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antibiotics and septic shock brilliant review 2015

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1 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/25643278/optimizing-antimicrobial-therapy-of-sepsis-and-septic-shock-focus-on-antibiotic-combination-therapy
#1
REVIEW
Gloria Vazquez-Grande, Anand Kumar
There has been little improvement in septic shock mortality in the past 70 years, despite ever more broad-spectrum and potent antimicrobials. In the past, resuscitative elements have been the primary area of clinical septic shock management and research. The question of the optimal use of antimicrobial therapy was relatively ignored in recent decades. This review explores the pathophysiology of sepsis in an attempt to produce a better understanding and define key determinants of antimicrobial therapy response in septic shock...
February 2015: Seminars in Respiratory and Critical Care Medicine
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