteria produced a reduction in combined 'other specified feeding or eating disorder' and 'unspecified feeding or eating disorder' from 46% to 29%, an increase in anorexia nervosa diagnoses from 35% to 47%, the same number of bulimia nervosa diagnoses and a 5% rate of binge eating disorder diagnoses...
June 2015: British Journal of Psychiatry
https://read.qxmd.com/read/25223374/the-neurobiology-of-eating-disorders-a-clinical-perspective
#5
REVIEW
Y von Hausswolff-Juhlin, S J Brooks, M Larsson
OBJECTIVE: To provide a neurobiological basis of eating disorders for clinicians and to enlighten how comparing neurobiology and eating disorders with neurobiology of other psychiatric illnesses can improve treatment protocols. METHOD: A selective review on the neurobiology of eating disorders. The article focuses on clinical research on humans with consideration of the anatomical, neural, and molecular basis of eating disorders. RESULTS: The neurobiology of people with eating disorders is altered...
April 2015: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/24194589/the-neurobiology-of-anorexia-nervosa-a-systematic-review
#6
REVIEW
Andrea Phillipou, Susan Lee Rossell, David Jonathan Castle
OBJECTIVE: Recent advances in neuroimaging techniques have enabled a better understanding of the neurobiological underpinnings of anorexia nervosa (AN). The aim of this paper was to summarise our current understanding of the neurobiology of AN. METHODS: The literature was searched using the electronic databases PubMed and Google Scholar, and by additional hand searches through reference lists and specialist eating disorders journals. Relevant studies were included if they were written in English, only used human participants, had a specific AN group, used clinical populations of AN, group comparisons were reported for AN compared to healthy controls and not merely AN compared to other eating disorders or other psychiatric groups, and were not case studies...
February 2014: Australian and New Zealand Journal of Psychiatry
https://read.qxmd.com/read/23333342/nothing-tastes-as-good-as-skinny-feels-the-neurobiology-of-anorexia-nervosa
#7
REVIEW
Walter H Kaye, Christina E Wierenga, Ursula F Bailer, Alan N Simmons, Amanda Bischoff-Grethe
Individuals with anorexia nervosa (AN) engage in relentless restrictive eating and often become severely emaciated. Because there are no proven treatments, AN has high rates of relapse, chronicity, and death. Those with AN tend to have childhood temperament and personality traits, such as anxiety, obsessions, and perfectionism, which may reflect neurobiological risk factors for developing AN. Restricted eating may be a means of reducing negative mood caused by skewed interactions between serotonin aversive or inhibitory and dopamine reward systems...
February 2013: Trends in Neurosciences
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