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Geriatric Psychiatry

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4 papers 0 to 25 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
https://www.readbyqxmd.com/read/26288246/antidepressant-response-trajectories-and-associated-clinical-prognostic-factors-among-older-adults
#1
Stephen F Smagula, Meryl A Butters, Stewart J Anderson, Eric J Lenze, Mary Amanda Dew, Benoit H Mulsant, Francis E Lotrich, Howard Aizenstein, Charles F Reynolds
IMPORTANCE: More than 50% of older adults with late-life major depressive disorder fail to respond to initial treatment with first-line pharmacological therapy. OBJECTIVES: To assess typical patterns of response to an open-label trial of extended-release venlafaxine hydrochloride (venlafaxine XR) for late-life depression and to evaluate which clinical factors are associated with the identified longitudinal response patterns. DESIGN, SETTING, AND PARTICIPANTS: Group-based trajectory modeling was applied to data from a 12-week open-label pharmacological trial conducted in specialty care as part of the Incomplete Response in Late Life: Getting to Remission Study...
October 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/25873038/decision-making-in-the-ageing-brain-changes-in-affective-and-motivational-circuits
#2
REVIEW
Gregory R Samanez-Larkin, Brian Knutson
As the global population ages, older decision makers will be required to take greater responsibility for their own physical, psychological and financial well-being. With this in mind, researchers have begun to examine the effects of ageing on decision making and associated neural circuits. A new 'affect-integration-motivation' (AIM) framework may help to clarify how affective and motivational circuits support decision making. Recent research has shed light on whether and how ageing influences these circuits, providing an interdisciplinary account of how ageing can alter decision making...
May 2015: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/25734354/cerebral-small-vessel-disease-and-association-with-higher-incidence-of-depressive-symptoms-in-a-general-elderly-population-the-ages-reykjavik-study
#3
Thomas T van Sloten, Sigurdur Sigurdsson, Mark A van Buchem, Caroline L Phillips, Palmi V Jonsson, Jie Ding, Miranda T Schram, Tamara B Harris, Vilmundur Gudnason, Lenore J Launer
OBJECTIVE: The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and depressive symptoms are scarce. The authors investigated the association between CSVD and incident depressive symptoms. METHOD: Longitudinal data were taken from the Age, Gene/Environment Susceptibility-Reykjavik Study of 1,949 participants free of dementia and without baseline depressive symptoms (mean age: 74...
June 2015: American Journal of Psychiatry
https://www.readbyqxmd.com/read/25677354/citalopram-methylphenidate-or-their-combination-in-geriatric-depression-a-randomized-double-blind-placebo-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Helen Lavretsky, Michelle Reinlieb, Natalie St Cyr, Prabha Siddarth, Linda M Ercoli, Damla Senturk
OBJECTIVE: The authors evaluated the potential of methylphenidate to improve antidepressant response to citalopram, as assessed by clinical and cognitive outcomes, in elderly depressed patients. METHOD: The authors conducted a 16-week randomized double-blind placebo-controlled trial for geriatric depression in 143 older outpatients diagnosed with major depression comparing treatment response in three treatment groups: methylphenidate plus placebo (N=48), citalopram plus placebo (N=48), and citalopram plus methylphenidate (N=47)...
June 2015: American Journal of Psychiatry
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